Identification and characterization of thiosemicarbazones with antifungal and antitumor effects: cellular iron chelation mediating cytotoxic activity.

abstract：:Carbon-13 NMR spectroscopy was used to study the effects of the peroxisome proliferator perfluoro-n-decanoic acid (PFDA) on hepatic carbohydrate metabolism in male Fischer-344 rats. The data indicate that PFDA-treated rats display an inhibition in hepatic [1-13C]glucose and [3-13C]alanine utilization on day 5 posttrea...

journal_title：Chemical research in toxicology

authors： Goecke CM,Jarnot BM,Reo NV

更新日期：1994-01-01 00:00:00

abstract：:The 2'-deoxyguanosine adduct of the dietary mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) has been synthesized and incorporated into DNA using solid state synthesis technology. The key step to obtaining the C8-dG adduct is a palladium (Xantphos-chelated)-catalyzed N-arylation (Buchwald-Hartwig reactio...

journal_title：Chemical research in toxicology

authors： Bonala R,Torres MC,Iden CR,Johnson F

更新日期：2006-06-01 00:00:00

abstract：:Epidemiological evidence suggests a lower incidence of Parkinson's disease in smokers than in nonsmokers. This evidence, together with the lower levels of brain monoamine oxidase (MAO) activity in smokers and the potential neuroprotective properties of MAO inhibitors, prompted studies which led to the isolation and ch...

journal_title：Chemical research in toxicology

authors： Castagnoli KP,Steyn SJ,Petzer JP,Van der Schyf CJ,Castagnoli N Jr

更新日期：2001-05-01 00:00:00

abstract：:Peroxynitrite (ONOO-), the reaction product of superoxide (O2.-) and nitric oxide (.NO), nitrates tyrosine and other phenolics. We report herein that tryptophan is also nitrated by peroxynitrite in the absence of transition metals to one predominant isomer of nitrotryptophan, as determined from spectral characteristic...

journal_title：Chemical research in toxicology

authors： Alvarez B,Rubbo H,Kirk M,Barnes S,Freeman BA,Radi R

更新日期：1996-03-01 00:00:00

abstract：:A potentiometric and spectroscopic (UV/vis and CD) study of Cu(II) and Ni(II) binding to the N-terminal pentadecapeptide of human protamine HP2 (HP2(1-15)) was performed. The results indicate that the N-terminal tripeptide motif Arg-Thr-His is the exclusive binding site for both metal ions at a metal to HP2(1-15) mola...

journal_title：Chemical research in toxicology

authors： Bal W,Jezowska-Bojczuk M,Kasprzak KS

更新日期：1997-08-01 00:00:00

abstract：:Inhalation of environmental particulate matter (PM) is correlated with adverse health effects in humans, but gene products that couple detection with cellular responses, and the specific properties of PM that target different pathways, have not been fully elucidated. TRPA1 and V1 are two cation channels expressed by s...

journal_title：Chemical research in toxicology

authors： Deering-Rice CE,Romero EG,Shapiro D,Hughen RW,Light AR,Yost GS,Veranth JM,Reilly CA

更新日期：2011-06-20 00:00:00

abstract：:Nitrogen mustards (NM) are an important class of chemotherapeutic drugs used in the treatment of malignant tumors. The accepted mechanism of action of NM is through the alkylation of DNA bases. NM-adducts block DNA replication in cancer cells by forming cytotoxic DNA interstrand cross-links. We previously characterize...

journal_title：Chemical research in toxicology

authors： Chen H,Cui Z,Hejazi L,Yao L,Walmsley SJ,Rizzo CJ,Turesky RJ

更新日期：2020-04-20 00:00:00

abstract：:So far, there is limited information on biotransformation mechanisms and products of polar contaminants in freshwater crustaceans. In the present study, metabolites of biocides and pharmaceuticals formed in Gammarus pulex and Daphnia magna were identified using liquid chromatography-high resolution mass spectrometry. ...

journal_title：Chemical research in toxicology

authors： Jeon J,Kurth D,Hollender J

更新日期：2013-03-18 00:00:00

abstract：:5'-d(CCTATAGATATCC) was reacted with each syn-enantiomer of trans-7,8-dihydroxy 9,10-epoxy 7,8,9,10-tetrahydrobenzo[a]pyrene (syn-BPDE). The (-)-enantiomer yielded one dominating adduct, whereas the (+)-enantiomer resulted in two major adducts. As indicated by optical spectroscopic methods, the major adduct derived fr...

journal_title：Chemical research in toxicology

authors： Pontén I,Seidel A,Gräslund A,Jernström B

更新日期：1996-01-01 00:00:00

abstract：:In this study, human glutathione transferases (GSTs) of alpha class have been assayed with the ultimate carcinogenic (-)-anti- and (+)-syn-diol epoxides (DEs) derived from the nonplanar dibenzo[a,l]pyrene (DBPDE) and the (+)-anti-diol epoxide of the planar benzo[a]pyrene [(+)-anti-BPDE] in the presence of glutathione ...

journal_title：Chemical research in toxicology

authors： Dreij K,Sundberg K,Johansson AS,Nordling E,Seidel A,Persson B,Mannervik B,Jernström B

更新日期：2002-06-01 00:00:00

abstract：:Human hepatocellular carcinoma cells, HepG2, are often used for drug mediated mitochondrial toxicity assessments. Glucose in HepG2 culture media is replaced by galactose to reveal drug-induced mitochondrial toxicity as a marked shift of drug IC50 values for the reduction of cellular ATP. It has been postulated that ga...

journal_title：Chemical research in toxicology

authors： Xu Q,Liu L,Vu H,Kuhls M,Aslamkhan AG,Liaw A,Yu Y,Kaczor A,Ruth M,Wei C,Imredy J,Lebron J,Pearson K,Gonzalez R,Mitra K,Sistare FD

更新日期：2019-08-19 00:00:00

abstract：:This study was conducted to investigate the protein adducts with pesticides in a cohort of 172 factory workers that were exposed to a mixture of pesticides. The 35 samples showing considerable variation in biochemical parameters, i.e., butyrylcholinestrase (BChE), serum glutamic pyruvic transaminase (SGPT), serum glut...

journal_title：Chemical research in toxicology

authors： Rehman T,Khan MM,Shad MA,Hussain M,Oyler BL,Goo YA,Goodlett DR

更新日期：2016-10-17 00:00:00

abstract：:While considerable effort has been expended on determining the health effects of exposure to typical urban concentrations of O3, little is known about the chemical events responsible for toxicity. Phospholipids containing unsaturated fatty acids in the cell membranes of lung cells are likely reaction sites for inhaled...

journal_title：Chemical research in toxicology

authors： Santrock J,Gorski RA,O'Gara JF

更新日期：1992-01-01 00:00:00

abstract：:Sugars and sugar degradation products react in vivo readily with proteins (glycation) resulting in the formation of a heterogeneous group of reaction products, which are called advanced glycation end products (AGEs). AGEs notably change the structure and function of proteins so that extended protein-AGE formation is l...

journal_title：Chemical research in toxicology

authors： Schneider M,Thoss G,Hübner-Parajsz C,Kientsch-Engel R,Stahl P,Pischetsrieder M

更新日期：2004-10-01 00:00:00

abstract：:( E)-4-Hydroxynon-2-enal (HNE), an electrophilic bifunctional cytotoxic lipid peroxidation product, forms covalent adducts with nucleophilic side chains of amino acid residues. HNE-derived adducts have been implicated in many pathophysiological processes including atherosclerosis, diabetes, and Alzheimer's disease. Tr...

journal_title：Chemical research in toxicology

authors： Annangudi SP,Deng Y,Gu X,Zhang W,Crabb JW,Salomon RG

更新日期：2008-07-01 00:00:00

abstract：:All pesticides must go through a rigorous risk assessment process in order to show that they are safe for use.With respect to dermal risk assessment for re-entry workers, the absorption value applied to predict systemic dose from this external exposure is obtained by testing liquid forms of the pesticide in vivo and/o...

journal_title：Chemical research in toxicology

authors： Clarke JF,Cordery SF,Morgan NA,Knowles PK,Guy RH

更新日期：2015-02-16 00:00:00

abstract：:We investigated the effect of a series of Maillard reaction products formed from carbohydrates under household heating conditions on the growth of human tumor cells in vitro. 4-Hydroxy-5-methyl-3-(2H)-furanone (1) was found to potently enhance the proliferation of human tumor cells. In contrast, the Maillard-type chro...

journal_title：Chemical research in toxicology

authors： Marko D,Habermeyer M,Kemény M,Weyand U,Niederberger E,Frank O,Hofmann T

更新日期：2003-01-01 00:00:00

abstract：:As COVID-19 swept across the world, it created a global pandemic and an unpredictable and challenging job market. This article discusses the future of the 2020-2021 job market in both academia and industry in the midst and aftermath of this pandemic. ...

journal_title：Chemical research in toxicology

authors： Perera HM,Griffin WC,Kankanamage RNT,Pathira Kankanamge LS

更新日期：2020-12-23 00:00:00

abstract：:Spin-trapping with 5,5-dimethyl-1-pyrroline 1-oxide (DMPO) was used to demonstrate that 3-nitrotyrosine (nitrotyrosine) promotes the formation of substantial amounts of reactive oxygen species (O2.- and *OH), when incubated with NAD(H)-cytochrome c reductase and a corresponding electron donor. Spin adduct formation is...

journal_title：Chemical research in toxicology

authors： Krainev AG,Williams TD,Bigelow DJ

更新日期：1998-05-01 00:00:00

abstract：:A method for the analysis of N-acetylcysteine conjugates of catechol estrogens [catechol estrogen mercapturates (CE SRs)], which are likely to be urinary markers of estrogen-induced tumors, was established in this study. The characteristics of the method that was established were (1) cleanup of urine using the immunoa...

journal_title：Chemical research in toxicology

authors： Nakagomi M,Suzuki E

更新日期：2000-12-01 00:00:00

abstract：:Premarin (Wyeth-Ayerst) is the estrogen replacement treatment of choice and continues to be one of the most widely dispensed prescriptions in the United States. In addition to endogenous estrogens, Premarin contains unsaturated estrogens including equilenin. We synthesized the catechol metabolite of equilenin, 4-hydro...

journal_title：Chemical research in toxicology

authors： Shen L,Qiu S,Chen Y,Zhang F,van Breemen RB,Nikolic D,Bolton JL

更新日期：1998-02-01 00:00:00

abstract：:Aryl radicals can react at the C8-site of 2'-deoxyguanosine (dG) to produce DNA adducts with a C8-C linkage (denoted C-linked). Such adducts are structurally distinct from those possessing a flexible amine (N-linked) or ether (O-linked) linkage, which separates the C8-aryl moiety from the guanine nucleobase. In the cu...

journal_title：Chemical research in toxicology

authors： Sproviero M,Verwey AM,Witham AA,Manderville RA,Sharma P,Wetmore SD

更新日期：2015-08-17 00:00:00

abstract：:Cryogenic (4-10 K) laser-induced vibrationless ground state and vibronic excited state fluorescence emission spectra of the adducts resulting from reaction in vitro of human serum albumin and the carcinogen (+-)-r-7,t-8-dihydroxy-c-9,c-10-epoxy-7,8,9,10- tetrahydrobenzo[a]-pyrene were recorded in order to determine th...

journal_title：Chemical research in toxicology

authors： Day BW,Doxtader MM,Rich RH,Skipper PL,Singh K,Dasari RR,Tannenbaum SR

更新日期：1992-01-01 00:00:00

abstract：:The efficacy of DNA-damaging anticancer drugs is highly influenced by cellular DNA repair capacity, and by inhibiting the relevant DNA repair pathway, efficacy of alkylating agents may be increased. Therefore, combining DNA repair inhibitors with anticancer agents that selectively target tumor tissue should improve ca...

journal_title：Chemical research in toxicology

authors： van Midwoud PM,Sturla SJ

更新日期：2013-11-18 00:00:00

abstract：:Exposure to fine particulate matter (PM2.5), of which secondary organic aerosol (SOA) is a major constituent, is linked to adverse health outcomes, including cardiovascular disease, lung cancer, and preterm birth. Atmospheric oxidation of isoprene, the most abundant nonmethane hydrocarbon emitted into Earth's atmosphe...

journal_title：Chemical research in toxicology

authors： Eaves LA,Smeester L,Hartwell HJ,Lin YH,Arashiro M,Zhang Z,Gold A,Surratt JD,Fry RC

更新日期：2020-02-17 00:00:00

abstract：:Methylmercury (MeHg) reacts readily with GSH, leading to the formation of a MeHg-SG adduct that is excreted into extracellular space through multidrug-resistance-associated protein (MRP), which is regulated by the transcription factor Nrf2. We previously reported that MeHg covalently modifies Keap1 and activates Nrf2 ...

journal_title：Chemical research in toxicology

authors： Yoshida E,Abiko Y,Kumagai Y

更新日期：2014-10-20 00:00:00

abstract：:2,4-Dichlorophenol (2,4-DCP), an environmental pollutant, was reported to cause hepatotoxicity. The biochemical mechanisms of 2,4-DCP induced liver injury remain unknown. The present study showed that 2,4-DCP is chemically reactive and spontaneously reacts with GSH and bovine serum albumin to form GSH conjugates and B...

journal_title：Chemical research in toxicology

authors： Li Q,Li W,Zhao J,Guo X,Zou Q,Yang Z,Tian R,Peng Y,Zheng J

更新日期：2020-09-21 00:00:00

abstract：:The crystal structure of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) has been determined by single-crystal X-ray crystallography. Crystals grown by evaporation of an aqueous solution form in the monoclinic space group P2(1)/n with two molecules of PhIP per asymmetric unit, along with six w...

journal_title：Chemical research in toxicology

authors： Parkin S,Marsch GA,Hope H,Whitney E,Winter NW,Colvin ME,Felton JS,Turteltaub KW

更新日期：1996-04-01 00:00:00

abstract：:Overexposure to biphenyl amine compounds, which are found in smoke and azo-dyes, is linked to the occurrence of bladder cancer. However, the molecular mechanisms of biphenyl amine compound-induced bladder cancer are still unclear. Many studies have demonstrated that overexpression of cyclooxygenase-2 (COX-2) in neopla...

journal_title：Chemical research in toxicology

authors： Chen CC,Cheng YY,Chen SC,Tuan YF,Chen YJ,Chen CY,Chen LC

更新日期：2012-03-19 00:00:00

abstract：:The Salmonella typhimurium (TA100) mutagenic compound, mucochloric acid [3,4-dichloro-5-hydroxy-2(5H)-furanone (MCA)], was inactivated by in vitro N-acetylcysteine (NAC). The reaction of MCA with NAC at pH7 was second order and gave products 4, 5, and 6a that resulted from the displacement of chlorine from C-3 or C-4 ...

journal_title：Chemical research in toxicology

authors： LaLonde RT,Xie S

更新日期：1992-09-01 00:00:00