Abstract:
INTRODUCTION:Pneumocystis jirovecii pneumonia (PJP) is a life-threatening condition in immunocompromised children. Our aim is to analyze the epidemiologic and clinical characteristics of PJP cases in our setting, describing the prognosis and related risk factors. METHODS:Retrospective study including all pediatric patients (≤18 years) with PJP admitted to our hospital (January 1989-December 2016). Case definition: patient with acute pneumonitis and P.jirovecii detection in bronchoalveolar lavage or tracheal aspirate using methenamine silver or direct antibody fluorescence staining, or Real-Time Polymerase Chain Reaction. RESULTS:Twenty-five cases (0.9 cases/year) were identified. Median age was 2.2 years (interquartile range: 0.5-12.3), 64% were male, and 12% were receiving appropriate antimicrobial prophylaxis. Cytomegalovirus coinfection was detected in 26% cases. The most common underlying diseases were primary immunodeficiencies (36%) and 16% were human immunodeficiency virus (HIV)-infected children. Eighteen were admitted to the pediatric intensive care unit (PICU) and overall 30-day mortality was 20% (31.25% in HIV non-infected vs 0% in HIV-infected patients; OR: 0.33, 95% CI: 0.02-7.24, p=0.55). Clinical outcome was worse in girls and those patients requiring adjuvant steroid therapy. HIV non-infected patients, higher initial LDH, younger age and shorter time elapsed between diagnosis of PJP and the underlying disease were identified as risk factors to be admitted to the PICU (p=0.05, p=0.026, p=0.04 and p=0.001 respectively). CONCLUSION:Accompanying the widespread use of combined antiretroviral therapy, PJP has been diagnosed almost exclusively in HIV non-infected children at our institution. Moreover, significant higher morbidity rates associated with PJP are seen in this group of patients.
journal_name
Enferm Infecc Microbiol Clinjournal_title
Enfermedades infecciosas y microbiologia clinicaauthors
García-Moreno J,Melendo-Pérez S,Martín-Gómez MT,Frick MA,Balcells-Ramírez J,Pujol-Jover M,Martín-Nalda A,Mendoza-Palomar N,Soler-Palacín Pdoi
10.1016/j.eimc.2019.05.005subject
Has Abstractpub_date
2020-03-01 00:00:00pages
111-118issue
3eissn
0213-005Xissn
1578-1852pii
S0213-005X(19)30187-9journal_volume
38pub_type
杂志文章abstract::The anaerobic bacteria resistance to antibiotics is increasing, and even has appeared against the most active of those, like metronidazol and carbapenems. This fact forces to make and periodical sensibility tests -at least in the most aggressive and virulent species, in cases that they are isolated from life locations...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
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abstract:INTRODUCTION:Small colony variants of Staphylococcus aureus (SCVSA) are a sub-population with special features. METHODS:The phenotypic features and antibiotic susceptibility of four clinical isolates SCVSA were studied. RESULTS:Colonies grew in the usual culture media, except in Mueller Hinton. All isolates were resi...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
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更新日期:2014-02-01 00:00:00
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journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:
更新日期:1996-08-01 00:00:00
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journal_title:Enfermedades infecciosas y microbiologia clinica
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abstract:OBJECTIVE:To study the possible viral etiology in 139 infants with lower respiratory tract infection who required hospitalization in the Infant Unit of our hospital, from October 1994 to June 1995. PATIENTS AND METHODS:139 patients were admitted, aged from 13 days to 14 months, during this period. The etiological agen...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:
更新日期:1998-12-01 00:00:00
abstract:INTRODUCTION:The aim of this study is to describe a Shigella sonnei outbreak in a school. METHOD:An epidemiological inquiry was performed. Stool samples from 5 patients were cultured. Molecular typing of the isolates was carried out by PFGE, MLST and plasmid analysis. RESULTS:The attack rate was 14.3% (67 students). ...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:10.1157/13100466
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abstract:INTRODUCTION:Knowledge of adherence to highly active antiretroviral treatment (HAART) and the variables associated with poor compliance is useful for the follow-up of HIV infected patients. PATIENTS, MATERIAL AND METHODS:Patients were consecutively recruited from the HIV outpatient clinics of the Hospitals of Leon and...
journal_title:Enfermedades infecciosas y microbiologia clinica
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journal_title:Enfermedades infecciosas y microbiologia clinica
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journal_title:Enfermedades infecciosas y microbiologia clinica
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更新日期:1995-02-01 00:00:00
abstract::The relevance of mixed genital infections in our area was evaluated, and we report their clinical and epidemiological features for both viral types. We evaluated overall 54 Herpes simplex virus (HSV) isolates from 44 patients seen at the clinic of sexually transmitted diseases (STD) of the Sevilla School of Medicine d...
journal_title:Enfermedades infecciosas y microbiologia clinica
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doi:
更新日期:1989-05-01 00:00:00
abstract::This review offers succinct, precise, and complete information based on the available data concerning new anaerobic bacterial species involved in infectious diseases in humans. All hitherto undescribed species, those not previously implicated in clinical conditions, those with confirmed implication in human disease th...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章,评审
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更新日期:2010-03-01 00:00:00
abstract::The results of the study of 117 outbreaks of food poisoning in the Basque Autonomous Community during 1984-1986 are reported. In 76% of these outbreaks the causative agent could be isolated. Bacteria of the genus Salmonella accounted for 86.5% of the outbreaks with a known etiology, S. enteritidis being the most commo...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:
更新日期:1989-12-01 00:00:00
abstract::The diagnostic effectiveness of a new test for the detection of bacteriuria (Filtrachek-UTI) was compared with Gram stain and semiquantitative culture in 955 urine samples. 276 of these were from inpatients (108 males and 168 females), and 677 from outpatients (206 males and 471 females). Overall 229 positive cultures...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:
更新日期:1989-08-01 00:00:00
abstract:BACKGROUND:The aim of this paper is to review the epidemiological, clinical and therapeutical characteristics of Haemophilus influenzae type b (Hib) epiglottitis in children at a time when an efficient and safe vaccination is available. METHODS:The clinical histories of 21 children admitted to Children's Hospital La F...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章,评审
doi:
更新日期:1997-11-01 00:00:00
abstract::Prosthetic joint infection is an increasing public health problem. The bacterial biofilms that form on these foreign bodies are resistant to host defence mechanisms and antimicrobial therapy. Sixty per cent of prosthetic joint infections are caused by Staphylococcus sp., and they are usually acquired during surgery or...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:10.1157/13123843
更新日期:2008-06-01 00:00:00
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journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:
更新日期:1996-12-01 00:00:00
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journal_title:Enfermedades infecciosas y microbiologia clinica
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doi:10.1016/j.eimc.2015.02.020
更新日期:2016-02-01 00:00:00
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journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
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journal_title:Enfermedades infecciosas y microbiologia clinica
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journal_title:Enfermedades infecciosas y microbiologia clinica
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更新日期:2011-10-01 00:00:00
abstract::The main objective of HAART is to achieve a complete suppression of the viral replication for long time. However, when the therapeutic drug levels are low, HIV can replicate and it can develop resistances. This fact can be the reason of treatment failure, HIV transmission of resistant strains and therefore an inapprop...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 指南,杂志文章,实务指引
doi:
更新日期:2000-01-01 00:00:00
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journal_title:Enfermedades infecciosas y microbiologia clinica
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更新日期:2006-12-01 00:00:00
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journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:10.1157/13083372
更新日期:2006-01-01 00:00:00
abstract::Quantification of hepatitis C virus (HCV) RNA (viral load) is the most widely used marker to diagnose and confirm active HCV infection. The HCV core antigen forms part of the internal structure of the virus and, like HCV RNA, its detection also indicates viral replication and presents certain advantages over viral loa...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:10.1016/j.eimc.2020.02.003
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:To determine: (a) The prevalence of active infection by the hepatitis C virus (HCV) and hepatitis B virus (HBV) in HIV-infected patients, as well as previous exposure to hepatitis A virus (HAV), HBV and HCV. (b) The proportion of patients who have been vaccinated against HAV and/or HBV. (c) The HCV genotype ...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:10.1016/j.eimc.2011.12.008
更新日期:2012-10-01 00:00:00
abstract::Tuberculosis is still a serious public health problem, with 10.8 million new cases and 1.8 million deaths worldwide in 2015. The diversity among members of the Mycobacterium tuberculosis complex, the causal agent of tuberculosis, is conducive to the design of different methods for rapid diagnosis. Mutations in the gen...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章,评审
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更新日期:2017-10-01 00:00:00
abstract:INTRODUCTION:To describe clinical features, complications, serotypes and antibiotic resistance in pneumococcal pneumonia in our environment after the generalization of the heptavalent conjugate vaccine (PCV-7) in paediatrics. MATERIAL AND METHODS:Prospective study of episodes of pneumococcal pneumonia, with positive c...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:10.1016/j.eimc.2010.09.014
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Evidence-based medicine (EBM) analyses scientific evidence for the efficacy/effectiveness of health interventions. It aims to identify and implement available interventions that have proved to be the best. This concept is now soundly established for clinical interventions, but just breaking for prevention, p...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章,评审
doi:
更新日期:1999-01-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to analyze the distribution of human papillomavirus (HPV) genotypes in cytologically abnormal cervical samples from 106 women living in a region of the north of Spain. METHODS:Cytological classification was reported according to the 2001 Bethesda System and HPV genotyping was per...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:10.1016/j.eimc.2011.10.021
更新日期:2012-05-01 00:00:00