Distribution of 3-hydroxy oxylipins and acetylsalicylic acid sensitivity in Cryptococcus species.

Abstract:

:Using a well tested antibody specific for 3-hydroxy oxylipins, we mapped the presence of these oxylipins in selected Cryptococcus (Filobasidiella) species. Immunofluorescence microscopy studies revealed that these compounds are deposited on cell wall surfaces, appendages, and collarettes. In vitro studies revealed that growth of Cryptococcus species was inhibited by acetylsalicylic acid (which is known to inhibit mitochondrial function, including the production of 3-hydroxy oxylipins) at concentrations as low as 1 mmol/L. The results suggest that acetylsalicylic acid is effective in controlling the growth of tested pathogens, probably by targeting their mitochondria. This study further expands the known function of this anti-inflammatory drug as anti-fungal agent.

journal_name

Can J Microbiol

authors

Sebolai OM,Pohl CH,Botes PJ,van Wyk PW,Mzizi R,Swart CW,Kock JL

doi

10.1139/w07-116

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

111-8

issue

2

eissn

0008-4166

issn

1480-3275

pii

w07-116

journal_volume

54

pub_type

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