Abstract：
BACKGROUND:In the general population, obesity is associated with an increased risk of all-cause death. However, the importance of obesity in patients with established coronary heart disease is less well defined. METHODS:As part of the Determinants of Myocardial Infarction Onset Study, we performed a prospective cohort study of 1898 patients hospitalized with confirmed acute myocardial infarction between 1989 and 1994, with a median follow-up of 3.8 years. We assessed all-cause death through December 1995, using the National Death Index. We categorized patients according to WHO criteria for body mass index (BMI). We compared long-term death according to BMI (kg/m2) by using Cox proportional hazards regression. RESULTS:Of the 1898 eligible patients, 607 (32%) were normal weight (18.5 to 24.9 kg/m2), 832 (44%) were overweight (25.0 to 29.9 kg/m2), 331 (17%) were class I obese (30.0 to 34.9 kg/m2), and 128 (7%) were class II or more obese (> or =35.0 kg/m2). A total of 311 patients died during follow-up. After adjustment for potentially confounding risk factors and excluding patients with noncardiac comorbidity, the risk for death appeared to increase linearly, with increasing BMI across all categories (P for trend =.08). The relative risk of death in all obese patients (> or =30 kg/m2) was 1.46, compared with those with normal weight (95% CI, 0.98 to 2.17). CONCLUSIONS:We found that BMI appeared to have a positive, graded relation with post-myocardial infarction death. Whether weight reduction and secondary prevention strategies would reverse this effect in obese population remains to be seen.
journal_name
Am Heart Jjournal_title
American heart journalauthors
Rana JS,Mukamal KJ,Morgan JP,Muller JE,Mittleman MAdoi
10.1016/j.ahj.2003.12.015subject
Has Abstractpub_date
2004-05-01 00:00:00pages
841-6issue
5eissn
0002-8703issn
1097-6744pii
S0002870303008792journal_volume
147pub_type
杂志文章,多中心研究abstract：:The purpose of this study was to compare the three most commonly used maximal graded exercise test (GXT) protocols in healthy women. Submaximal and maximal metabolic and hemodynamic responses were determined from two treadmill protocols, Bruce and Balke, and a bicycle protocol, in 49 women. Maximum oxygen uptake (VO2 ...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(82)90275-7
更新日期：1982-03-01 00:00:00
abstract：:The results of percutaneous transluminal coronary angioplasty (PTCA) in 307 lesions in 235 patients within 60 days of myocardial infarction (MI) were compared with the PTCA results in 591 lesions in 489 patients without recent MI, and the effect of fibrinolysis to treat recurring occlusive clot during angioplasty was ...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(90)90065-6
更新日期：1990-08-01 00:00:00
abstract：BACKGROUND:The aim of this study was to describe the effect of intravenous metoprolol on the intensity of chest pain before hospital admission in patients with suspected acute myocardial infarction AMI). METHODS AND RESULTS:Two hundred sixty-two patients with acute chest pain and suspected AMI were randomly assigned b...
journal_title：American heart journal
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0002-8703(99)70405-9
更新日期：1999-05-01 00:00:00
abstract：:The rate and form of creatine kinase-MB (CK-MB) enzyme release following reflow to ischemic myocardium has not been specifically examined in man. In this investigation, we examined the combined CK-MB time-activity curves during acute transmural myocardial infarction (AMI) in a group of patients receiving conventional ...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(83)90084-4
更新日期：1983-10-01 00:00:00
abstract：:The neutral alkaloid, ryanodine, has several actions on cardiac muscle. To delineate better its mode of action, we studied ryanodine's effect upon contracting cat papillary muscles under changing loading conditions and stimulation frequencies. We also studied ryanodine's physiologic and metabolic effects upon isolated...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(85)90161-9
更新日期：1985-08-01 00:00:00
abstract：:To evaluate the stability of precordial ST-segment mapping techniques in assessing ischemic myocardial injury, we studied 28 patients with acute anterior myocardial infarction using a 49-lead electrocardiographic system (1 mV. = 10 mm.). The sum of ST elevations in millimeters was taken as an index of ischemic injury,...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/s0002-8703(77)80011-2
更新日期：1977-05-01 00:00:00
abstract：:Patent foramen ovale (PFO) and atrial septal aneurysm (ASA) have been identified as potential risk factors for stroke, but information about the risk of recurrent cerebral ischemia is scarce. The aim of this retrospective study was to assess the absolute risk of recurrent cerebrovascular events in 132 patients under 6...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(95)90212-0
更新日期：1995-11-01 00:00:00
abstract：:Electrolyte balance has been regarded as a factor important to cardiovascular stability, particularly in congestive heart failure. Among the common electrolytes, the significance of magnesium has been debated because of difficulty in accurate measurement and other associated factors, including other electrolyte abnorm...
journal_title：American heart journal
pub_type： 杂志文章,评审
doi：10.1016/s0002-8703(96)90253-7
更新日期：1996-09-01 00:00:00
abstract：BACKGROUND:Diabetes mellitus and impaired glucose metabolism are associated with increased risk for cardiovascular disease (CVD). However, it is still not clear whether glucose levels can predict CVD risk among patients without diabetes. The primary aim of this study is to assess whether normoglycemic fasting plasma gl...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2012.03.023
更新日期：2012-07-01 00:00:00
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journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(89)90673-x
更新日期：1989-01-01 00:00:00
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journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/s0002-8703(76)80020-8
更新日期：1976-12-01 00:00:00
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journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(81)90608-6
更新日期：1981-06-01 00:00:00
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journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2010.06.039
更新日期：2010-09-01 00:00:00
abstract：BACKGROUND:Data on left atrial/left atrial appendage (LA/LAA) thrombus resolution after non-vitamin K antagonist (VKA) oral anticoagulant treatment are scarce. The primary objective of X-TRA was to explore the use of rivaroxaban for the resolution of LA/LAA thrombi in patients with nonvalvular atrial fibrillation (AF) ...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2016.05.007
更新日期：2016-08-01 00:00:00
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journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(75)90183-0
更新日期：1975-06-01 00:00:00
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journal_title：American heart journal
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ahj.2015.02.002
更新日期：2015-05-01 00:00:00
abstract：:In order to properly advise cardiac patients in the regulation of their sexual activity, more basic physiologic information is needed concerning the cardiovascular effects of sexual intercourse. This study examined the effects of the male's position during sexual intercourse on heart rate and blood pressure responses....
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/s0002-8703(76)80106-8
更新日期：1976-09-01 00:00:00
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journal_title：American heart journal
pub_type： 临床试验,杂志文章
doi：10.1016/j.ahj.2015.04.025
更新日期：2015-08-01 00:00:00
abstract：:Chronic exposure to fine particulate matter (PM2.5) is accepted as a causal risk factor for coronary heart disease (CHD). However, most of the evidence for this hypothesis is based upon cohort studies in whites, comprised of either only males or females who live in urban areas. It is possible that many estimates of th...
journal_title：American heart journal
pub_type： 杂志文章
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更新日期：2018-03-01 00:00:00
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journal_title：American heart journal
pub_type： 杂志文章,多中心研究,随机对照试验
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journal_title：American heart journal
pub_type： 杂志文章
doi：
更新日期：2002-08-01 00:00:00
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journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(91)90567-2
更新日期：1991-11-01 00:00:00
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journal_title：American heart journal
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1994-04-01 00:00:00
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journal_title：American heart journal
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ahj.2008.05.022
更新日期：2008-10-01 00:00:00
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journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(79)90467-8
更新日期：1979-12-01 00:00:00
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journal_title：American heart journal
pub_type： 杂志文章,评审
doi：10.1016/j.ahj.2008.10.009
更新日期：2009-02-01 00:00:00
abstract：:In this study, we reviewed M-mode and two-dimensional (2DE) echocardiographic observations in 13 patients with pulmonary atresia with ventricular septal defect and in six patients with truncus arteriosus in order to attempt to identify echocardiographic features distinguishing these two abnormalities in which no anato...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(83)90528-8
更新日期：1983-02-01 00:00:00
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journal_title：American heart journal
pub_type： 杂志文章
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journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(93)91056-k
更新日期：1993-08-01 00:00:00
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journal_title：American heart journal
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1067/mhj.2002.121806
更新日期：2002-05-01 00:00:00
