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[Estimation of infection by Aspergillus fumigatus in mice infected experimentally by the respiratory route].

Abstract：

BACKGROUND:To evaluate a new chitin detection technique for the quantification of Aspergillus fumigatus infection in organs from air-borne infected mice. METHODS:Different groups of mice were air-borne infected with A. fumigatus spores. The mortality rate was studied as well as the extension of the infection by means of colony counts (UFC) and quantification of chitin . RESULTS:The inhalation of A. fumigatus spores by non-immunosuppressed mice produces a 34% mortality rate, with an initial invasion of lung tissue followed by the spleen, kidneys, heart and liver thereafter. CONCLUSION:The quantification of chitin in involved organs allowed us to estimate the degree of organ-specific fungal infections and perhaps could be an useful method for studying the pathogenesis of A. fumigatus infections.

journal_name

Enferm Infecc Microbiol Clin

journal_title

Enfermedades infecciosas y microbiologia clinica

authors

Jáuregui A,Martínez Palacios ML,Arnaiz I,Pontón J,Cisterna R

subject

Has Abstract

pub_date

1993-03-01 00:00:00

pages

126-30

issue

3

eissn

0213-005X

issn

1578-1852

journal_volume

11

pub_type

杂志文章

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