Abstract:
:The 5-hydroxytryptamine-1A (5-HT1A) receptors are known to be involved in the inhibition of seizures in epilepsy. Moreover, studies propose a role for the 5-HT1A receptor in memory function; it is believed that the higher density of this receptor in the hippocampus plays an important role in its regulation. Positron emission tomography (PET) studies in patients with mesial temporal lobe epilepsy (mTLE) have demonstrated that a decrease in 5-HT1A receptor binding in temporal regions may play a role in memory impairment. The evidences lead us to speculate whether this decrease in receptor binding is associated with a reduced receptor number or if the functionality of the 5-HT1A receptor-induced G-protein activation and/or the second messenger cascade is modified. The purpose of the present study is to determine 5-HT1A receptor-induced G-protein functional activation by 8-OH-DPAT-stimulated [(35)S]GTPγS binding assay in hippocampal tissue of surgical patients with mTLE. We correlate functional activity with epilepsy history and neuropsychological assessment of memory. We found that maximum functional activation stimulation values (Emax) of [(35)S]GTPγS binding were significantly increased in mTLE group when compared to autopsy samples. Furthermore, significant correlations were found: (1) positive coefficients between the Emax with the age of patient and frequency of seizures; (2) negative coefficients between the Emax and working memory, immediate recall and delayed recall memory tasks. Our data suggest that the epileptic hippocampus of patients with mTLE presents an increase in 5-HT1A receptor-induced G-protein functional activation, and that this altered activity is related to age and seizure frequency, as well as to memory consolidation deficit.
journal_name
Epilepsy Resjournal_title
Epilepsy researchauthors
Cuellar-Herrera M,Velasco AL,Velasco F,Trejo D,Alonso-Vanegas M,Nuche-Bricaire A,Vázquez-Barrón D,Guevara-Guzmán R,Rocha Ldoi
10.1016/j.eplepsyres.2014.09.013subject
Has Abstractpub_date
2014-12-01 00:00:00pages
1853-63issue
10eissn
0920-1211issn
1872-6844pii
S0920-1211(14)00246-0journal_volume
108pub_type
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journal_title:Epilepsy research
pub_type: 杂志文章
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journal_title:Epilepsy research
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journal_title:Epilepsy research
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journal_title:Epilepsy research
pub_type: 杂志文章
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journal_title:Epilepsy research
pub_type: 杂志文章
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journal_title:Epilepsy research
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journal_title:Epilepsy research
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/0920-1211(92)90035-r
更新日期:1992-07-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/j.eplepsyres.2016.02.012
更新日期:2016-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0920-1211(87)90047-7
更新日期:1987-01-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/j.eplepsyres.2007.05.001
更新日期:2007-07-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
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更新日期:2012-12-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/j.eplepsyres.2018.08.009
更新日期:2018-11-01 00:00:00
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journal_title:Epilepsy research
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doi:10.1016/0920-1211(95)00053-4
更新日期:1996-02-01 00:00:00
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journal_title:Epilepsy research
pub_type: 临床试验,杂志文章
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更新日期:2000-05-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/j.eplepsyres.2006.06.009
更新日期:2006-10-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/j.eplepsyres.2008.08.010
更新日期:2008-12-01 00:00:00
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journal_title:Epilepsy research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-05-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/j.eplepsyres.2011.04.007
更新日期:2011-08-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/0920-1211(92)90092-8
更新日期:1992-06-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/0920-1211(94)90074-4
更新日期:1994-01-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/0920-1211(96)00014-9
更新日期:1996-07-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/0920-1211(91)90054-j
更新日期:1991-09-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/j.eplepsyres.2012.03.019
更新日期:2012-08-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/s0920-1211(98)00122-3
更新日期:1999-04-01 00:00:00