The novel compounds that activate farnesoid X receptor: the diversity of their effects on gene expression.

abstract：:Hyperglycemia, which occurs under the diabetic condition, induces serious diabetic complications. Diabetic neuropathies, affecting the autonomic, sensory, and motor peripheral nervous system, are among the most frequent complications of diabetes. Little is known about the direct toxic effect of high glucose concentrat...

journal_title：Journal of pharmacological sciences

authors： Sharifi AM,Mousavi SH,Farhadi M,Larijani B

更新日期：2007-07-01 00:00:00

abstract：:At the end of the last century, microarray technology that examines the total genes and transcripts present in a cell became available as a laboratory tool. Mast cells are known to play a pivotal role in initiating allergic inflammation by releasing various mediators and cytokines. According to the recent microarray-b...

journal_title：Journal of pharmacological sciences

authors： Saito H

更新日期：2008-03-01 00:00:00

abstract：:Simultaneous administration of psychostimulants and opioids is a major drug abuse problem worldwide. This combination appears to produce synergistic effects on behavior at low doses; however, there is little direct evidence that the combination is stronger than either drug alone. Therefore, we investigated interaction...

journal_title：Journal of pharmacological sciences

authors： Mori T,Ito S,Narita M,Suzuki T,Sawaguchi T

更新日期：2004-12-01 00:00:00

abstract：:Aspirin (acetylsalicylic acid) is a well-known nonsteroidal anti-inflammatory drug that can potentiate some acute allergies and causes adverse immunological reactions collectively referred to as aspirin intolerance, a disorder that induces urticaria, asthma, and anaphylaxis in response to oral administration of the dr...

journal_title：Journal of pharmacological sciences

authors： Suzuki Y,Ra C

更新日期：2009-07-01 00:00:00

abstract：:Glutamate excitotoxicity mediated by N-methyl-d-aspartate (NMDA) receptors is an important cause of retinal ganglion cell death in glaucoma. To elucidate whether apelin protects against retinal neuronal cell death, we examined protective effects of exogenous and endogenous apelin on neuronal cell death induced by intr...

journal_title：Journal of pharmacological sciences

authors： Ishimaru Y,Sumino A,Kajioka D,Shibagaki F,Yamamuro A,Yoshioka Y,Maeda S

更新日期：2017-01-01 00:00:00

abstract：:The role of extracellular calcium in the interaction between intracellular cAMP and nitric oxide (NO)/cGMP on the contractility of rat diaphragm pretreated with cumulative concentrations of aminophylline (0.36 - 3.60 mM) was investigated. In a Ca2+-free medium, NG-nitro-L-arginine methyl ester (L-NAME) (1 and 3 mM) de...

journal_title：Journal of pharmacological sciences

authors： Stojanovic R,Todorović Z,Nesić Z,Vućković S,Cerovac-Cosić N,Prostran M

更新日期：2004-12-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a group of small noncoding RNAs that regulate translational repression of multiple target mRNAs. The miRNAs in a whole cell regulate greater than 30% of all protein-coding genes. The vast majority of presently identified miRNAs are expressed in the brain in a spatially and temporally controlled ...

journal_title：Journal of pharmacological sciences

authors： Satoh J

更新日期：2010-01-01 00:00:00

abstract：:The specific toxicity to dopaminergic neurons of psychostimulants and neurotoxins has been extensively studied in vivo and in vitro, and findings have been used to establish animal models of amphetamine psychosis or Parkinson's disease. The multiple mechanisms of neurotoxicity operating in these disorders are known to...

journal_title：Journal of pharmacological sciences

authors： Kita T,Asanuma M,Miyazaki I,Takeshima M

更新日期：2014-01-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNFalpha)-induced cell death is regulated through the release of arachidonic acid (AA) by group IVA cytosolic phospholipase A2 (cPLA2alpha) in the murine fibroblast cell line L929. However, the signaling pathway by which TNFalpha activates cPLA2alpha remained to be solved. We examined AA r...

journal_title：Journal of pharmacological sciences

authors： Shimizu M,Azuma C,Taniguchi T,Murayama T

更新日期：2004-11-01 00:00:00

abstract：:Schisandra chinensis is a hepatoprotective herb that has been used for centuries in China. Polysaccharide is one of the major active components in S. chinensis, which has been reported to improve liver injuries induced by carbon tetrachloride, alcohol, or high-fat diet. In this study, we observed the effects and corre...

journal_title：Journal of pharmacological sciences

authors： Che J,Yang S,Qiao Z,Li H,Sun J,Zhuang W,Chen J,Wang C

更新日期：2019-07-01 00:00:00

abstract：:Butyrate is widely accepted as a proliferation inhibitor in colon cancer but less thoroughly characterized in the colonic epithelium of objects with type 2 diabetes mellitus. The present study investigated the regulatory effect of butyrate on proliferation, the related molecule high-mobility group box 1 (HMGB1) and th...

journal_title：Journal of pharmacological sciences

authors： Wang SY,Li JY,Xu JH,Xia ZS,Cheng D,Zhong W,Lai Y,Yu T,Chen QK

更新日期：2019-04-01 00:00:00

abstract：:The hippocampus is a brain region well-known to exhibit structural and functional changes in temporal lobe epilepsy. Studies analyzing the brains of patients with epilepsy and those from animal models of epilepsy have revealed that microglia are excessively activated, especially in the hippocampus. These findings sugg...

journal_title：Journal of pharmacological sciences

authors： Andoh M,Ikegaya Y,Koyama R

更新日期：2020-12-01 00:00:00

abstract：:It has been shown that enhancement of vasoconstrictor prostanoids plays an important role in the development of cardiovascular diseases. The aim of the present study was to examine the effects of pyrrolidine dithiocarbamate (PDTC), a low-molecular-weight thiol antioxidant and a potent inhibitor of nuclear factor-kappa...

journal_title：Journal of pharmacological sciences

authors： Matsumoto T,Ishida K,Kobayashi T,Kamata K

更新日期：2009-07-01 00:00:00

abstract：:By using immunofluorostaining and confocal laser microscopy, acetylcholine-induced translocation of RhoA was visualized in freshly isolated bronchial smooth muscle cells of the rat. The cellular distribution of RhoA at rest was observed uniformly in the cytosolic space with no staining in the nucleus, whereas acetylch...

journal_title：Journal of pharmacological sciences

authors： Chiba Y,Uchida T,Sakai H,Oku T,Itoh S,Tsuji T,Misawa M

更新日期：2004-08-01 00:00:00

abstract：:Lymphangiogenesis is related to the growth of endometriosis. Here, we examined whether vascular endothelial growth factor (VEGF) receptor 1 (VEGFR1) signaling plays a role in lymphangiogenesis during endometriosis. Endometrial fragments from wild-type (WT) mice transplanted into the peritoneal wall of host WT mice (WT...

journal_title：Journal of pharmacological sciences

authors： Hattori K,Ito Y,Honda M,Sekiguchi K,Hosono K,Shibuya M,Unno N,Majima M

更新日期：2020-08-01 00:00:00

abstract：:Lig-8, a lignophenol derivative from bamboo lignin, potently suppresses oxidative stress-induced apoptosis. Here, we first examined in vitro whether lig-8 protects against neuronal damage induced by oxygen-glucose deprivation (OGD) followed by reoxygenation, tunicamycin [endoplasmic reticulum (ER)-stress inducer], or ...

journal_title：Journal of pharmacological sciences

authors： Ito Y,Shimazawa M,Akao Y,Nakajima Y,Seki N,Nozawa Y,Hara H

更新日期：2006-10-01 00:00:00

abstract：:Primary osteoporosis (POP), which is caused by unbalanced bone remodeling, leads to significant economic and societal burdens globally. Gushukang (GSK) granule serves as one commonly used prescription for POP in Traditional Chinese Medicine (TCM). The present study aimed to clarify the exact roles of GSK in bone remod...

journal_title：Journal of pharmacological sciences

authors： Wang Q,Zhao Y,Sha N,Zhang Y,Li C,Zhang H,Tang D,Lu S,Shi Q,Wang Y,Shu B,Zhao D

更新日期：2018-03-01 00:00:00

abstract：:We studied the pronociceptive role of proteinase-activated receptor-2 (PAR2) in mouse bladder. In female mice, intravesical infusion of the PAR2-activating peptide, SLIGRL-amide (SL), caused delayed mechanical hypersensitivity in the lower abdomen, namely 'referred hyperalgesia', 6-24 h after the administration. The P...

journal_title：Journal of pharmacological sciences

authors： Tsubota M,Ozaki T,Hayashi Y,Okawa Y,Fujimura A,Sekiguchi F,Nishikawa H,Kawabata A

更新日期：2018-01-01 00:00:00

abstract：:Our previous study showed that organobismuth compounds induce apoptosis in human promyelocytic leukemia cells, although solid tumor cell lines were relatively resistant. Herein, we investigated the primary cellular target of these compounds in HeLa cells. One organobismuth compound, bi-chlorodibenzo[c,f][1,5]thiabismo...

journal_title：Journal of pharmacological sciences

authors： Iuchi K,Akagi K,Yagura T

更新日期：2009-04-01 00:00:00

abstract：:Metformin has received increasing attention for its potential anticancer activity against certain human leukemia cells, but its effects on human megakaryoblastic cells are unclear. This study aimed to investigate the effects of metformin on proliferation and apoptosis of human megakaryoblastic cells (Dami and MEG-01) ...

journal_title：Journal of pharmacological sciences

authors： Liang X,Kong P,Wang J,Xu Y,Gao C,Guo G

更新日期：2017-09-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is defined as elevation of mean pulmonary arterial pressure to ≥25 mmHg within the low pressure pulmonary circulatory system. PAH is characterized by obstructive vascular remodeling, partially due to excessive pulmonary arterial smooth muscle cell (PASMC) proliferation. Puerarin i...

journal_title：Journal of pharmacological sciences

authors： Zhang X,Liu Q,Zhang C,Sheng J,Li S,Li W,Yang X,Wang X,He S,Bai J,Zhu D

更新日期：2019-10-01 00:00:00

abstract：:Polyriboinosinic-polyribocytidilic acid (polyI:C) is a synthetic analog that elicits viral-like immune responses in mammals. We have recently found that polyI:C treatment in neonatal mice induced abnormalities of emotional, cognitive, and sensorimotor gating and dysfunction of glutamatergic neurotransmission in adulth...

journal_title：Journal of pharmacological sciences

authors： Nagai T,Yu J,Kitahara Y,Nabeshima T,Yamada K

更新日期：2012-01-01 00:00:00

abstract：:Cyclophosphamide (CPA) is a widely used chemotherapeutic drug for neoplasias. It is a DNA and protein alkylating agent having a broad spectrum of activity against a variety of neoplasms including breast cancer. The therapeutic effectiveness of CPA is limited by the high-dose hematopoietic, renal, and cardiac toxicity ...

journal_title：Journal of pharmacological sciences

authors： Singh N,Nigam M,Ranjan V,Sharma R,Balapure AK,Rath SK

更新日期：2009-04-01 00:00:00

abstract：:The aim of this study was to classify antiarrhythmic drugs based on their effectiveness on 6 in vivo arrhythmia models, mainly using dogs. The models were produced by two-stage coronary ligation, digitalis, halothane-adrenaline, programmed electrical stimulation in old myocardial infarction dogs, coronary artery occlu...

journal_title：Journal of pharmacological sciences

authors： Hashimoto K

更新日期：2007-04-01 00:00:00

abstract：:Aggressive tumor growth and diffuse tissue invasion are hallmarks of malignant glioma. Embelin is an active compound identified as a novel XIAP inhibitor from the Embelia ribes that exhibits various medicinal effects including anti-inflammatory and anti-cancer activities. In the present study, we investigated whether ...

journal_title：Journal of pharmacological sciences

authors： Park SY,Lim SL,Jang HJ,Lee JH,Um JY,Kim SH,Ahn KS,Lee SG

更新日期：2013-01-01 00:00:00

abstract：:The aim of this study was to characterize the effects of rebamipide on the oxidative burst of human neutrophils. The neutrophil oxidative burst was measured in the presence of rebamipide and cimetidine using lucigenin- or luminol-dependent chemiluminescence (LgCL or LmCL). Rebamipide inhibited the LmCL response stimul...

journal_title：Journal of pharmacological sciences

authors： Shimoyama T,Fukuda S,Liu Q,Fukuda Y,Nakaji S,Sugawara K

更新日期：2003-02-01 00:00:00

abstract：:To ascertain whether steroid therapy evokes dentin hypersensitivity (DH)-like tooth pain, we performed a study based on compelling evidence from patients receiving steroid therapy. An exploratory study was conducted using a questionnaire for 220 patients prescribed steroids who attended the Department of Hematology an...

journal_title：Journal of pharmacological sciences

authors： Shoji N,Endo Y,Iikubo M,Ishii T,Harigae H,Aida J,Sakamoto M,Sasano T

更新日期：2016-11-01 00:00:00

abstract：:We recently developed a novel cognitive enhancer, ST101 (spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one), that activates T-type voltage-gated calcium channels (VGCCs). Here, we address whether T-type VGCC activation with ST101 mediates its cognitive effects in vivo and the relevance of T-type VGCC activation to ace...

journal_title：Journal of pharmacological sciences

authors： Yamamoto Y,Shioda N,Han F,Moriguchi S,Fukunaga K

更新日期：2013-01-01 00:00:00

abstract：:B cells are important in the development of autoimmune disorders through mechanisms involving dysregulated polyclonal B-cell activation, production of pathogenic antibodies, and targeting which reduces inflammation and tissue damage effectively but often leads to patients suffering from secondary infection. Paeoniflor...

journal_title：Journal of pharmacological sciences

authors： Zhang J,Li H,Huo R,Zhai T,Li H,Sun Y,Shen B,Li N

更新日期：2015-05-01 00:00:00

abstract：:Kursi Wufarikun Ziyabit (KWZ) is a traditional prescription that used in folk tea drinking for its health care effect in treatment of type 2 diabetes mellitus (T2DM) in central Asia. However, the underlying mechanism of KWZ in T2DM has not been investigated extensively. This study designed to observe the effect of KWZ...

journal_title：Journal of pharmacological sciences

authors： Edirs S,Jiang L,Xin X,Aisa HA

更新日期：2018-06-01 00:00:00