[Christopher Columbus flu. A hypothesis for an ecological catastrophe].


:When Christopher Columbus and his men embarked on the second Colombian expedition to the New World (1493), the crew suffered from fever, respiratory symptoms and malaise. It is generally accepted that the disease was influenza. Pigs, horses and hens acquired in Gomera (Canary Islands) traveled in the same ship. The pigs may well have been the origin of the flu and the intermediary hosts for genetic recombination of other viral subtypes. The Caribbean archipelago had a large population of birds, the natural reservoir of the avian influenza virus. In this ecological scenario there was a concurrence of several biological elements that had never before coexisted in the New World: pigs, horses, the influenza virus and humans. We propose that birds are likely to have played an important role in the epidemiology of the flu occurring on the second Colombian trip, which caused a fatal demographic catastrophe, with an estimated mortality of 90% among the natives.


Muñoz-Sanz A




Has Abstract


2006-05-01 00:00:00














  • [Outbreak of gastroenteritis in a nursery school caused by a strain of Salmonella enterica serovar Typhimurium carrying the hybrid virulence-resistance plasmid pUO-StVR2].

    abstract:OBJECTIVE:Epidemiological and microbiological study of a salmonellosis outbreak, affecting 22 children in a nursery school in Oviedo (Spain). METHODS:Attack rates and epidemic curves were determined, and bacterial typing methods were applied. RESULTS:The outbreak was attributed to a Salmonella enterica serovar Typhim...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: Bances M,Herrero A,González Y,Rodicio MR,González-Hevia MA

    更新日期:2007-06-01 00:00:00

  • [Microbiological parameters of clinical interest in pulmonary infection in cystic fibrosis].

    abstract:BACKGROUND:A 5-year study in patients with cystic fibrosis was carried out in order to gain a better understanding of the microbiological factors influencing clinical status and evolution. METHODS:Fifty-two patients were evaluated (mean age 16.6 years, range 0-36) during a 5 years-period (July 1988- July 1992). The cl...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: Ballestero S,Escobar H,Suárez L,Baquero F

    更新日期:1996-04-01 00:00:00

  • [Interpretive reading of enterobacteria antibiograms].

    abstract::The resistance pattern observed in the antibiogram of an isolate should be the sum of its natural resistance pattern, characteristic of the species, plus the acquired resistances. In Enterobacteriaceae, the production of inactivating enzymes is the main mechanism of resistance to beta-lactams and aminoglycosides. Each...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审


    authors: Navarro F,Miró E,Mirelis B

    更新日期:2010-11-01 00:00:00

  • Strategies for the cure of HIV infection.

    abstract::The disadvantages of the long-term administration of antiretroviral therapy as well as the huge number of affected persons have placed the cure of HIV as a primary goal of Public Health. HIV may persist in the organism by at least four mechanisms: a latently infected cellular reservoir, the persistent replication of H...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审


    authors: Rodríguez-Muñoz J,Moreno S

    更新日期:2019-04-01 00:00:00

  • [Fecal colonization by extended-spectrum beta-lactamase-producing Klebsiella pneumoniae in a neonatal intensive care unit].

    abstract:BACKGROUND:Fecal colonization by multiresistant bacteria can be a source of nosocomial infections. The aim of this work was to study fecal colonization by Klebsiella pneumoniae in neonatal intensive care unit (NICU) patients and investigate the resistance profiles of the strains. METHODS:From May to October 2001, 11 s...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: Desimoni MC,Esquivel GP,Merino LA

    更新日期:2004-11-01 00:00:00

  • [Antimicrobial resistance and bacterial virulence].

    abstract::Hospitals are places with high selective pressure by antimicrobial agents. For this reason, bacteria producing nosocomial infections need to be not only virulent, but also resistant to antimicrobial agents. In the present review we analyse the effect of the acquisition of an antibiotic resistance phenotype in bacteria...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审


    authors: Linares-Rodríguez JF,Martínez-Menéndez JL

    更新日期:2005-02-01 00:00:00

  • First national survey of the diagnosis of Helicobacter pylori infection in Clinical Microbiology Laboratories in Spain.

    abstract:INTRODUCTION:The aim of this study was to know, through a national survey, the methods and techniques used for the diagnosis of Helicobacter pylori (Hp) in the different Clinical Microbiology Services/Laboratories in Spain, as well as antibiotic resistance data. METHODS:The survey requested information about the diagn...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: Miqueleiz-Zapatero A,Alba-Rubio C,Domingo-García D,Cantón R,Gómez-García de la Pedrosa E,Aznar-Cano E,Leiva J,Montes M,Sánchez-Romero I,Rodríguez-Díaz JC,Alarcón-Cavero T,Grupo de Trabajo de Diagnóstico Microbiológico de Helicobact

    更新日期:2020-11-01 00:00:00

  • [The recommendations of GESIDA/SEFH/PNS for improving adherence to antiretroviral treatment. AIDS Study Group of the Spanish Society of Hospital Pharmacy and the National Plan on AIDS of the Minister of Health and Consumers].

    abstract::The main objective of HAART is to achieve a complete suppression of the viral replication for long time. However, when the therapeutic drug levels are low, HIV can replicate and it can develop resistances. This fact can be the reason of treatment failure, HIV transmission of resistant strains and therefore an inapprop...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 指南,杂志文章,实务指引


    authors: Knobel H,Codina C,Miró JM,Carmona A,García B,Antela A,Gómez-Domingo MR,Arrizabalaga J,Iruin A,Laguna F,Jiménez I,Rubio R,Lluch A,Viciana P

    更新日期:2000-01-01 00:00:00

  • [Viral infections associated with intestinal invagination].

    abstract::Intestinal invagination is rather frequently associated with local tumors, adenovirus infections, and occasionally with Yersinia enterocolitica. However, in many cases the etiology is not known. We have studied 88 children with intestinal invagination in whom cellular cultures of Hep 2 and pulmonary fibroblasts of hum...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审


    authors: Calicó I,Bertrán Sangués JM,Elcuaz Romano RI,Casal J,Suñé Gracia MJ

    更新日期:1990-08-01 00:00:00

  • [Renal transplantation in patients with HIV infection].

    abstract::The prevalence of human immunodeficience virus (HIV) infection among patients under renal replacement therapy varies, with estimates of 1% for Europe and 1.5% for the United States. Survival in HIV infected individuals receiving renal replacement therapy has improved since the introduction of high activity antiretrovi...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审


    authors: Trullás JC,Miró JM,Barril G,Ros S,Burgos FJ,Moreno A,Mazuecos A,Alvarez-Vijande R,Oppenheimer F,Carmen Sánchez M,Blanco JL,Tuset M,Torre-Cisneros J,Polo R,González J

    更新日期:2005-06-01 00:00:00

  • [Subacute endocarditis caused by Actinobacillus actinomycetemcomitans].

    abstract:BACKGROUND:We describe the cases of endocarditis caused by Actinobacillus actinomycetemcomitans (EAA) observed at our hospital. PATIENTS AND METHODS:We revised clinical records and microbiological documents from patients admitted at our hospital, with A. actinomycetemcomitans in blood cultures occurred from 1972-1998....

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: Belloch SL,Salavert M,Lacruz J,López-Aldeguer J,Pérez-Bellés C

    更新日期:2000-10-01 00:00:00

  • [Fever of intermediate duration].

    abstract::Fever of intermediate duration (FID) is defined as non-localized fever occurring in the community, lasting from one to four weeks, and having no diagnostic orientation after basic clinical, analytical and radiological evaluations are completed. These may include careful recording of clinical history, physical examinat...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审


    authors: Rivero A,Zambrana JL,Pachón J

    更新日期:2003-03-01 00:00:00

  • Antimicrobial defined daily dose adjusted by weight: a proposal for antibiotic consumption measurement in children.

    abstract:INTRODUCTION:Antimicrobial defined daily dose (DDD), has limitations for antimicrobial consumption measurement in paediatrics. An alternative DDD design applicable for children is proposed. METHODS:Children (<16 years-old) from 10 Spanish hospitals during a 12-months period were included. Weight for age (50th percenti...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,多中心研究


    authors: Montecatine-Alonso E,Gil-Navarro MV,Fernández-Llamazares CM,Fernández-Polo A,Soler-Palacín P,Llorente-Gutiérrez J,Gómez-Travecedo Calvo MT,Esquivel-Mora MD,Pérez-Rodrigo I,Cisneros JM,Goycochea-Valdivia WA,Neth O,Paediatric Antim

    更新日期:2019-05-01 00:00:00

  • [Lipid alterations and cardiovascular risk associated with antiretroviral therapy].

    abstract::Dyslipidemia is common in HIV-infected patients receiving antiretroviral therapy (ART) and it is often associated with the use of specific antiretroviral drugs. The phenotypic profile can include elevated triglycerides or cholesterol alone, or mixed patterns with varying changes in LDL and HDL lipoproteins, which impl...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审


    authors: Masiá-Canuto M,Bernal-Morell E,Gutiérrez-Rodero F

    更新日期:2006-12-01 00:00:00

  • [Staphylococcus aureus infections: new challenges from an old pathogen].

    abstract::Staphylococcus aureus is a versatile organism with several virulent characteristics and resistance mechanisms at its disposal. It is also a significant cause of a wide range of infectious diseases in humans. S. aureus often causes life-threatening deep seated infections like bacteremia, endocarditis and pneumonia. Whi...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审


    authors: Kanafani ZA,Fowler VG Jr

    更新日期:2006-03-01 00:00:00

  • [Infection in heart transplantation].

    abstract::Heart transplantation has emerged as the therapy of choice for selected patients with life-threatening, irremediable heart disease. Infectious complications are frequent, but are no longer the leading cause of death. Late infections (particularly viral infections), however, are still a threat to long-term graft surviv...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审


    authors: Gurguí M,Muñoz P

    更新日期:2007-11-01 00:00:00

  • [Role of the hospital environment and equipment in the transmission of nosocomial infections].

    abstract::The hospital environment is both a reservoir and source of infection for the hospital patient. Several areas around the patient should be considered: air, toilet water coming into contact with the patient, staff and medical devices, food, surfaces, and instruments contacting the patient's skin and mucosa, and sterile ...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: López-Cerero L

    更新日期:2014-08-01 00:00:00

  • [Comparison of 3 methods for determining sensitivity to imipenem and meropenem in Acinetobacter baumannii with a carbapenem-heteroresistant phenotype].

    abstract:INTRODUCTION:We assessed agreement among 3 assays for determining susceptibility to imipenem (IMP) and meropenem (MPM) of Acinetobacter baumannii (Ab) heteroresistant to carbapenems (Hr-CP). METHODS:Thirty Ab clinical isolates belonging to 6 clones (REP-PCR) were studied, in which IMP and MPM MICs were between < or = ...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: Fernández-Cuenca F,Egea P,López-Cerero L,Díaz-De Alba P,Vila J,Pascual A

    更新日期:2008-10-01 00:00:00

  • Present epidemiology of tuberculosis. Prevention and control programs.

    abstract::Tuberculosis (TB) has affected humanity since the beginning of the recorded time and is associated with poverty, malnutrition, overcrowding, and immunosuppression. Since Koch discovered the infectious nature of the disease in 1882, knowledge about its history and physiopathology has advanced, but it continues to be a ...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审


    authors: Orcau À,Caylà JA,Martínez JA

    更新日期:2011-03-01 00:00:00

  • [In vitro bactericide activity of different antibiotic combinations to Streptococcus pneumoniae resistant to penicillin and cefotaxime].

    abstract:BACKGROUND:To determinate the bactericidal activity of vancomycin, rifampicin, cefotaxime, ceftriaxone and their double and triple combinations against penicillin and third generation cephalosporin-resistant. Streptococcus pneumoniae strain. METHODS:A study of the bactericidal activity of antibiotics alone and in comb...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: Tubau F,Liñares J,Ardanuy C,Martínez-Lacasa J,Fernández A,Cabellos C,Fernández-Viladrich P,Martín R

    更新日期:1996-12-01 00:00:00

  • Bacterial/fungal infection in hospitalized patients with COVID-19 in a tertiary hospital in the Community of Castilla y León, Spain.

    abstract:INTRODUCTION:Bacterial/fungal coinfection and superinfections contribute to the increased morbi-mortality of viral respiratory infections (RIs). The main objective of this study was to determine the incidence of these infections in hospitalized patients with COVID-19. METHOD:Retrospective observational study of all pa...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: Nebreda-Mayoral T,Miguel-Gómez MA,March-Rosselló GA,Puente-Fuertes L,Cantón-Benito E,Martínez-García AM,Muñoz-Martín AB,Orduña-Domingo A

    更新日期:2020-12-03 00:00:00

  • Phlebovirus-associated diseases transmitted by phlebotominae in Spain: Are we at risk?

    abstract::The genera Phlebovirus transmitted by Diptera belonging to the Psychodidae family are a cause of self-limited febrile syndrome in the Mediterranean basin in summer and autumn. Toscana virus can also cause meningitis and meningoencephalitis. In Spain, Toscana, Granada, Naples, Sicily, Arbia and Arrabida-like viruses ha...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审


    authors: García San Miguel L,Sierra MJ,Vazquez A,Fernandez-Martínez B,Molina R,Sanchez-Seco MP,Lucientes J,Figuerola J,de Ory F,Monge S,Suarez B,Simón F

    更新日期:2020-04-25 00:00:00

  • Q fever in Logroño: an attack scenario.

    abstract::Bioterrorism has emerged as an important infectious disease and public health challenge in the 21st century, and issues of preparedness and response are now prominent. The development of attack scenarios for assessing this problem contributes to the organization of response systems and identifies aspects that may need...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: Pappas G,Blanco JR,Oteo JA

    更新日期:2007-03-01 00:00:00

  • [Antimicrobial prophylaxis in surgery].

    abstract::Antimicrobial prophylaxis in surgery refers to a very brief course of an antimicrobial agent initiated just before the start of the procedure. The efficacy of antimicrobials to prevent postoperative infection at the site of surgery (incisional superficial, incisional deep, or organ/space infection) has been demonstrat...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: Cisneros JM,Rodríguez-Baño J,Mensa J,Trilla A,Cainzos M,Grupo de Estudio de Infeccion Hospitalaria (GEIH) de la Sociedad Espanola de Enfermedades Infecciosas y Microbiologia Clinica (SEIMC).

    更新日期:2002-08-01 00:00:00

  • [Prevalence of hepatitis virus infection markers in HIV-infected patients in Southern Spain].

    abstract:OBJECTIVES:To determine: (a) The prevalence of active infection by the hepatitis C virus (HCV) and hepatitis B virus (HBV) in HIV-infected patients, as well as previous exposure to hepatitis A virus (HAV), HBV and HCV. (b) The proportion of patients who have been vaccinated against HAV and/or HBV. (c) The HCV genotype ...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: Cifuentes C,Mira JA,Vargas J,Neukam K,Escassi C,García-Rey S,Gilabert I,González-Monclova M,Bernal S,Pineda JA

    更新日期:2012-10-01 00:00:00

  • [Sternoclavicular staphylococcal arthritis in non-immunodepressed patients. Study of 4 cases].

    abstract::We report four patients (3 males and one female) suffering a sternoclavicular staphylococcal arthritis in whom risk factors such as parenteral drug addiction, alcoholism, diabetes, or immunosuppression were not observed. The etiopathogenesis, clinical picture, and diagnosis of this uncommon septic arthritis in reviewe...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: Gómez Rodríguez N,Vidal Gayoso R,Graña Gil J,Lorenzo Porto JA,Sánchez Bursón JM,Galdo Fernández F,Atanes Sandoval A

    更新日期:1990-12-01 00:00:00

  • [Methicillin-resistant Staphylococcus aureus in patients with cystic fibrosis].

    abstract:OBJECTIVE:To determine the prevalence of chronic colonization with methicillin-resistant Staphylococcus aureus (MRSA) in patients with cystic fibrosis, describe antibiotic sensitivity of the strains, and compare the patients' clinical characteristics with those of patients infected with methicillin-sensitive S. aureus ...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: Girón RM,Buendía B,Pinedo C,Casanova A,Hoyos N,Ancochea J

    更新日期:2009-02-01 00:00:00

  • [Severe or life-threatening interactions between antiretrovirals and non-HIV drugs].

    abstract::Highly active antiretroviral therapy has helped to improved control of the HIV infection, and has led to a progressively older population with the infection having a life expectancy quite similar to that of the general population. On the other hand, it is also known that HIV infection, even in patients with undetectab...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审


    authors: Manzardo C,Tuset M,Miró JM,Gatell JM

    更新日期:2015-08-01 00:00:00

  • Antibacterial activity of Citrus hystrix toward Salmonella spp. infection.

    abstract:INTRODUCTION:Citrus hystrix is widely used by Indonesians as a traditional medicine for gastrointestinal diseases, including Salmonella spp. infection. We investigated the antibacterial activity of the ethanolic peel extract of C. hystrix against Salmonella typhimurium. METHODS:The antibacterial activity was evaluated...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: Ulhaq ZS,Hendyatama TH,Hameed F,Santosaningsih D

    更新日期:2020-07-04 00:00:00

  • [C reactive protein as marker of infection among patients with severe closed trauma].

    abstract:BACKGROUND:Injury and infection are characterized by the activation of the acute phase proteins response. C-reactive protein (CRP), an acute phase protein, has been mentioned as an useful indicator of infection and sepsis in critically ill patients. OBJECTIVE:To study the evolution of serum CRP in patients with severe...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: Flores JM,Jiménez PI,Rincón D,Márquez J,Navarro H,Muñoz A,Murillo F

    更新日期:2001-02-01 00:00:00