当前位置： SCI文献检索 > CLINICAL & EXPERIMENTAL METASTASIS期刊下所有文献 > Differential growth and responsiveness to cancer therapy of tumor cells in different environments.

Differential growth and responsiveness to cancer therapy of tumor cells in different environments.

Abstract：

:Tumor metastasis often confers poor prognosis for cancer patients due to lack of comprehensive strategy in dealing with cells growing in different environment. Current anticancer therapies have incomplete effectiveness because they were designed assuming metastatic tumors behave similarly in different organs. We hypothesize that tumors growing in different sites are biologically heterogeneous in growth potential, as well as in tumor response to anti-cancer therapies. To test this hypothesis, we have developed a multi-organ tumor growth model using the hydrodynamic cell delivery method to establish simultaneous and quantifiable tumor growth in the liver, lungs and kidneys of mice. We demonstrated that growth rate of melanoma tumor in the liver is higher than that of the lungs and kidneys. Tumors in the lungs and kidneys grew minimally at the early stage and aggressively thereafter. Tumors in different organs were also heterogeneous in response to chemotherapy and immune gene therapy using dacarbazine and interferon beta gene, respectively. Lung tumors responded to chemotherapy better than tumors in the liver, but showed minimal response to interferon beta gene therapy, compared to tumors in the liver and kidneys. We also confirmed differential tumor growth of the metastatic colon cancer in mice. Our results point out the importance of a better understanding of the differences in tumor growing in diverse environments. The biological heterogeneity of metastatic tumors demonstrated in this study necessitates establishing new drug screening strategies that take into account the environmental difference at the sites of tumor growth.

journal_name

Clin Exp Metastasis

journal_title

Clinical & experimental metastasis

authors

Alsaggar M,Yao Q,Cai H,Liu D

doi

10.1007/s10585-015-9761-y

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

115-24

issue

2

eissn

0262-0898

issn

1573-7276

pii

10.1007/s10585-015-9761-y

journal_volume

33

pub_type

杂志文章

相关文献

CLINICAL & EXPERIMENTAL METASTASIS文献大全
  • Investigation of the role of signal transduction in attachment of ocular melanoma cells to matrix proteins: inhibition of attachment by calmodulin antagonists including tamoxifen.

    abstract：:We investigated the role of signal transduction systems in the attachment of human uveal melanoma cells to matrix proteins. Ocular melanoma cells established from primary tumours attached rapidly to all substrates examined. Preferred substrates of attachment were collagens type I, III and IV and fibronectin rather tha...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/BF01755881

    authors： Mac Neil S,Wagner M,Rennie IG

    更新日期：1994-11-01 00:00:00

  • Solitary bone metastasis in the tibia as a presenting sign of endometrial adenocarcinoma: a case report and the review of the literature.

    abstract：BACKGROUND:Metastasis to bone from endometrial adenocarcinoma is rare, when metastasises it usually locates in axial skeleton. Metastasis to extremities is extremely rare. Additionally the detection of the bone metastasis as a presenting feature is uncommon. In the present study we report the 10th cases of bone metasta...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/s10585-007-9061-2

    authors： Kaya A,Olmezoglu A,Eren CS,Bayol U,Altay T,Karapinar L,Ozturk H,Oztekin D,Guvenli Y,Karadogan I

    更新日期：2007-01-01 00:00:00

  • Inhibition of prostate cancer metastasis by administration of a tissue vaccine.

    abstract：:Immunotherapy by vaccination represents a novel method for treatment of cancer. In this regard, vaccines with the broadest possible menu of relevant antigens stand the greatest chance of success. Tissue vaccines are composed of material harvested directly from tumors and contain not only antigens associated with neopl...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/s10585-008-9213-z

    authors： Suckow MA,Wolter WR,Sailes VT

    更新日期：2008-01-01 00:00:00

  • The expression of neurokinin-1 and preprotachykinin-1 in breast cancer cells depends on the relative degree of invasive and metastatic potential.

    abstract：:Breast cancer has a predilection for metastasis to the bone marrow. The preprotachykinin-I (PPT-I) gene has a central role in the early migration of breast cancer cells into the bone marrow, making this organ a latent repository of the cancer cells. This study investigated whether the invasive and metastatic potential...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/s10585-006-9001-6

    authors： Castro TA,Cohen MC,Rameshwar P

    更新日期：2005-01-01 00:00:00

  • The clinicopathological evaluation of the breast cancer patients with brain metastases: predictors of survival.

    abstract：:We aimed to define the clinicopathologic characteristics of breast cancer (BC) patients with brain metastasis (BM) and to investigate the effect of these parameters on survival. Seventy-nine patients diagnosed with BC and symptomatic BM between 1995 and 2011 were retrospectively evaluated. The relationship between cli...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/s10585-012-9528-7

    authors： Tarhan MO,Demir L,Somali I,Yigit S,Erten C,Alacacioglu A,Ellidokuz H,Seseogullari O,Kucukzeybek Y,Can A,Dirican A,Bayoglu V,Akyol M

    更新日期：2013-02-01 00:00:00

  • Anti-metastatic properties of RGD-peptidomimetic agents S137 and S247.

    abstract：:Integrins expressed on endothelial cells modulate cell migration and survival during angiogenesis. Integrins expressed on carcinoma cells potentiate metastasis by facilitating invasion and movement across blood vessels. We describe the activities of two synthetic low-molecular-weight peptidomimetics of the ligand amin...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1023/b:clin.0000024764.93092.5f

    authors： Shannon KE,Keene JL,Settle SL,Duffin TD,Nickols MA,Westlin M,Schroeter S,Ruminski PG,Griggs DW

    更新日期：2004-01-01 00:00:00

  • Treatment with human recombinant leukocyte interferons inhibits in vitro invasive ability of human lung carcinoma cells.

    abstract：:The effects of treatment of human lung carcinoma cell line A 549 with recombinant DNA-derived human leukocyte interferons A (rIFN-alpha A) or D (rIFN-alpha D), and human lymphoblastoid interferon (Wellferon) on in vitro cell invasion were investigated in a quantitative invasion assay using human amnion. The A 549 cell...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/BF00117932

    authors： Ravine TJ,Ledinko N

    更新日期：1986-07-01 00:00:00

  • Association of SIBA treatment and a Met-depleted diet inhibits in vitro growth and in vivo metastatic spread of experimental tumor cell lines.

    abstract：:We have used 5'-deoxy-5'-S isobutyl-thioadenosine (SIBA), an analog of S-adenosylhomocysteine, alone or in association with a methionine-depleted diet in order to obtain an antitumoral effect in two different tumor models: a transplantable rat rhabdomyosarcoma (RMS-J1) induced by i.m. injection of nickel and the well-...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/BF01580402

    authors： Breillout F,Poupon MF,Blanchard P,Lascaux V,Echinard-Garin P,Robert-Gero M

    更新日期：1988-01-01 00:00:00

  • Malignant and other properties of human colon carcinoma cells after suppression of sulfomucin production in vitro.

    abstract：:Although the loss of sulfomucins was known as an indicator of carcinogenesis and malignant progression of colonic epithelia, it was not known whether the loss was directly related to the malignant behavior of colon carcinoma cells. We have studied the biological properties of LS174T human colon carcinoma cells before ...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1023/a:1006654027742

    authors： Tsuiji H,Nakatsugawa S,Ishigaki T,Irimura T

    更新日期：1999-03-01 00:00:00

  • Soft tissue invasion of papillary thyroid carcinoma.

    abstract：:Extrathyroidal extension (ETE) of papillary thyroid carcinoma (PTC) is common and clinical presentation can vary from minimal to extensive locoregional involvement. Although PTC is generally considered the most benign among all thyroid carcinomas, it may present with local invasion with poor prognosis. Our retrospecti...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/s10585-016-9800-3

    authors： Lin JD,Hsueh C,Chao TC

    更新日期：2016-08-01 00:00:00

  • Role of the beta1-integrin subunit in the adhesion, extravasation and migration of T24 human bladder carcinoma cells.

    abstract：:The abilities of tumor cells to extravasate from the blood vessel system and to migrate through the connective tissue are prerequisites in metastasis formation. Both processes are chiefly mediated by integrins, which mediate both cell-cell and cell-matrix interactions. We investigated the role of integrin subunits in ...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/s10585-005-4335-z

    authors： Heyder C,Gloria-Maercker E,Hatzmann W,Niggemann B,Zänker KS,Dittmar T

    更新日期：2005-01-01 00:00:00

  • Role of tissue factor pathway inhibitor-2 (TFPI-2) in amelanotic melanoma (C-32) invasion.

    abstract：:Human tissue factor pathway inhibitor-2 (TFPI-2), also known as placental protein (PP5) and matrix-associated serine protease inhibitor (MSPI), is a 32-kDa extracellular matrix (ECM) protein consisting of three tandomly arranged Kunitz-type domains that inhibits plasmin, trypsin, chymotrypsin, cathepsin G and plasma k...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1023/a:1011085820250

    authors： Konduri SD,Tasiou A,Chandrasekar N,Nicolson GL,Rao JS

    更新日期：2000-01-01 00:00:00

  • Human and rat glioma growth, invasion, and vascularization in a novel chick embryo brain tumor model.

    abstract：:The mechanisms that control the insidiously invasive nature of malignant gliomas are poorly understood, and their study would be facilitated by an in vivo model that is easy to manipulate and inexpensive. The developing chick embryo brain was assessed as a new xenograft model for the production, growth, and study of h...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/s10585-005-7889-x

    authors： Cretu A,Fotos JS,Little BW,Galileo DS

    更新日期：2005-01-01 00:00:00

  • Suppression by nimesulide of bombesin-enhanced peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane in Wistar rats.

    abstract：:The effects of the cyclooxygenase (COX)-2 inhibitor nimesulide on bombesin-enhanced peritoneal metastasis of azoxymethane (AOM)-induced intestinal adenocarcinomas were investigated in male Wistar rats. From the beginning of the study, the rats were given 10 weekly s.c. injections of AOM (7.4 mg/kg body weight) and s.c...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1023/a:1025883129932

    authors： Iishi H,Tatsuta M,Baba M,Yano H,Higashino K,Mukai M,Akedo H

    更新日期：2003-01-01 00:00:00

  • Cathepsin L inhibition by the small molecule KGP94 suppresses tumor microenvironment enhanced metastasis associated cell functions of prostate and breast cancer cells.

    abstract：:Metastasis remains the major cause of therapeutic failure, poor prognosis and high mortality in breast and prostate cancer patients. Aberrant microenvironments including hypoxia and acidic pH are common features of most solid tumors that have been long associated with enhanced metastasis and poor patient outcomes. Nov...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/s10585-013-9590-9

    authors： Sudhan DR,Siemann DW

    更新日期：2013-10-01 00:00:00

  • Circulating microRNAs in head and neck cancer: a scoping review of methods.

    abstract：:Circulating microRNAs have been described as head and neck cancer biomarkers in multiple anatomical subsites including the oral cavity, nasopharynx, larynx, salivary glands and the skin. While there is an expanding volume of published literature showing the significance of individual or panels of microRNAs, the clinic...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章,评审

    doi：10.1007/s10585-019-09961-6

    authors： Dharmawardana N,Ooi EH,Woods C,Hussey D

    更新日期：2019-06-01 00:00:00

  • Adhesion properties, intermediate filaments and malignant behaviour of head and neck squamous cell carcinoma cells in vitro.

    abstract：:This study compared phenotype and behaviour of seven head and neck squamous cell carcinoma (HNSCC) cell lines and normal epithelial cells. Indications were found that in HNSCC cells: 1) loss of the cell-cell adhesion molecule E-cadherin was correlated with loss of epithelioid cell morphology but not with loss of cell-...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/BF00115110

    authors： Tomson AM,Scholma J,Meijer B,Koning JG,de Jong KM,van der Werf M

    更新日期：1996-11-01 00:00:00

  • Bladder metastasis from renal cell carcinoma: retrospective analysis of 65 reported cases.

    abstract：:This study was carried out to clarify the presentation, treatment options, and prognosis of renal cell carcinoma (RCC) metastasis to the bladder in which we do not yet have a comprehensive understanding. A systematic Medline, Web of Science, Embase, Google, and Ichushi Web search was performed to identify articles des...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章,评审

    doi：10.1007/s10585-015-9698-1

    authors： Matsumoto K,Hayakawa N,Nakamura S,Oya M

    更新日期：2015-02-01 00:00:00

  • Trks are novel oncogenes involved in the induction of neovascularization, tumor progression, and nodal metastasis in oral squamous cell carcinoma.

    abstract：:The function of tropomyosin receptor kinase (Trk) family including TrkA, TrkB, and TrkC in cancer remains unknown. The role of Trks in oral squamous cell carcinoma (OSCC) was examined. Knockdown of Trks provided inhibition of growth or invasion and decrease of apoptosis in OSCC cells, which expressed Trks at high leve...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/s10585-012-9525-x

    authors： Sasahira T,Ueda N,Yamamoto K,Bhawal UK,Kurihara M,Kirita T,Kuniyasu H

    更新日期：2013-02-01 00:00:00

  • An improved method to study NK-independent mechanisms of MTLn3 breast cancer lung metastasis.

    abstract：:To study the tumor cell autonomous processes of metastasis, an in vivo tumor metastasis model is required that excludes the involvement of the innate immune system. For this purpose we used the established syngeneic MTLn3 cell - Fischer 344 tumor model. MTLn3 cells are efficiently eradicated by NK cells in vivo. Using...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/s10585-007-9075-9

    authors： van Nimwegen MJ,Verkoeijen S,Kuppen PJ,Velthuis JH,van de Water B

    更新日期：2007-01-01 00:00:00

  • Preoperative sentinel lymph node mapping of the prostate using PET/CT fusion imaging and Ga-68-labeled tilmanocept in an animal model.

    abstract：:Sentinel lymph node (SLN) identification with preoperative image guidance may improve pathological staging of prostate cancer by identifying nodes outside the standard template of dissection. Four anesthetized male dogs received an intra-prostatic injection of Ga-68-labeled tilmanocept. Every 20 min the pelvic lymph n...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/s10585-012-9498-9

    authors： Stroup SP,Kane CJ,Farchshchi-Heydari S,James CM,Davis CH,Wallace AM,Hoh CK,Vera DR

    更新日期：2012-10-01 00:00:00

  • Potentiation of antitumor effect of NKT cell ligand, alpha-galactosylceramide by combination with IL-12 on lung metastasis of malignant melanoma cells.

    abstract：:The combined therapeutic effect of natural killer T (NKT) cell ligand alpha-galactosylceramide (alpha-GalCer) and IL-12 against highly metastatic B16-BL6-HM melanoma cells was investigated. In comparison with a single administration of alpha-GalCer or IL-12, the combined treatment of tumor-bearing mice with alpha-GalC...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1023/a:1006715221088

    authors： Nakui M,Ohta A,Sekimoto M,Sato M,Iwakabe K,Yahata T,Kitamura H,Koda T,Kawano T,Makuuchi H,Taniguchi M,Nishimura T

    更新日期：2000-01-01 00:00:00

  • Leptin utilizes Jun N-terminal kinases to stimulate the invasion of MCF-7 breast cancer cells.

    abstract：:In breast tumors, high levels of leptin have been associated with increased incidence of breast cancer metastasis. Breast cancer metastasis is directly associated with breast cancer cell invasion. However, whether leptin could augment breast cancer cell invasion is not known. Here we showed that leptin increased the i...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/s10585-008-9231-x

    authors： McMurtry V,Simeone AM,Nieves-Alicea R,Tari AM

    更新日期：2009-01-01 00:00:00

  • Parathyroid hormone-related protein and ezrin are up-regulated in human lung cancer bone metastases.

    abstract：:Lung cancer often metastasizes to bone in patients with advanced disease. Identification of the factors involved in the interactions between lung cancer cells and bone will improve the prevention and treatment of bone metastases. We identified changes in metastasis-related gene expression of human HARA lung squamous c...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/s10585-007-9059-9

    authors： Deng X,Tannehill-Gregg SH,Nadella MV,He G,Levine A,Cao Y,Rosol TJ

    更新日期：2007-01-01 00:00:00

  • Comparison of metastatic cell lines derived from a murine mammary tumour, and reduction of metastasis by heparin.

    abstract：:A murine mammary carcinoma, which had a high potential for metastasis to the lungs, was established in culture, and from the parent line several clonally derived variants were isolated, showing different characteristics including metastatic potential. C1, a high metastatic clone, and C2, a low one, were selected for f...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/BF01784377

    authors： Lee AE,Rogers LA,Jeffery RE,Longcroft JM

    更新日期：1988-11-01 00:00:00

  • Molecular phenotype is associated with survival in breast cancer patients with spinal bone metastases.

    abstract：:To aid in therapy selection for patients with spinal bone metastases (SBM), predictive models have been developed. These models consider SBM from breast cancer a positive predictive factor, but do not take phenotypes based on estrogen (ER), progesterone (PR) and human epidermal growth factor 2 (HER2) receptors into ac...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s10585-014-9685-y

    authors： Bollen L,Wibmer C,Wang M,van der Linden YM,Leithner A,Bünger CE,Jensen AB,Fiocco M,Bratschitsch G,Pondaag W,Bovée JV,Dijkstra PD

    更新日期：2015-01-01 00:00:00

  • Metrazol enhances brain penetration and therapeutic efficacy of some anticancer agents: implications for brain metastases.

    abstract：:The concurrent administration of Metrazol (60 mg/kg, i.v.) to anaesthetized rats enhances the cerebral penetration of the anticancer agent razoxane. Such an enhancement leads to an increase in the therapeutic efficacy of razoxane against intracerebrally sequestered L1210 leukaemia cells in mice. The combination of Met...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/BF00132306

    authors： Greig N,Newell D,Hellmann K

    更新日期：1984-01-01 00:00:00

  • The protein kinase C inhibitor, H7, inhibits tumor cell invasion and metastasis in mouse melanoma via suppression of ERK1/2.

    abstract：:Protein kinase C (PKC) has been shown to be a signal transducer during tumorigenesis, tumor cell invasion, and metastasis. Recent studies have reported that the PKC inhibitor, 7-hydroxystaurosporine, inhibits tumor cell invasion. However, the molecular mechanisms of this inhibition of invasion and metastasis are not w...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/s10585-007-9080-z

    authors： Tsubaki M,Matsuoka H,Yamamoto C,Kato C,Ogaki M,Satou T,Itoh T,Kusunoki T,Tanimori Y,Nishida S

    更新日期：2007-01-01 00:00:00

  • The anti-adhesive mucin podocalyxin may help initiate the transperitoneal metastasis of high grade serous ovarian carcinoma.

    abstract：:High grade serous ovarian tumors often metastasize transperitoneally, a process that begins when small tumor nodules de-adhere and are released into the fluid of the abdominal cavity where they float freely to reach new sites on the peritoneal wall. Podocalyxin, a small anti-adhesive sialomucin, has been shown to cont...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/s10585-011-9446-0

    authors： Cipollone JA,Graves ML,Köbel M,Kalloger SE,Poon T,Gilks CB,McNagny KM,Roskelley CD

    更新日期：2012-03-01 00:00:00

  • Mitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancer.

    abstract：:Inflammatory breast cancer (IBC) is the most lethal form of locally advanced breast cancer known. IBC carries a guarded prognosis primarily due to rapid onset of disease, typically within six months, and the propensity of tumor emboli to invade the dermal lymphatics and spread systemically. Although the clinical manif...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1023/a:1015518114931

    authors： van Golen KL,Bao LW,Pan Q,Miller FR,Wu ZF,Merajver SD

    更新日期：2002-01-01 00:00:00