Maternal glucose levels after dexamethasone for fetal lung development in twin vs singleton pregnancies.

Abstract:

OBJECTIVE:Betamethasone administration in singleton pregnancies causes maternal hyperglycemia. With the increased risk of glucose intolerance in twin pregnancies, we sought to determine whether maternal hyperglycemia after dexamethasone administration is different in twin vs singleton pregnancies. STUDY DESIGN:Patients with singleton or twin pregnancies admitted between 24 and 34 weeks' gestation with diagnoses requiring steroid administration were approached. Exclusion criteria included diabetes, abnormal glucose tolerance test, infection, or medications known to interfere with glucose metabolism. Patients were NPO for 24 hours and received dexamethasone per protocol. Maternal glucose levels were checked at baseline and then at specified intervals after the initial dose; appropriate statistical analysis was performed. RESULTS:Ten singleton and 9 twin gestations were enrolled. There were no differences in mean maternal or gestational ages. Mean glucose levels were significantly higher in the twin group at 4 hours (114 mg/dL vs 95.6 mg/dL), 8 hours (121.4 mg/dL vs 90.9 mg/dL), and 24 hours (116 mg/dL vs 81 mg/dL) (P < .01 for all). CONCLUSION:Twin pregnancies had higher mean glucose values than singleton pregnancies in the first 24 hours after dexamethasone administration.

journal_name

Am J Obstet Gynecol

authors

Foglia LM,Deering SH,Lim E,Landy H

doi

10.1016/j.ajog.2008.08.004

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

380.e1-4

issue

4

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(08)00912-5

journal_volume

199

pub_type

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