当前位置： SCI文献检索 > ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA期刊下所有文献 > Human papillomavirus (HPV) genotype distribution in women with abnormal cervical cytology in the Basque Country, Spain.

Human papillomavirus (HPV) genotype distribution in women with abnormal cervical cytology in the Basque Country, Spain.

Abstract：

INTRODUCTION:The aim of this study was to analyze the distribution of human papillomavirus (HPV) genotypes in cytologically abnormal cervical samples from 106 women living in a region of the north of Spain. METHODS:Cytological classification was reported according to the 2001 Bethesda System and HPV genotyping was performed by Roche Linear Array. RESULTS:The overall HPV prevalence was 69.8% with 30 different HPV genotypes detected. The prevalence of HR (high-risk) HPV types and pHR (probable high-risk) HPV types in positive samples was 94.3%, 78.1% and 100% in patients with ASCUS, LSIL and HSIL/CC, respectively, with no significant differences. The most frequent type was the HPV 16, present in 29.7% of all positive samples, followed by HPV 51 (17.5%), HPV 53 and 42 (16%), HPV 52 (12%), HPV 39 (10.8%), HPV 18 and 58 (9.4%) and HPV 66 (8.1%). No significant differences in the percentage of any HPV genotype with the grade of the cytological lesion were detected. The prevalence of HPV co-infection was 58.1% of HPV positive. CONCLUSIONS:This study confirms the high prevalence of high-risk genotypes in women with abnormal cytology living in our geographical area. This information may be useful for the formulation of algorithms for patient management according to the different risks associated with specific high-risk genotypes.

journal_name

Enferm Infecc Microbiol Clin

journal_title

Enfermedades infecciosas y microbiologia clinica

authors

Delgado D,Marín JM,de Diego J,Guerra S,González B,Barrios JL,Canut A

doi

10.1016/j.eimc.2011.10.021

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

230-5

issue

5

eissn

0213-005X

issn

1578-1852

pii

S0213-005X(11)00365-X

journal_volume

30

pub_type

杂志文章

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