当前位置： SCI文献检索 > EUROPEAN HEART JOURNAL期刊下所有文献 > Rate of telomere shortening and cardiovascular damage: a longitudinal study in the 1946 British Birth Cohort.

Rate of telomere shortening and cardiovascular damage: a longitudinal study in the 1946 British Birth Cohort.

Abstract：

AIM:Cross-sectional studies reported associations between short leucocyte telomere length (LTL) and measures of vascular and cardiac damage. However, the contribution of LTL dynamics to the age-related process of cardiovascular (CV) remodelling remains unknown. In this study, we explored whether the rate of LTL shortening can predict CV phenotypes over 10-year follow-up and the influence of established CV risk factors on this relationship. METHODS AND RESULTS:All the participants from the MRC National Survey of Health and Development (NSHD) with measures of LTL and traditional CV risk factors at 53 and 60-64 years and common carotid intima-media thickness (cIMT), cardiac mass and left ventricular function at 60-64 years were included. LTL was measured by real-time polymerase chain reaction and available at both time points in 1033 individuals. While LTL at 53 years was not linked with any CV phenotype at 60-64 years, a negative association was found between LTL and cIMT at 60-64 years (β = -0.017, P = 0.015). However, the strongest association was found between rate of telomere shortening between 53 and 60-64 years and values of cIMT at 60-64 years (β = -0.020, P = 0.006). This association was not affected by adjustment for traditional CV risk factors. Cardiac measurements were not associated with cross-sectional or longitudinal measures of LTL. CONCLUSION:These findings suggest that the rate of progression of cellular ageing in late midlife (reflected by the rate of LTL attrition) relates to vascular damage, independently from contribution of CV risk factor exposure.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Masi S,D'Aiuto F,Martin-Ruiz C,Kahn T,Wong A,Ghosh AK,Whincup P,Kuh D,Hughes A,von Zglinicki T,Hardy R,Deanfield JE,NSHD scientific and data collection teams.

doi

10.1093/eurheartj/ehu226

subject

Has Abstract

pub_date

2014-12-07 00:00:00

pages

3296-303

issue

46

eissn

0195-668X

issn

1522-9645

pii

ehu226

journal_volume

35

pub_type

杂志文章

相关文献

EUROPEAN HEART JOURNAL文献大全
  • Angiographic follow-up results of a randomized study on angioplasty versus bypass surgery (GABI trial). GABI Study Group.

    abstract：:Although several randomized trials have been performed to compare the outcomes of percutaneous transluminal coronary angioplasty (PTCA) and coronary artery bypass surgery (CABG) in patients with multivessel disease, there is little data available on angiographic follow-up results. The present substudy of the German an...

    journal_title：European heart journal

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1093/oxfordjournals.eurheartj.a015036

    authors： Rupprecht HJ,Hamm C,Ischinger T,Dietz U,Reimers J,Meyer J

    更新日期：1996-08-01 00:00:00

  • Triiodothyronine therapy in open-heart surgery: from hope to disappointment.

    abstract：:A controversy persists as to whether cardiopulmonary bypass (CPB) decreases plasma levels of triiodothyronine (T3), thereby justifying peri-operative administration of T3 to improve haemodynamic recovery. To examine the effects of T3 therapy on post-CPB haemodynamics and to determine whether the potential inotropic ef...

    journal_title：European heart journal

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1093/eurheartj/14.5.629

    authors： Teiger E,Menasché P,Mansier P,Chevalier B,Lajeunie E,Bloch G,Piwnica A

    更新日期：1993-05-01 00:00:00

  • First myocardial infarction: 5-year survival predicted from routine clinical, laboratory, and radionuclide findings during the acute stage.

    abstract：:Five-year survival amongst 485 consecutive patients with their first acute myocardial infarction (AMI) was 78.2%. Univariate survival analysis showed that the following variables during the acute stage were of prognostic significance for survival: signs of left ventricular heart failure, enlarged cardiac volume, pulmo...

    journal_title：European heart journal

    pub_type： 杂志文章

    doi：

    authors： Rollag A,Abdelnoor M,Mangschau A,Jonsbu J,Aase O,Erikssen J

    更新日期：1991-09-01 00:00:00

  • Altered limbic and autonomic processing supports brain-heart axis in Takotsubo syndrome.

    abstract：AIMS:Takotsubo syndrome (TTS) is characterized by acute left ventricular dysfunction often triggered by emotional or physical stress. Severe activation of the sympathetic nervous system with catecholamine release caused by a dysfunctional limbic system has been proposed as a potential mechanism. We hypothesize that bra...

    journal_title：European heart journal

    pub_type： 杂志文章

    doi：10.1093/eurheartj/ehz068

    authors： Templin C,Hänggi J,Klein C,Topka MS,Hiestand T,Levinson RA,Jurisic S,Lüscher TF,Ghadri JR,Jäncke L

    更新日期：2019-04-14 00:00:00

  • The European Study of Epidemiology and Treatment of Cardiac Inflammatory Disease (ESETCID).

    abstract：:Diagnosis of myocarditis has improved with the application of new techniques such as immunohistochemistry, polymerase chain reaction, in situ hybridization and Southern blot in endomyocardial biopsies. Treatment of inflammatory heart disease is still difficult and not yet validated by a study with patient numbers suff...

    journal_title：European heart journal

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1093/eurheartj/16.suppl_o.173

    authors： Maisch B,Hufnagel G,Schönian U,Hengstenberg C

    更新日期：1995-12-01 00:00:00

  • Influence of coronary vessel dominance on short- and long-term outcome in patients after ST-segment elevation myocardial infarction.

    abstract：AIMS:Prognostic importance of coronary vessel dominance in patients with ST-elevation myocardial infarction (STEMI) remains uncertain. The aim of this study was to assess influence of coronary vessel dominance on the short- and long-term outcome after STEMI. METHODS AND RESULTS:Coronary angiographic images of consecut...

    journal_title：European heart journal

    pub_type： 杂志文章

    doi：10.1093/eurheartj/ehu236

    authors： Veltman CE,van der Hoeven BL,Hoogslag GE,Boden H,Kharbanda RK,de Graaf MA,Delgado V,van Zwet EW,Schalij MJ,Bax JJ,Scholte AJ

    更新日期：2015-05-01 00:00:00

  • Non-invasive assessment of cardiac physiology by tissue Doppler echocardiography. A comparison with invasive haemodynamics.

    abstract：BACKGROUND:Tissue Doppler echocardiography reveals characteristic patterns of myocardial velocities within systole and diastole which are not well understood. AIM:The purpose of this study was to determine the relationship of myocardial velocity patterns, as assessed by tissue Doppler echocardiography, to the contract...

    journal_title：European heart journal

    pub_type： 杂志文章

    doi：10.1093/oxfordjournals.eurheartj.a015236

    authors： Zamorano J,Wallbridge DR,Ge J,Drozd J,Nesser J,Erbel R

    更新日期：1997-02-01 00:00:00

  • Restenosis and adverse clinical events after successful percutaneous mitral valvuloplasty: immediate post-procedural mitral valve area as an important prognosticator.

    abstract：AIMS:We sought to investigate the factors associated with restenosis and its potential association with late clinical deterioration after successful percutaneous mitral valvuloplasty (PMV). METHODS AND RESULTS:We analysed echocardiographic (median 74 months) and clinical (median 109 months) follow-up data of 329 patie...

    journal_title：European heart journal

    pub_type： 杂志文章

    doi：10.1093/eurheartj/ehp096

    authors： Song JK,Song JM,Kang DH,Yun SC,Park DW,Lee SW,Kim YH,Lee CW,Hong MK,Kim JJ,Park SW,Park SJ

    更新日期：2009-05-01 00:00:00

  • Molecular signature of cardiogenic shock.

    abstract：:The incidence of cardiogenic shock (CS) has increased remarkably over the past decade and remains a challenging condition with mortality rates of ∼50%. Cardiogenic shock encompasses cardiac contractile dysfunction; however, it is also a multiorgan dysfunction syndrome, often complicated by a systemic inflammatory resp...

    journal_title：European heart journal

    pub_type： 杂志文章

    doi：10.1093/eurheartj/ehz783

    authors： Iborra-Egea O,Rueda F,García-García C,Borràs E,Sabidó E,Bayes-Genis A

    更新日期：2020-10-14 00:00:00

  • Natriuretic peptide-guided heart failure management.

    abstract：:The natriuretic peptides are important tools to establish diagnosis and prognosis in heart failure (HF). With application of therapies for HF, changes in both B-type natriuretic peptide (BNP) and its amino terminal cleavage fragment (NT-proBNP) parallel the benefits of the HF therapy applied. This dynamic nature of BN...

    journal_title：European heart journal

    pub_type： 杂志文章,评审

    doi：10.1093/eurheartj/eht463

    authors： Troughton R,Michael Felker G,Januzzi JL Jr

    更新日期：2014-01-01 00:00:00

  • Impact of anatomical and functional severity of coronary atherosclerotic plaques on the transmural perfusion gradient: a [15O]H2O PET study.

    abstract：BACKGROUND:Myocardial ischaemia occurs principally in the subendocardial layer, whereas conventional myocardial perfusion imaging provides no information on the transmural myocardial blood flow (MBF) distribution. Subendocardial perfusion measurements and quantification of the transmural perfusion gradient (TPG) could ...

    journal_title：European heart journal

    pub_type： 杂志文章

    doi：10.1093/eurheartj/ehu170

    authors： Danad I,Raijmakers PG,Harms HJ,Heymans MW,van Royen N,Lubberink M,Boellaard R,van Rossum AC,Lammertsma AA,Knaapen P

    更新日期：2014-08-14 00:00:00

  • Beta adrenergic blockade does not improve effort tolerance in patients with mitral stenosis in sinus rhythm.

    abstract：OBJECTIVES:This study was designed to assess the effects of beta-blockade on cardiopulmonary exercise performance in symptomatic patients with tight mitral stenosis in sinus rhythm. BACKGROUND:The role of beta-blockers in these patients has been controversial and assessment of effort tolerance using treadmill exercise...

    journal_title：European heart journal

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1093/oxfordjournals.eurheartj.a061084

    authors： Patel JJ,Dyer RB,Mitha AS

    更新日期：1995-09-01 00:00:00

  • Creatine kinase-MB elevation after percutaneous coronary intervention predicts adverse outcomes in patients with acute coronary syndromes.

    abstract：AIM:To study the relationship between outcomes and peak creatine kinase (CK)-MB levels after percutaneous coronary intervention (PCI) in patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS). METHODS AND RESULTS:Peak CK-MB ratios (peak CK-MB level/upper limit of normal [ULN]) after PCI were analys...

    journal_title：European heart journal

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.ehj.2003.12.009

    authors： Roe MT,Mahaffey KW,Kilaru R,Alexander JH,Akkerhuis KM,Simoons ML,Harrington RA,Tardiff BE,Granger CB,Ohman EM,Moliterno DJ,Lincoff AM,Armstrong PW,Van de Werf F,Califf RM,Topol EJ

    更新日期：2004-02-01 00:00:00

  • Haemodynamic effects of high doses of insulin during acute left ventricular failure in dogs.

    abstract：:Haemodynamic effects of pharmacological doses of insulin during acute ischaemic heart failure were studied in 8 dogs. Severe depression of left ventricular function was induced by the injection of 50 micron plastic microspheres into the left main coronary artery. This was demonstrated by a significant increase in left...

    journal_title：European heart journal

    pub_type： 杂志文章

    doi：10.1093/oxfordjournals.eurheartj.a061885

    authors： Reikerås O,Gunnes P,Sørlie D,Ekroth R,Jorde R,Mjøs OD

    更新日期：1985-05-01 00:00:00

  • Systematic review of thienopyridine discontinuation and its impact upon clinical outcomes.

    abstract：:The optimal length of clopidogrel therapy in patients with acute coronary syndromes or in those who have undergone percutaneous coronary intervention (PCI) remains controversial. We therefore sought to determine the risk of both perioperative and premature discontinuation of clopidogrel. PubMed and EMBASE databases we...

    journal_title：European heart journal

    pub_type： 杂志文章,评审

    doi：10.1093/eurheartj/ehr141

    authors： Gaglia MA Jr,Waksman R

    更新日期：2011-10-01 00:00:00

  • DNA testing for hypertrophic cardiomyopathy: a cost-effectiveness model.

    abstract：:Aims To explore the cost-effectiveness of alternative methods of screening family members for hypertrophic cardiomyopathy (HCM), the most common monogenic cardiac disorder and the most frequent cause of sudden cardiac death (SCD) in young people. Methods and results Economic decision model comparing cascade screening ...

    journal_title：European heart journal

    pub_type： 杂志文章,评审

    doi：10.1093/eurheartj/ehq067

    authors： Wordsworth S,Leal J,Blair E,Legood R,Thomson K,Seller A,Taylor J,Watkins H

    更新日期：2010-04-01 00:00:00

  • Survival rate and causes of death in patients with pacemakers: dependence on symptoms leading to pacemaker implantation.

    abstract：:The survival rate of 2256 patients with pacemakers was analyzed. Patients paced for Adams-Stokes equivalents (e.g. dizziness) showed a significantly better survival rate than did patients with pacemakers implanted for Adam-Stokes attacks or heart failure (P less than 0.0001). The estimated survival of the latter two g...

    journal_title：European heart journal

    pub_type： 杂志文章

    doi：10.1093/oxfordjournals.eurheartj.a062591

    authors： Müller C,Cernin J,Glogar D,Laczkovics A,Mayr H,Scheibelhofer W,Schmidinger H,Schuster E,Sedlacek K,Kaliman J

    更新日期：1988-09-01 00:00:00

  • Is there a need for routine testing of ICD defibrillation capacity? Results from more than 1000 studies.

    abstract：AIMS:Benefits and complications of postoperative implantable cardioverter-defibrillator tests are controversial matters. This study sought to assess the necessity of defibrillation function tests after implantation. METHODS AND RESULTS:We retrospectively analysed 1007 implantable cardioverter-defibrillator tests in 58...

    journal_title：European heart journal

    pub_type： 杂志文章

    doi：10.1053/euhj.1999.1716

    authors： Brunn J,Böcker D,Weber M,Castrucci M,Gradaus R,Borggrefe M,Breithardt G,Block M

    更新日期：2000-01-01 00:00:00

  • Potent inhibition of thrombin with a monoclonal antibody against tissue factor (Sunol-cH36): results of the PROXIMATE-TIMI 27 trial.

    abstract：AIMS:Exposure of tissue factor (TF) is a critical proximal step in the pathogenesis of acute coronary syndromes. Sunol-cH36, a chimaeric monoclonal antibody to TF, blocks binding of factor X to the TF:VIIa complex. This report describes the first completed trial of Sunol-cH36 in humans. METHODS AND RESULTS:We assessed...

    journal_title：European heart journal

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1093/eurheartj/ehi094

    authors： Morrow DA,Murphy SA,McCabe CH,Mackman N,Wong HC,Antman EM

    更新日期：2005-04-01 00:00:00

  • Platelet glycoprotein IIb/IIIa receptor inhibition as adjunctive treatment during saphenous vein graft stenting: differential effects after randomization to occlusion or filter-based embolic protection.

    abstract：AIMS:Although embolic protection devices reduce complications during saphenous vein graft (SVG) stenting, adverse events still occur in approximately 10% of patients. IIb/IIIa antagonists have not been proven effective during SVG intervention. We hypothesized that adjunctive use of these agents might enhance the effica...

    journal_title：European heart journal

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1093/eurheartj/ehi736

    authors： Jonas M,Stone GW,Mehran R,Hermiller J,Feldman R,Herrmann HC,Cox DA,Kuntz RE,Popma JJ,Rogers C,FilterWire EX Randomized Evalulation (FIRE) Investigators.

    更新日期：2006-04-01 00:00:00

  • Subaortic aneurysm of the left ventricle obstructing a coronary artery.

    abstract：:We report a subaortic aneurysm of the left ventricle causing compression of a coronary artery in a 52-year-old white man presenting with angina on effort. Endocarditis seemed to be implicated as the cause of this rare condition. To what extent coronary obstruction influenced the development of myocardial ischaemia was...

    journal_title：European heart journal

    pub_type： 杂志文章

    doi：10.1093/oxfordjournals.eurheartj.a062318

    authors： Bartorelli A,Sala A

    更新日期：1987-05-01 00:00:00

  • Time-to-treatment significantly affects the extent of ST-segment resolution and myocardial blush in patients with acute myocardial infarction treated by primary angioplasty.

    abstract：AIMS:The prognostic role of time-to-treatment in primary angioplasty is still a matter of debate. The aim of our study was to evaluate the relationship between time-to-treatment and myocardial perfusion in patients with ST-segment-elevation myocardial infarction (STEMI) treated by primary angioplasty. METHODS AND RESU...

    journal_title：European heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ehj.2004.03.021

    authors： De Luca G,van 't Hof AW,de Boer MJ,Ottervanger JP,Hoorntje JC,Gosselink AT,Dambrink JH,Zijlstra F,Suryapranata H

    更新日期：2004-06-01 00:00:00

  • Valve replacement in octogenarians: increased early mortality but good long-term result.

    abstract：:Between January 1983 and December 1990, 20 patients aged 80 years or older underwent valvular surgery. The patients' ages varied from 80 to 87 years (mean, 82 +/- 1.5 years). The indication for operation was aortic stenosis in 19 patients, and mitral insufficiency after previous mitral valve replacement with a biopros...

    journal_title：European heart journal

    pub_type： 杂志文章

    doi：10.1093/oxfordjournals.eurheartj.a060205

    authors： Pasic M,Carrel T,Laske A,Bauer E,Turina J,Jenni R,von Segesser L,Turina M

    更新日期：1992-04-01 00:00:00

  • Myocardial map derived from two-dimensional echocardiography: reproducible and standardized description of infarction topographies.

    abstract：:The aim of this study was to improve the reproducibility and the standardization of the topographical assessment of myocardial infarctions in routine two-dimensional echocardiography. A myocardial map of the left ventricle was derived from a necropsy study of normal human hearts; interventricular grooves and papillary...

    journal_title：European heart journal

    pub_type： 杂志文章

    doi：10.1093/oxfordjournals.eurheartj.a061399

    authors： Touche T,Vervin P,Prasquier R,Diebold B,Curien N,Gourgon R

    更新日期：1983-11-01 00:00:00

  • Cabins, castles, and constant hearts: rhythm control therapy in patients with atrial fibrillation.

    abstract：:Recent innovations have the potential to improve rhythm control therapy in patients with atrial fibrillation (AF). Controlled trials provide new evidence on the effectiveness and safety of rhythm control therapy, particularly in patients with AF and heart failure. This review summarizes evidence supporting the use of ...

    journal_title：European heart journal

    pub_type： 杂志文章,评审

    doi：10.1093/eurheartj/ehz782

    authors： Willems S,Meyer C,de Bono J,Brandes A,Eckardt L,Elvan A,van Gelder I,Goette A,Gulizia M,Haegeli L,Heidbuchel H,Haeusler KG,Kautzner J,Mont L,Ng GA,Szumowski L,Themistoclakis S,Wegscheider K,Kirchhof P

    更新日期：2019-12-07 00:00:00

  • Phenotypic variability of cardiovascular manifestations in Marfan Syndrome. Possible role of hyperhomocysteinemia and C677T MTHFR gene polymorphism.

    abstract：AIMS:The aim of this study was to evaluate (1) homocysteinemia and the prevalence of the C677T MTHFR polymorphism in Marfan patients and (2) whether the severity of cardiovascular manifestations is associated with homocysteinemia and/or C677T polymorphism. METHODS AND RESULTS:We studied 107 patients subdivided into th...

    journal_title：European heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ehj.2003.08.020

    authors： Giusti B,Porciani MC,Brunelli T,Evangelisti L,Fedi S,Gensini GF,Abbate R,Sani G,Yacoub M,Pepe G

    更新日期：2003-11-01 00:00:00

  • Sudden cardiac death while taking amiodarone therapy: the role of abnormal repolarization.

    abstract：:Torsade de pointes may occur as a complication of amiodarone therapy. We report a patient receiving amiodarone who was resuscitated from cardiovascular collapse and documented ventricular fibrillation. At subsequent electrophysiology study, while the patient was taking amiodarone therapy, monophasic action potentials ...

    journal_title：European heart journal

    pub_type： 杂志文章

    doi：10.1093/oxfordjournals.eurheartj.a059849

    authors： Morgan JM,Lopes A,Rowland E

    更新日期：1991-10-01 00:00:00

  • Standard vs double dose of N-acetylcysteine to prevent contrast agent associated nephrotoxicity.

    abstract：AIMS:Prophylactic administration of N-acetylcysteine (NAC) (600mg orally twice daily), along with hydration, prevents contrast agent-associated nephrotoxicity (CAN) induced by a low dose of non-ionic, low-osmolality contrast dye. We tested whether a double dose of NAC is more effective to prevent CAN. METHODS AND RESU...

    journal_title：European heart journal

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.ehj.2003.11.016

    authors： Briguori C,Colombo A,Violante A,Balestrieri P,Manganelli F,Paolo Elia P,Golia B,Lepore S,Riviezzo G,Scarpato P,Focaccio A,Librera M,Bonizzoni E,Ricciardelli B

    更新日期：2004-02-01 00:00:00

  • Increased risk of atrial fibrillation in patients with coeliac disease: a nationwide cohort study.

    abstract：AIMS:Inflammatory markers are established risk factors for atrial fibrillation (AF), but the role of autoimmune diseases is unknown. The aim of the study was to examine the association between coeliac disease (CD) and AF in a large cohort of patients with biopsy-verified CD. METHODS AND RESULTS:We identified 28,637 pa...

    journal_title：European heart journal

    pub_type： 杂志文章

    doi：10.1093/eurheartj/ehr167

    authors： Emilsson L,Smith JG,West J,Melander O,Ludvigsson JF

    更新日期：2011-10-01 00:00:00

  • Progress in the diagnosis of unstable angina and perspectives for treatment.

    abstract：:Unstable angina is a high-risk phase of coronary heart disease defined by clinical symptoms. Electrocardiographic findings are heterogeneous and creatine kinase is only rarely elevated. However, troponin T and troponin I are found in about 30-40% of patients with angina at rest disclosing minor myocardial cell injury....

    journal_title：European heart journal

    pub_type： 杂志文章

    doi：

    authors： Hamm CW

    更新日期：1998-11-01 00:00:00