What are critical outcome measures for patients receiving pituitary replacement following brain injury?

abstract：PURPOSE:Secondary empty sella syndrome (SESS) following pituitary surgery remains a diagnostic and therapeutic challenge. The aim of this study was to specify the diagnostic criteria, surgical indications and results of chiasmapexy in the SESS. METHODS:Three cases from two experienced neurosurgical centers were collec...

journal_title：Pituitary

authors： Graillon T,Passeri T,Boucekine M,Meyer M,Abritti R,Bernat AL,Labidi M,Dufour H,Froelich S

更新日期：2020-11-02 00:00:00

abstract：:Silent growth hormone adenomas (SGHA) are a rare entity of non-functioning pituitary neuroendocrine tumors. Diagnosis is invariably made post-operatively of a tumor immunopositive for GH (and Pit-1 in selected cases) but without clinical acromegaly. Mainly young females are affected, and tumors are often uncovered by ...

journal_title：Pituitary

authors： Langlois F,Woltjer R,Cetas JS,Fleseriu M

更新日期：2018-04-01 00:00:00

abstract：:The diagnosis of disorders of growth hormone (GH) is dependent upon accurate measurement of insulin-like growth factor-I (IGF-I) concentrations since serum IGF-I assays have been found to be useful as a screening tests for the presence of growth hormone deficiency (GHD) in children and in both children and adults they...

journal_title：Pituitary

authors： Clemmons DR

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:Nelson's syndrome is a challenging condition that can develop following bilateral adrenalectomy for Cushing's disease, with high circulating ACTH levels, pigmentation and an invasive pituitary tumor. There is no established medical therapy. The aim of the study was to assess the effects of pasireotide on plasma...

journal_title：Pituitary

authors： Daniel E,Debono M,Caunt S,Girio-Fragkoulakis C,Walters SJ,Akker SA,Grossman AB,Trainer PJ,Newell-Price J

更新日期：2018-06-01 00:00:00

abstract：:Growth hormone excess has been associated with hypercalciuria and nephrolithiasis. Hypercalcemia in acromegaly is rare and usually due to coexistent primary hyperparathyroidism. To report two cases of 1,25-dihydroxyvitamin D (1,25 (OH)(2) D)-dependent hypercalcemia in cromegaly. A 50 year-old female with 2 years histo...

journal_title：Pituitary

authors： Shah R,Licata A,Oyesiku NM,Ioachimescu AG

更新日期：2012-12-01 00:00:00

abstract：PURPOSE:Approximately 25 % of cases of clinically active acromegaly cases treated in our academic center between 1996 and 2000, were diagnosed in patients who had elevated plasma IGF-1 levels, but apparently "normal" 24-h mean plasma GH levels. The current study served to update the data for patients with acromegaly re...

journal_title：Pituitary

authors： Butz LB,Sullivan SE,Chandler WF,Barkan AL

更新日期：2016-12-01 00:00:00

abstract：:Pituitary adenomas rarely originate outside the sella turcica. Ectopic locations include the suprasellar region, sphenoid sinus, cavernous sinus and clivus. We describe a 50-year-old female who presented with clinical signs and biochemical evidence of acromegaly. Pituitary MRI demonstrated a 2 mm hypointense lesion on...

journal_title：Pituitary

authors： Appel JG,Bergsneider M,Vinters H,Salamon N,Wang MB,Heaney AP

更新日期：2012-12-01 00:00:00

abstract：:A diabetic acromegalic man, not cured after surgery and radiosurgery, received lanreotide i.m. with great clinical and biochemical improvement. He required NPH insulin (76 to 84 units/day) to control his diabetes mellitus. Thirty-six hours after changing to LAR-octreotide (20 mg i.m/month) he presented symptomatic hyp...

journal_title：Pituitary

authors： Webb SM,Ortega E,Rodríguez-Espinosa J,Mato ME,Corcoy R

更新日期：2001-09-01 00:00:00

abstract：:A 57-year-old woman presented with 2-year history of polyuria and polydipsia. Hormonal studies revealed almost normal anterior pituitary function and central diabetes insipidus. Magnetic resonance imaging showed thickening of the pituitary stalk and enlargement of the neurohypophysis without high intensity of the post...

journal_title：Pituitary

authors： Waki K,Yamada S,Ozawa Y,Seki K,Endo Y

更新日期：1999-05-01 00:00:00

abstract：INTRODUCTION:Cushing's syndrome is associated with a number of clinical manifestations and co-morbidities which may not resolve even after long-term remission leading to excessive mortality. MATERIALS AND METHODS:This review summarizes the main manifestations of Cushing's syndrome (active or in remission) with particu...

journal_title：Pituitary

authors： Ntali G,Grossman A,Karavitaki N

更新日期：2015-04-01 00:00:00

abstract：:Isolated familial somatotropinomas (IFS) rarely occurs in the absence of multiple endocrine neoplasia type I (MEN1) or the Carney complex. In the present study we report two Italian siblings affected by GH-secreting adenomas. There was no history of parental consanguinity. The sister presented at 18 years of age with ...

journal_title：Pituitary

authors： De Menis E,Prezant TR

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Xanthogranulomas are inflammatory masses most commonly found at peripheral sites such as the skin. Sellar and parasellar xanthogranulomas are rare and present a diagnostic challenge as they are difficult to differentiate from other sellar lesions such as craniopharyngiomas and Rathke's cleft cysts pre-operat...

journal_title：Pituitary

authors： Ved R,Logier N,Leach P,Davies JS,Hayhurst C

更新日期：2018-06-01 00:00:00

abstract：:We report the case of a 60 year old male who complained of headache and blurry vision--that progressed to left ophthalmoplegia and ptosis--after receiving a dose of leuprolide for Prostate cancer therapy. Imaging showed a hemorrhagic sellar mass. The patient underwent transsphenoidal debulking, and the tissue obtained...

journal_title：Pituitary

authors： Guerra Y,Lacuesta E,Marquez F,Raksin PB,Utset M,Fogelfeld L

更新日期：2010-01-01 00:00:00

abstract：:In this report, an extremely rare case of pediatric thyrotropin-secreting pituitary macroadenoma (TSHoma) is described. An 8-year-old boy, complaining of unsteady gait, was suspected of endocrinopathy because of emaciation and muscle weakness of the legs. Endocrinological work-up established a diagnosis of hyperthyroi...

journal_title：Pituitary

authors： Nakayama Y,Jinguji S,Kumakura S,Nagasaki K,Natsumeda M,Yoneoka Y,Saito T,Fujii Y

更新日期：2012-03-01 00:00:00

abstract：PURPOSE:The pituitary gland is an unusual site for metastatic spread, but as patients with metastatic malignancy are living longer, it may become more prevalent. Compression of important anatomy adjacent to the sella may produce disabling symptoms and endocrine derangement, leading to significant morbidity. METHODS:An...

journal_title：Pituitary

authors： Castle-Kirszbaum M,Goldschlager T,Ho B,Wang YY,King J

更新日期：2018-10-01 00:00:00

abstract：:It is estimated that up to one in five individuals develops pituitary gland tumors, despite the common occurrence of these tumors, the pathogenetic mechanisms underlying their development mainly remain unknown. We studied the gene expression in null cell adenomas compared with normal pituitary by expressed sequence ta...

journal_title：Pituitary

authors： Hu J,Song H,Wang X,Shen Y,Chen F,Liu Y,Li S,Wang Y,Shou X,Zhang Y,Hu R

更新日期：2007-01-01 00:00:00

abstract：:Dopamine agonists have been shown to reduce growth hormone secretion in some patients with acromegaly, but their effect on adenoma size has not been well appreciated. We describe a 69 year-old woman with acromegaly caused by a somatotroph macroadenoma who received primary treatment with the dopamine agonist cabergolin...

journal_title：Pituitary

authors： Rickels MR,Snyder PJ

更新日期：2004-01-01 00:00:00

abstract：:Primary autoimmune hypophysitis (PAH) is considered an underdiagnosed disease, due to the difficulty in reaching a definitive diagnosis. PAH clinical diagnosis remains an exclusion diagnosis. We aimed to correlate PAH neuro-radiological signs to endocrine features and evaluate their prognostic role. 24 PAH cases were ...

journal_title：Pituitary

authors： Tartaglione T,Chiloiro S,Laino ME,Giampietro A,Gaudino S,Zoli A,Bianchi A,Pontecorvi A,Colosimo C,De Marinis L

更新日期：2018-08-01 00:00:00

abstract：:Surgical cure cannot be achieved in most patients with invasive non-functioning pituitary macroadenoma (NFPA). Short-term residual tumor treatment with somatostatin analogs has produced disappointing results. This prospective case-control study assessed the efficacy of chronic treatment with long acting octreotide (oc...

journal_title：Pituitary

authors： Fusco A,Giampietro A,Bianchi A,Cimino V,Lugli F,Piacentini S,Lorusso M,Tofani A,Perotti G,Lauriola L,Anile C,Maira G,Pontecorvi A,De Marinis L

更新日期：2012-12-01 00:00:00

abstract：:Double pituitary adenomas are rare in surgical specimens and the most common clinical feature in reported patients has been acromegaly. We report 3 cases of double pituitary lesions in patients who presented with Cushing's disease. In a 22-year-old man (case 1) with delayed puberty and low testosterone levels, mild hy...

journal_title：Pituitary

authors： Meij BP,Lopes MB,Vance ML,Thorner MO,Laws ER Jr

更新日期：2000-11-01 00:00:00

abstract：PURPOSE:It is estimated that approximately 69 million individuals worldwide will sustain a TBI each year, which accounts for substantial morbidity and mortality in both children and adults. TBI may lead to significant neuroendocrine changes, if the delicate pituitary is ruptured. In this review, we focus on the anterio...

journal_title：Pituitary

authors： Ntali G,Tsagarakis S

更新日期：2019-06-01 00:00:00

abstract：:Cis-unsaturated free fatty acids (FFA) like oleic acid are strong blockers of both basal and stimulated GH secretion in vivo by acting directly on the somatotroph cell. Several lines of evidence suggest that this inhibitory action is the result of a perturbation of the function of several plasma membrane integral prot...

journal_title：Pituitary

authors： Pérez FR,Camiña JP,Menéndez C,Beiras A,Casabiell X,Casanueva FF

更新日期：1998-04-01 00:00:00

abstract：:The morphology of the various pituitary cell types is highly dynamic and allows recognition of many cellular functions. Most pituitary cells show morphologic changes that reflect stimulation or inhibition by hormones. Drugs have also been shown to alter the morphology of several pituitary tumor types, allowing a measu...

journal_title：Pituitary

authors： Asa SL,Ezzat S

更新日期：2002-01-01 00:00:00

abstract：:Acromegaly is a consequence of chronic growth hormone (GH) excess, due in the majority of cases to a GH-secreting pituitary adenoma, and occurring with a population prevalence of 60 per million and an incidence of 3-4 per million per year. Males and females appear to be equally affected with an average age of presenta...

journal_title：Pituitary

authors： Holdaway IM,Rajasoorya C

更新日期：1999-06-01 00:00:00

abstract：INTRODUCTION:Early disease onset, clinical manifestation, histomorphology, and increased tendency to relapse distinguish the adamantinomatous craniopharyngioma (adaCP) from the more favorable papillary variant (papCP). A molecular hallmark of adaCP is the activated Wnt signaling pathway indicated by nuclear β-catenin a...

journal_title：Pituitary

authors： Hölsken A,Stache C,Schlaffer SM,Flitsch J,Fahlbusch R,Buchfelder M,Buslei R

更新日期：2014-12-01 00:00:00

abstract：:We describe two young men with cystic pituitary enlargement on magnetic resonance imaging (MRI) causing hypopituitarism. The first patient presented acutely unwell with headache and vomiting associated with anterior and posterior pituitary dysfunction. The second patient presented with hypopituitarism after a long his...

journal_title：Pituitary

authors： Burt MG,Morey AL,Turner JJ,Pell M,Sheehy JP,Ho KK

更新日期：2003-01-01 00:00:00

abstract：:Non-functioning pituitary neuroendocrine tumors do not cause endocrine symptoms related to hypersecretion of adenohypophyseal hormones and are clinically characterized by symptoms due to growing sellar tumor mass. Histopathological classification of this tumor group has always been challenging due to their heterogenei...

journal_title：Pituitary

authors： Manojlovic-Gacic E,Engström BE,Casar-Borota O

更新日期：2018-04-01 00:00:00

abstract：:Anemia and other hematological abnormalities are common in patients with Sheehan's syndrome. The response of these abnormalities to replacement of thyroxine and glucocorticoids is not clear. The aim of the present study was to document the profile of hematological abnormalities and response to treatment in patients wi...

journal_title：Pituitary

authors： Laway BA,Mir SA,Bashir MI,Bhat JR,Samoon J,Zargar AH

更新日期：2011-03-01 00:00:00

abstract：:In western countries, the process of "ageing of the population" is increasingly forcing clinical medicine to find answers for pathologies affecting the elder segments of our community. In this respect, pituitary adenomas often raise difficult questions on surgical indications, since little is known about postoperative...

journal_title：Pituitary

authors： Locatelli M,Bertani G,Carrabba G,Rampini P,Zavanone M,Caroli M,Sala E,Ferrante E,Gaini SM,Spada A,Mantovani G,Lania A

更新日期：2013-06-01 00:00:00

abstract：PURPOSE:Hypophysitis develops in up to 19% of melanoma patients treated with ipilimumab, a cytotoxic T-lymphocyte antigen-4 antibody. Early detection may avert life-threatening hypopituitarism. We aimed to assess the incidence of ipilimumab-induced hypophysitis (IH) at a quaternary melanoma referral centre, and to dete...

journal_title：Pituitary

authors： De Sousa SMC,Sheriff N,Tran CH,Menzies AM,Tsang VHM,Long GV,Tonks KTT

更新日期：2018-06-01 00:00:00