Reusability of entrapped cells of Pseudomonas diminuta for production of 7-aminocephalosporanic acid.

Abstract:

:Entrapped cells of P. diminuta were used for the production of 7-aminocephalosporanic acid (7-ACA), a key intermediate required for the production of most of the clinically used cephalosporin derivatives, i.e., semisynthetic cephalosporins. The repeated batch production of 7-ACA with entrapped cells of P. diminuta in different carriers were carried out for six cycles at optimal conditions. It was found that 33% , 38%, and 47% of activity was lost with chitosan, gelatin, and agar, respectively as immobilizing supports after the sixth cycle of operation.

authors

Nigam VK,Kundu S,Ghosh P

doi

10.1007/s12010-007-9214-4

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

119-26

issue

1

eissn

0273-2289

issn

1559-0291

pii

ABAB:141:1:119

journal_volume

141

pub_type

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