Abstract：
:Pharmacogenetics, the study of how individual genetic profiles influence the response to drugs, is an important topic. Results from pharmacogenetics studies in various clinical settings may lead to personalized medicine. Herein, we present the most important concepts of this discipline, as well as currently-used study methods.
journal_name
Enferm Infecc Microbiol Clinjournal_title
Enfermedades infecciosas y microbiologia clinicaauthors
Lubomirov R,Telenti A,Rotger Mdoi
10.1016/s0213-005x(08)76506-6subject
Has Abstractpub_date
2008-05-01 00:00:00pages
4-9eissn
0213-005Xissn
1578-1852pii
13123749journal_volume
26 Suppl 6pub_type
杂志文章abstract：INTRODUCTION:The increase in infections due to dermatophytes in recent years led us to study the effectiveness of new antifungal formulations against these microorganisms. METHODS:The in vitro activity of a new antifungal agent, voriconazole, was compared with three other antifungal agents, itraconazole, fluconazole a...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1016/s0213-005x(03)72992-9
更新日期：2003-11-01 00:00:00
abstract：INTRODUCTION:There is scant information available in Spain regarding virological markers and clinical status in Sub-Saharan patients infected with HVB. METHODS:A cross-sectional and retrospective study of virological markers and clinical status of HBV infection in 510 adult patients from Sub-Saharan Africa, not co-inf...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1016/j.eimc.2010.07.013
更新日期：2011-02-01 00:00:00
abstract：AIMS:Francisella tularensis is a facultative intracellular gramnegative aerobic coccobacilli which is difficult to isolate. The appearance of an epidemic outbreak of tularemia in Castilla y Leon (Spain) during the first months of 1998 led bur microbiology laboratory to develop the diagnostic methods of this disease whi...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：
更新日期：1999-11-01 00:00:00
abstract：:We present here 6 patients with Fasciola hepatica infection, all from rural origin, and with the risk factors of eating wild watercress. The more common symptoms were: fever (83%), abdominal pain (100%), weight loss (83%) and generalized myalgia and joint pain (67%). All patients presented with an absolute eosinophil ...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：
更新日期：1992-11-01 00:00:00
abstract：INTRODUCTION:Pneumocystis jirovecii pneumonia (PJP) is a life-threatening condition in immunocompromised children. Our aim is to analyze the epidemiologic and clinical characteristics of PJP cases in our setting, describing the prognosis and related risk factors. METHODS:Retrospective study including all pediatric pat...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1016/j.eimc.2019.05.005
更新日期：2020-03-01 00:00:00
abstract：:Prosthetic joint infection is an increasing public health problem. The bacterial biofilms that form on these foreign bodies are resistant to host defence mechanisms and antimicrobial therapy. Sixty per cent of prosthetic joint infections are caused by Staphylococcus sp., and they are usually acquired during surgery or...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1157/13123843
更新日期：2008-06-01 00:00:00
abstract：:Interest in simplification arises from the need to dispense with nucleoside analogs due to their long-term toxicity. Since the first trials analyzing the safety and effectiveness of the strategy with lopinavir/ritonavir (LPV/r) emerged more than 10 years ago, simplification continues to arouse scientific, clinical and...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1016/S0213-005X(14)70162-4
更新日期：2014-11-01 00:00:00
abstract：INTRODUCTION:Burkholderia cepacia (B. cepacia) complex is composed of 20 phylogenetically closely related bacterial species. Some species have emerged as opportunistic pathogens in immunocompromised patients and are responsible for nosocomial outbreaks. The B. cepacia complex is a recognized respiratory pathogen in pat...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章,多中心研究
doi：10.1016/j.eimc.2017.09.002
更新日期：2018-01-01 00:00:00
abstract：:The majority of healthcare associated infections are endemic, but outbreaks or epidemic infections also occur. The most frequent nosocomial endemic infections are catheter associated bacteremia, ventilator-associated pneumonia, surgical site infections and urinary catheter associated infections. These are conditions w...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1016/j.eimc.2012.10.010
更新日期：2013-03-01 00:00:00
abstract：:Monotherapy with LPV/r maintains blocked viral replication when used as a simplification strategy from antiretroviral therapy with a boosted protease inhibitor and two nucleoside analogs in patients with an undetectable viral load for at least 6 months. This simplification strategy can be recommended to patients in th...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章,评审
doi：10.1016/s0213-005x(08)76606-0
更新日期：2008-12-01 00:00:00
abstract：BACKGROUND:To evaluate a new chitin detection technique for the quantification of Aspergillus fumigatus infection in organs from air-borne infected mice. METHODS:Different groups of mice were air-borne infected with A. fumigatus spores. The mortality rate was studied as well as the extension of the infection by means ...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：
更新日期：1993-03-01 00:00:00
abstract：:Measles is a rash illness of moderate severity and high risk of serious complications, with recovery in several weeks. It is a viral disease caused by one of the most infectious and contagious pathogens that exists, whose only known reservoir is human. In 1998, the European Region of the WHO set a target of eliminatin...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章,评审
doi：10.1016/j.eimc.2015.10.013
更新日期：2015-12-01 00:00:00
abstract：:The development of novel direct antiviral agents (DAAs) against hepatitis C virus (HCV) has represented a breakthrough in the treatment of chronic hepatitis C. Telaprevir and boceprevir are the first two protease inhibitor (PI) DAAs to be approved for combination therapy with pegylated interferon (PEG-IFN) and ribavir...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1016/S0213-005X(13)70113-7
更新日期：2013-02-01 00:00:00
abstract：:Epidemiological data are useful to determine changes in forms of clinical expression and in the microbial agents causing infections. This allows empirical or preemptive treatments to be designed and can guide diagnostic tests. Empirical data also allow patients to be classified by risk group in order to decide on the ...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章,评审
doi：10.1157/13091240
更新日期：2005-12-01 00:00:00
abstract：BACKGROUND:Antibiotics account for 30% of hospital pharmacy expenses. More than 50% of the prescriptions are considered inappropriate; hence, programs devoted to optimizing the prescription of antibiotics should be developed. We present the results of a non-compulsory program for the assessment and control of antibioti...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1157/13073141
更新日期：2005-04-01 00:00:00
abstract：BACKGROUND:Pseudomonas aeruginosa neurosurgical meningitis is a rare entity, usually related with intraventricular catheters and associated with high mortality rates. We describe the clinical characteristics, treatment and outcomes of a series of neurosurgical meningitis caused by P. aeruginosa along 1990-2016. METHOD...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1016/j.eimc.2019.04.003
更新日期：2020-02-01 00:00:00
abstract：INTRODUCTION:In Venezuela, there have been some reports of carbapenemase KPC-producing Klebsiella pneumoniae. Nevertheless, since the first report in 2008, only a few studies have been done on their molecular epidemiology in this country. METHODS:The aims of this study were to detect extended-spectrum betalactamase (E...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1016/j.eimc.2017.12.004
更新日期：2019-02-01 00:00:00
abstract：INTRODUCTION:Only automated phenotypic methods are currently used in Colombian hospitals for identifying isolates of the Acinetobacter calcoaceticus-A. baumannii complex (ACB). The phenotypical similarities in these species mean that they cannot be differentiated by manual or automated methods, thereby leading to their...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1016/j.eimc.2012.07.013
更新日期：2013-03-01 00:00:00
abstract：BACKGROUND:Fecal colonization by multiresistant bacteria can be a source of nosocomial infections. The aim of this work was to study fecal colonization by Klebsiella pneumoniae in neonatal intensive care unit (NICU) patients and investigate the resistance profiles of the strains. METHODS:From May to October 2001, 11 s...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1157/13067617
更新日期：2004-11-01 00:00:00
abstract：INTRODUCTION:Citrus hystrix is widely used by Indonesians as a traditional medicine for gastrointestinal diseases, including Salmonella spp. infection. We investigated the antibacterial activity of the ethanolic peel extract of C. hystrix against Salmonella typhimurium. METHODS:The antibacterial activity was evaluated...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1016/j.eimc.2020.05.016
更新日期：2020-07-04 00:00:00
abstract：INTRODUCTION:Genotypic resistance was tested to investigate changes in the rates of resistance to antiretroviral drugs in non-treated patients in Spain. MATERIAL AND METHOD:A total of 209 HIV-infected patients from different autonomous communities in Spain without prior antiretroviral (AR) drug treatment were studied ...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1016/s0213-005x(05)75040-0
更新日期：2005-12-01 00:00:00
abstract：INTRODUCTION:In order to assess the relationship between the concentrations of airborne fungi and particles, particle counting was combined with fungal air sampling in several rooms of a hospital. METHODS:Concentrations of ≥0.5μm particles (P05) and ≥1μm particles (P1) were measured using a particle counter; fungal ai...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1016/j.eimc.2012.01.005
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND:Methicillin-resistant Staphylococcus aureus (MRSA) has become an important hospital-acquired pathogen, with transfer of the organism from a carrier or infected patient to uninfected patients by the hands or clothing of staff as the main mode of transmission. METHODS:Investigation of a cluster of new cases o...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1016/j.eimc.2012.10.002
更新日期：2013-10-01 00:00:00
abstract：INTRODUCTION:During the year 2000, the 1st nationwide project (GEIH-BLEE Project 2000) on Escherichia coli and Klebsiella pneumoniae producing extended-spectrum ss-lactamases (ESBL) was carried out in Spain. The 2nd nationwide study was developed in 2006 to investigate the evolution of this problem. METHODS:A prospect...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章,多中心研究
doi：10.1016/j.eimc.2008.09.006
更新日期：2009-11-01 00:00:00
abstract：:Bacteremia due to Campylobacter is a rare infection. Patients with HIV infection are an important risk group for this condition. We describe here two patients with Campylobacter bacteremia and advanced HIV infection. One case was due to C. jejuni infection in a drug addict, being also isolated C. jejuni in stool sampl...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：
更新日期：1992-03-01 00:00:00
abstract：:Intestinal parasite infections are very frequent in HIV patients with severe immunodeficiency (CD4 < 100/mm3) causing chronic diarrhea and malabsorption in the majority of cases. The most frequent microorganisms are microsporidia and Cryptosporidium parvum while Cyclospora cayetanensis and Isospora belli are more prev...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章,评审
doi：
更新日期：1998-01-01 00:00:00
abstract：UNLABELLED:The role of influenza viruses in severe acute respiratory infection (SARI) in Intensive Care Units (ICU) remains unknown. The post-pandemic influenza A(H1N1)pdm09 period, in particular, has been poorly studied. OBJECTIVE:To identify influenza SARI patients in ICU, to assess the usefulness of the symptoms of...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1016/j.eimc.2015.04.004
更新日期：2016-03-01 00:00:00
abstract：:The choice of antibiotic therapy in respiratory tract infections is usually empirical. However, this choice is complicated by the increasing prevalence of resistant strains among the major bacterial pathogens involved in these infections, particularly Streptococcus pneumoniae. The aim of antimicrobial therapy in respi...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章,评审
doi：10.1157/13059054
更新日期：2004-04-01 00:00:00
abstract：:Gonococcal infection is a current public health problem worldwide, being the second most prevalent bacterial sexually transmitted infection. The etiologic agent is Neisseria gonorrhoeae, a gram-negative diplococcus, and mainly causes urethritis in men. In women up to 50% of infections can be asymptomatic. N. gonorrhoe...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章,评审
doi：10.1016/j.eimc.2018.12.008
更新日期：2019-01-01 00:00:00
abstract：INTRODUCTION:The pathophysiological changes that determine the severity of dengue are still not well known, therefore it is important to study the probable relationship with the host genetic. METHODS:We analyzed the possible association between the FcγRIIa polymorphism and clinical signs in individuals who suffered de...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1016/j.eimc.2012.05.011
更新日期：2012-12-01 00:00:00
