Increase in efficacy of cancer radiotherapy by combination with whole-body low dose irradiation.

abstract：PURPOSE:To assess intestinal radioprotection by systemic or lumenal tirilazad mesylate and to test potential tumour radioprotection. MATERIALS AND METHODS:Segments of the mid small bowel were surgically exteriorized. Tirilazad was given either intravenously or intralumenally 30 min prior to 11 Gy of X-irradiation to t...

journal_title：International journal of radiation biology

authors： Felemovicius I,Bonsack ME,Griffin RJ,Delaney JP

更新日期：1998-02-01 00:00:00

abstract：PURPOSE:The chromosomal radiosensitivity of a selected group of familial breast cancer patients carrying a mutation in BRCA1 (n=11) or BRCA2 (n=9) and a group of healthy mutation carriers (n=12) was investigated and compared to a reference group of breast cancer patients without a BRCA1/2 mutation (n=78) and a group of...

journal_title：International journal of radiation biology

authors： Baeyens A,Thierens H,Claes K,Poppe B,de Ridder L,Vral A

更新日期：2004-10-01 00:00:00

abstract：PURPOSE:Ifosfamide as a chemotherapeutic drug is used for the treatment of different cancer types. The purpose of this study is the preparation of 99mTc-ifosfamide complex to be evaluated as a potential candidate for tumor imaging. MATERIALS AND METHODS:The radiolabeling of ifosfamide with technetium-99m was carried o...

journal_title：International journal of radiation biology

authors： Motaleb MA,El-Safoury DM,Abd-Alla WH,Awad GAS,Sakr TM

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:The effect of boronophenylalanine (BPA)-mediated boron neutron capture therapy (BNCT) on human oral squamous cell carcinoma (SCC) xenografts in nude mice was examined. MATERIALS AND METHODS:Tumor-bearing mice were given BPA at a dose of 250 mg/kg body weight. The tumor (10)B concentration 2 h after an injectio...

journal_title：International journal of radiation biology

authors： Kamida A,Obayashi S,Kato I,Ono K,Suzuki M,Nagata K,Sakurai Y,Yura Y

更新日期：2006-01-01 00:00:00

abstract：:Electron transfer to 5-bromouracil (5-BrU) from nucleobase (N) electron adducts (and their protonated forms) has been studied by product analysis and pulse radiolysis. When an electron is transferred to 5-BrU, the ensuing 5-BrU radical anion rapidly loses a bromide ion; the uracilyl radical thus formed reacts with add...

journal_title：International journal of radiation biology

authors： Nese C,Yuan Z,Schuchmann MN,Von Sonntag C

更新日期：1992-11-01 00:00:00

abstract：PURPOSE:To investigate the influence of chromatin organization and scavenging capacity in relation to irradiation temperature on the induction of double-strand breaks (DSB) in structures derived from human diploid fibroblasts. MATERIALS AND METHODS:Agarose plugs with different chromatin structures (intact cells+/-wort...

journal_title：International journal of radiation biology

authors： Elmroth K,Nygren J,Stenerlöw B,Hultborn R

更新日期：2003-10-01 00:00:00

abstract：:The repair activity of verbascoside (VER), isolated from Pedicularis spicata, towards the oxidizing hydroxyl radical adduct of dGMP and its reaction mechanism were studied using pulse radiolysis. Upon pulse radiolysis of nitrous oxide saturated aqueous solution of 2'-deoxyguanosine-5'-monophosphate (dGMP) and VER, it ...

journal_title：International journal of radiation biology

authors： Li W,Zheng R,Su B,Jia Z,Li H,Jiang Y,Yao S,Lin N

更新日期：1996-04-01 00:00:00

abstract：:I calculate the probability that a single high-energy ionizing particle or photon makes two widely spaced double-strand breaks in the same DNA molecule. Deletions (or inversions) between two breaks formed by the same incident particle are linear in radiation dose and occur even at extremely low dose-rates; deletions b...

journal_title：International journal of radiation biology

authors： Hutchinson F

更新日期：1996-11-01 00:00:00

abstract：:We have previously described a cell-free assay that can be employed to study rejoining of radiation-induced DNA double-stranded breaks (dsb) in 'naked' DNA prepared from agarose-embedded cells using an extract of HeLa cells as a source of enzymes. Rejoining of dsb in this assay is absolutely dependent on cell extract ...

journal_title：International journal of radiation biology

authors： Cheong N,Iliakis G

更新日期：1997-04-01 00:00:00

abstract：:The radiation chemistry of the oligomer d(TpApCpG) X-irradiated in aqueous solution containing glutathione was studied. Four products were isolated by HPLC and characterized by NMR spectroscopy. Two of the major products are isomers of a 5-hydroxy-5,6-dihydrothymine modification of d(TpApCpG). A dihydrothymine modific...

journal_title：International journal of radiation biology

authors： Paul CR,Budzinski EE,Maccubbin A,Wallace JC,Box HC

更新日期：1990-11-01 00:00:00

abstract：:Ionizing radiation induces both quantitative and qualitative changes in the lymphoid cells of both man and experimental animals, including inhibition of antibody responses. However, the cellular basis of this immunological lesion is not clear. In the present study, groups of mice were exposed to 2.0 Gy gamma-rays or s...

journal_title：International journal of radiation biology

authors： Goud SN

更新日期：1995-04-01 00:00:00

abstract：PURPOSE:The assessment of biological effects caused by radiation exposure has been currently carried out with the linear-quadratic (LQ) model as an extension of the linear non-threshold (LNT) model. In this study, we suggest a new mathematical model named as SeaSaw (SS) model, which describes proliferation and cell dea...

journal_title：International journal of radiation biology

authors： Bando M,Tsunoyama Y,Suzuki K,Toki H

更新日期：2020-12-15 00:00:00

abstract：PURPOSE:To develop a reproducible single-cell gel electrophoresis assay for DNA damage and repair in buccal mucosa and sublingual exfoliated cells. MATERIALS AND METHODS:Buccal mucosa and sublingual cells and lymphocytes from six individuals (three males, three females, aged 34-45 years) were challenged with increasin...

journal_title：International journal of radiation biology

authors： Dhillon VS,Thomas P,Fenech M

更新日期：2004-07-01 00:00:00

abstract：PURPOSE:To examine whether the levels of micronuclei induction, as a marker for genomic instability in the progeny of X-irradiated cells, correlates with DNA repair function. MATERIALS AND METHODS:Two repair deficient cell lines (X-ray repair cross-complementing 1 [XRCC1] deficient cell line [EM9] and X-ray repair cro...

journal_title：International journal of radiation biology

authors： Kashino G,Suzuki K,Kodama S,Watanabe M,Prise KM

更新日期：2013-04-01 00:00:00

abstract：PURPOSE:RENEB, 'Realising the European Network of Biodosimetry and Physical Retrospective Dosimetry,' is a network for research and emergency response mutual assistance in biodosimetry within the EU. Within this extremely active network, a number of new dosimetry methods have recently been proposed or developed. There ...

journal_title：International journal of radiation biology

authors： Ainsbury E,Badie C,Barnard S,Manning G,Moquet J,Abend M,Antunes AC,Barrios L,Bassinet C,Beinke C,Bortolin E,Bossin L,Bricknell C,Brzoska K,Buraczewska I,Castaño CH,Čemusová Z,Christiansson M,Cordero SM,Cosler G,Mo

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:To investigate the possible role of vitamin E, coenzyme Q10 and rutin in ameliorating the biochemical changes in brain and serum induced by cerebral ischemia/reperfusion (I/R) in whole body γ-irradiated rats. MATERIALS AND METHODS:Cerebral ischemia was induced in male Wistar rats (either irradiated or non-irra...

journal_title：International journal of radiation biology

authors： Abd-El-Fattah AA,El-Sawalhi MM,Rashed ER,El-Ghazaly MA

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:To study the natural radionuclides in the freshwater fish samples around the uranium mining areas of Bagjata and Banduhurang, East Singhbhum, Jharkhand, India. MATERIALS AND METHODS:The naturally occurring radioisotopes of uranium, U(nat), consisting of (234)U, (235)U and (238)U; (226)Ra, (230)Th and (210)Po w...

journal_title：International journal of radiation biology

authors： Giri S,Singh G,Jha VN,Tripathi RM

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:The need to determine a reliable relative biological effectiveness (RBE) value for alpha exposures has become important as reports remain controversial. Although a radiation-weighting factor of 20 has been designated for alpha particles, uncertainty exists on realistic value of the RBE of alpha radiation. The a...

journal_title：International journal of radiation biology

authors： Meenakshi C,Mohankumar MN

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:To investigate the relationship between the susceptibility of B-chronic lymphoid leukaemia (B-CLL) cells to DNA damage-induced apoptosis, the kinetics of DNA strand-break rejoining, and chromosome damage after exposure to ionizing irradiation. MATERIALS AND METHODS:Lymphocytes from B-CLL patients were gamma-ir...

journal_title：International journal of radiation biology

authors： Blaise R,Alapetite C,Masdehors P,Merle-Beral H,Roulin C,Delic J,Sabatier L

更新日期：2002-08-01 00:00:00

abstract：:Chromosomes are located within the interphase nucleus in regions called domains. Using fluorescence in situ hybridization with whole chromosome paints, a pain of homologous chromosomes can be visualized as two discrete domains and their relative spatial location determined. This study examines the effects of an ionizi...

journal_title：International journal of radiation biology

authors： Dolling JA,Boreham DR,Brown DL,Raaphorst GP,Mitchel RE

更新日期：1997-09-01 00:00:00

abstract：PURPOSE:Zearalenone is a potent estrogenic metabolite produced by some Fusarium and Gibberella species. Therefore, the aim of this study was to determine the accumulation of Technetium-[99m]-labeled zearalenone in mice organs as well as to study the protective effect of Lactobacillus plantarum. MATERIALS AND METHODS:T...

journal_title：International journal of radiation biology

authors： Sanad MH,Fouzy ASM,Sobhy HM,Hathout AS,Hussain OA

更新日期：2018-12-01 00:00:00

abstract：:The past recommendations of the ICRP about dose limits to the skin are reviewed. Recently, an ICRP Task Group has been revisiting the old arguments and setting them against new data. With the exception of the function of cells in the skin associated with immunocompetence, non-stochastic effects have been well characte...

journal_title：International journal of radiation biology

authors： Fry RJ

更新日期：1990-04-01 00:00:00

abstract：:The accumulation and repair of radiation-induced DNA double-strand breaks (dsbs) were determined by neutral filter elution on 20 primary cultures obtained from ovarian cancer and malignant melanoma clinical specimens. The initial frequency of DNA dsbs after exposure to 50 Gy gamma-irradiation varied greatly for the in...

journal_title：International journal of radiation biology

authors： Zaffaroni N,Orlandi L,Villa R,Bearzatto A,Rofstad EK,Silvestrini R

更新日期：1994-09-01 00:00:00

abstract：PURPOSE:To illustrate how probability-generating functions (PGFs) can be employed to derive a simple probabilistic model for clonogenic survival after exposure to ionizing irradiation. METHODS:Both repairable and irreparable radiation damage to DNA were assumed to occur by independent (Poisson) processes, at intensiti...

journal_title：International journal of radiation biology

authors： Kendal WS

更新日期：2000-04-01 00:00:00

abstract：PURPOSE:Primary fibroblasts are not suitable for in vitro macrocolony assay due to their inability to form distinct colonies. Here we present a modification of agarose overlay that yielded extensive improvement in their colony formation and assessment of radiosensitivity. MATERIALS AND METHODS:Macrocolony formation wa...

journal_title：International journal of radiation biology

authors： Chandna S,Dagur RS,Mathur A,Natarajan AT,Harms-Ringdahl M,Haghdoost S

更新日期：2014-05-01 00:00:00

abstract：PURPOSE:The exploration of immune mechanisms of the tumour-inhibitory effect of exposures to low-level fractions of X-rays. MATERIALS AND METHODS:BALB/c mice were exposed to whole-body daily irradiations with 0.01, 0.02, or 0.1 Gy X-rays per day for 5 days/week for two weeks. Then, mice were intravenously injected wit...

journal_title：International journal of radiation biology

authors： Nowosielska EM,Cheda A,Wrembel-Wargocka J,Janiak MK

更新日期：2011-02-01 00:00:00

abstract：UNLABELLED:Abstract Purpose: Sensitizing cancer cells to irradiation is a major challenge in clinical oncology. We aimed to define the signal transduction pathways involved in poly(ADP-ribose) polymerase (PARP) inhibitor-induced radiosensitization in various mammalian cancer lines. MATERIALS AND METHODS:Clonogenic sur...

journal_title：International journal of radiation biology

authors： Hocsak E,Cseh A,Szabo A,Bellyei S,Pozsgai E,Kalai T,Hideg K,Sumegi B,Boronkai A

更新日期：2014-12-01 00:00:00

abstract：:The bacterial enzyme PvuII, which generates blunt-ended DNA double-strand breaks, and T4 DNA ligase, which seals adjacent DNA fragments in coupling to ATP cleavage, were introduced in mouse C3H10T1/2 fibroblasts using osmolytic shock of pinocytic vesicles. Cells were then assayed for their clonogenic ability. In agree...

journal_title：International journal of radiation biology

authors： Durante M,Grossi GF,Napolitano M,Gialanella G

更新日期：1991-04-01 00:00:00

abstract：:An assay system was developed to detect changes of restriction fragment profiles obtained after pulsed-field gel electrophoresis (PFGE) for DNA from mammalian cells that were irradiated and incubated for repair. DNA was prepared from irradiated log-phase human melanoma cells (MRI 221) after incubation for repair (6 h)...

journal_title：International journal of radiation biology

authors： Latz D,Dewey WC,Flentje M,Lohr F,Wenz F,Weber KJ

更新日期：1996-12-01 00:00:00

abstract：:Objective: To quantify DNA damage in patients undergoing non-contrast and contrast-enhanced 18F-FDG PET/CT whole body positron emission tomography/computed tomography (WB PET/CT) investigations using comet assay technique and micronucleus assay, and to study the effect of other baseline parameters of patients on DNA d...

journal_title：International journal of radiation biology

authors： Nautiyal A,Mondal T,Mukherjee A,Mitra D,Kaushik A,Goel HC,Goel A,Dey SK

更新日期：2019-06-01 00:00:00