Abstract:
BACKGROUND:Emerging evidence suggests that a mildly elevated body mass index (BMI), is related to improved survival and fewer cardiovascular events in patients with coronary artery disease (CAD). We hypothesize that these results are related to the poor diagnostic performance of BMI to detect adiposity, especially in the intermediate BMI ranges. METHODS AND RESULTS:A cross-sectional study of 95 patients with CAD referred to phase II cardiac rehabilitation. Body fat (BF)% was estimated by air displacement plethysmography. Height, weight, BMI and waist circumference were measured the same day. We calculated the correlation between BMI and both, BF% and lean mass and assessed the diagnostic performance of BMI to detect obesity defined as a BF% > 25% in men and > 35% in women. Although BMI had a good correlation with BF% (rho = 0.66, P < 0.0001), it also had a good correlation with lean mass (rho = 0.41, P < 0.0001), and BMI failed to discriminate between both (P-value = 0.72). A BMI >or= 30 kg/m2 had a good specificity (95%; 95% CI, 83-100) but a poor sensitivity (43%; 95% CI, 32-54) while a BMI >or= 25 kg/m2 had a good sensitivity (91%; 95% CI, 84-97) but a poor specificity (65%; 95% CI, 42-88) to detect BF%-obesity. CONCLUSIONS:In patients with CAD, BMI does not discriminate between BF% and lean mass, and a BMI < 30 kg/m(2) is a poor index to diagnose obesity. These findings may explain the controversial findings that link mild elevations of BMI to better survival and fewer cardiovascular events in patients with CAD. Body composition techniques to accurately diagnose obesity in patients with CAD might be necessary.
journal_name
Eur Heart Jjournal_title
European heart journalauthors
Romero-Corral A,Somers VK,Sierra-Johnson J,Jensen MD,Thomas RJ,Squires RW,Allison TG,Korinek J,Lopez-Jimenez Fdoi
10.1093/eurheartj/ehm243subject
Has Abstractpub_date
2007-09-01 00:00:00pages
2087-93issue
17eissn
0195-668Xissn
1522-9645pii
ehm243journal_volume
28pub_type
杂志文章abstract::Myocardial protection and the control of ischemic injury has been highly successful clinically in the field of cardiac surgery where hearts are made globally ischemic. By contrast, protection of the regionally ischemic myocardium, as found during evolving myocardial infarction, has been less successful and, despite nu...
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pub_type: 杂志文章,评审
doi:10.1093/eurheartj/4.suppl_c.43
更新日期:1983-05-01 00:00:00
abstract:AIMS:Support with left ventricular assist devices (LVAD) improves cardiac performance in patients with end-stage heart failure. In some cases this strategy, combined with pharmacological treatment, has led to a clinical improvement which remained after LVAD explant. This study defines changes in Ca handling at the cell...
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pub_type: 杂志文章
doi:10.1093/eurheartj/ehq072
更新日期:2010-08-01 00:00:00
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更新日期:1984-03-01 00:00:00
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更新日期:2007-09-01 00:00:00
abstract:AIMS:Habitual cigarette smokers, paradoxically, present improved short-term prognosis after acute myocardial infarction, a phenomenon often termed "smoker's paradox". We sought to examine cigarette smokers' post-infarction survival advantage in a countrywide survey of unselected, consecutive patients presenting with ac...
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pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a061429
更新日期:1983-02-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1988-01-01 00:00:00
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doi:10.1016/j.ehj.2003.09.016
更新日期:2003-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/eurheartj/14.1.129
更新日期:1993-01-01 00:00:00
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更新日期:2017-05-14 00:00:00
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更新日期:2015-03-21 00:00:00
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pub_type: 杂志文章
doi:10.1093/eurheartj/9.suppl_a.141
更新日期:1988-01-01 00:00:00
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更新日期:2009-09-01 00:00:00
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更新日期:2012-06-01 00:00:00
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pub_type: 杂志文章,meta分析
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更新日期:2019-05-14 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1987-11-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2016-06-14 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2011-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1053/euhj.1999.1530
更新日期:1999-07-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-01-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2008-06-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,评审
doi:
更新日期:1998-05-01 00:00:00