IL-4-induced AID expression and its relevance to IgA class switch recombination.

Abstract:

:Activation-induced cytidine deaminase (AID) is an inducible gene that plays a critical role in Ig class switch recombination and somatic hypermutation in B cells. We explored the mechanisms by which IL-4 induces AID expression in mouse B cells. IL-4 increased AID expression and over-expression of Stat6 further augmented IL-4-induced promoter activity. The involvement of Stat6 in the promoter activity was confirmed using ChIP assays and site-directed mutagenesis. Treatment with H89, a PKA inhibitor, markedly decreased IL-4-induced AID expression, and over-expression of CREB enhanced it. These results indicate that Stat6 and PKA/CREB are involved in IL-4-induced AID expression. The relevance of these signal transducing molecules was verified using the TGFbeta1-induced IgA isotype switching model. Our results indicate that IL-4, through Stat6 and PKA/CREB, induces AID expression leading to Ig isotype switching event.

authors

Kim RJ,Kim HA,Park JB,Park SR,Jeon SH,Seo GY,Seo DW,Seo SR,Chun GT,Kim NS,Yie SW,Byeon WH,Kim PH

doi

10.1016/j.bbrc.2007.07.022

subject

Has Abstract

pub_date

2007-09-21 00:00:00

pages

398-403

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(07)01472-6

journal_volume

361

pub_type

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