Abstract:
:Dermatophyte infections, while not life-threatening, are very common, and there is great interest in developing new antifungal agents. Transcriptional profiling of Trichophyton on keratin has identified some antioxidant genes as induced on this host substrate, including a thioredoxin gene TmTRX1. If thioredoxin is a virulence factor, or necessary for the growth on keratin, thioredoxin inhibitors should act as antifungals. As a first evaluation of this hypothesis, we have tested the activity of a thioredoxin-inhibitory natural product, pleurotin, against a clinical isolate of each of two fungal pathogens: the dermatophyte T. mentagrophytes and Candida albicans. Pleurotin inhibited the growth of the dermatophyte in vitro and in an ex vivo skin model, but had no effect on Candida. It may be possible to develop and optimise thioredoxin inhibitors, some of which are already under study in cancer chemotherapy, as antifungals.
journal_name
Mycosesjournal_title
Mycosesauthors
Berdicevsky I,Kaufman G,Newman DJ,Horwitz BAdoi
10.1111/j.1439-0507.2008.01620.xsubject
Has Abstractpub_date
2009-07-01 00:00:00pages
313-7issue
4eissn
0933-7407issn
1439-0507pii
MYC1620journal_volume
52pub_type
杂志文章相关文献
MYCOSES文献大全abstract::A 38-year-old woman infected with human immunodeficiency virus (HIV) presented with persistent oral candidosis in which non-albicans Candida strains were the predominant yeasts in most of the examinations performed over a period of 6 years. Oral treatment with fluconazole had no effect on clinical signs of oral candid...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1998.tb00347.x
更新日期:1998-09-01 00:00:00
abstract::In Malassezia furfur, tryptophan as the main nitrogen source induces production of the potent ultraviolet-absorbing indole compound pityriacitrin. An in vitro study about the effects of pityriacitrin on other human skin microorganisms is presented, with special focus on Candida albicans and staphylococci in which its ...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.2006.01265.x
更新日期:2006-09-01 00:00:00
abstract::The minimum inhibitory concentrations (MIC, microg ml-1) of itraconazole and terbinafine against overall 34 Aspergillus isolates from the external ear canals with otomycosis have been determined with M38-P microdilution method suggested by National Committee for Clinical Laboratory Standards (NCCLS). MIC intervals in ...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.2004.00988.x
更新日期:2004-08-01 00:00:00
abstract::The Aspergillus fumigatus group splits into the anamorphic A. fumigatus series and the teleomorphic Neosartorya fischeri series. The species A. fumigatus Fresenius is the most common species within the A. fumigatus series. Forty-seven clinical isolates out of the A. fumigatus group were obtained from patients with dis...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1997.tb00248.x
更新日期:1997-12-01 00:00:00
abstract::To determine the ecological and epidemiological significance of pigeon excrement in cryptococcosis in Mexico City, 251 samples of pigeon droppings were studied. These were collected from houses, public buildings, churches, parks and pigeon nests. Each sample was suspended 1:10 in isotonic saline solution and then cult...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.1994.37.9-10.325
更新日期:1994-09-01 00:00:00
abstract::Bacterial superinfections often occur in dermatomycoses, resulting in greatly inflamed or eczematous skin. The objective of this study was to evaluate the antibacterial efficacy of isoconazole nitrate (ISN), a broad-spectrum antimicrobial imidazole, commonly used to treat dermatomycoses. Several gram-positive bacteria...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.12055
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:We aimed to implement and to assess the impact of the antifungal stewardship programme (AFSp) on prescription appropriateness of antifungals, management and outcomes of candidaemia patients, and antifungal consumption and costs at our solid organ transplant (SOT) institute. METHODS:Local epidemiology of invasi...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.13098
更新日期:2020-07-01 00:00:00
abstract::A mycological survey was conducted on non-neutropenic patients in three distinct intensive care units in two hospitals in Marseille (France) from November 1993 to November 1995. Candida albicans positive cultures from 62 patients were included in this study. Every first isolate of each patient was typed by multilocus ...
journal_title:Mycoses
pub_type: 杂志文章,多中心研究
doi:10.1046/j.1439-0507.2000.00552.x
更新日期:2000-01-01 00:00:00
abstract::Trichophyton rubrum, T. mentagrophytes, T. verrucosum, Microsporum canis, M. gypseum and Epidermophyton flocoosum represent the cause of human dermatomycoses isolated most often at the University Hospital of Dermatology in Graz, Austria, between 1991 and 1998. So far, identification was mainly based on the cultivation...
journal_title:Mycoses
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::Invasive candidiasis is a common nosocomial infection among critically ill patients, constitutes an important cause of sepsis, and is associated with significant morbidity and mortality. The Infectious Diseases Society of America (IDSA) has created evidence-based guidelines for the management of invasive candidiasis. ...
journal_title:Mycoses
pub_type: 杂志文章,评审
doi:10.1111/j.1439-0507.2008.01571.x
更新日期:2008-09-01 00:00:00
abstract::The MIC values of the antifungal drug ketoconazole were evaluated on 66 Candida albicans strains. These strains were isolated from 26 HIV-1 infected patients with oral recurrent candidosis. Each episode of oral candidosis observed in these patients was orally treated with ketoconazole (200 mg/day) until the clinical d...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1992.tb00819.x
更新日期:1992-01-01 00:00:00
abstract::Cryptococcus neoformans is an encapsulated yeast-like fungus that causes life-threatening infections, particularly in immunocompromised patients. The formation of brown pigment on many media described in the literature, such as that in Niger seed (Guizotia abyssinica) agar, has been used to identify C. neoformans. The...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.2010.01877.x
更新日期:2011-07-01 00:00:00
abstract::Studies of the genetic diversity of Candida albicans strains and the correlation between the antifungal susceptibility and gene diversity of C. albicans were carried out and the results were found to be inconsistent. To investigate antifungal susceptibility and genotypes of C. albicans strains from patients with vulvo...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.2008.01539.x
更新日期:2009-01-01 00:00:00
abstract::We report a case of cerebral mucormycosis in a 28-year-old male who was affected by chronic myeloid leukaemia and underwent allogeneic bone marrow transplantation. Nine months post-transplantation, he was admitted to the hospital with fever, bilateral eyelid oedema and neutropenia. X-ray analysis showed numerous areas...
journal_title:Mycoses
pub_type: 信件
doi:10.1111/j.1439-0507.2009.01689.x
更新日期:2010-05-01 00:00:00
abstract::Mycetoma is a chronic granulomatous, subcutaneous disease endemic in tropical and subtropical countries. It is currently a health problem in rural areas of Africa, Asia and South America. Nine cases of mycetoma were analysed in a retrospective study. All isolates were identified by morphological features. The level of...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.12579
更新日期:2017-02-01 00:00:00
abstract::The aim of this study was to investigate a possible effect of optical brighteners on the growth of dermatophytes. Typical strains of Trichophyton rubrum, T. mentagrophytes, Microsporum canis and Epidermophyton floccosum were grown on agar plates containing two different brighteners of stilbenedisulfonic acid type in c...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1046/j.1439-0507.2003.00857.x
更新日期:2003-04-01 00:00:00
abstract::Infections caused by yeast of the genus Candida are the most common fungal infections, being Candida albicans the most common isolated species among them. The rapid identification of this yeast is mostly based on the production of germ tube in human or animal serum. This study describes the use of 12 different liquid ...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.2007.01359.x
更新日期:2007-07-01 00:00:00
abstract::In this prospective study 197 serum and 152 urine samples were collected from 40 bone marrow and solid organ transplant recipients with clinically suspected invasive fungal infection before, during and after empirical treatment with lipid formulation of amphotericin B or fluconazole. Serum was analysed by Candida poly...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1046/j.1439-0507.1999.00451.x
更新日期:1999-01-01 00:00:00
abstract::During the last decade cryptococcoses were most frequently diagnosed in AIDS patients, where serologically high amounts of glucoronoxylomannan (GXM) were detectable. Disseminated cryptococcoses without cryptococcal antigen detection is unusual. Between August and October 1998 disseminated cryptococcoses were diagnosed...
journal_title:Mycoses
pub_type: 信件
doi:10.1046/j.1439-0507.2000.00556.x
更新日期:2000-01-01 00:00:00
abstract::Onychomycosis is one of the most common dermatological diseases, primarily caused by dermatophytes, and sometimes, also by yeast and moulds. This study aims to clarify the frequency of isolated pathogens from mycotic toenails in the reference centre of the central Alpine mountain region of South Tyrol, northern Italy....
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.12528
更新日期:2016-12-01 00:00:00
abstract::Patients with acute lymphoblastic leukaemia (ALL) after cytotoxic chemotherapy or haematopoietic stem cell transplantation (HSCT) are at risk for life-threatening invasive fungal disease (IFD). The aim was to evaluate the characteristics, antifungal therapy and outcome of adult patients with ALL after chemotherapy or ...
journal_title:Mycoses
pub_type: 杂志文章,多中心研究
doi:10.1111/myc.12277
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVES:Patients with acute respiratory distress syndrome (ARDS) due to viral infection are at risk for secondary complications like invasive aspergillosis. Our study evaluates coronavirus disease 19 (COVID-19) associated invasive aspergillosis at a single centre in Cologne, Germany. METHODS:A retrospective chart r...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.13096
更新日期:2020-06-01 00:00:00
abstract::Breakthrough invasive fungal infections (IFIs) have emerged as a significant problem in patients receiving systemic antifungals; however, consensus criteria for defining breakthrough IFI are missing. This position paper establishes broadly applicable definitions of breakthrough IFI for clinical research. Representativ...
journal_title:Mycoses
pub_type: 杂志文章,评审
doi:10.1111/myc.12960
更新日期:2019-09-01 00:00:00
abstract::A review is presented of the emerging problem of resistant and chronic vaginitis due to Candida glabrata. Although accurate numbers are lacking, several investigators report encountering increased numbers of women with vaginitis due to C. glabrata. Possible reasons for this apparent increase are discussed. Risk factor...
journal_title:Mycoses
pub_type: 杂志文章,评审
doi:10.1111/j.1439-0507.1998.tb00594.x
更新日期:1998-01-01 00:00:00
abstract::Mucorales are saprobes, ubiquitously distributed and able to infect a heterogeneous population of human hosts. The fungi require robust stress responses to survive in human host. We tested the growth of Mucorales in the presence of different abiotic stress. Eight pathogenic species of Mucorales, including Rhizopus arr...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.12512
更新日期:2016-10-01 00:00:00
abstract::The secreted aspartyl proteinases (Saps) of Candida albicans have been implicated as immunodominant antigens and virulence factors associated with adherence and tissue invasion. A hybrid phage displaying the Sap epitope VKYTS was constructed by cloning the corresponding DNA fragments into the pfd88 vector. Similar to ...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.2006.01349.x
更新日期:2007-05-01 00:00:00
abstract::Candida wangnamkhiaoensis is a species clustered under the Hyphopichia clade has not ever been isolated from any clinical specimens. To the best of our knowledge, this is the first report of C. wangnamkhiaoensis associated with fungaemia in immunocompromised paediatric patient. The isolate was assigned a strain name a...
journal_title:Mycoses
pub_type:
doi:10.1111/myc.12509
更新日期:2016-11-01 00:00:00
abstract::Two hundred and seventy isolates of Trichophyton rubrum from 182 patients were subjected to susceptibility testing with griseofulvin according to Granade & Artis. A slight modification of the method concerning homogenization procedures gave better growth of controls in our investigation. In 245 cases an MIC could be d...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1991.tb00804.x
更新日期:1991-09-01 00:00:00
abstract::Chronic mucocutaneous candidosis has been described in patients with impaired cell-mediated immunity. We describe a female patient with sarcoidosis who developed a Candida granuloma on her upper lip. Moderate impairment of the cell-mediated immunity was detected. Three months' treatment with ketoconazole was successfu...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1993.tb00770.x
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND:Patients undergoing allogeneic stem cell transplantation (aSCT) are at high risk to develop an invasive fungal disease (IFD). Optimisation of antifungal prophylaxis strategies may improve patient outcomes and reduce treatment costs. OBJECTIVES:To analyse the clinical and economical impact of using continuou...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.13232
更新日期:2020-12-22 00:00:00