Achieving rapid reperfusion with primary percutaneous coronary intervention remains a challenge: insights from American Heart Association's Get With the Guidelines program.

abstract：BACKGROUND:The APEX trial assessed the safety and efficacy of extended-duration thromboprophylaxis using betrixaban versus standard dosing of enoxaparin among hospitalized, acutely ill medical patients. The 80-mg betrixaban dose was halved to 40 mg among subjects with severe renal insufficiency and those receiving a co...

journal_title：American heart journal

authors： Gibson CM,Halaby R,Korjian S,Daaboul Y,Arbetter DF,Yee MK,Goldhaber SZ,Hull R,Hernandez AF,Lu SP,Bandman O,Leeds JM,Gold A,Harrington RA,Cohen AT,APEX Investigators.

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVES:To define the incidence and cumulative risk of atrial fibrillation (AF) in a population-based cohort of whites and African Americans. BACKGROUND:African-Americans reportedly have a lower risk of AF than whites despite their higher exposure to AF risk factors. However, precise estimates of AF incidence in Af...

journal_title：American heart journal

authors： Alonso A,Agarwal SK,Soliman EZ,Ambrose M,Chamberlain AM,Prineas RJ,Folsom AR

更新日期：2009-07-01 00:00:00

abstract：:There is evidence that the endothelium plays an important role in the control of human vascular tone by releasing endothelium-derived nitric oxide and, therefore, a defective endothelial function could be involved in the increased peripheral vasoconstriction of patients with chronic congestive heart failure. To invest...

journal_title：American heart journal

authors： Drexler H,Hayoz D,Münzel T,Just H,Zelis R,Brunner HR

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:Recent work has demonstrated a link between retinopathy, a marker of microvascular disease, and the development of heart failure, a finding particularly relevant in individuals with diabetes. Our objective was to assess the relationship between retinopathy and cardiac structure and function in a cohort of in...

journal_title：American heart journal

authors： Aguilar D,Hallman DM,Piller LB,Klein BE,Klein R,Devereux RB,Arnett DK,Gonzalez VH,Hanis CL

更新日期：2009-03-01 00:00:00

abstract：:Inhibition of the enzyme that synthesizes thromboxanes may protect against the development of ventricular fibrillation (VF) during acute myocardial ischemia. This study was carried out to test this hypothesis with a new thromboxane synthetase inhibitor, and to extend the studies to alternative animal models of myocard...

journal_title：American heart journal

authors： O'Connor KM,Friehling TD,Kowey PR

更新日期：1989-04-01 00:00:00

abstract：:Baroreflex modulation of forearm vascular resistance (FVR) has been reported to be abnormal in patients with congestive heart failure (CHF). However, the neurohumoral mechanisms for this impairment are not defined. We assessed the responses of arterial pressure, FVR, plasma norepinephrine, and plasma renin activity to...

journal_title：American heart journal

authors： Mohanty PK,Arrowood JA,Ellenbogen KA,Thames MD

更新日期：1989-07-01 00:00:00

abstract：:The method for evaluating right ventricular and pulmonary artery systolic pressures by subtracting the systolic pressure gradient across the ventricular septal defect from the cuff systolic blood pressure is documented. To confirm the reliability and accuracy of this method, simultaneous continuous wave Doppler echoca...

journal_title：American heart journal

authors： Ge Z,Zhang Y,Kang W,Fan D,Ji X,Duran C

更新日期：1993-04-01 00:00:00

abstract：:Left ventricular angiography frequently produces one or more premature atrial or ventricular contractions which may make quantitative volume analysis unreliable. Three hundred left ventricular power injections were analyzed and found to produce premature ventricular contractions (PVC's) in 28 per cent of injections an...

journal_title：American heart journal

authors： Caldwell JH,Kennedy JW

更新日期：1977-02-01 00:00:00

abstract：OBJECTIVE:To determine the effect of exercise training on cardiac autonomic modulation in normal older adults by using analysis of heart rate variability. SUBJECTS:The exercise group consisted of 7 men and 9 women aged 66 +/- 4 years. The comparison group consisted of 7 men and 9 women also aged 66 +/- 4 years. METHO...

journal_title：American heart journal

authors： Stein PK,Ehsani AA,Domitrovich PP,Kleiger RE,Rottman JN

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:In the general population, obesity is associated with an increased risk of all-cause death. However, the importance of obesity in patients with established coronary heart disease is less well defined. METHODS:As part of the Determinants of Myocardial Infarction Onset Study, we performed a prospective cohort...

journal_title：American heart journal

authors： Rana JS,Mukamal KJ,Morgan JP,Muller JE,Mittleman MA

更新日期：2004-05-01 00:00:00

abstract：:To test the hypothesis that elevated plasma levels of natriuretic peptides may serve to identify patients with left ventricular (LV) dysfunction, we assessed the predictive diagnostic value of natriuretic peptide levels, in addition to clinical and electro-cardiographic risk factors, as noninvasive indicators of cardi...

journal_title：American heart journal

authors： Muders F,Kromer EP,Griese DP,Pfeifer M,Hense HW,Riegger GA,Elsner D

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND:Chronic periodontal infection is associated with an increased risk of coronary heart disease. Although the mechanism responsible for the relationship between periodontal disease and cardiovascular events is not fully understood, it is hypothesized that the chronic inflammatory burden of periodontal disease m...

journal_title：American heart journal

authors： Elter JR,Hinderliter AL,Offenbacher S,Beck JD,Caughey M,Brodala N,Madianos PN

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Aldosterone antagonist therapy is recommended for selected patients with heart failure and reduced ejection fraction. Adherence to therapy in the transition from hospital to home is not well understood. METHODS:We identified patients with heart failure and reduced ejection fraction who were ≥65 years old, e...

journal_title：American heart journal

authors： Curtis LH,Mi X,Qualls LG,Check DK,Hammill BG,Hammill SC,Heidenreich PA,Masoudi FA,Setoguchi S,Hernandez AF,Fonarow GC

更新日期：2013-06-01 00:00:00

abstract：:An acute thrombus at the proximal border of a high-grade atherosclerotic obstruction is the usual cause of myocardial infarction. Although intracoronary thrombolysis is potentially an exciting new therapy for reducing the extent of myocardial infarction by lysing coronary clot, a number of major difficulties limit its...

journal_title：American heart journal

authors： Spann JF,Sherry S,Carabello BA,Mann RH,McCann WD,Gault JH,Gentzler RD,Rosenberg KM,Maurer AH,Denenberg BS,Warner HF,Rubin RN,Malmud LS,Comerota A

更新日期：1982-10-01 00:00:00

abstract：:Abnormal interventricular septal motion is a frequent finding after cardiac surgery. However, the time course and underlying mechanisms are not well understood. Nineteen patients, mean age 54 years (range 20 to 82 years), were studied with intraoperative transesophageal echocardiography at five specific times: with th...

journal_title：American heart journal

authors： Wranne B,Pinto FJ,Siegel LC,Miller DC,Schnittger I

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:In 10,001 patients with stable coronary artery disease (CAD) enrolled in the Treating to New Targets (TNT) trial, 80 mg/d of atorvastatin (high-dose regimen) reduced the composite primary end point of death from CAD, nonfatal myocardial infarction, resuscitation from cardiac arrest, or stroke by 22% relative...

journal_title：American heart journal

authors： Mark DB,Knight JD,Cowper PA,Davidson-Ray L,Anstrom KJ

更新日期：2008-10-01 00:00:00

abstract：:We tested the efficacy of microwave-frequency energy for ablating atrial tachycardia in eight open-chest dogs. Five other dogs served as controls. Atrial tachycardia was induced by direct application of aconitine crystals to the epicardial atrial surface or by injection of aconitine solution (0.15 mg/ml) into the righ...

journal_title：American heart journal

authors： Rho TH,Ito M,Pride HP,Waller B,Zipes DP

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:Although the safety and cost-effectiveness of same-day discharge after uncomplicated transradial percutaneous coronary intervention (TR-PCI) is well established in Europe and Asia, such data are not available for US patients. METHODS:All patients who underwent TR-PCI at our high-volume US medical center bet...

journal_title：American heart journal

authors： Jabara R,Gadesam R,Pendyala L,Chronos N,Crisco LV,King SB,Chen JP

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:The long-term prognostic significance of elevated cardiac markers in an undifferentiated patient population with chest pain is unknown. METHODS:Serum troponin I (cTnI), creatine kinase-MB (CK-MB), and myoglobin were measured at presentation in 951 consecutive patients evaluated in the emergency department f...

journal_title：American heart journal

authors： Jaffery Z,Nowak R,Khoury N,Tokarski G,Lanfear DE,Jacobsen G,McCord J

更新日期：2008-11-01 00:00:00

abstract：:One hundred thirty-three patients with dilated heart failure, 80 with coronary artery disease, and 53 with idiopathic dilated cardiomyopathy were followed for a mean of 29 months. Patients with ischemic heart disease had a worse prognosis than those classified as having idiopathic cardiomyopathy. Features from history...

journal_title：American heart journal

authors： Kelly TL,Cremo R,Nielsen C,Shabetai R

更新日期：1990-05-01 00:00:00

abstract：OBJECTIVE:To examine the safety and efficacy of cangrelor in patients with single-vessel disease (SVD) and multi-vessel disease (MVD). BACKGROUND:Cangrelor, an intravenous, rapidly acting P2Y12 inhibitor, is superior to clopidogrel in reducing ischemic events among patients receiving percutaneous coronary intervention...

journal_title：American heart journal

authors： Abnousi F,Sundaram V,Yong CM,Prats J,Deliargyris EN,Stone GW,Hamm CW,Steg PG,Gibson CM,White HD,Price MJ,Généreux P,Desai M,Yang L,Ding VY,Harrington RA,Bhatt DL,Mahaffey KW

更新日期：2017-06-01 00:00:00

abstract：:In 14 patients with severe congestive heart failure, the effects of captopril on the forearm circulation were evaluated with strain gauge plethysmography. Changes in plasma renin activity, angiotensin II, norepinephrine, epinephrine, bradykinin, prostaglandin E2, and 6-keto-prostaglandin F1 alpha concentrations were a...

journal_title：American heart journal

authors： Nishimura H,Kubo S,Ueyama M,Kubota J,Kawamura K

更新日期：1989-01-01 00:00:00

abstract：:The Salt Substitute and Stroke Study is an ongoing 5-year large-scale cluster randomized trial investigating the effects of potassium-enriched salt substitute compared to usual salt on the risk of stroke. The study involves 600 villages and 20,996 individuals in rural China. Intermediate risk markers were measured in ...

journal_title：American heart journal

authors： Huang L,Tian M,Yu J,Li Q,Liu Y,Yin X,Wu JH,Marklund M,Wu Y,Li N,Elliott P,Yan LL,Labarthe DR,Hao Z,Shi J,Feng X,Zhang J,Zhang Y,Zhang R,Zhou B,Li Z,Sun J,Zhao Y,Yu Y,Neal B

更新日期：2020-03-01 00:00:00

abstract：:Combination therapy with mexiletine (MEX) and quinidine (Q) may be more efficacious than monotherapy with either drug in suppressing ventricular arrhythmias, but its effects on ventricular performance are not known. Thus, right ventricular ejection fraction (RVEF) and left ventricular ejection fraction (LVEF) and wall...

journal_title：American heart journal

authors： Sheldon RS,Duff HJ,Mitchell LB,Wyse DG,Manyari DE

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND:Recent data indicate that cardiac antibodies play an active role in the pathogenesis of dilated cardiomyopathy (DCM) and may contribute to cardiac dysfunction in patients with DCM. The present study investigated the influence of immunoadsorption with subsequent immunoglobulin G substitution (IA/IgG) on cardi...

journal_title：American heart journal

authors： Herda LR,Trimpert C,Nauke U,Landsberger M,Hummel A,Beug D,Kieback A,Dörr M,Empen K,Knebel F,Ewert R,Angelow A,Hoffmann W,Felix SB,Staudt A

更新日期：2010-05-01 00:00:00

abstract：:The aim of this study was to determine whether paroxysmal atrial fibrillation (PAF) and/or restoration to sinus rhythm with electric or pharmacologic cardioversion induce modifications to the coagulation system. Thirty-five patients with PAF undergoing either electric (n = 11) or pharmacologic (n = 24) cardioversion w...

journal_title：American heart journal

authors： Giansante C,Fiotti N,Miccio M,Altamura N,Salvi R,Guarnieri G

更新日期：2000-09-01 00:00:00

abstract：:Adenosine infusion is accompanied by increases in coronary blood flow and myocardial blood volume. Myocardial blood volume may produce changes in diastolic left ventricular (LV) performance by increasing myocardial turgor. Diastolic dysfunction may also be the result of myocardial ischemia. The relation between change...

journal_title：American heart journal

authors： Ren JF,Pancholy SB,Kegel JG,Lighty GW Jr,Heo J,Iskandrian AS

更新日期：1995-04-01 00:00:00

abstract：:Left ventricular (LV) adaptation to the hemodynamic load of pregnancy has been studied with load-sensitive ejection-phase indexes, but the results of these studies are conflicting. The aim of this study was to examine the effects of the hemodynamic load of pregnancy on the contractile state of the left ventricle by us...

journal_title：American heart journal

authors： Geva T,Mauer MB,Striker L,Kirshon B,Pivarnik JM

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Fractional flow reserve (FFR) has become a gold standard in physiological assessment of coronary artery stenosis. An FFR < 0.75 is considered as a reliable physiological parameter indicating functionally significant lesion. Lesion length (LL) may affect the translesional hemodynamics. However, the effect of ...

journal_title：American heart journal

authors： Brosh D,Higano ST,Lennon RJ,Holmes DR Jr,Lerman A

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:Research has shown that vaccination with Streptococcus pneumoniae reduced the extent of atherosclerosis in experimental animal models. It is thought that phosphorylcholine lipid antigens in the S. pneumoniae cell wall induce the production of antibodies that cross-react with oxidized low-density lipoprotein,...

journal_title：American heart journal

authors： Ren S,Hure A,Peel R,D'Este C,Abhayaratna W,Tonkin A,Hopper I,Thrift AG,Levi C,Sturm J,Durrheim D,Hung J,Briffa T,Chew DP,Anderson P,Moon L,McEvoy M,Hansbro P,Newby D,Attia J,AUSPICE study group.

更新日期：2016-07-01 00:00:00