当前位置： SCI文献检索 > CHEMICAL RESEARCH IN TOXICOLOGY期刊下所有文献 > Effects of the peroxisome proliferator perfluoro-n-decanoic acid on hepatic gluconeogenesis and glycogenesis: a 13C NMR investigation.

Effects of the peroxisome proliferator perfluoro-n-decanoic acid on hepatic gluconeogenesis and glycogenesis: a 13C NMR investigation.

Abstract：

:Carbon-13 NMR spectroscopy was used to study the effects of the peroxisome proliferator perfluoro-n-decanoic acid (PFDA) on hepatic carbohydrate metabolism in male Fischer-344 rats. The data indicate that PFDA-treated rats display an inhibition in hepatic [1-13C]glucose and [3-13C]alanine utilization on day 5 posttreatment. PFDA rats show hepatic mean glucose and alanine intensities which are significantly greater (ca. 10-100%) than controls. With [1-13C]-glucose as substrate, PFDA rats show severe to complete inhibition in glycogenesis on days 3 and 5 posttreatment. With [3-13C]alanine as substrate, both groups show functional gluconeogenesis and glycogenesis; however, treated rats show a more transient and less intense C1-glycogen resonance relative to control. These data suggest that PFDA inhibits either the hepatocellular transport of glucose and/or its phosphorylation by glucokinase. The effect of PFDA on TCA cycle activity was determined by monitoring the flow of [3-13C]alanine into glutamate. The relative activity of pyruvate carboxylase (PC) versus pyruvate dehydrogenase (PDH) is represented by the ratio of the glutamate NMR signal intensities (C2 + C3)/C4. PFDA rats show a lower (C2 + C3)/C4 glutamate ratio, suggesting greater relative activity of PDH versus PC in PFDA rats relative to controls. Differences in PDH activity may arise from differences in lipolytic activity. Our data suggest a dysfunction in fatty acid metabolism in PFDA rats and corroborate other studies which show that PFDA inhibits fatty acid oxidation.

journal_name

Chem Res Toxicol

journal_title

Chemical research in toxicology

authors

Goecke CM,Jarnot BM,Reo NV

doi

10.1021/tx00037a003

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

15-22

issue

1

eissn

0893-228X

issn

1520-5010

journal_volume

7

pub_type

杂志文章

相关文献

CHEMICAL RESEARCH IN TOXICOLOGY文献大全
  • Alkylation of 2'-deoxynucleosides and DNA by the Premarin metabolite 4-hydroxyequilenin semiquinone radical.

    abstract：:Premarin (Wyeth-Ayerst) is the estrogen replacement treatment of choice and continues to be one of the most widely dispensed prescriptions in the United States. In addition to endogenous estrogens, Premarin contains unsaturated estrogens including equilenin. We synthesized the catechol metabolite of equilenin, 4-hydro...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx970181r

    authors： Shen L,Qiu S,Chen Y,Zhang F,van Breemen RB,Nikolic D,Bolton JL

    更新日期：1998-02-01 00:00:00

  • Differences in the tumorigenic activity of a pure hydrocarbon and a complex mixture following ingestion: benzo[a]pyrene vs manufactured gas plant residue.

    abstract：:The tumorigenic activity of manufactured gas plant residue (MGP) was evaluated in female A/J mice using a F0927 basal gel diet system. Adulterated diets containing MGP (0.10% or 0.25%) or benzo[a]pyrene (B[alpha]P; 16 or 98 ppm) were fed for 260 days. A negative control group was maintained on a nonadulterated basal g...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx00049a008

    authors： Weyand EH,Chen YC,Wu Y,Koganti A,Dunsford HA,Rodriguez LV

    更新日期：1995-10-01 00:00:00

  • Interactions of TiO2 Nanoparticles with Ingredients from Modern Lifestyle Products and Their Effects on Human Skin Cells.

    abstract：:The number of consumer products containing nanoparticles (NPs) experienced a rapid increase during the past decades. However, most studies of nanosafety have been conducted using only pure NPs produced in the laboratory, while the interactions with other ingredients in consumer products have rarely been considered so ...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/acs.chemrestox.9b00428

    authors： Geppert M,Schwarz A,Stangassinger LM,Wenger S,Wienerroither LM,Ess S,Duschl A,Himly M

    更新日期：2020-05-18 00:00:00

  • In Vitro Method to Quantify Dermal Absorption of Pesticide Residues.

    abstract：:All pesticides must go through a rigorous risk assessment process in order to show that they are safe for use.With respect to dermal risk assessment for re-entry workers, the absorption value applied to predict systemic dose from this external exposure is obtained by testing liquid forms of the pesticide in vivo and/o...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx500509z

    authors： Clarke JF,Cordery SF,Morgan NA,Knowles PK,Guy RH

    更新日期：2015-02-16 00:00:00

  • Identification of Quinone Methide Intermediate Resulting from Metabolic Activation of Icaritin in Vitro and in Vivo.

    abstract：:Many herbal medicines such as epimedium have been reported to cause adverse effects, and icaritin is the common aglycone of many glucosides in epimedium. Our present work aimed at the clarification of the metabolic activation of icaritin possibly responsible for the adverse effects of epimedium. A quinone methide meta...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/acs.chemrestox.8b00418

    authors： Chen Y,Guo X,Ma Y,Hu X,Peng Y,Zheng J

    更新日期：2019-06-17 00:00:00

  • Exposure to the Heavy-Metal Lead Induces DNA Copy Number Alterations in Zebrafish Cells.

    abstract：:DNA copy number variants are associated with the development of complex neurological diseases and disorders including autism spectrum disorder, schizophrenia, Alzheimer's disease, and Parkinson's disease. Exposure to multiple environmental chemicals including various heavy metals is suggested as a risk factor in these...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/acs.chemrestox.0c00156

    authors： Lee J,Freeman JL

    更新日期：2020-08-17 00:00:00

  • Molecular recognition between oligopeptides and nucleic acids: DNA binding specificity of a series of bis netropsin analogues deduced from footprinting analysis.

    abstract：:A series of tether-linked bis netropsins have been synthesized in order to assess the phasing problem, which arises because of the lack of dimensional correspondence between oligopeptides and oligonucleotides in DNA binding characteristics. The consequences of incorporating variable-length flexible and rigid tethers [...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx00014a013

    authors： Kissinger KL,Dabrowiak JC,Lown JW

    更新日期：1990-03-01 00:00:00

  • Oxidation of a dimethylthiourea metabolite by iodine and acidified iodate: N,N'-dimethylaminoiminomethanesulfinic acid (1).

    abstract：:The two major metabolites after S-oxygenation of dimethylthiourea (dimethylaminoiminomethane sulfinic acid, DMAIMSA, and dimethylaminoiminomethane sulfonic acid, DMAIMSOA) were synthesized and tested for their reactivities in the presence of mild oxidants, aqueous iodine and acidic iodate. The stoichiometry of the iod...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx050089s

    authors： Otoikhian A,Simoyi RH,Petersen JL

    更新日期：2005-07-01 00:00:00

  • UVA-Induced DNA single-strand cleavage by 1-hydroxypyrene and formation of covalent adducts between DNA and 1-hydroxypyrene.

    abstract：:1-Hydroxypyrene (HOP), a metabolite found in the urine of humans and laboratory animals exposed to polycyclic aromatic hydrocarbons (PAHs), is known to be both acutely toxic and genotoxic. It has been widely used as a biomarker for studying PAH exposure. In this research, we have found that, upon UVA irradiation, HOP ...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx990199x

    authors： Dong S,Hwang HM,Shi X,Holloway L,Yu H

    更新日期：2000-07-01 00:00:00

  • Endocrine disruption screening by protein and gene expression of vitellogenin in freshly isolated and cryopreserved rainbow trout hepatocytes.

    abstract：:Xenobiotics may activate the estrogen receptor, resulting in alteration of normal endocrine functions in animals and humans. Consequently, this necessitates development of assay end points capable of identifying estrogenic xenobiotics. In the present study, we screened the potential estrogenicity of chemicals via thei...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx5002089

    authors： Markell LK,Mingoia RT,Peterson HM,Yao J,Waters SM,Finn JP,Nabb DL,Han X

    更新日期：2014-08-18 00:00:00

  • Monitoring Cr intermediates and reactive oxygen species with fluorescent probes during chromate reduction.

    abstract：:Cr(VI) genotoxicity is caused by products of its reductive metabolism inside the cells. Reactive oxygen species (ROS) and Cr(V,IV) intermediates are potential sources of oxidative damage by Cr(VI). Here, we investigated seven fluorescent probes for the detection of ROS and non-ROS oxidants in Cr(VI) reactions with its...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx500028x

    authors： DeLoughery Z,Luczak MW,Zhitkovich A

    更新日期：2014-05-19 00:00:00

  • Prostaglandin H synthase-1-catalyzed bioactivation of neurotransmitters, their precursors, and metabolites: oxidative DNA damage and electron spin resonance spectroscopy studies.

    abstract：:The role of prostaglandin H synthase-1 (PHS-1) and a related model enzyme, horseradish peroxidase (HRP), in catalyzing the bioactivation of dopamine (DA) and epinephrine and their precursors and metabolites to potential neurodegenerative free radical intermediates was examined. To determine the potential contribution ...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx800423s

    authors： Gonçalves LL,Ramkissoon A,Wells PG

    更新日期：2009-05-01 00:00:00

  • Inhibition of gap junctional intercellular communication by toxic metals.

    abstract：:As metals are ubiquitous in the environment, humans are continuously exposed to them. Although some metallic ions play key roles in human physiology, most metals are redundant and are actually hazardous to humans. A frequent event in the toxicological cascade triggered by nonessential metals concerns the abrogation of...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章,评审

    doi：10.1021/tx100276f

    authors： Vinken M,Ceelen L,Vanhaecke T,Rogiers V

    更新日期：2010-12-20 00:00:00

  • Comparative Toxicogenomic Responses to the Flame Retardant mITP in Developing Zebrafish.

    abstract：:Monosubstituted isopropylated triaryl phosphate (mITP) is a major component of Firemaster 550, an additive flame retardant mixture commonly used in polyurethane foams. Developmental toxicity studies in zebrafish established mITP as the most toxic component of FM 550, which causes pericardial edema and heart looping fa...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/acs.chemrestox.6b00423

    authors： Haggard DE,Das SR,Tanguay RL

    更新日期：2017-02-20 00:00:00

  • Up-Regulation of T-Cell Activation MicroRNAs in Drug-Specific CD4+ T-Cells from Hypersensitive Patients.

    abstract：:Dysregulation in the expression of microRNAs (miRNAs), single-stranded RNAs which regulate gene expression, has been associated with diseases such as Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), although their cellular origin has not been explored. Thus, the focus of this work was to study expressi...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/acs.chemrestox.7b00330

    authors： Monroy-Arreola A,Durán-Figueroa NV,Méndez-Flores S,Domínguez-Cherit J,Watkinson J,Badillo-Corona JA,Whitaker P,Naisbitt DJ,Castrejón-Flores JL

    更新日期：2018-06-18 00:00:00

  • In vitro replication and repair studies of tandem lesions containing neighboring thymidine glycol and 8-oxo-7,8-dihydro-2'-deoxyguanosine.

    abstract：:Reactive oxygen species can induce the formation of tandem DNA lesions. We recently showed that the treatment of calf thymus DNA with Cu2+/H2O2/ascorbate could result in the efficient formation of a tandem lesion where a 5,6-dihydroxy-5,6-dihydrothymidine (or thymidine glycol) is situated on the 5' side of an 8-oxo-7,...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx8003449

    authors： Jiang Y,Wang Y,Wang Y

    更新日期：2009-03-16 00:00:00

  • Base flipping free energy profiles for damaged and undamaged DNA.

    abstract：:Lesion-induced thermodynamic destabilization is believed to facilitate β-hairpin intrusion by the human XPC/hHR23B nucleotide excision repair (NER) recognition factor, accompanied by partner-base flipping, as suggested by the crystal structure of the yeast orthologue (Min, J. H., and Pavletich, N. P. (2007) Nature 449...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx1003613

    authors： Zheng H,Cai Y,Ding S,Tang Y,Kropachev K,Zhou Y,Wang L,Wang S,Geacintov NE,Zhang Y,Broyde S

    更新日期：2010-12-20 00:00:00

  • Synthesis and characterization of adducts derived from the syn-diastereomer of benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide and the 5'-d(CCTATAGATATCC) oligonucleotide.

    abstract：:5'-d(CCTATAGATATCC) was reacted with each syn-enantiomer of trans-7,8-dihydroxy 9,10-epoxy 7,8,9,10-tetrahydrobenzo[a]pyrene (syn-BPDE). The (-)-enantiomer yielded one dominating adduct, whereas the (+)-enantiomer resulted in two major adducts. As indicated by optical spectroscopic methods, the major adduct derived fr...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx950041m

    authors： Pontén I,Seidel A,Gräslund A,Jernström B

    更新日期：1996-01-01 00:00:00

  • Oxidative Release of Thiol-Conjugated Forms of the Mycotoxin 4-Deoxynivalenol.

    abstract：:Deoxynivalenol (DON) is a trichothecene mycotoxin that is produced by several species of Fusarium, which may infect grain crops. DON, as well as other type-B trichothecenes, contain an α,β-unsaturated carbonyl group that may react with sulfhydryl groups in, for example, amino acids and peptides. Such conjugates have b...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/acs.chemrestox.9b00385

    authors： Uhlig S,Ivanova L,Miles CO

    更新日期：2020-02-17 00:00:00

  • Mutagenic Replication of N2-Deoxyguanosine Benzo[a]pyrene Adducts by Escherichia coli DNA Polymerase I and Sulfolobus solfataricus DNA Polymerase IV.

    abstract：:Benzo[a]pyrene, a potent human carcinogen, is metabolized in vivo to a diol epoxide that reacts with the N2-position of guanine to produce N2-BP-dG adducts. These adducts are mutagenic causing G to T transversions. These adducts block replicative polymerases but can be bypassed by the Y-family translesion synthesis po...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/acs.chemrestox.6b00466

    authors： Gowda ASP,Krzeminski J,Amin S,Suo Z,Spratt TE

    更新日期：2017-05-15 00:00:00

  • Directed evolution reveals requisite sequence elements in the functional expression of P450 2F1 in Escherichia coli.

    abstract：:Cytochrome P450 2F1 (P450 2F1) is expressed exclusively in the human respiratory tract and is implicated in 3-methylindole (3MI)-induced pneumotoxicity via dehydrogenation of 3MI to a reactive electrophilic intermediate, 3-methyleneindolenine (3-MEI). Studies of P450 2F1 to date have been limited by the failure to exp...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx300281g

    authors： Behrendorff JB,Moore CD,Kim KH,Kim DH,Smith CA,Johnston WA,Yun CH,Yost GS,Gillam EM

    更新日期：2012-09-17 00:00:00

  • Potential Modulation of Human NAD[P]H-Quinone Oxidoreductase 1 (NQO1) by EGCG and Its Metabolites-A Systematic Computational Study.

    abstract：:At high doses, green tea extracts and green tea's major active constituent, (-)-epigallocatechin gallate (EGCG), despite their generally perceived health benefits, have been suspected to cause hepatotoxicity in certain human populations. It has been reported that o-quinone metabolites of gallic acid or EGCG are causat...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/acs.chemrestox.9b00450

    authors： Pandey P,Avula B,Khan IA,Khan SI,Navarro VJ,Doerksen RJ,Chittiboyina AG

    更新日期：2020-11-16 00:00:00

  • Enzyme induction by L-buthionine (S,R)-sulfoximine in cultured mouse hepatoma cells.

    abstract：:Induction of Phase II enzymes of the [Ah] gene battery by L-buthionine (S,R)-sulfoximine (BSO) and other agents was examined in mouse hepatoma Hepa-1c1c7 cells. BSO, a nonelectrophilic inhibitor of gamma-glutamylcysteine synthetase (GCS), is routinely used to examine the toxicological implications of GSH depletion. Ex...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx00045a015

    authors： Shertzer HG,Vasiliou V,Liu RM,Tabor MW,Nebert DW

    更新日期：1995-04-01 00:00:00

  • Intracellular activation of cytotoxic agents: kinetic models for methylnitrosoureas and N-methyl-N'-nitro-N-nitrosoguanidine in cell culture.

    abstract：:The cytotoxic activity of N-methyl-N-nitrosourea (MNU), streptozotocin, and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was determined in cell culture by using a P388 cell growth rate inhibition assay. These agents appear to have very different activities when inhibition is related to the agent concentration in the cu...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx00009a006

    authors： Weinkam RJ,Dolan ME

    更新日期：1989-05-01 00:00:00

  • Nitroxidative, nitrosative, and nitrative stress: kinetic predictions of reactive nitrogen species chemistry under biological conditions.

    abstract：:A freely available Windows-based program, RNSim1A, is utilized to predict metal-independent reactive nitrogen species (RNS) chemistry (oxidation, nitrosation, and nitration) under simulated biological conditions and make the following specific predictions. (1) The peak in oxidative reactions that occurs in vitro with ...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx060061w

    authors： Lancaster JR Jr

    更新日期：2006-09-01 00:00:00

  • Reaction of CO2 with ONOO-: One Molecule of CO2 Is Not Enough.

    abstract：:With CO2 present in excess, ONOO- reacts to form an adduct in solution and in the solid state, most likely ONOOCO2-. In solution, the adduct appears within 2 ms and absorbs at 300 with an extinction coefficient, which is either 50% or 100% (preferred) of that of ONOO-, 1.70 × 103 M-1 cm-1, and at 685 nm with an extinc...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/acs.chemrestox.8b00068

    authors： Serrano-Luginbuehl S,Kissner R,Koppenol WH

    更新日期：2018-08-20 00:00:00

  • Mass spectrometric characterization of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine N-oxidized metabolites bound at Cys34 of human serum albumin.

    abstract：:2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a heterocyclic aromatic amine that is formed during the cooking of meats and poultry. PhIP is a carcinogen in rodents and a potential human carcinogen. Several short-term biomarkers of PhIP have been established for human biomonitoring, but validated long-term ...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx2003504

    authors： Peng L,Turesky RJ

    更新日期：2011-11-21 00:00:00

  • Identification of protein targets of 4-hydroxynonenal using click chemistry for ex vivo biotinylation of azido and alkynyl derivatives.

    abstract：:Polyunsaturated fatty acids (PUFA) are primary targets of free radical damage during oxidative stress. Diffusible electrophilic alpha,beta-unsaturated aldehydes, such as 4-hydroxynonenal (HNE), have been shown to modify proteins that mediate cell signaling (e.g., IKK and Keap1) and alter gene expression pathways respo...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx700347w

    authors： Vila A,Tallman KA,Jacobs AT,Liebler DC,Porter NA,Marnett LJ

    更新日期：2008-02-01 00:00:00

  • Oxidation of polychlorinated biphenyls by liver tissue slices from phenobarbital-pretreated mice is congener-specific and atropselective.

    abstract：:Mouse models are powerful tools to study the developmental neurotoxicity of polychlorinated biphenyls (PCBs); however, studies of the oxidation of chiral PCB congeners to potentially neurotoxic hydroxylated metabolites (OH-PCBs) in mice have not been reported. Here, we investigate the atropselective oxidation of chira...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx400229e

    authors： Wu X,Duffel M,Lehmler HJ

    更新日期：2013-11-18 00:00:00

  • Allyl alcohol activation of protein kinase C delta leads to cytotoxicity of rat hepatocytes.

    abstract：:Hepatotoxicity of allyl alcohol involves its bioactivation to acrolein and subsequent protein sulfhydryl loss and lipid peroxidation. However, the links between these events and hepatocellular death are not known. The purpose of these studies was to examine whether specific signal transduction pathways are associated ...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx025655n

    authors： Maddox JF,Roth RA,Ganey PE

    更新日期：2003-05-01 00:00:00