Co-occurrence of major depression or suicide attempt with migraine with aura and risk for unprovoked seizure.

abstract：:In control rats, we examined the effects of ketogenic diet on NKCC1 and KCC2 expression levels in hippocampus. Neither the number of NKCC1 immunoreactive cells nor the intensity of labeling of KCC2 was found to modify in hippocampus of the rats after ketogenic diet treatment. These results indicate that ketogenic diet...

journal_title：Epilepsy research

authors： Gómez-Lira G,Mendoza-Torreblanca JG,Granados-Rojas L

更新日期：2011-09-01 00:00:00

abstract：:The prevailing understanding of generalized epilepsy is shaped by the traditional definition that "the responsible neuronal discharge takes place, if not throughout the entire grey matter, then at least in the greater part of it and simultaneously on both sides". This view is no longer tenable since concurrent finding...

journal_title：Epilepsy research

authors： Wolf P,Yacubian EM,Avanzini G,Sander T,Schmitz B,Wandschneider B,Koepp M

更新日期：2015-08-01 00:00:00

abstract：:The 5-hydroxytryptamine-1A (5-HT1A) receptors are known to be involved in the inhibition of seizures in epilepsy. Moreover, studies propose a role for the 5-HT1A receptor in memory function; it is believed that the higher density of this receptor in the hippocampus plays an important role in its regulation. Positron e...

journal_title：Epilepsy research

authors： Cuellar-Herrera M,Velasco AL,Velasco F,Trejo D,Alonso-Vanegas M,Nuche-Bricaire A,Vázquez-Barrón D,Guevara-Guzmán R,Rocha L

更新日期：2014-12-01 00:00:00

abstract：:Pregabalin (PGB) is a new antiepileptic drug (AED) which is a structural, non-functional analogue of gamma-aminobutyric acid. It acts at presynaptic calcium channels to modulate neurotransmitter release in the CNS. While the efficacy and tolerability of PGB have been demonstrated in several randomised controlled trial...

journal_title：Epilepsy research

authors： Yuen AW,Singh R,Bell GS,Bhattacharjee A,Neligan A,Heaney DC,Duncan JS,Sander JW

更新日期：2009-12-01 00:00:00

abstract：:The experimental antiepileptic drug, levetiracetam (UCB L059), a piracetam analogue has been investigated in photosensitive patients in the "photosensitivity model", an early phase II study. A total of 12 patients (10 females, 2 males) with a mean age of 21.5 years (range 13-38) were investigated during a 3 day period...

journal_title：Epilepsy research

authors： Kasteleijn-Nolst Trenité DG,Marescaux C,Stodieck S,Edelbroek PM,Oosting J

更新日期：1996-11-01 00:00:00

abstract：:The present study used Nissl stains and glutamate decarboxylase immunoreactivity (GAD-IR) to quantify the acute and chronic toxicity of kainic acid (KA) on focal and remote hippocampal principal neurons (i.e., pyramidal and granule cells) and on putative inhibitory neurons (GAD-IR or GABAergic) following intrahippocam...

journal_title：Epilepsy research

authors： Davenport CJ,Brown WJ,Babb TL

更新日期：1990-01-01 00:00:00

abstract：:Tiagabine is a novel antiepileptic drug which has clinical efficacy against complex refractory and myoclonic seizures. The anticonvulsant mechanism of action of tiagabine results from its blockade of neuronal and glial GABA-uptake, thereby increasing GABA levels in the synaptic cleft. Here we present a comparison of t...

journal_title：Epilepsy research

authors： Dalby NO,Nielsen EB

更新日期：1997-07-01 00:00:00

abstract：:Recognition of the role of genetics in the epilepsies has increased dramatically, impacting on clinical practice across many epilepsy syndromes. There is limited research investigating the impact of gene identification on individuals and families with epilepsy. While research has focused on the impact of delivering ge...

journal_title：Epilepsy research

authors： Vears DF,Dunn KL,Wake SA,Scheffer IE

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:Using the gamma-butyrolactone (GBL) model of absence seizures in Long-Evans rats, this study investigated if 2.5-6 Hz paroxysmal discharges (PDs) induced by GBL were synchronized among the thalamocortical system and the hippocampus, and whether inactivation of the hippocampus affected PDs. METHODS:Local fiel...

journal_title：Epilepsy research

authors： Arcaro J,Ma J,Chu L,Kuo M,Mirsattari SM,Stan Leung L

更新日期：2016-02-01 00:00:00

abstract：:The subjects were 106 SMIDS with epilepsy. They were classified into four epileptic syndromes: (1) SE-MISF (34.0%), (2) SGE (25.5%), (3) SLRE (20.7%), and (4) epileptic discharge-free patients (EDFP) (19.8%). Clinical electroencephalographic studies elucidated the following result: (1) The seizure disappearance rate w...

journal_title：Epilepsy research

authors： Matsumoto A,Miyazaki S,Hayakawa C,Komori T,Nakamura M

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:EEG monitoring is important for the early detection of seizures during the course of critical illness. However, the logistics of real time EEG interpretation is challenging for the neurophysiology and critical care medicine teams. This study evaluated factors affecting the utility of digital trend analysis (...

journal_title：Epilepsy research

authors： Akman CI,Micic V,Thompson A,Riviello JJ Jr

更新日期：2011-01-01 00:00:00

abstract：:An intravenous formulation of carbamazepine (CBZ) was administered to 113 (60 male; 53 female) persons with epilepsy aged 19-87 years. Subjects received 100mg of study drug as replacement for 100mg of their usual morning dose of CBZ. There were no significant changes in blood pressure or heart rate suggesting that thi...

journal_title：Epilepsy research

authors： Conway JM,White JR,Birnbaum AK,Eugene Ramsay R,Pennell PB,Rarick JO,Musib L,Leppik IE,Cloyd JC

更新日期：2009-04-01 00:00:00

abstract：:Treating a patient with antiepileptic drugs (AEDs) may give rise to unexpected life-threatening adverse events. Despite extensive experimental and clinical testing to ensure safety, most AEDs on the market have been associated with cases of severe cutaneous reactions, serious hematological disorders, or hepatic failur...

journal_title：Epilepsy research

authors： Arroyo S,de la Morena A

更新日期：2001-11-01 00:00:00

abstract：:The Mongolian gerbil is known as an animal model that often exhibits spontaneous seizures that are characteristic of human epilepsy. Whereas there is much more information available relating this phenomenon to anatomical and electrophysiological characteristics of the hippocampal formation, the somatosensory cortex ha...

journal_title：Epilepsy research

authors： Kato M,Ito M,Seto-Ohshima A

更新日期：2000-07-01 00:00:00

abstract：:Surgical treatment of mesial temporal lobe epilepsy (mTLE) patients involves the removal either of the left or the right hippocampus. Since the mesial temporal lobe is responsible for emotion recognition abilities, we aimed to assess facial emotion recognition (FER) in two homogeneous patient cohorts that differed onl...

journal_title：Epilepsy research

authors： Wendling AS,Steinhoff BJ,Bodin F,Staack AM,Zentner J,Scholly J,Valenti MP,Schulze-Bonhage A,Hirsch E

更新日期：2015-03-01 00:00:00

abstract：PURPOSE:To evaluate the influence of aging on the pharmacokinetics of valproic acid (VPA) at steady-state and on the susceptibility of VPA metabolism to enzyme induction by antiepileptic comedication. METHODS:The database of the therapeutic drug monitoring service of a large neurological hospital was searched to ident...

journal_title：Epilepsy research

authors： Fattore C,Messina S,Battino D,Croci D,Mamoli D,Perucca E

更新日期：2006-08-01 00:00:00

abstract：PURPOSE:Although absence epilepsy is considered to be a prototypic type of generalized epilepsy, it is still under debate whether generalized 3 Hz spike-and-wave discharges (SWDs) might have a cortical focal origin. Here it is investigated whether focal interictal epileptiform discharges (IEDs), which typically occur i...

journal_title：Epilepsy research

authors： Rozendaal YJ,van Luijtelaar G,Ossenblok PP

更新日期：2016-01-01 00:00:00

abstract：:This paper reports the results of a 12-month prospective follow-up study on the effects of carbamazepine (CBZ) medication on serum sex and pituitary hormone concentrations in 21 male patients with recently diagnosed epilepsy. The results of the present study indicate that a change occurs in the androgen balance during...

journal_title：Epilepsy research

authors： Isojärvi JI,Pakarinen AJ,Myllylä VV

更新日期：1991-07-01 00:00:00

abstract：:The present study examined whether the perceived behavioral problems of children with idiopathic epilepsy differed from those of healthy controls according to parent proxy-reports and which factors are associated with these problems. The parents of 106 children with idiopathic epilepsy and 305 healthy controls aged 6-...

journal_title：Epilepsy research

authors： Dafoulis V,Kalyva E

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Epilepsy is among the more stigmatising diseases, leading to a negative impact on the quality of life (QoL) of people with epilepsy (PWE). Assessment of the QoL and stigma in PWE reflects the outcome of their disease, and the findings can be used to improve the management of epilepsy. To fill a gap in the li...

journal_title：Epilepsy research

authors： Mroueh L,Boumediene F,Jost J,Ratsimbazafy V,Preux PM,Salameh P,Al-Hajje A

更新日期：2020-11-01 00:00:00

abstract：:Vigabatrin increases GABA concentrations by inhibiting GABA transaminase. In previous studies, it was shown that vigabatrin increases the incidence of Spike and Wave Discharges (SWD) in the WAG/Rij rat model for absence epilepsy. Since following a single dose of vigabatrin GABA concentrations are known to be increased...

journal_title：Epilepsy research

authors： Perescis MFJ,van Luijtelaar G,van Rijn CM

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate by a prospective, self-controlled method, whether treatment with carbamazepine (CBZ) and sodium valproate (VPA) monotherapy may alter serum lipoprotein (a) [Lp(a)] concentrations in epileptic children. METHODS:Serum Lp(a) concentrations have been determined in 18 epilep...

journal_title：Epilepsy research

authors： Voudris KA,Attilakos A,Katsarou E,Drakatos A,Dimou S,Mastroyianni S,Skardoutsou A,Prassouli A,Garoufi A

更新日期：2006-08-01 00:00:00

abstract：PURPOSE:Focal cortical dysplasia (FCD) has been recognized as one of the most frequent causes of drug resistant epilepsy, especially in children. In infancy, onset of FCD-related epilepsy is substantially characterized by epileptic spasms (ES) or focal seizures. Which elements pertaining to the FCD are responsible for ...

journal_title：Epilepsy research

authors： Serino D,Freri E,Ragona F,D'Incerti L,Bernardi B,Di Ciommo V,Granata T,Vigevano F,Fusco L

更新日期：2015-01-01 00:00:00

abstract：:The distribution and kinetics of specific binding sites for gamma-hydroxybutyrate (GHB), a naturally occurring compound known to produce absence-like seizures, was studied in the brains of Wistar rats with spontaneous, bilaterally synchronous spike wave discharges (SWDs), a model of petit mal epilepsy, and non-epilept...

journal_title：Epilepsy research

authors： Snead OC 3rd,Hechler V,Vergnes M,Marescaux C,Maitre M

更新日期：1990-11-01 00:00:00

abstract：:Generalized seizures can induce both hypertension and hyperglycemia which may aggravate preexisting cerebral or medical conditions in patients. In vivo fluorescent imaging of regional cortical blood flow and brain intracellular pH (pHi) was performed in fasted New Zealand rabbits (n = 35) in which either mean arterial...

journal_title：Epilepsy research

authors： Tomlinson FH,Anderson RE,Meyer FB

更新日期：1993-02-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate whether there may be a correlation between the anatomical variants of Circle of Willis (CoW) and presence/laterality of mesial temporal sclerosis (MTS). METHODS:We retrospectively identified the CoW variants on Wada angiograms in 71 patients with pathologically proven...

journal_title：Epilepsy research

authors： Kuyumcu G,Byrne RW,Dawe RJ,Kocak M

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE:Despite increasing amounts of research on periodic discharges (PDs), large clinical studies regarding their prognostic value are lacking. The aim of the current study was to evaluate the clinical implications and prognostic value of PDs. METHODS:In this single-center retrospective cohort study, we included p...

journal_title：Epilepsy research

authors： Li HT,Wu T,Lin WR,Tseng WJ,Chang CW,Cheng MY,Hsieh HY,Chiang HI,Lee CH,Chang BL,Lim SN

更新日期：2017-03-01 00:00:00

abstract：:The novel anticonvulsant, remacemide HCl [(+/-)-2-amino-N-(1-methyl-1,2-diphenylethyl)acetamide monohydrochloride; FPL12924AA], and a desglycinated metabolite [(+/-)-1-methyl-1,2-diphenylethylamine monohydrochloride; FPL 12495AA] reversibly limited sustained high-frequency repetitive firing (SRF) of sodium-dependent a...

journal_title：Epilepsy research

authors： Wamil AW,Cheung H,Harris EW,McLean MJ

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND:Diffusion tensor tractography of the anterior extent of the optic radiation - Meyer's loop - prior to temporal lobe resection (TLR) may reduce the risk for postoperative visual field defect. Currently there is no standardized way to perform tractography. OBJECTIVE:To visualize Meyer's loop using determinist...

journal_title：Epilepsy research

authors： Lilja Y,Ljungberg M,Starck G,Malmgren K,Rydenhag B,Nilsson DT

更新日期：2014-03-01 00:00:00

abstract：:Catamenial epilepsy is a multifaceted neuroendocrine condition in which seizures are clustered around specific points in the menstrual cycle, most often around perimenstrual or periovulatory period. Generally, a twofold or greater increase in seizure frequency during a particular phase of the menstrual cycle could be ...

journal_title：Epilepsy research

authors： Reddy DS

更新日期：2009-07-01 00:00:00