In vitro activity of terbinafine and itraconazole against Aspergillus species isolated from otomycosis.

Abstract:

:The minimum inhibitory concentrations (MIC, microg ml-1) of itraconazole and terbinafine against overall 34 Aspergillus isolates from the external ear canals with otomycosis have been determined with M38-P microdilution method suggested by National Committee for Clinical Laboratory Standards (NCCLS). MIC intervals in 48 h determined by taking MIC-2 value of itraconazole (the lowest drug concentration causing 50% inhibition of visible fungal growth) and MIC-0 value of terbinafine (the lowest drug concentration causing 100% inhibition of visible fungal growth) as a basis have been found as follows: 0.125-1 and 0.06-0.5 microg ml-1 for A. niger (22 strains), 0.06-0.25 and 0.06-0.125 microg ml-1 for A. flavus (10 strains), 0.125 and 0.125-0.5 microg ml-1 for A. terreus (two strains). It has been observed that both of the antifungal agents showed an in vitro activity against all Aspergillus species tested.

journal_name

Mycoses

journal_title

Mycoses

authors

Karaarslan A,Arikan S,Ozcan M,Ozcan KM

doi

10.1111/j.1439-0507.2004.00988.x

subject

Has Abstract

pub_date

2004-08-01 00:00:00

pages

284-7

issue

7

eissn

0933-7407

issn

1439-0507

pii

MYC988

journal_volume

47

pub_type

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