Analyses of the role of endogenous SPARC in mouse models of prostate and breast cancer.

abstract：:We have investigated the role of sialylation on cell-cell adhesion mediated by E-cadherin. Two MCF-7 human breast cancer cell variants were studied: MCF-7/AZ cells showed a spontaneous cell-cell adhesion in the fast and slow aggregation assay. whereas the adhesion deficient MCF-7/6 cell variant failed to form larger a...

journal_title：Clinical & experimental metastasis

authors： Steelant WF,Recchi MA,Noë VT,Boilly-Marer Y,Bruyneel EA,Verbert A,Mareel MM,Delannoy P

更新日期：1999-05-01 00:00:00

abstract：:Breast cancer metastasizes to bone with high frequency and incidence. However, studies of breast cancer metastasis to bone have been limited by two factors. First, the number of models that colonize bone are limited. Second, detection of bone metastases is too insensitive or too laborious for routine, large-scale stud...

journal_title：Clinical & experimental metastasis

authors： Harms JF,Welch DR

更新日期：2003-01-01 00:00:00

abstract：:Lung cancer is the most frequent and one of the most deadly cancer types and is classified into small cell lung cancer and non-small cell lung cancer (NSCLC). Transforming growth factor beta (TGFβ) regulates a wide array of cell functions and plays a major role in lung diseases, including NSCLC. TGFβ signals through t...

journal_title：Clinical & experimental metastasis

authors： Vázquez PF,Carlini MJ,Daroqui MC,Colombo L,Dalurzo ML,Smith DE,Grasselli J,Pallotta MG,Ehrlich M,Bal de Kier Joffé ED,Puricelli L

更新日期：2013-12-01 00:00:00

abstract：:A variant cell line (EL-4ad) which adhered to a tissue culture dish was isolated from highly metastatic EL-4 murine T-lymphoma. The experimental and spontaneous metastatic ability of EL-4ad was lower than that of the EL-4 parent cell line. The cell surface phenotypes of both cell lines were CD2+3+4-8-45+TCR alpha beta...

journal_title：Clinical & experimental metastasis

authors： Ota T,Tanino M,Kohno H,Funamoto H,Odashima S

更新日期：1992-09-01 00:00:00

abstract：:Bone sialoprotein (BSP) and osteopontin (OPN) are important factors in the metastasis of breast cancer, which were examined as targets for antineoplastic therapy by siRNA. In addition, the effect of gene silencing on their transcription factor Runx2 and their interaction partners integrin β(3) and matrix metalloprotei...

journal_title：Clinical & experimental metastasis

authors： Reufsteck C,Lifshitz-Shovali R,Zepp M,Bäuerle T,Kübler D,Golomb G,Berger MR

更新日期：2012-06-01 00:00:00

abstract：:Tumor metastases are extremely rare in striated muscles. This is surprising given the fact that this tissue constitutes 60% of body weight. The present study focuses on small molecules produced and secreted by muscle cells which possess anti-cancer activity in vivo. Recently we have shown that a low molecular weight f...

journal_title：Clinical & experimental metastasis

authors： Bar-Yehuda S,Farbstein T,Barer F,Ohana G,Fishman P

更新日期：1999-01-01 00:00:00

abstract：:In this study the relationship between brain structure and brain metastases (BM) occurrence was analyzed. A model for predicting the time of BM onset in patients with non-small cell lung cancer (NSCLC) was proposed. Twenty patients were used to develop the model, whereas the remaining 69 were used for independent vali...

journal_title：Clinical & experimental metastasis

authors： Yin G,Li C,Chen H,Luo Y,Orlandini LC,Wang P,Lang J

更新日期：2017-02-01 00:00:00

abstract：:The growth of metastatic prostate cancer cells in the bone involves an intimate interaction between the tumor cells and various elements of the bone microenvironment, resulting in increased rate of bone turnover and rapid tumor growth. The alpha(v)beta3 integrin has been shown to play an important role in tumor growth...

journal_title：Clinical & experimental metastasis

authors： Nemeth JA,Cher ML,Zhou Z,Mullins C,Bhagat S,Trikha M

更新日期：2003-01-01 00:00:00

abstract：:We have previously isolated a series of MCF-7 human breast cancer cell variants which no longer require estrogen-supplementation for tumor growth in nude mice (Clarke et al. Proc Natl Acad Sci USA 86: 3649-3653, 1989). We now report that these hormone-independent and hormone-responsive variants (MIII, MCF7/LCC1) can i...

journal_title：Clinical & experimental metastasis

authors： Thompson EW,Brünner N,Torri J,Johnson MD,Boulay V,Wright A,Lippman ME,Steeg PS,Clarke R

更新日期：1993-01-01 00:00:00

abstract：:The chemokine CXCL12/SDF-1 and its receptors CXCR4 and CXCR7 play a major role in tumor invasion, proliferation and metastasis. Since both receptors are overexpressed on distinct tumor cells and on the tumor vasculature, we evaluated their potential as targets for detection of cancers by molecular imaging. We synthesi...

journal_title：Clinical & experimental metastasis

authors： Meincke M,Tiwari S,Hattermann K,Kalthoff H,Mentlein R

更新日期：2011-12-01 00:00:00

abstract：:We investigated the role of signal transduction systems in the attachment of human uveal melanoma cells to matrix proteins. Ocular melanoma cells established from primary tumours attached rapidly to all substrates examined. Preferred substrates of attachment were collagens type I, III and IV and fibronectin rather tha...

journal_title：Clinical & experimental metastasis

authors： Mac Neil S,Wagner M,Rennie IG

更新日期：1994-11-01 00:00:00

abstract：:Metastatic bone disease is an important clinical problem which has proven difficult to study because of a lack of noninvasive investigative modalities. Here we show that dual-energy X-ray absorptiometry (DXA) scanning provides clinically useful information about the status of metastatic bone lesions in cancer patients...

journal_title：Clinical & experimental metastasis

authors： Smith GL,Doherty AP,Banks LM,Dutton J,Hanham LW,Christmas TJ,Epstein RJ

更新日期：2000-01-01 00:00:00

abstract：:Treating metastatic osteosarcoma (OS) remains a challenge in oncology. Current treatment strategies target the primary tumour rather than metastases and have a limited efficacy in the treatment of metastatic disease. Metastatic cells have specific features that render them less sensitive to therapy and targeting these...

journal_title：Clinical & experimental metastasis

authors： PosthumaDeBoer J,Witlox MA,Kaspers GJ,van Royen BJ

更新日期：2011-06-01 00:00:00

abstract：:In order to study the usefulness of treatment with vinblastine (VLB) in the prevention of cancer metastasis in squamous cell lung cancer, 50 patients with locoregional disease were randomized to receive either locoregional RT alone (group A) or a weekly intravenous bolus injection of VLB (6 mg/m2) concurrently with an...

journal_title：Clinical & experimental metastasis

authors： Schallier DC,De Neve WJ,De Greve JL,Van Belle SP,De Wasch GJ,Dotremont G,Storme GA

更新日期：1988-01-01 00:00:00

abstract：:Prostate cancer metastases form selectively in the bone marrow. Previously we demonstrated motility was important for the formation of primary prostatic epithelial cell colonies in bone marrow stroma (BMS) co-culture. In this study we looked at the influence of motility factors on the colony formation of epithelial ce...

journal_title：Clinical & experimental metastasis

authors： Lang SH,Clarke NW,George NJ,Testa NG

更新日期：1999-06-01 00:00:00

abstract：:Tumor metastasis often confers poor prognosis for cancer patients due to lack of comprehensive strategy in dealing with cells growing in different environment. Current anticancer therapies have incomplete effectiveness because they were designed assuming metastatic tumors behave similarly in different organs. We hypot...

journal_title：Clinical & experimental metastasis

authors： Alsaggar M,Yao Q,Cai H,Liu D

更新日期：2016-02-01 00:00:00

abstract：:The spinal column is the most frequent site of bone metastasis in patients with breast cancer. It is important to understand how the pattern of vertebral lesions may be affected by the introduction of modern cancer therapies. The purpose of this study was to characterize changes in the radiological appearance of spina...

journal_title：Clinical & experimental metastasis

authors： Skrinskas T,Clemons M,Freedman O,Weller I,Whyne CM

更新日期：2009-01-01 00:00:00

abstract：:The BRMS1 metastasis suppressor was recently shown to negatively regulate NF-kappaB signaling and down regulate NF-kappaB-dependent uPA expression. Here we confirm that BRMS1 expression correlates with reduced NF-kappaB DNA binding activity in independently derived human melanoma C8161.9 cells stably expressing BRMS1....

journal_title：Clinical & experimental metastasis

authors： Cicek M,Fukuyama R,Cicek MS,Sizemore S,Welch DR,Sizemore N,Casey G

更新日期：2009-01-01 00:00:00

abstract：:We studied the influence of 10 synthetic glycoamine analogs on colony formation in 0.3 and 0.9% agarose by metastatic human breast carcinoma (MDA-MB-435) and melanoma (TXM-13) cells. Nine synthetic analogs significantly inhibited the colony formation in 0.9% agarose of MDA-MB-435 human breast carcinoma cells; five com...

journal_title：Clinical & experimental metastasis

authors： Glinsky GV,Mossine VV,Price JE,Bielenberg D,Glinsky VV,Ananthaswamy HN,Feather MS

更新日期：1996-05-01 00:00:00

abstract：:The concurrent administration of Metrazol (60 mg/kg, i.v.) to anaesthetized rats enhances the cerebral penetration of the anticancer agent razoxane. Such an enhancement leads to an increase in the therapeutic efficacy of razoxane against intracerebrally sequestered L1210 leukaemia cells in mice. The combination of Met...

journal_title：Clinical & experimental metastasis

authors： Greig N,Newell D,Hellmann K

更新日期：1984-01-01 00:00:00

abstract：:Using alternative splicing reporters we have previously observed mesenchymal epithelial transitions in Dunning AT3 rat prostate tumors. We demonstrate here that the Dunning DT and AT3 cells, which express epithelial and mesenchymal markers, respectively, represent an excellent model to study epithelial transitions sin...

journal_title：Clinical & experimental metastasis

authors： Oltean S,Febbo PG,Garcia-Blanco MA

更新日期：2008-01-01 00:00:00

abstract：:Melanoma is an aggressive cutaneous malignancy with rapidly rising incidence. Diagnosis of controversial melanocytic lesions, correct prognostication of patients, selection of appropriate adjuvant and systemic therapies, and prediction of response to a given therapy remain very real challenges. Despite these challenge...

journal_title：Clinical & experimental metastasis

authors： Ankeny JS,Labadie B,Luke J,Hsueh E,Messina J,Zager JS

更新日期：2018-08-01 00:00:00

abstract：:Growth of human tumor cells as three-dimensional (3D) multicellular spheroids modifies their invasive properties. Here we study the differences in the biological features of MCF-7, a human breast cancer cell line, and its multidrug resistant variant (MDR-MCF-7) cultured as spheroids or as monolayers. Three-dimensional...

journal_title：Clinical & experimental metastasis

authors： dit Faute MA,Laurent L,Ploton D,Poupon MF,Jardillier JC,Bobichon H

更新日期：2002-01-01 00:00:00

abstract：:Evidence suggests that multiple tumors, including pancreatic adenocarcinoma, display heterogeneity in parameters that are critical for tumor formation, progression and metastasis. Understanding heterogeneity in solid tumors is increasingly providing a plethora of new diagnostic and therapeutic approaches. In this stud...

journal_title：Clinical & experimental metastasis

authors： Dembinski JL,Krauss S

更新日期：2009-01-01 00:00:00

abstract：:Basement membrane forms widespread barriers to tumor invasion. It has been shown that tumor-secreted, basement membrane-degrading enzymes, namely metalloproteinases (MMPs) play an important role in tumor invasion and metastasis. In this study, we determined the enzymatic activity, content, and mRNA of both the 72 kDa ...

journal_title：Clinical & experimental metastasis

authors： Rao VH,Bridge JA,Neff JR,Schaefer GB,Buehler BA,Vishwanatha JK,Pollock RE,Nicolson GL,Yamamoto M,Gokaslam ZL

更新日期：1995-11-01 00:00:00

abstract：:Vascularization of solid tumors is thought to occur by sprouting or intussusceptive angiogenesis, co-option of existing vessels, and vasculogenic mimicry after the onset of tumor hypoxia, when the tumor radius exceeds the oxygen diffusion distance. In contrast, here we show that individual endothelial cells that are i...

journal_title：Clinical & experimental metastasis

authors： Elzarrad K,Haroon A,Reed D,Al-Mehdi AB

更新日期：2009-01-01 00:00:00

abstract：:Single cell progenies (SCPs) inherit biological properties from their isogenetic mother cells. If a single cancer cell can give rise to progenies, which can be passaged sustainably in vitro and produce tumor in xenotransplantation, the cell should be cancer initiating cell. CD133 (Prominin-1, Prom1) is the marker of h...

journal_title：Clinical & experimental metastasis

authors： Li G,Liu C,Yuan J,Xiao X,Tang N,Hao J,Wang H,Bian X,Deng Y,Ding Y

更新日期：2010-10-01 00:00:00

abstract：:Metastasis is the most devastating aspect of cancer and it is the main cause of morbidity and mortality in cancer patients. Tumor cell adhesion to the vascular endothelial cell lining is an important step in metastatic progression and is prompted by platelets. Mucin 1 is over-expressed and aberrantly glycosylated in m...

journal_title：Clinical & experimental metastasis

authors： Sudha T,Phillips P,Kanaan C,Linhardt RJ,Borsig L,Mousa SA

更新日期：2012-06-01 00:00:00

abstract：:Although the loss of sulfomucins was known as an indicator of carcinogenesis and malignant progression of colonic epithelia, it was not known whether the loss was directly related to the malignant behavior of colon carcinoma cells. We have studied the biological properties of LS174T human colon carcinoma cells before ...

journal_title：Clinical & experimental metastasis

authors： Tsuiji H,Nakatsugawa S,Ishigaki T,Irimura T

更新日期：1999-03-01 00:00:00

abstract：:Metastasis is a vital target for cancer treatment, since the majority of cancer patients die from metastatic, rather than the primary disease. KiSS1 has been identified as a metastasis suppressor gene in melanoma and breast carcinomas. We show here that KiSS1 is also a metastasis suppressor in human ovarian cancer. Ov...

journal_title：Clinical & experimental metastasis

authors： Jiang Y,Berk M,Singh LS,Tan H,Yin L,Powell CT,Xu Y

更新日期：2005-01-01 00:00:00