Opposite central cardiovascular effects of various morphine-like drugs and opiate peptides in the rat.

Abstract:

:Opiate agonists were administered into the cisterna magna of normotensive urethane-anaesthetized artificially-ventilated rats. Increases in blood pressure and heart rate were produced by fentanyl (0.3-3.0 nmol). [D-ala]2-met-enkephalinamide (17 nmol), and beta-endorphin (2.9 nmol). On the contrary, ethylketocyclazocine (78.7 nmol) and dynorphin (1-13) (62.3 nmol) produced decreases in blood pressure and heart rate. The cardiovascular effects of ethylketocyclazocine and dynorphin (1-13) were antagonized by higher doses of naloxone than that required to counteract the effects of fentanyl. These results suggest that opposite central cardiovascular effects could be induced by activation of various opiate receptors.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Laurent S,Schmitt H

doi

10.1093/eurheartj/4.suppl_g.61

subject

Has Abstract

pub_date

1983-11-01 00:00:00

pages

61-5

eissn

0195-668X

issn

1522-9645

journal_volume

4 Suppl G

pub_type

杂志文章
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    pub_type: 杂志文章,评审

    doi:

    authors: Sharpe N,Doughty RN

    更新日期:1998-02-01 00:00:00

  • SYNTAX score and Clinical SYNTAX score as predictors of very long-term clinical outcomes in patients undergoing percutaneous coronary interventions: a substudy of SIRolimus-eluting stent compared with pacliTAXel-eluting stent for coronary revascularizatio

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    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

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    authors: Girasis C,Garg S,Räber L,Sarno G,Morel MA,Garcia-Garcia HM,Lüscher TF,Serruys PW,Windecker S

    更新日期:2011-12-01 00:00:00

  • Low-dose oral sotalol for monomorphic ventricular tachycardia: effects during programmed electrical stimulation and follow-up.

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    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a059469

    authors: Jordaens LJ,Palmer A,Clement DL

    更新日期:1989-03-01 00:00:00

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    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/5.suppl_f.225

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    更新日期:1984-12-01 00:00:00

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    journal_title:European heart journal

    pub_type: 杂志文章

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    更新日期:2009-05-01 00:00:00

  • Multicentre, randomized comparison of two-stent and provisional stenting techniques in patients with complex coronary bifurcation lesions: the DEFINITION II trial.

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    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehaa543

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    更新日期:2020-07-14 00:00:00

  • Cardiac structure and function and leisure-time physical activity in the elderly: The Atherosclerosis Risk in Communities Study.

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    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehw121

    authors: Hegde SM,Gonçalves A,Claggett B,Evenson KR,Cheng S,Shah AM,Folsom AR,Solomon SD

    更新日期:2016-08-21 00:00:00

  • Prognostic relevance of symptoms versus objective evidence of coronary artery disease in diabetic patients.

    abstract:AIM:Little is known about the prognostic significance of silent versus symptomatic coronary artery disease (CAD) in diabetic patients. We therefore assessed the incidence of scintigraphic evidence of CAD in diabetic patients without known CAD and the impact of symptoms and scintigraphic findings on prognosis. METHODS ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ehj.2004.02.013

    authors: Zellweger MJ,Hachamovitch R,Kang X,Hayes SW,Friedman JD,Germano G,Pfisterer ME,Berman DS

    更新日期:2004-04-01 00:00:00

  • Variable response to atrial pacing after intravenous propranolol in patients with stable exertional angina.

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    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a059640

    authors: De Servi S,Ferrario M,Ghio S,Cioffi P,Angoli L,Bramucci E,Aimè E,Montericcio V,Specchia G

    更新日期:1990-11-01 00:00:00

  • Ventricular premature beats in young subjects without evidence of cardiac disease: histological findings.

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    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060248

    authors: Di Biase M,Chiddo A,Caruso G,Tritto M,Marchese A,Rizzon P

    更新日期:1992-06-01 00:00:00

  • Myocardial infarction and prevalence of diabetes mellitus. Is increased casual blood glucose at admission a reliable criterion for the diagnosis of diabetes?

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    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.2000.2445

    authors: Tenerz A,Lönnberg I,Berne C,Nilsson G,Leppert J

    更新日期:2001-07-01 00:00:00

  • Clinical and economic impact of exercise electrocardiography and exercise echocardiography in clinical practice.

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    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1016/s0195-668x(03)00113-1

    authors: Marwick TH,Shaw L,Case C,Vasey C,Thomas JD

    更新日期:2003-06-01 00:00:00

  • Creatine kinase-MB elevation after percutaneous coronary intervention predicts adverse outcomes in patients with acute coronary syndromes.

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    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/j.ehj.2003.12.009

    authors: Roe MT,Mahaffey KW,Kilaru R,Alexander JH,Akkerhuis KM,Simoons ML,Harrington RA,Tardiff BE,Granger CB,Ohman EM,Moliterno DJ,Lincoff AM,Armstrong PW,Van de Werf F,Califf RM,Topol EJ

    更新日期:2004-02-01 00:00:00

  • Transthyretin cardiac amyloidosis in continental Western Europe: an insight through the Transthyretin Amyloidosis Outcomes Survey (THAOS).

    abstract:AIMS:Transthyretin amyloidosis (ATTR amyloidosis) is a heterogeneous disorder with cardiac, neurologic, and mixed phenotypes. We describe the phenotypic and genotypic profiles of this disease in continental Western Europe as it appears from the Transthyretin Amyloidosis Survey (THAOS). METHODS AND RESULTS:THAOS is an ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehz173

    authors: Damy T,Kristen AV,Suhr OB,Maurer MS,Planté-Bordeneuve V,Yu CR,Ong ML,Coelho T,Rapezzi C,THAOS Investigators.

    更新日期:2019-04-01 00:00:00

  • Sudden death in the working population: a collaborative study in central Japan.

    abstract:AIM:Few epidemiological data are available describing the sudden death of persons in their prime. This study aims to elucidate when and how sudden death occurs among employees. METHODS:A total of 196775 employees from 10 workplaces in Central Japan were surveyed for non-traumatic sudden death during 1989-1995. Demogra...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.1998.1189

    authors: Kawamura T,Kondo H,Hirai M,Wakai K,Tamakoshi A,Terazawa T,Osugi S,Ohno M,Okamoto N,Tsuchida T,Ohno Y,Toyama J

    更新日期:1999-03-01 00:00:00

  • Electrocardiographic patterns during Holter monitoring in patients with first and second degree A-V block due to 'dual A-V nodal pathways'.

    abstract::The electrocardiographic patterns, observed during 24-h Holter monitoring, of 10 patients (mean age 35 +/- 22 years) with first and second degree A-V block due to dual A-V nodal pathways are reported. Recordings were selected according to the presence of: sudden and persistent prolongation of the PR interval: sudden n...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a059904

    authors: Di Biase M,Tritto M,Sabato G,Pitzalis MV,Rizzon P

    更新日期:1991-03-01 00:00:00

  • A stepwise mapping approach for localization and ablation of ectopic right, left, and septal atrial foci using electroanatomic mapping.

    abstract:AIMS:We describe a new strategic stepwise mapping approach for fast and accurate identification and ablation of ectopic atrial foci using an electroanatomic mapping system. METHODS AND RESULTS:Mapping procedures started with the acquisition of four points at the superior/septal part of the tricuspid annulus. According...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.2002.3192

    authors: Wetzel U,Hindricks G,Schirdewahn P,Dorszewski A,Fleck A,Heinke F,Kottkamp H

    更新日期:2002-09-01 00:00:00

  • Coronary artery spasm in a transplant patient.

    abstract::The mechanism of coronary spasm is poorly understood. We report a case of coronary artery spasm in a cardiac transplant patient. Pharmacologic testing indicated denervation of the patient's heart. Therefore coronary artery spasm may occur despite cardiac denervation. This case demonstrates that intact autonomic nervou...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a062543

    authors: Cattan S,Drobinski G,Artigou JY,Grogogeat Y,Cabrol C

    更新日期:1988-05-01 00:00:00

  • Differential change in left ventricular mass and regional wall thickness after cardiac resynchronization therapy for heart failure.

    abstract:AIMS:LV reverse remodelling has been shown to be a favourable response after cardiac resynchronization therapy (CRT) in many clinical trials. This study investigated whether left ventricular (LV) reverse remodelling after CRT has any structural benefit, which include the improvement of LV mass or regional wall thicknes...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehi885

    authors: Zhang Q,Fung JW,Auricchio A,Chan JY,Kum LC,Wu LW,Yu CM

    更新日期:2006-06-01 00:00:00

  • Myocardial reperfusion injury: looking beyond primary PCI.

    abstract::Coronary heart disease (CHD) is the leading cause of death and disability in Europe. For patients presenting with an acute ST-segment elevation myocardial infarction (STEMI), timely myocardial reperfusion using either thrombolytic therapy or primary percutaneous coronary intervention (PPCI) is the most effective thera...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/eht090

    authors: Fröhlich GM,Meier P,White SK,Yellon DM,Hausenloy DJ

    更新日期:2013-06-01 00:00:00

  • Comparison of the effects of two doses of bisoprolol on exercise tolerance in exercise-induced stable angina pectoris.

    abstract::Recently, bisoprolol has been investigated regarding its effects on exercise tolerance and the duration of action in patients with coronary heart disease (CHD) following single oral administration. It appears, however, that the extent of effects of 5 mg bisoprolol is not fully established yet. Therefore, the effects o...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/eurheartj/8.suppl_m.31

    authors: de Muinck E,Wagner G,vd Ven LL,Lie KI

    更新日期:1987-12-01 00:00:00

  • Community intervention to control plasma lipids.

    abstract::A necessary part of the strategy of modification of hypercholesterolaemia to prevent coronary heart disease (CHD) is the detection and treatment, by diet or by drugs, of high risk individuals. There are several drawbacks to this approach: (1) the cost of screening to find individuals at risk and of monitoring by physi...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/8.suppl_e.71

    authors: Marmot MG

    更新日期:1987-08-01 00:00:00

  • From guidelines to clinical practice: the impact of hospital and geographical characteristics on temporal trends in the management of acute coronary syndromes. The Global Registry of Acute Coronary Events (GRACE).

    abstract:AIMS:The extent to which hospital and geographic characteristics influence the time course of uptake of evidence from key clinical trials and practice guidelines is unknown. The gap between evidence and practice is well recognized but the factors influencing this disjunction, and the extent to which such factors are mo...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1016/s0195-668x(03)00315-4

    authors: Fox KA,Goodman SG,Anderson FA Jr,Granger CB,Moscucci M,Flather MD,Spencer F,Budaj A,Dabbous OH,Gore JM,GRACE Investigators.

    更新日期:2003-08-01 00:00:00

  • Microalbuminuria during acute myocardial infarction; a strong predictor for 1-year mortality.

    abstract:AIMS:Urinary albumin excretion increases during acute myocardial infarction but little is known on the prognostic significance and the pathophysiological mechanisms of microalbuminuria in this clinical setting. The primary aim of the study was to examine whether urinary albumin excretion has predictive power for 1-year...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.2000.2582

    authors: Berton G,Cordiano R,Palmieri R,Cucchini F,De Toni R,Palatini P

    更新日期:2001-08-01 00:00:00

  • Exercise echocardiography performed early and late after percutaneous transluminal coronary angioplasty for prediction of restenosis.

    abstract::The purpose of this prospective study was to examine the incidence of exercise-induced ischaemia before and after angioplasty as well as 4 months later by exercise echocardiography, to evaluate the prognostic value of exercise echocardiography performed after angioplasty as regards the development of restenosis and to...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060841

    authors: Hoffmann R,Lethen H,Flachskampf FA,Hanrath P

    更新日期:1995-12-01 00:00:00

  • Peptides in coronary circulation: basis for therapeutic strategies.

    abstract::Promising approaches towards new therapeutic strategies in coronary heart disease might emerge from an improved pathophysiological understanding of the role of certain peptides, which require a localizing event for their accumulation or expression in the coronary vasculature. Temporal myocardial ischaemia or hypoperfu...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/12.suppl_f.112

    authors: Holtz J,Goetz RM

    更新日期:1991-12-01 00:00:00

  • Stenosed bicuspid aortic valves in twins.

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    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a062276

    authors: Godden DJ,Sandhu PS,Kerr F

    更新日期:1987-03-01 00:00:00

  • Prasugrel achieves greater inhibition of platelet aggregation and a lower rate of non-responders compared with clopidogrel in aspirin-treated patients with stable coronary artery disease.

    abstract:AIMS:This study was designed to compare the degree of inhibition of platelet aggregation (IPA) of prasugrel with that of clopidogrel in stable aspirin-treated patients with coronary artery disease (CAD). METHODS AND RESULTS:Subjects (n=101) were randomly assigned to the following loading dose (LD) (day 1)/maintenance ...

    journal_title:European heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurheartj/ehi877

    authors: Jernberg T,Payne CD,Winters KJ,Darstein C,Brandt JT,Jakubowski JA,Naganuma H,Siegbahn A,Wallentin L

    更新日期:2006-05-01 00:00:00

  • Haemodynamic effects of high doses of insulin during acute left ventricular failure in dogs.

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    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061885

    authors: Reikerås O,Gunnes P,Sørlie D,Ekroth R,Jorde R,Mjøs OD

    更新日期:1985-05-01 00:00:00

  • A randomized controlled trial of dapagliflozin on left ventricular hypertrophy in people with type two diabetes: the DAPA-LVH trial.

    abstract:AIM:We tested the hypothesis that dapagliflozin may regress left ventricular hypertrophy (LVH) in people with type 2 diabetes (T2D). METHODS AND RESULTS:We randomly assigned 66 people (mean age 67 ± 7 years, 38 males) with T2D, LVH, and controlled blood pressure (BP) to receive dapagliflozin 10 mg once daily or placeb...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehaa419

    authors: Brown AJM,Gandy S,McCrimmon R,Houston JG,Struthers AD,Lang CC

    更新日期:2020-09-21 00:00:00