Abstract：
:New generation antipsychotic (NGA) drugs introduced to the US market after clozapine (aripiprazole, olanzapine, paliperidone, quetiapine, risperidone, and ziprasidone) are frequently used in individuals with intellectual disabilities (ID). However, there is very limited research to fully establish evidence-based or personalized medicine approaches for their use in this population. These guidelines take a pragmatic approach to establishing frameworks for their use by utilizing the prescribing information and reviewing the available literature on other relevant neuropsychiatric disorders. In the absence of expert consensus guidance and well-controlled comparison trials, we present a set of guidelines to inform initiation, dosing and monitoring of use in adults. Further, in these guidelines we provide practical information on drug-drug interactions and adverse drug reactions, and a brief review of discontinuation syndromes, potential for abuse, use during pregnancy and cost considerations. We also provide drug utilization review forms for each NGA to facilitate implementation of these guidelines, these guidelines provide a practical and necessary resource for practitioners treating psychiatric disorders and challenging behaviors in adult individuals with ID.
journal_name
Res Dev Disabiljournal_title
Research in developmental disabilitiesauthors
de Leon J,Greenlee B,Barber J,Sabaawi M,Singh NNdoi
10.1016/j.ridd.2008.10.010subject
Has Abstractpub_date
2009-07-01 00:00:00pages
613-69issue
4eissn
0891-4222issn
1873-3379pii
S0891-4222(08)00124-8journal_volume
30pub_type
杂志文章,评审abstract：:We compared the effectiveness of a problem-solving and an external control intervention to teach social skills to five adults with mild intellectual disabilities. The social skills of "responding to corrective feedback" and "managing conflict" were targeted for intervention. Each participant received the problem-solvi...
journal_title：Research in developmental disabilities
pub_type： 临床试验,杂志文章
doi：10.1016/j.ridd.2003.07.003
更新日期：2004-09-01 00:00:00
abstract：:This study aimed to objectively compare the daily physical activity (PA), as indicated by moderate-to-vigorous physical activity (MVPA) during a week and metabolic equivalents (METs) per minute, between children with attention deficit hyperactivity disorder (ADHD) and typically developing children. Moreover, sensory m...
journal_title：Research in developmental disabilities
pub_type： 杂志文章
doi：10.1016/j.ridd.2013.07.021
更新日期：2013-10-01 00:00:00
abstract：:The Aberrant Behavior Checklist-Community (ABC-C; Aman et al., 1995) has been increasingly adopted as a primary tool for measuring behavioral change in clinical trials for individuals with fragile X syndrome (FXS). To our knowledge, however, no study has documented the longitudinal trajectory of aberrant behaviors in ...
journal_title：Research in developmental disabilities
pub_type： 杂志文章
doi：10.1016/j.ridd.2014.07.003
更新日期：2014-11-01 00:00:00
abstract：:This study examined whether the number of psychotropic medications an individual is taking across classes influences side effects among adults with Intellectual Disability (ID). Participants were 80 adults diagnosed with ID. Dependent variables were the composite score and domain scores of the Matson Evaluation of Dru...
journal_title：Research in developmental disabilities
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ridd.2010.05.006
更新日期：2010-11-01 00:00:00
abstract：:This study assessed the possibility of training three people with cognitive impairments using an augmented reality (AR)-based task prompting system. Using AR technology, the system provided picture cues, identified incorrect task steps on the fly, and helped users make corrections. Based on a multiple baseline design,...
journal_title：Research in developmental disabilities
pub_type： 临床试验,杂志文章
doi：10.1016/j.ridd.2013.06.026
更新日期：2013-10-01 00:00:00
abstract：:The relation between psychiatric symptoms and different types of challenging behaviour in adults with mental retardation was investigated, using an instrument designed for use by non-specialist informants. A sample of 165 persons with mental retardation was surveyed for the presence of psychiatric symptoms, level of m...
journal_title：Research in developmental disabilities
pub_type： 杂志文章
doi：10.1016/s0891-4222(03)00060-x
更新日期：2003-09-01 00:00:00
abstract：:This study assessed whether three patients with Alzheimer's disease could learn to use urine alarms and caregivers' prompts to eliminate large urinary accidents. As soon as the patient began to release urine, the alarm system presented auditory and vibratory signals. In relation to those signals, the caregiver would p...
journal_title：Research in developmental disabilities
pub_type： 临床试验,杂志文章
doi：10.1016/j.ridd.2011.04.011
更新日期：2011-09-01 00:00:00
abstract：BACKGROUND:The presence of child disabilities might affect the amount of caregiving attention the child receives, with potential ramifications on the development of the child and increasing the likelihood of developing a more severe condition. Little is known about the association between child disabilities and caregiv...
journal_title：Research in developmental disabilities
pub_type： 杂志文章
doi：10.1016/j.ridd.2020.103795
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Previous studies have shown that children with developmental coordination disorder (DCD) have a higher body fat and greater gait variability. Little research has investigated the gait muscle activity and lean mass measures in children with DCD. AIMS:To compare the leg muscle activation patterns of the gait ...
journal_title：Research in developmental disabilities
pub_type： 杂志文章
doi：10.1016/j.ridd.2017.12.014
更新日期：2018-02-01 00:00:00
abstract：:The purpose of the present research project was to examine change in interactive behaviors between staff and residents of facilities that serve individuals with mental retardation. Twelve staff members were trained using an adapted component of the Nursing Child Assessment Satellite Training model, the Mental Retardat...
journal_title：Research in developmental disabilities
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0891-4222(96)00022-4
更新日期：1996-09-01 00:00:00
abstract：:Children with Down syndrome (DS) display less stable and coordinated gait patterns in the time domain than their healthy peers. However, little is known about whether this group difference exists in the frequency domain. The purpose of this study was to investigate differences in vertical ground reaction force (GRF) i...
journal_title：Research in developmental disabilities
pub_type： 杂志文章
doi：10.1016/j.ridd.2014.03.019
更新日期：2014-06-01 00:00:00
abstract：:This study examined the frequency with which behavioral interventions reported in the research literature were being incorporated into residential treatment programs addressing identical skill deficits. A sample of 113 research articles involving 299 subjects and a corresponding sample of 299 adaptive skill programs i...
journal_title：Research in developmental disabilities
pub_type： 杂志文章
doi：10.1016/0891-4222(94)00031-4
更新日期：1995-01-01 00:00:00
abstract：:To determine the accuracy of the published percentage body fat (%BF) prediction equations (Durnin et al., Johnston et al., Brook and Slaughter et al.) from skinfold thickness compared to air displacement plethysmography (ADP) in children and adolescents with Down syndrome (DS). Twenty-eight children and adolescents wi...
journal_title：Research in developmental disabilities
pub_type： 临床试验,杂志文章
doi：10.1016/j.ridd.2011.03.006
更新日期：2011-09-01 00:00:00
abstract：:This study assessed the prevalence and type of associated neuropsychiatric problems in children and adults with 22q11 deletion syndrome. One-hundred consecutively referred individuals with 22q11 deletion syndrome were given in-depth neuropsychiatric assessments and questionnaires screens. Autism spectrum disorders (AS...
journal_title：Research in developmental disabilities
pub_type： 杂志文章
doi：10.1016/j.ridd.2008.10.007
更新日期：2009-07-01 00:00:00
abstract：:Reliability and concurrent validity of the Behavior Problems Inventory (BPI-01; Rojahn et al., 2001) was examined in a sample of 130 community residing adults with mild to profound intellectual disabilities with high rates of behavior problems and concurrent mental health problems. The BPI-01 and the Inventory for Cli...
journal_title：Research in developmental disabilities
pub_type： 杂志文章
doi：10.1016/j.ridd.2009.08.004
更新日期：2010-01-01 00:00:00
abstract：:The cognitive profile of individuals with Down syndrome (DS) is known to be characterized by an impaired executive functioning, but inhibition-related processes have not been extensively examined in this setting. The aim of the present study was to investigate whether individuals with DS have any specific or general d...
journal_title：Research in developmental disabilities
pub_type： 杂志文章
doi：10.1016/j.ridd.2012.07.017
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:In general, there is extensive research on parents of young children with ID, particularly studies on stress and coping, social support as associated with quality of life. Unfortunately, there is scarce evidence -based knowledge on parental coping resources and well-being during the transition of their offsp...
journal_title：Research in developmental disabilities
pub_type： 杂志文章
doi：10.1016/j.ridd.2020.103740
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:Although adults are known to have sensory sensitivity differences, existing sensitivity scales have been mostly developed for children. The limited number of adult scales measure social/emotional features and modalities together. AIMS:To develop scales for adults that evaluate visual, auditory and somatosen...
journal_title：Research in developmental disabilities
pub_type： 杂志文章
doi：10.1016/j.ridd.2020.103612
更新日期：2020-05-01 00:00:00
abstract：:A multiple baseline across tasks design was used to evaluate the production effects of video self-modeling on three activities of daily living tasks of an adult male with Autism Spectrum Disorder and Intellectual Disability. Results indicated large increases in task accuracy after the production of a self-modeling vid...
journal_title：Research in developmental disabilities
pub_type： 杂志文章
doi：10.1016/j.ridd.2017.09.012
更新日期：2017-12-01 00:00:00
abstract：:We investigated the effects of response effort on the use of mands during functional communication training (FCT) in a participant with autism. The number of links in a picture exchange response chain determined two levels of response effort. Each level was paired with a fixed ratio (FR3) schedule of reinforcement for...
journal_title：Research in developmental disabilities
pub_type： 临床试验,杂志文章
doi：10.1016/j.ridd.2004.07.004
更新日期：2005-01-01 00:00:00
abstract：:Three experiments were conducted to evaluate the effects of a training program implemented in a community setting for teaching receptive language skills to profoundly mentally retarded persons. In Experiment 1, the program was implemented in a local department store and consisted of a least-to-most intrusive prompting...
journal_title：Research in developmental disabilities
pub_type： 杂志文章
doi：10.1016/0891-4222(88)90016-9
更新日期：1988-01-01 00:00:00
abstract：:Prior studies evaluating the response of developmentally disabled persons to relaxation training procedures are largely limited to case study reports. Most often relaxation training procedures are vaguely described in these studies, and limited outcome measures are employed. In the present comparative group outcome st...
journal_title：Research in developmental disabilities
pub_type： 杂志文章
doi：10.1016/0891-4222(87)90040-0
更新日期：1987-01-01 00:00:00
abstract：BACKGROUND:People with intellectual and developmental disabilities (IDD) are at risk of developing long term health conditions, and a preventative health agenda research is emerging. However, little is known about the recruitment settings, delivery contexts, intervention techniques and outcomes of health promotion prog...
journal_title：Research in developmental disabilities
pub_type： 杂志文章
doi：10.1016/j.ridd.2020.103592
更新日期：2020-02-05 00:00:00
abstract：:Sleep EEG alterations are emerging features of several developmental disabilities, but detailed quantitative EEG data on the sleep phenotype of patients with Williams syndrome (WS, 7q11.23 microdeletion) is still lacking. Based on laboratory (Study I) and home sleep records (Study II) here we report WS-related feature...
journal_title：Research in developmental disabilities
pub_type： 杂志文章
doi：10.1016/j.ridd.2011.09.004
更新日期：2012-01-01 00:00:00
abstract：:The purpose of this study was to examine the unique contributions of (social) cognitive skills such as inhibition, working memory, perspective taking, facial emotion recognition, and interpretation of situations to the variance in social information processing in children with mild to borderline intellectual disabilit...
journal_title：Research in developmental disabilities
pub_type： 杂志文章
doi：10.1016/j.ridd.2011.09.025
更新日期：2012-03-01 00:00:00
abstract：BACKGROUND:Motor development research has seen substantial recent growth. However, much remains to be understood about the nature and extent of motor impairments in neurodevelopmental disorders, including their potential as early markers and/or causal determinants of downstream functioning in other domains. AIMS AND M...
journal_title：Research in developmental disabilities
pub_type： 杂志文章
doi：10.1016/j.ridd.2020.103739
更新日期：2020-10-01 00:00:00
abstract：:Individuals with the neurodevelopmental disorder Williams syndrome (WS) often report difficulty processing and acting in depth, such as crossing roads or reaching for objects; however little research attention has been directed at understanding depth perception and action in depth in WS and whether deficits in depth p...
journal_title：Research in developmental disabilities
pub_type： 杂志文章
doi：10.1016/j.ridd.2014.04.013
更新日期：2014-08-01 00:00:00
abstract：:This meta-analysis examined the effect of behavioral parent training on child and parental outcomes for children with attention deficit hyperactivity disorder. Meta-analytic procedures were used to estimate the effect of behavioral parent training on children with attention deficit hyperactivity disorder. Variables mo...
journal_title：Research in developmental disabilities
pub_type： 杂志文章,meta分析
doi：10.1016/j.ridd.2012.05.011
更新日期：2012-11-01 00:00:00
abstract：:Intellectual disability is associated with an increased risk of behavioral disturbances and also complicates their treatment. Despite increases in the sophistication of medical detection of early risk for intellectual disability, there is remarkably little data about the detection of intellectual disability in cases r...
journal_title：Research in developmental disabilities
pub_type： 杂志文章
doi：10.1016/j.ridd.2014.03.012
更新日期：2014-07-01 00:00:00
abstract：:Aggression can present as a significant problem behavior in individuals with a diagnosis of developmental disability. Much research has focused on the prevalence of aggression in individuals with varying degrees of severity of intellectual disability (AD), autism spectrum disorders (ASD) and co-morbidity of ID and ASD...
journal_title：Research in developmental disabilities
pub_type： 杂志文章,评审
doi：10.1016/j.ridd.2010.12.023
更新日期：2011-03-01 00:00:00
