Maillard reaction products modulating the growth of human tumor cells in vitro.

abstract：:Chloroprene (2-chloro-1,3-butadiene, 1) is an important industrial chemical, which is carcinogenic in experimental animals and possibly in humans. It is metabolized to the monoepoxides, 2-chloro-2-ethenyloxirane (2a,b) and (1-chloroethenyl)oxirane (3a,b), together with electrophilic chlorinated aldehydes and ketones. ...

journal_title：Chemical research in toxicology

authors： Munter T,Cottrell L,Golding BT,Watson WP

更新日期：2003-10-01 00:00:00

abstract：:Iron (Fe) chelation therapy was initially designed to alleviate the toxic effects of excess Fe evident in Fe-overload diseases. However, the novel toxicological properties of some Fe chelator-metal complexes have shifted appreciable focus to their application in cancer chemotherapy. Redox-inactive Fe chelator complexe...

journal_title：Chemical research in toxicology

authors： Kalinowski DS,Richardson DR

更新日期：2007-05-01 00:00:00

abstract：:The neurotrophic factor pleiotrophin (PTN) is upregulated in different brain areas after the administration of different drugs of abuse, including psychostimulants. PTN has been shown to prevent cocaine-induced cytotoxicity in NG108-15 and PC12 cells. We previously demonstrated that specific phosphoproteins related to...

journal_title：Chemical research in toxicology

authors： Vicente-Rodríguez M,Herradón G,Ferrer-Alcón M,Uribarri M,Pérez-García C

更新日期：2015-07-20 00:00:00

abstract：:Trans-Resveratrol (tRes) has been shown to have powerful antioxidant, anti-inflammatory, anticarcinogenic, and antiaging properties; however, its use as a therapeutic agent is limited by its rapid metabolism into its conjugated forms by UDP-glucuronosyltransferases (UGTs). The aim of the current study was to test the ...

journal_title：Chemical research in toxicology

authors： Greer AK,Madadi NR,Bratton SM,Eddy SD,Mazerska Z,Hendrickson HP,Crooks PA,Radominska-Pandya A

更新日期：2014-04-21 00:00:00

abstract：:The development of a unique bioassay for cytotoxicity analysis of coal fly ash (CFA) particulate matter (PM) and its potential application for air quality monitoring is described. Using human cell lines, A549 and SK-MES-1, as live probes on microelectrode-embedded 96-well sensors, impedance changes over time are measu...

journal_title：Chemical research in toxicology

authors： Moe B,Yuan C,Li J,Du H,Gabos S,Le XC,Li XF

更新日期：2016-06-20 00:00:00

abstract：:Nitroaromatic compounds represent a major class of industrial chemicals that are also found in nature. Polycyclic derivatives are regarded as potent mutagens and carcinogens following bioactivation to produce nitrenium electrophiles that covalently modify DNA to afford N-linked C8-2'-deoxyguanosine (C8-dG) lesions tha...

journal_title：Chemical research in toxicology

authors： Manning TW,Al-Abdul-Wahid MS,Manderville RA,Josephy PD,Kung RW,Wetmore SD

更新日期：2020-02-17 00:00:00

abstract：:Cyclic imides are known for their antitumor activity, especially the naphthalimide derivatives, such as Mitonafide and Amonafide. Recently, we have demonstrated the cytotoxic effect of a series of naphthalimide derivatives against B16F10 melanoma cells. On the basis of this fact, we have developed a study starting fro...

journal_title：Chemical research in toxicology

authors： Machado KE,de Oliveira KN,Andreossi HM,Bubniak Ldos S,de Moraes AC,Gaspar PC,Andrade Eda S,Nunes RJ,Santos-Silva MC

更新日期：2013-12-16 00:00:00

abstract：:Two novel pectenotoxins (PTXs) were detected by LC-MS in solid phase extracts of net hauls taken at Flødevigen, Norway, in June 2002 that were dominated by Dinophysis acuminata and Dinophysis norvegica. The new compounds were isolated as minor components from a large collection of a Dinophysis acuta-dominated bloom ob...

journal_title：Chemical research in toxicology

authors： Miles CO,Wilkins AL,Samdal IA,Sandvik M,Petersen D,Quilliam MA,Naustvoll LJ,Rundberget T,Torgersen T,Hovgaard P,Jensen DJ,Cooney JM

更新日期：2004-11-01 00:00:00

abstract：:1-Hydroxypyrene (HOP), a metabolite found in the urine of humans and laboratory animals exposed to polycyclic aromatic hydrocarbons (PAHs), is known to be both acutely toxic and genotoxic. It has been widely used as a biomarker for studying PAH exposure. In this research, we have found that, upon UVA irradiation, HOP ...

journal_title：Chemical research in toxicology

authors： Dong S,Hwang HM,Shi X,Holloway L,Yu H

更新日期：2000-07-01 00:00:00

abstract：:Exposure to polychlorinated biphenyls (PCBs) has been implicated in adverse human health effects, including developmental neurotoxicity. Several neurotoxic PCBs are chiral and undergo atropisomeric enrichment in vivo due to atropselective metabolism by cytochrome P450 enzymes. Here we study how the liver-specific dele...

journal_title：Chemical research in toxicology

authors： Li X,Wu X,Kelly KM,Veng-Pedersen P,Lehmler HJ

更新日期：2019-04-15 00:00:00

abstract：:A series of (alkylthio)trifluoropropanones containing a heterocyclic moiety was synthesized. The compounds were tested for in vitro inhibition of four hydrolytic enzymes including insect juvenile hormone esterase (JHE), eel acetylcholinesterase (AChE), yeast lipase (LP), and bovine alpha-chymotrypsin. The I50 values r...

journal_title：Chemical research in toxicology

authors： Székács A,Halarnkar PP,Olmstead MM,Prag KA,Hammock BD

更新日期：1990-07-01 00:00:00

abstract：:The antioxidant properties of a number of water-soluble diorganyl tellurides have been investigated. These organotellurium compounds efficiently protect against peroxynitrite-mediated oxidation of dihydrorhodamine 123, hydroxylation of benzoate, and nitration of 4-hydroxyphenyl acetate. The peroxidation of the zinc st...

journal_title：Chemical research in toxicology

authors： Jacob C,Arteel GE,Kanda T,Engman L,Sies H

更新日期：2000-01-01 00:00:00

abstract：:Overexposure to biphenyl amine compounds, which are found in smoke and azo-dyes, is linked to the occurrence of bladder cancer. However, the molecular mechanisms of biphenyl amine compound-induced bladder cancer are still unclear. Many studies have demonstrated that overexpression of cyclooxygenase-2 (COX-2) in neopla...

journal_title：Chemical research in toxicology

authors： Chen CC,Cheng YY,Chen SC,Tuan YF,Chen YJ,Chen CY,Chen LC

更新日期：2012-03-19 00:00:00

abstract：:Spin adducts are observed when the unfiltered smoke produced during the aerobic pyrolysis of perfluoro polymers (PFP) is bubbled through a solution of the ESR spin trap alpha-phenyl-N-tert-butylnitrone (PBN). The spin adducts include those from an oxy radical and the fluorine atom, and in addition the spin trap is oxi...

journal_title：Chemical research in toxicology

authors： Lachocki TM,Nuggehalli SK,Scherer KV,Church DF,Pryor WA

更新日期：1989-05-01 00:00:00

abstract：:Reactive oxygen species can induce the formation of tandem DNA lesions. We recently showed that the treatment of calf thymus DNA with Cu2+/H2O2/ascorbate could result in the efficient formation of a tandem lesion where a 5,6-dihydroxy-5,6-dihydrothymidine (or thymidine glycol) is situated on the 5' side of an 8-oxo-7,...

journal_title：Chemical research in toxicology

authors： Jiang Y,Wang Y,Wang Y

更新日期：2009-03-16 00:00:00

abstract：:2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a heterocyclic aromatic amine that is formed during the cooking of meats. PhIP is a potential human carcinogen: it undergoes metabolic activation to form electrophilic metabolites that bind to DNA and proteins, including serum albumin (SA). The structures of Ph...

journal_title：Chemical research in toxicology

authors： Peng L,Dasari S,Tabb DL,Turesky RJ

更新日期：2012-10-15 00:00:00

abstract：:Pesticide biotransformation, especially by cytochrome P450 enzymes (CYPs), may produce metabolites with substantially altered toxicological and physicochemical profiles, which has drawn great attention as a basis for environmental risk assessment. CYPs are active in the metabolism of various reactions of pesticides, a...

journal_title：Chemical research in toxicology

authors： Chai L,Ji S,Zhang S,Yu H,Zhao M,Ji L

更新日期：2020-06-15 00:00:00

abstract：:The purpose of this study was to investigate the degree of chlorination of catechol (CAT) derivatives of pentachlorophenol (PCP) on the induction of cytotoxicity and DNA damaging effects in calf thymus DNA (ct-DNA) and in two human breast carcinoma cell lines. Results indicated that with the addition of the transition...

journal_title：Chemical research in toxicology

authors： Lin CH,Leow HT,Huang SC,Nakamura J,Swenberg JA,Lin PH

更新日期：2005-02-01 00:00:00

abstract：:A correct estimate of ligand binding modes and a ratio of their occupancies is crucial for calculations of binding free energies. The newly developed method BLUES combines molecular dynamics with nonequilibrium candidate Monte Carlo. Nonequilibrium candidate Monte Carlo generates a plethora of possible binding modes a...

journal_title：Chemical research in toxicology

authors： Jandova Z,Gill SC,Lim NM,Mobley DL,Oostenbrink C

更新日期：2019-07-15 00:00:00

abstract：:Aflatoxin Q1 8,9-oxide was synthesized and found to yield lower levels of N7-guanyl adducts than obtained from aflatoxin B1 8,9-oxide when mixed with calf thymus DNA or Salmonella typhimurium TA 98 cells. However, when S. typhimurium TA 98 was treated with the (analogous) epoxides of aflatoxin B1, aflatoxin G1, aflato...

journal_title：Chemical research in toxicology

authors： Raney KD,Shimada T,Kim DH,Groopman JD,Harris TM,Guengerich FP

更新日期：1992-03-01 00:00:00

abstract：:2'-Deoxyoxanosine (dOxo) is a novel DNA lesion produced from dGuo by reaction with nitrous acid or nitric oxide [Suzuki, T., Yamaoka, R., Nishi, M., Ide, H., and Makino, K. (1996) J. Am. Chem. Soc. 118, 2515-2516]. We investigated the reaction of dOxo with glycine (Gly) under physiological conditions. When 5 mM dOxo w...

journal_title：Chemical research in toxicology

authors： Suzuki T,Yamada M,Ide H,Kanaori K,Tajima K,Morii T,Makino K

更新日期：2000-04-01 00:00:00

abstract：:The importance of adsorption, distribution, metabolism, excretion, and toxicity (ADMET) analysis is expected to grow substantially due to recent failures in detecting severe toxicity issues of new chemical entities during preclinical/clinical development. Traditionally, safety risk assessment studies for humans have b...

journal_title：Chemical research in toxicology

authors： Goracci L,Valeri A,Sciabola S,Aleo MD,Moritz W,Lichtenberg J,Cruciani G

更新日期：2020-01-21 00:00:00

abstract：:Complex formation between nitrosoglutathione (GSNO) and Zn(II), Cd(II), and Ni(II) ions was studied by potentiometry and spectroscopic techniques. GSNO forms simple ML and ML2 type complexes (L = GSNO) with these ions. The stability of GSNO in HEPES buffer solution, pH 7.4, increased in the presence of both Zn(II) and...

journal_title：Chemical research in toxicology

authors： Krezel A,Bal W

更新日期：2004-03-01 00:00:00

abstract：:Anxiolytic kava products have been associated with rare but severe hepatotoxicity in humans. This adverse potential has never been captured in animal models, and the responsible compound(s) remains to be determined. The lack of such knowledge greatly hinders the preparation of a safer kava product and limits its benef...

journal_title：Chemical research in toxicology

authors： Narayanapillai SC,Leitzman P,O'Sullivan MG,Xing C

更新日期：2014-10-20 00:00:00

abstract：:Isoeugenol is widely used by the cosmetic and fragrance industries, but it also represents a known cause of skin sensitization adverse effects. Although devoid of a structural alert, isoeugenol has been classified as prehapten in virtue of the presence of a pre-Michael acceptor domain. Isoeugenol oxidation could theor...

journal_title：Chemical research in toxicology

authors： Ahn J,Avonto C,Chittiboyina AG,Khan IA

更新日期：2020-04-20 00:00:00

abstract：:We report on the generation of computer-based models for the prediction of the chromosome-damaging potential of chemicals as assessed in the in vitro chromosome aberration (CA) test. On the basis of publicly available CA-test results of more than 650 chemical substances, half of which are drug-like compounds, we gener...

journal_title：Chemical research in toxicology

authors： Rothfuss A,Steger-Hartmann T,Heinrich N,Wichard J

更新日期：2006-10-01 00:00:00

abstract：:The two major metabolites after S-oxygenation of dimethylthiourea (dimethylaminoiminomethane sulfinic acid, DMAIMSA, and dimethylaminoiminomethane sulfonic acid, DMAIMSOA) were synthesized and tested for their reactivities in the presence of mild oxidants, aqueous iodine and acidic iodate. The stoichiometry of the iod...

journal_title：Chemical research in toxicology

authors： Otoikhian A,Simoyi RH,Petersen JL

更新日期：2005-07-01 00:00:00

abstract：:Skin protein modification (haptenation) is thought to be a key step in the manifestation of sensitization to low molecular mass chemicals (<500 g/mol). For sensitizing chemicals that are not protein reactive, it is hypothesised that metabolic activation can convert such chemicals into protein reactive toxins within th...

journal_title：Chemical research in toxicology

authors： Elahi EN,Wright Z,Hinselwood D,Hotchkiss SA,Basketter DA,Pease CK

更新日期：2004-03-01 00:00:00

abstract：:The genotoxicity of the dihydrofurans aflatoxin B1 (AFB1), aflatoxin G1 (AFG1), and sterigmatocystin (STG) was examined in a bacterial system in which the induction of SOS repair is monitored with the umuC gene linked to a lacZ reporter gene in plasmid pSK1002. Human liver microsomal cytochrome P-450NF oxidized the di...

journal_title：Chemical research in toxicology

authors： Baertschi SW,Raney KD,Shimada T,Harris TM,Guengerich FP

更新日期：1989-03-01 00:00:00

abstract：:Inhaled glucocorticoid (GC) therapy is a vital part of the management of chronic asthma. GCs are metabolized by members of the cytochrome P450 3A family in both liver and lung, but the enzymes are differentially expressed. Selective inhibition of one or more P450 3A enzymes could substantially modify target and system...

journal_title：Chemical research in toxicology

authors： Murai T,Reilly CA,Ward RM,Yost GS

更新日期：2010-08-16 00:00:00