Abstract:
AIMS:This study was designed to compare the degree of inhibition of platelet aggregation (IPA) of prasugrel with that of clopidogrel in stable aspirin-treated patients with coronary artery disease (CAD). METHODS AND RESULTS:Subjects (n=101) were randomly assigned to the following loading dose (LD) (day 1)/maintenance dose (MD) (days 2-28) combinations: prasugrel, 40 mg/5 mg; 40 mg/7.5 mg; 60 mg/10 mg; 60 mg/15 mg; or clopidogrel, 300 mg/75 mg. Turbidometric platelet aggregation was measured at multiple timepoints during the study. At 4 h after dosing, with 20 microM ADP, both prasugrel LDs achieved significantly higher mean IPA levels (60.6% and 68.4 vs. 30.0%, respectively; all P<0.0001) and lower percentage (3 vs. 52%, P<0.0001) of pharmacodynamic non-responders (defined as IPA <20%) than clopidogrel. Prasugrel 10 and 15 mg MDs achieved consistently higher mean IPA than clopidogrel 75 mg at day 28 (all P<0.0001). At pre-MD on day 28, there were no non-responders in the 10 and 15 mg prasugrel group, compared with 45% in the clopidogrel group (P=0.0007). CONCLUSION:In this population, prasugrel (40-60 mg LD and 10-15 mg MD) achieves greater IPA and a lower proportion of pharmacodynamic non-responders compared with the approved clopidogrel dosing.
journal_name
Eur Heart Jjournal_title
European heart journalauthors
Jernberg T,Payne CD,Winters KJ,Darstein C,Brandt JT,Jakubowski JA,Naganuma H,Siegbahn A,Wallentin Ldoi
10.1093/eurheartj/ehi877subject
Has Abstractpub_date
2006-05-01 00:00:00pages
1166-73issue
10eissn
0195-668Xissn
1522-9645pii
ehi877journal_volume
27pub_type
杂志文章,随机对照试验abstract:AIMS:Kinetics of recovery oxygen consumption after exercise plays an important role in determining exercise capacity. This study was performed to assess the kinetics of recovery oxygen consumption in mitral stenosis and evaluate the effects of percutaneous balloon mitral valvuloplasty and exercise training on the kinet...
journal_title:European heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1053/euhj.1998.1146
更新日期:1998-12-01 00:00:00
abstract:AIMS:Valve compliance might determine the onset of symptoms better than resting measures of aortic stenosis. This study compared valve compliance measured by dobutamine stress echocardiography with resting haemodynamic variables against the end-point of symptoms at low workload during exercise testing. METHODS AND RES...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1016/s0195-668x(03)00235-5
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abstract:AIMS:Magnetic resonance imaging (MRI) is well established as an important diagnostic tool in medicine. However, the presence of a cardiac pacemaker is usually regarded as a contraindication for MRI due to safety reasons. In this study, heating effects at the myocardium-pacemaker lead tip interface have been investigate...
journal_title:European heart journal
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doi:10.1093/eurheartj/ehi009
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abstract::Dr Martin Stiles talks about the electrophysiology scene in NZ with Iona MacDonald. ...
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abstract::The purpose of this prospective study was to examine the incidence of exercise-induced ischaemia before and after angioplasty as well as 4 months later by exercise echocardiography, to evaluate the prognostic value of exercise echocardiography performed after angioplasty as regards the development of restenosis and to...
journal_title:European heart journal
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doi:10.1093/oxfordjournals.eurheartj.a060841
更新日期:1995-12-01 00:00:00
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doi:10.1093/eurheartj/9.suppl_n.169
更新日期:1988-12-01 00:00:00
abstract::A new European Heart Journal, Cardiovascular Pharmacotherapy, was launched at the ESC Congress 2014 in Barcelona and begins publication in February 2014. ...
journal_title:European heart journal
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更新日期:2014-09-07 00:00:00
abstract:AIM:Cross-sectional studies reported associations between short leucocyte telomere length (LTL) and measures of vascular and cardiac damage. However, the contribution of LTL dynamics to the age-related process of cardiovascular (CV) remodelling remains unknown. In this study, we explored whether the rate of LTL shorten...
journal_title:European heart journal
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abstract:AIMS:This study investigated the functional outcome of wall-thinned, akinetic myocardium after revascularization and evaluated the accuracy of dobutamine echocardiography in predicting post-revascularization functional recovery with the assessment of end-diastolic wall thickness in chronic ischaemic patients. METHODS ...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a015345
更新日期:1997-05-01 00:00:00
abstract::Subclinical thyroid dysfunction comprises subclinical hypothyroidism (SHypo), defined as elevated thyroid-stimulating hormone (TSH) by normal free thyroxine (FT4), and subclinical hyperthyroidism (SHyper) with decreased or undetectable TSH and normal FT4. Up to 10% of the elderly have SHypo, which is usually asymptoma...
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journal_title:European heart journal
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doi:10.1093/eurheartj/ehq142
更新日期:2010-07-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,评审
doi:10.1093/eurheartj/10.suppl_b.45
更新日期:1989-06-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2007-05-01 00:00:00
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journal_title:European heart journal
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doi:10.1053/euhj.1998.1313
更新日期:1999-05-01 00:00:00
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journal_title:European heart journal
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1993-05-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1093/eurheartj/ehn577
更新日期:2009-04-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2016-01-07 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/ehq371
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journal_title:European heart journal
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:European heart journal
pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1053/euhj.1998.1096
更新日期:1998-11-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
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journal_title:European heart journal
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2003-01-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
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更新日期:1988-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a060259
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