Inhibitory mechanisms in Down syndrome: is there a specific or general deficit?

Abstract:

:The cognitive profile of individuals with Down syndrome (DS) is known to be characterized by an impaired executive functioning, but inhibition-related processes have not been extensively examined in this setting. The aim of the present study was to investigate whether individuals with DS have any specific or general deficit in inhibitory processes. Tasks measuring prepotent response inhibition (the animal Stroop test), proactive interference (proactive interference task and intrusion errors), and response to distracters (directed forgetting task) were administered together with a working memory test to 19 individuals with DS and 19 typically developing (TD) children matched for mental age. Confirming previous findings, our results showed that the DS group performed less well in a verbal working memory task than the TD children. Analyzing our findings for the three inhibitory tasks yielded a picture of the DS children having a generalized difficulty in suppressing information that is irrelevant, or no longer relevant, to the goals of the task. These results suggest that DS is related not to specific, but rather to generalized inhibitory difficulties.

journal_name

Res Dev Disabil

authors

Borella E,Carretti B,Lanfranchi S

doi

10.1016/j.ridd.2012.07.017

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

65-71

issue

1

eissn

0891-4222

issn

1873-3379

pii

S0891-4222(12)00184-9

journal_volume

34

pub_type

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