Juvenile myoclonic epilepsy: A system disorder of the brain.

abstract：OBJECTIVE:The aim of this study was to investigate whether there may be a correlation between the anatomical variants of Circle of Willis (CoW) and presence/laterality of mesial temporal sclerosis (MTS). METHODS:We retrospectively identified the CoW variants on Wada angiograms in 71 patients with pathologically proven...

journal_title：Epilepsy research

authors： Kuyumcu G,Byrne RW,Dawe RJ,Kocak M

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVES:Cryosurgery is an alternative technique for minimally invasive treatment of lesions. We have recently examined cryosurgery for epilepsy in animal models, and found that penicillin G (PG)-induced epileptiform discharges (EDs) mostly vanished after freezing. However, EDs were provoked again after insufficient ...

journal_title：Epilepsy research

authors： Tokiwa T,Zimin L,Inoue T,Nomura S,Suzuki M,Yamakawa T

更新日期：2018-07-01 00:00:00

abstract：:The present study examined the relationship between the patterns and densities of glutamate AMPA receptor sub-units GluR1 and GluR2/3 in the molecular layer of the fascia dentata and aberrant mossy fiber neoinnervation in human and kainate rat hippocampal epilepsy. Because AMPA sub-units modulate the fast glutamate sy...

journal_title：Epilepsy research

authors： Babb TL,Mathern GW,Leite JP,Pretorius JK,Yeoman KM,Kuhlman PA

更新日期：1996-12-01 00:00:00

abstract：:Seizures induced by the convulsant methionine sulfoximine (MSO) resemble human "grand mal" epilepsy, and brain glutamine synthetase is inhibited. We recently selected two inbred lines of mice: sensitive to MSO (MSO-Fast) and resistant (MSO-Slow). In the present study, the selection pressure was increased and consangui...

journal_title：Epilepsy research

authors： Boissonnet A,Hévor T,Cloix JF

更新日期：2012-01-01 00:00:00

abstract：:Multiple subpial transection (MST) is an effective surgical therapy for patients with intractable seizures whose epileptogenic lesions lie in the cortex and are unresectable. Morrell developed this procedure and reported clinical results obtained using it. However, only the disappearance of epileptiform discharges aft...

journal_title：Epilepsy research

authors： Sugiyama S,Fujii M,Ito H

更新日期：1995-05-01 00:00:00

abstract：:The deletion of a sodium channel gene cluster located on chromosome 2q24.3 is associated with variable epilepsy phenotypes, including Dravet syndrome and migrating partial seizures of infancy. Although SCN1A is considered as the major contributor to the epilepsy phenotype, the role of other sodium channel genes that m...

journal_title：Epilepsy research

authors： Lim BC,Hwang H,Kim H,Chae JH,Choi J,Kim KJ,Hwang YS,Yum MS,Ko TS

更新日期：2015-01-01 00:00:00

abstract：:Here we describe a new non-human primate model of temporal lobe epilepsy (TLE) to better investigate the cause/effect relationships of human TLE. Status epilepticus (SE) was induced in adult marmosets by pilocarpine injection (250mg/kg; i.p.). The animals were divided in 2 groups: acute (8h post-SE) and chronic (3 and...

journal_title：Epilepsy research

authors： Perez-Mendes P,Blanco MM,Calcagnotto ME,Cinini SM,Bachiega J,Papoti D,Covolan L,Tannus A,Mello LE

更新日期：2011-09-01 00:00:00

abstract：:Focal epilepsy (FE) is one of the most common forms of adult epilepsy and is usually regarded as a multifactorial disorder. Febrile seizures (FS) often appear during childhood in a subtype of FE patients, i.e. with temporal lobe epilepsy (TLE) and hippocampal sclerosis (HS). FS are the most common human convulsive eve...

journal_title：Epilepsy research

authors： Belhedi N,Perroud N,Karege F,Vessaz M,Malafosse A,Salzmann A

更新日期：2014-01-01 00:00:00

abstract：:The ketogenic diet has been used to treat intractable epilepsy for many years, yet the mechanism(s) underlying its effectiveness have not been completely elucidated. However, emerging evidence indicates that the ketogenic diet may correct or otherwise alter a 'dystopic' gut microbiota that exhibits altered fecal micro...

journal_title：Epilepsy research

authors： Pittman QJ

更新日期：2020-10-01 00:00:00

abstract：:The inbred Wistar Albino Glaxo Rats from Rijswijk (WAG/Rij) and the Genetic Absence Epilepsy Rats from Strasbourg (GAERS) are well-validated genetic models of absence epilepsy. Although they share similar characteristics including the spike-and-wave discharges (SWDs) in the EEG, some differences have been reported bet...

journal_title：Epilepsy research

authors： Akman O,Demiralp T,Ates N,Onat FY

更新日期：2010-05-01 00:00:00

abstract：:Recently, mutations of KCNQ2 or KCNQ3, members of the KCNQ-related K(+)-channel (KCNQ-channel) family, were identified as cause of benign familial neonatal convulsions (BFNC). However, the exact pathogenic mechanisms of age-dependent development and spontaneous remission of BFNC remain to be elucidated. To clarify the...

journal_title：Epilepsy research

authors： Okada M,Zhu G,Hirose S,Ito KI,Murakami T,Wakui M,Kaneko S

更新日期：2003-02-01 00:00:00

abstract：:The limbic/mesial temporal lobe epilepsy syndrome has been defined as a focal epilepsy, with the implication that there is a well defined focus of onset, traditionally centered around the hippocampus. The pathology of the hippocampus in this syndrome has been well described and a number of physiological abnormalities ...

journal_title：Epilepsy research

authors： Bertram EH,Zhang DX,Mangan P,Fountain N,Rempe D

更新日期：1998-09-01 00:00:00

abstract：:The genetically epilepsy-prone rat (GEPR) has become an important model to study genetic predisposition to epilepsy involving not only the brainstem but also forebrain structures. Previous work in CA1 hippocampal cells showed a reduction in spike frequency adaptation and only subtle changes in slow afterhyperpolarizat...

journal_title：Epilepsy research

authors： Verma-Ahuja S,Evans MS,Pencek TL

更新日期：1995-10-01 00:00:00

abstract：:Kindling, in the classical sense, involves progressively increasing responsivity to the intermittent repetition of the same 1-s subthreshold electrical stimulation over time, with the amygdala being the area most frequently studied. Such repeated subthreshold stimulation is associated with: lowering of the after-disch...

journal_title：Epilepsy research

authors： Post RM

更新日期：2002-06-01 00:00:00

abstract：:The monoamine content in cerebral structures has been related to neuronal excitability and several approaches have been used to study this phenomenon during seizure vulnerability. In the present work, we have described the effects of serotonin (5-HT) depletion after the administration of 5,7-dihydroxytryptamine (5,7-D...

journal_title：Epilepsy research

authors： Trindade-Filho EM,de Castro-Neto EF,de A Carvalho R,Lima E,Scorza FA,Amado D,Naffah-Mazzacoratti Mda G,Cavalheiro EA

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Previous studies have identified numerous biological, psychological and social characteristics of persons with psychogenic non-epileptic seizures (PNES) however the strength of many of these factors have not been evaluated to determine which are predictive of the diagnosis compared to those that may only be ...

journal_title：Epilepsy research

authors： Elliott JO,Charyton C

更新日期：2014-11-01 00:00:00

abstract：INTRODUCTION:Tuberous sclerosis complex (TSC) is a multisystem genetic disorder affecting multiple organs, including the brain, and very often associated with epileptic activity. Language acquisition and development seems to be altered in a significant proportion of patients with TSC. In the present study, we used magn...

journal_title：Epilepsy research

authors： Gallagher A,Tanaka N,Suzuki N,Liu H,Thiele EA,Stufflebeam SM

更新日期：2013-03-01 00:00:00

abstract：:There is increasing clinical and experimental evidence that hormones, in particular sex steroid hormones, influence neuronal excitability and other brain functions. The term 'neuroactive steroids' has been coined for steroids that interact with neurotransmitter receptors. One of the best characterized actions of neuro...

journal_title：Epilepsy research

authors： Beyenburg S,Stoffel-Wagner B,Bauer J,Watzka M,Blümcke I,Bidlingmaier F,Elger CE

更新日期：2001-05-01 00:00:00

abstract：:The ideal proof-of-principle study design provides a strong efficacy signal over the shortest duration, while exposing the fewest patients possible. Data from a large database (Pfizer Inc) which studied add-on pregabalin for the treatment of partial seizures was used to model how duration of baseline, post-randomizati...

journal_title：Epilepsy research

authors： French JA,Cabrera J,Emir B,Whalen E,Lu F

更新日期：2013-09-01 00:00:00

abstract：PURPOSE:Caffeine is a non-selective antagonist of A1 and A2A adenosine receptors (ARs). In this regard, nitric oxide (NO) is partly involved in the central effects of caffeine. In this study, we examined the effect of acute caffeine administration on pentylenetetrazole (PTZ)-induced seizure threshold by focusing on A1R...

journal_title：Epilepsy research

authors： Esmaili Z,Heydari A

更新日期：2019-01-01 00:00:00

abstract：:Novel treatments for epilepsy are necessary because many epilepsy patients are resistant to medication. Metabotropic glutamate receptors (mGluRs), specifically mGluR 2 and 3, may serve as antiepileptic drug targets because of their role in controlling synaptic release. In this study, we administered a Group 2 mGluR ag...

journal_title：Epilepsy research

authors： Caulder EH,Riegle MA,Godwin DW

更新日期：2014-02-01 00:00:00

abstract：:A battery of psychometric tests was administered to 110 patients with epilepsy and to 24 non-epileptic controls. Eighty-four patients had been established on treatment with a single anticonvulsant drug (35 carbamazepine (CBZ), 30 sodium valproate (VPA), 19 phenytoin (PHT)) at unaltered dosage for the previous 3 months...

journal_title：Epilepsy research

authors： Gillham RA,Williams N,Wiedmann KD,Butler E,Larkin JG,Brodie MJ

更新日期：1990-12-01 00:00:00

abstract：PURPOSE:Activation of the neurokinin-1 (NK1) receptor by neuropeptide substance P (SP) induces and maintains epileptic activity in various experimental models of epilepsy. The primary objective of this study was to investigate whether neurobiological changes linked to NK1-SP receptor system are associated with hyperexc...

journal_title：Epilepsy research

authors： Danfors T,Åhs F,Appel L,Linnman C,Fredrikson M,Furmark T,Kumlien E

更新日期：2011-11-01 00:00:00

abstract：:Comorbid conditions may affect the quality of life in persons with epilepsy (PWE) more than seizures. Using legally mandated healthcare encounter data, somatic, psychiatric, and neurodevelopmental comorbidities in a large population-based cohort of PWE, were compared to persons with migraine (PWM), a similar neurologi...

journal_title：Epilepsy research

authors： Selassie AW,Wilson DA,Martz GU,Smith GG,Wagner JL,Wannamaker BB

更新日期：2014-02-01 00:00:00

abstract：:Previous work showed that bilateral lesions made between the inferior and superior colliculi reduced the severity of audiogenic seizures in genetically epilepsy-prone rats (GEPR-9s), and indicated that the connections between these two structures are vital for the propagation of seizure activity. To determine the invo...

journal_title：Epilepsy research

authors： Ribak CE,Manio AL,Navetta MS,Gall CM

更新日期：1997-03-01 00:00:00

abstract：:Resting motor threshold (rMT) assessed by means of Transcranial Magnetic Stimulation (TMS) is thought to reflect trans-synaptic excitability of cortico-spinal neurons. TMS studies reporting rMT in idiopathic generalized epilepsies (IGEs) yielded discrepant results, so that it is difficult to draw a definitive conclusi...

journal_title：Epilepsy research

authors： Brigo F,Storti M,Benedetti MD,Rossini F,Nardone R,Tezzon F,Fiaschi A,Bongiovanni LG,Manganotti P

更新日期：2012-08-01 00:00:00

abstract：:The Fourth Eilat Conference on New Antiepileptic Drugs (AEDs) was held at the Royal Beach Hotel, Eilat, Israel, from 6th to 10th September 1998. Epileptologists and scientists from 20 countries attended the conference, which was held to discuss a number of issues in drug development, including outcome assessment in ep...

journal_title：Epilepsy research

authors： Bialer M,Johannessen SI,Kupferberg HJ,Levy RH,Loiseau P,Perucca E

更新日期：1999-03-01 00:00:00

abstract：OBJECTIVE:To characterize, in adolescents aged 12-17, the pharmacokinetic (PK) profile of perampanel, the impact of intrinsic and extrinsic factors on PK, and the relationships between perampanel exposure and cognitive function, seizure frequency, and responder status. METHODS:Population PK analysis used plasma concen...

journal_title：Epilepsy research

authors： Villanueva V,Majid O,Nabangchang C,Yang H,Laurenza A,Ferry J,Hussein Z

更新日期：2016-11-01 00:00:00

abstract：:The idiopathic generalized epilepsies (IGE), for which a genetic cause is widely accepted, account for 20-30% of all epilepsies. Mapping these epilepsies is difficult, but progress in the positional cloning of idiopathic epilepsy genes responsible for monogenic forms provide emerging evidence that many idiopathic epil...

journal_title：Epilepsy research

authors： Sáez-Hernández L,Peral B,Sanz R,Gómez-Garre P,Ramos C,Ayuso C,Serratosa JM

更新日期：2003-10-01 00:00:00

abstract：:Previous investigations in seizure-prone mice have suggested that an abnormally elevated production of the astrocyte-derived neuroexcitant, quinolinic acid (QUIN), plays a role in seizure susceptibility. In order to evaluate further the role of QUIN metabolism in genetic murine seizure models, the activities of its bi...

journal_title：Epilepsy research

authors： Eastman CL,Urbańska EM,Chapman AG,Schwarcz R

更新日期：1994-07-01 00:00:00