Abstract：
BACKGROUND:Antibiotics account for 30% of hospital pharmacy expenses. More than 50% of the prescriptions are considered inappropriate; hence, programs devoted to optimizing the prescription of antibiotics should be developed. We present the results of a non-compulsory program for the assessment and control of antibiotic treatment in the University Hospital 12 de Octubre in Madrid. METHODS:The program was applied in the hospitalization units of six medical and surgical departments. Treatments in all patients were checked daily and recommendations were made in writing, according to previously established criteria. The program was used for 12 months and the results were compared with those of the previous 12 months. RESULTS:1,280 treatments were reviewed and 524 recommendations were made (80% of them were accepted). There was a 13.82% reduction in the number of defined daily doses of antibiotics/100 inpatient-days. Antibiotic expenditure decreased by 65,352 euros (5,446 euros/month), implying a reduction of 1.21 euros/hospitalization-bed/day. There were no statistically significant differences in length of hospital stay or mortality between the two periods. A reduction in the incidence of Clostridium difficile diarrhea (p < 0.0001) and Candida spp. isolations (p < 0.05) was observed. CONCLUSIONS:Following application of a non-compulsory control program, antibiotic prescription improved and expenditure decreased, with no change in length of hospital stay or mortality. There was a reduction in the incidence of some nosocomial infections. Acceptation of the program by the physicians of the departments implicated was favorable.
journal_name
Enferm Infecc Microbiol Clinjournal_title
Enfermedades infecciosas y microbiologia clinicaauthors
López-Medrano F,San Juan R,Serrano O,Chaves F,Lumbreras C,Lizasoaín M,Herreros de Tejada A,Aguado JMdoi
10.1157/13073141subject
Has Abstractpub_date
2005-04-01 00:00:00pages
186-90issue
4eissn
0213-005Xissn
1578-1852pii
13073141journal_volume
23pub_type
杂志文章abstract：INTRODUCTION:Vancomycin-resistant enterococci (VRE) among haemodialysis patients has increased rapidly and, to date, there is no report of this incidence in Portugal. METHODS:A total of 121 faecal samples were collected from haemodialysis patients, and then tested for VRE. Antimicrobial resistance, virulence and multi...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1016/j.eimc.2013.09.001
更新日期：2014-03-01 00:00:00
abstract：INTRODUCTION AND OBJECTIVES:The primary aim of this study was to evaluate associated factors, clinical features and prognosis of healthcare-related infective endocarditis cases compared with community-acquired and intravenous drug user-related episodes. Changes in the distribution of healthcare-related infective endoca...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1016/j.eimc.2012.03.014
更新日期：2013-01-01 00:00:00
abstract：INTRODUCTION:Sustained virological response (SVR) 12 weeks after the end-of-therapy (EOT) has been correlated with SVR24 for HCV-monoinfection. We aim to validate SVR12 as criterion for definition of HCV cure in HIV-coinfected patients treated with all-oral direct-acting antivirals (DAA). METHODS:Prospectively observa...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1016/j.eimc.2019.07.009
更新日期：2020-01-01 00:00:00
abstract：:We analyze the experience in serologic diagnosis of Lyme's borreliosis. From a total of 551 patients studied from 1987 to 1989, we further evaluate 80 cases with erythema chronicum migrans or a clinical diagnosis of Lyme's disease and positive serological tests. The techniques used were IFI, ELISA1 (Whittaker Bioprodu...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：
更新日期：1991-06-01 00:00:00
abstract：:Urinary tract infections (UTI) are one of the most common infections in solid organ transplant (SOT) recipients. A systematic review was performed to assess the management of UTI in SOT recipients. Recommendations are provided on the management of asymptomatic bacteriuria, and prophylaxis and treatment of UTI in SOT r...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 共识发展会议,杂志文章,实务指引
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更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:The aim of the present study was to know the usefulness of a enzyme immunoanalysis (EIA) technique for the monitorization of the serologic to treatment of infection by Helicobacter pylori in Spanish children. METHODS:17 children with digestive symptomatology in whom the diagnosis of infection by Helicobacte...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:Mycobacterial culture has a high sensitivity and is the test of choice for the microbiological diagnosis of tuberculosis and nontuberculous mycobacterial infections. However, the results of this culture require at least 2-3 weeks to obtain positivity. Staining is rapid and can be used as a complementary study, althoug...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1016/j.eimc.2017.11.009
更新日期：2018-02-01 00:00:00
abstract：OBJECTIVE:To determine the number of strains of classic enteropathogenic E. coli (EPEC) that have the eae gene, that is considered a pathogenicity factor. MATERIAL AND METHODS:The presence of the eae gene has been evaluated on 62 EPEC strains of ten different serogroups, isolated from children with gastroenteritis. R...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：
更新日期：1998-06-01 00:00:00
abstract：INTRODUCTION:Colonization plays a major role in the epidemiology and pathogenesis of Staphylococcus aureus infections. The child population is one of the most susceptible to colonization; however, community and children studies are limited in Colombia. OBJECTIVE:To assess the clonal relationship of S.aureus strains is...
journal_title：Enfermedades infecciosas y microbiologia clinica
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更新日期：2016-03-01 00:00:00
abstract：OBJECTIVES:To prospectively study the emergence and diagnostic problems of bronchiolitis caused by influenza A virus among children durign the 1999-2000 influenza epidemic. MATERIALS AND METHODS:Negative respiratory syncitial virus (RSV) specimens (ELISA dot-blot) were seeded in the MDCK cell line for the isolation of...
journal_title：Enfermedades infecciosas y microbiologia clinica
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doi：10.1016/s0213-005x(01)72703-6
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abstract：BACKGROUND:The analysis of the immune response to rotavirus infection and the characterization of the viral antigens recognized by specific antibodies are of great concern in evaluating the protection against rotavirus. MATERIAL AND METHODS:The levels of rotavirus-specific fecal (sIgA) and serum antibodies (IgM, IgG a...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：
更新日期：1998-02-01 00:00:00
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journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章,多中心研究
doi：
更新日期：1998-08-01 00:00:00
abstract：AIMS:In this study, the potential of matrix-assisted laser desorption/ionization time-of-flight intact cell mass spectrometry (MALDI-TOF ICMS) was investigated for the identification of clinical isolates. The isolates were analyzed at the species and strain level. METHODS:Spectral identification by MALDI-TOF ICMS was ...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1016/j.eimc.2013.01.009
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Study of the serologic response in two groups of patients with pulmonary tuberculosis: with and without treatment. METHODS:Antibodies (type IgG) against the A60 antigen were studied in 103 patients with pulmonary tuberculosis: 46 without specific treatment and 57 after the application of the chemotherapy. ...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:The recovery rate of Moraxella catarrhalis in a selective culture medium with acetazolamide and in a conventional blood-agar medium was compared from 1291 samples from the respiratory tract and conjunctivae of children and adults with respiratory and ocular symptomatology. M. catarrhalis was recovered in 215 samples o...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：
更新日期：1992-08-01 00:00:00
abstract：INTRODUCTION:Collaboration is essential for biomedical research. The Carlos III Health Institute (the Spanish national public organization responsible for promoting biomedical research) has encouraged scientific collaboration by promoting Thematic Networks and Cooperative Research Centres. Scientific collaboration in E...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1016/j.eimc.2009.12.011
更新日期：2010-10-01 00:00:00
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journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章,评审
doi：10.1016/S0213-005X(09)73440-8
更新日期：2009-09-01 00:00:00
abstract：OBJECTIVES:To determine: (a) The prevalence of active infection by the hepatitis C virus (HCV) and hepatitis B virus (HBV) in HIV-infected patients, as well as previous exposure to hepatitis A virus (HAV), HBV and HCV. (b) The proportion of patients who have been vaccinated against HAV and/or HBV. (c) The HCV genotype ...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1016/j.eimc.2011.12.008
更新日期：2012-10-01 00:00:00
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journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：
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journal_title：Enfermedades infecciosas y microbiologia clinica
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更新日期：2010-11-01 00:00:00
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journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章,评审
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更新日期：2010-01-01 00:00:00
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journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1016/s0213-005x(08)72692-2
更新日期：2008-04-01 00:00:00
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journal_title：Enfermedades infecciosas y microbiologia clinica
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doi：
更新日期：1999-06-01 00:00:00
abstract：INTRODUCTION:The incidence of human immunodeficiency virus (HIV) and other sexually transmitted diseases increases in males who have sex with males (MSM), despite the knowledge on how to prevent them. To determine the mechanisms that are driving this lack of prevention is important to reverse the trend. PATIENTS AND M...
journal_title：Enfermedades infecciosas y microbiologia clinica
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更新日期：2014-04-01 00:00:00
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journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
abstract：INTRODUCTION:The use of the matrix-assisted laser desorption/ionization time of flight (MALDI-TOF) mass spectrometry has shown to be effective and fast in some clinical specimens for the identification of colonizing microorganisms. The objective of the study was to analyze the validity values for the prediction of colo...
journal_title：Enfermedades infecciosas y microbiologia clinica
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更新日期：2014-06-01 00:00:00
abstract：:Sexually transmitted infections are a global public health problem both due to their high prevalence and due to their morbidity. A rapid and precise diagnosis is key to establishing appropriate targeted treatment and also to decreasing dissemination of these diseases among the high-risk population. To perform adequate...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章,评审
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更新日期：2019-02-01 00:00:00
abstract：:Clinical microbiology today is a well established specialty in Spain whose development has necessarily been linked to improvements in the diagnosis, treatment and prevention of infectious diseases. Over time, clinical, teaching, and research structures have been organized around these diseases. In addition, a scientif...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 历史文章,杂志文章
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更新日期：2010-10-01 00:00:00
abstract：:Bioterrorism has emerged as an important infectious disease and public health challenge in the 21st century, and issues of preparedness and response are now prominent. The development of attack scenarios for assessing this problem contributes to the organization of response systems and identifies aspects that may need...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1157/13099373
更新日期：2007-03-01 00:00:00
abstract：BACKGROUND:The aim of this paper is to review the epidemiological, clinical and therapeutical characteristics of Haemophilus influenzae type b (Hib) epiglottitis in children at a time when an efficient and safe vaccination is available. METHODS:The clinical histories of 21 children admitted to Children's Hospital La F...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章,评审
doi：
更新日期：1997-11-01 00:00:00
