当前位置： SCI文献检索 > EPILEPSY RESEARCH期刊下所有文献 > Effect of acute caffeine administration on PTZ-induced seizure threshold in mice: Involvement of adenosine receptors and NO-cGMP signaling pathway.

Effect of acute caffeine administration on PTZ-induced seizure threshold in mice: Involvement of adenosine receptors and NO-cGMP signaling pathway.

Abstract：

PURPOSE:Caffeine is a non-selective antagonist of A1 and A2A adenosine receptors (ARs). In this regard, nitric oxide (NO) is partly involved in the central effects of caffeine. In this study, we examined the effect of acute caffeine administration on pentylenetetrazole (PTZ)-induced seizure threshold by focusing on A1Rs, A2ARs, and NO-cGMP signaling pathway. METHODS:NMRI male mice (25-30 g) received caffeine (5, 50, and 100 mg/kg) alone, whereas 8-CPT (1 and 5 mg/kg, a selective A1Rs antagonist), SCH-442416 (5 and 10 mg/kg, a selective A2ARs antagonist) or sildenafil (5 and 10 mg/kg, a phosphodiesterase 5 inhibitor) were administrated alone or as pre-treatment before caffeine. Seizure threshold was assessed by intravenous infusion of PTZ. Nitric oxide metabolites (NOx) were measured with the Griess method. RESULTS:When administrated alone, caffeine (5 and 50 mg/kg) and 8-CPT (1 and 5 mg/kg) significantly decreased seizure threshold, while 100 mg/kg of caffeine, SCH-442416 or sildenafil did not change it. Only pre-treatment with SCH-442416 (5 and 10 mg/kg) or sildenafil (5 and 10 mg/kg) before 100 mg/kg of caffeine significantly decreased seizure threshold. Moreover, NOx levels significantly decreased following alone administration of caffeine (100 mg/kg) or 8-CPT (5 mg/kg). CONCLUSION:The results of present study showed that 5 and 50 mg/kg of caffeine had a proconvulsant effect but caffeine at a dose of 100 mg/kg had no effect on seizure threshold. In addition, it seems that the effect caffeine on seizure threshold is partly mediated through ARs or modulation of the NO-cGMP signaling pathway.

journal_name

Epilepsy Res

journal_title

Epilepsy research

authors

Esmaili Z,Heydari A

doi

10.1016/j.eplepsyres.2018.10.013

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

1-8

eissn

0920-1211

issn

1872-6844

pii

S0920-1211(18)30368-1

journal_volume

149

pub_type

杂志文章

相关文献

EPILEPSY RESEARCH文献大全
  • Visualizing Meyer's loop: A comparison of deterministic and probabilistic tractography.

    abstract：BACKGROUND:Diffusion tensor tractography of the anterior extent of the optic radiation - Meyer's loop - prior to temporal lobe resection (TLR) may reduce the risk for postoperative visual field defect. Currently there is no standardized way to perform tractography. OBJECTIVE:To visualize Meyer's loop using determinist...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2014.01.017

    authors： Lilja Y,Ljungberg M,Starck G,Malmgren K,Rydenhag B,Nilsson DT

    更新日期：2014-03-01 00:00:00

  • Increased membrane shedding--indicated by an elevation of CD133-enriched membrane particles--into the CSF in partial epilepsy.

    abstract：PURPOSE:Recent analyses provided evidence that human adult cerebrospinal fluid (CSF) in addition to soluble proteins also contains membrane particles that moreover carry the somatic stem cell marker CD133. The significance of CD133 as a potential marker of cellular proliferation, including neurogenesis, remains unresol...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2011.10.029

    authors： Huttner HB,Corbeil D,Thirmeyer C,Coras R,Köhrmann M,Mauer C,Kuramatsu JB,Kloska SP,Doerfler A,Weigel D,Klucken J,Winkler J,Pauli E,Schwab S,Hamer HM,Kasper BS

    更新日期：2012-03-01 00:00:00

  • GABA and epileptogenesis: comparing gabrb3 gene-deficient mice with Angelman syndrome in man.

    abstract：:The GABAergic system has long been implicated in epilepsy with defects in GABA neurotransmission being linked to epilepsy in both experimental animal models and human syndromes (Olsen and Avoli, 1997). However, to date no human epileptic syndrome has been directly attributed to an altered GABAergic system. The observe...

    journal_title：Epilepsy research

    pub_type： 杂志文章,评审

    doi：10.1016/s0920-1211(99)00046-7

    authors： DeLorey TM,Olsen RW

    更新日期：1999-09-01 00:00:00

  • Evolution of neuropsychological changes after partial callosotomy in intractable epilepsy.

    abstract：:Early neuropsychological changes following partial anterior callosotomy were evaluated in 15 patients with epilepsy (10 secondary generalized and 5 Lennox-Gastaut syndromes) by comparing their performances 1 month before surgery and then 15-20 and 90-100 days postoperatively without modifying the anticonvulsant treatm...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/0920-1211(90)90091-9

    authors： Provinciali L,Del Pesce M,Censori B,Quattrini A,Paggi A,Ortenzi A,Mancini S,Papo I,Rychlicki F

    更新日期：1990-07-01 00:00:00

  • The influence of old age and enzyme inducing comedication on the pharmacokinetics of valproic acid at steady-state: A case-matched evaluation based on therapeutic drug monitoring data.

    abstract：PURPOSE:To evaluate the influence of aging on the pharmacokinetics of valproic acid (VPA) at steady-state and on the susceptibility of VPA metabolism to enzyme induction by antiepileptic comedication. METHODS:The database of the therapeutic drug monitoring service of a large neurological hospital was searched to ident...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2006.04.002

    authors： Fattore C,Messina S,Battino D,Croci D,Mamoli D,Perucca E

    更新日期：2006-08-01 00:00:00

  • Use of cooking oils in a 2:1 ratio classical ketogenic diet for intractable pediatric epilepsy: Long-term effectiveness and tolerability.

    abstract：BACKGROUND:In many parts of eastern Asia, rice is a dietary staple and therefore the ketogenic diet (KD) can be difficult to administer. The aim of this study was to assess the long-term effectiveness and tolerability of the classical KD using a 2:1 ratio of fat to protein plus net carbohydrates, which is lower than th...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2018.09.002

    authors： Lee HF,Chi CS,Liao JH

    更新日期：2018-11-01 00:00:00

  • Immunotherapy for GRIN2A and GRIN2D-related epileptic encephalopathy.

    abstract：BACKGROUND:GRIN-related developmental-epileptic encephalopathies are associated with a spectrum of neurodevelopmental disorders, including intellectual disability, epilepsy including continuous spike-and-wave during sleep syndrome (CSWS), or epilepsy-aphasia spectrum phenotypes such as in Landau-Kleffner syndrome. Effi...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2020.106325

    authors： Hausman-Kedem M,Menascu S,Greenstein Y,Fattal-Valevski A

    更新日期：2020-07-01 00:00:00

  • Tiagabine in glial tumors.

    abstract：RATIONALE AND PURPOSE:Preliminary reports have suggested a possible 'aetiology-specific' efficacy of tiagabine (TGB) in patients with drug-resistant partial epilepsy (DRPE) related to cerebral glial tumors (GTs). This efficacy should be related to selective blocking of GAT-1 transporter by TGB. We presented our open-la...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/s0920-1211(02)00005-0

    authors： Striano S,Striano P,Boccella P,Nocerino C,Bilo L

    更新日期：2002-03-01 00:00:00

  • Topiramate as add-on drug in children, adolescents and young adults with Lennox-Gastaut syndrome: an Italian multicentric study.

    abstract：:The purpose of the study was to evaluate the efficacy and safety of topiramate (TPM) as adjunctive therapy in children, adolescents and young adults with Lennox-Gastaut syndrome (LGS). We performed a prospective open label add-on study in 45 patients (age 4-34 years, mean 15.9 years) with LGS and refractory seizures. ...

    journal_title：Epilepsy research

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/s0920-1211(02)00103-1

    authors： Coppola G,Caliendo G,Veggiotti P,Romeo A,Tortorella G,De Marco P,Pascotto A

    更新日期：2002-09-01 00:00:00

  • Long-term functional consequences of transient occlusion of the middle cerebral artery in rats: a 1-year follow-up of the development of epileptogenesis and memory impairment in relation to sensorimotor deficits.

    abstract：:Post-stroke seizures occur in 5-20% of patients. Modeling of stroke-induced seizures in animals provides a useful tool for investigating the molecular basis of epileptogenesis and for developing therapies for stroke patients at increased risk for epileptogenesis. The questions addressed in the study were: (1) Do rats ...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/s0920-1211(03)00034-2

    authors： Karhunen H,Pitkänen A,Virtanen T,Gureviciene I,Pussinen R,Ylinen A,Sivenius J,Nissinen J,Jolkkonen J

    更新日期：2003-04-01 00:00:00

  • Vascular risk factors and oxidative stress as independent predictors of asymptomatic atherosclerosis in adult patients with epilepsy.

    abstract：PURPOSE:This study aimed to evaluate the carotid artery intima-media thickness (CA-IMT) in adult patients with epilepsy and its contribution to oxidative stress and vascular risk biomarkers. METHODS:This study included 225 adult epileptic and 60 control subjects. For all, CA-IMT, fasting lipid profile (TC, TG, HDL-c a...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2007.03.010

    authors： Hamed SA,Hamed EA,Hamdy R,Nabeshima T

    更新日期：2007-05-01 00:00:00

  • Ketogenic diet increases calbindin-D28k in the hippocampi of male ICR mice with kainic acid seizures.

    abstract：:The ketogenic diet (KD) increased the expression of calbindin-D(28k) (CB) in the interneurons of the hippocampus compared with the normal diet (ND)-fed mice. Also, 2 days after kainic acid (KA) administration, numerous CB-expressing astrocytes were found in the KD-fed mice compared with those of the ND-fed mice. These...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2005.05.008

    authors： Noh HS,Kang SS,Kim DW,Kim YH,Park CH,Han JY,Cho GJ,Choi WS

    更新日期：2005-07-01 00:00:00

  • Electroencephalographic evidence for a dose-related biphasic effect of morphine on bicuculline-induced seizures in the rat.

    abstract：:The effects of systemic pretreatment with morphine sulfate (MS) on electroencephalographic (EEG) manifestations of seizures due to bicuculline (BIC) were studied in freely moving rats. Electrodes were placed on frontal and occipital cortices, into the hippocampus and into a region of the prepiriform cortex, area tempe...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/0920-1211(89)90012-0

    authors： Massotti M,Gale K

    更新日期：1989-09-01 00:00:00

  • Hemodynamic monitoring prior to and at the time of death in status epilepticus.

    abstract：:Status epilepticus (SE) is a common neurological and medical emergency. Despite the significant mortality associated with SE, no human data have been available regarding cardiovascular changes prior to death in patients with this condition. This study was conducted to measure hemodynamic trends in the 24 h prior to de...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/s0920-1211(98)00031-x

    authors： Boggs JG,Marmarou A,Agnew JP,Morton LD,Towne AR,Waterhouse EJ,Pellock JM,DeLorenzo RJ

    更新日期：1998-08-01 00:00:00

  • Sensorimotor seizures of pediatric onset with unusual posteriorly oriented rolandic spikes.

    abstract：BACKGROUND:Benign childhood epilepsy with centro-temporal spikes (BECCT) is usually associated with anteriorly oriented rolandic discharges. We report an unusual type of childhood-onset epilepsy with sensorimotor seizures associated with posteriorly oriented rolandic discharges. METHODS:Among 942 patients who underwen...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2009.01.012

    authors： Kakisaka Y,Nakasato N,Haginoya K,Kanno A,Tsuchiya S

    更新日期：2009-04-01 00:00:00

  • Amygdaloid kindling in brainstem bisected cats.

    abstract：:Results of previous studies suggested that the brainstem participates in amygdaloid (AM) kindled seizure generalization and the positive transfer effect at the secondary site AM. This study was undertaken to define the role of the brainstem in the patterning of AM kindling, the maintenance of AM kindled seizure and th...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/s0920-1211(97)00068-5

    authors： Hamada K,Wada JA

    更新日期：1998-01-01 00:00:00

  • The serum zinc, copper, iron, and chromium concentrations in epileptic children.

    abstract：:To assess whether epileptic children have abnormal values of some trace elements, the aim of this preliminary study was to assess the serum zinc (Zn), copper (Cu), iron (Fe), and chromium (Cr) concentrations in 23 children with initial recognition of epilepsy before beginning of pharmacological therapy in comparison w...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2012.09.009

    authors： Wojciak RW,Mojs E,Stanislawska-Kubiak M,Samborski W

    更新日期：2013-03-01 00:00:00

  • LPDs - «Linked to penumbra» discharges or EEG correlate of excitotoxicity: A review based hypothesis.

    abstract：:Periodic lateralized epileptiform discharges (PLEDs) or lateralized periodic discharges (LPDs) are a well-known variant of pathological EEG activity. However, the mechanisms underpinning the appearance of this pattern are not completely understood. The heterogeneity of the features derived from LPDs patterns, and the ...

    journal_title：Epilepsy research

    pub_type： 杂志文章,评审

    doi：10.1016/j.eplepsyres.2020.106429

    authors： Chegodaev D,Pavlova NV,Pavlova P,Lvova O

    更新日期：2020-10-01 00:00:00

  • Exposure of hippocampal slices to magnesium-free medium produces epileptiform activity and simultaneously decreases calcium and calmodulin-dependent protein kinase II activity.

    abstract：:The effect of magnesium-free medium on electrical and CaM kinase II activity in the rat hippocampal slice was examined. Experimental slices were incubated in 2 mM Mg, then exposed to magnesium-free medium for 1 h. Control slices were concurrently run in 2 mM Mg. Slices were then frozen and CaM kinase II activity was m...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/0920-1211(91)90054-j

    authors： Churn SB,Anderson WW,DeLorenzo RJ

    更新日期：1991-09-01 00:00:00

  • Inhalation of 10% carbon dioxide rapidly terminates Scn1a mutation-related hyperthermia-induced seizures.

    abstract：:The aim of this study was to assess the anticonvulsant effect of carbon dioxide (CO2) on Scn1a mutation-related febrile seizures. We examined physiological changes in the blood gas levels after the induction of hyperthermia-induced seizures (HISs), which were associated with the Scn1a missense mutation. We determined ...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2013.01.003

    authors： Ohmori I,Hayashi K,Wang H,Ouchida M,Fujita N,Inoue T,Michiue H,Nishiki T,Matsui H

    更新日期：2013-07-01 00:00:00

  • The impact of epilepsy duration in a series of patients with mesial temporal lobe epilepsy due to unilateral hippocampal sclerosis.

    abstract：PURPOSE:To evaluate if the duration of epilepsy influences MRI volumes of the hippocampus, amygdala, parahippocampal gyrus, entorhinal cortex and temporal pole of both hemispheres and epileptogenic hippocampus neuronal cell density and dentate gyrus granular cells distribution in patients with refractory mesial tempora...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2018.08.009

    authors： Duarte JTC,Jardim AP,Comper SM,De Marchi LR,Gaça LB,Garcia MTFC,Sandim GB,Assunção-Leme IB,Carrete H Jr,Centeno RS,Lancellotti CLP,Jackowski AP,Cavalheiro EA,Guaranha MSB,Yacubian EMT

    更新日期：2018-11-01 00:00:00

  • Co-occurrence of major depression or suicide attempt with migraine with aura and risk for unprovoked seizure.

    abstract：:We hypothesized and found that the co-occurrence of migraine with aura (MA) with major depression (MD) or with suicide attempt (SA) increases the risk for developing unprovoked seizure more than these conditions alone. Number of conditions showed a linear relationship to seizure risk. This may reflect a new condition ...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2007.05.001

    authors： Hesdorffer DC,Lúdvígsson P,Hauser WA,Olafsson E,Kjartansson O

    更新日期：2007-07-01 00:00:00

  • Effect of valproic acid on sodium currents in cortical neurons from patients with pharmaco-resistant temporal lobe epilepsy.

    abstract：:In a selected group of temporal lobe epilepsy patients with seizures refractory to pharmacological treatment, pharmacological seizure control can be attained by surgical resection of the epileptic zone. We investigated to what extent pharmaco-resistance is reflected in a reduced response at the cellular level, in neur...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/s0920-1211(98)00061-8

    authors： Vreugdenhil M,van Veelen CW,van Rijen PC,Lopes da Silva FH,Wadman WJ

    更新日期：1998-09-01 00:00:00

  • A genetic epidemiological survey of idiopathic epilepsy in the Chinese Han population.

    abstract：BACKGROUND:Idiopathic epilepsy (IE) is a syndrome that comprises epilepsy only, with no underlying structural brain lesion or other neurological signs or symptoms. Numerous studies have shown that genetic factors play an important role in IE. IE is a common disease in the Chinese Han population. However, the genetic ep...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2011.09.013

    authors： Li M,Heng X,Tao R,Liu J,Zhang L,Sun X,Wang L,Wu Q,Che F,Xue F

    更新日期：2012-02-01 00:00:00

  • Prognostic factors, morbidity and mortality in tonic-clonic status epilepticus: a review.

    abstract：OBJECTIVES:to determine how the duration of SE, the EEG findings during/after SE, the depth of coma at presentation and age impact on the prognosis of convulsive status epilepticus indepedent of aetiology and to analyse the outcome of status epilepticus with respect to mortality and morbidity (the latter measured in te...

    journal_title：Epilepsy research

    pub_type： 杂志文章,评审

    doi：10.1016/j.eplepsyres.2010.09.003

    authors： Neligan A,Shorvon SD

    更新日期：2011-01-01 00:00:00

  • Altered extrafocal iomazenil activity in mesial temporal lobe epilepsy.

    abstract：:To investigate involvement of extrafocal regions in mesial temporal lobe epilepsy (MTLE), we retrospectively explored abnormalities in distribution of iomazenil (IMZ) activity by identifying interhemispheric asymmetry on IMZ-SPECT images of patients with MTLE. Fourteen MTLE patients in whom a good surgical outcome was...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2012.07.001

    authors： Hosomi K,Kishima H,Oshino S,Hirata M,Tani N,Maruo T,Khoo HM,Shimosegawa E,Hatazawa J,Kato A,Yoshimine T

    更新日期：2013-02-01 00:00:00

  • The relationship between seizure frequency, seizure type and quality of life: findings from three European countries.

    abstract：:Understanding the relationship between seizure frequency, seizure type and scores obtained from quality of life (QOL) measures is important if the incorporation of QOL measures into epilepsy clinical trials is to become standard practice. There is also a need to consider cross-cultural differences obtained from QOL me...

    journal_title：Epilepsy research

    pub_type： 杂志文章,多中心研究

    doi：10.1016/s0920-1211(98)00010-2

    authors： Baker GA,Gagnon D,McNulty P

    更新日期：1998-05-01 00:00:00

  • Correlation between cerebral perfusion and hyperventilation enhanced focal spiking activity.

    abstract：:Single photon emission computed tomography (SPECT) has frequently been used to investigate cerebral brain perfusion (CBP) occurring ictally and inter-ictally in epileptic patients. Several studies have addressed the multimodal analysis of the modifications occurring in cerebral areas involved in seizure activity, by c...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/s0920-1211(00)00111-x

    authors： Marrosu F,Puligheddu M,Giagheddu M,Cossu G,Piga M

    更新日期：2000-06-01 00:00:00

  • An epileptic case with mosaic ring chromosome 6 and 6q terminal deletion.

    abstract：:Ring chromosomes are rare chromosome disorders that arise usually de novo. Children with ring chromosome 6 have a wide range of intellectual functioning and congenital anomalies. We report an epileptic case of a 10-year-old boy to be mild psychomotor retardation and dysmorphic traits including microcephaly, brachyceph...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2008.03.020

    authors： Kara N,Okten G,Guneş SO,Saglam Y,Tasdemir HA,Pinarli FA

    更新日期：2008-08-01 00:00:00

  • Unilateral cortical spreading depression is an early marker of audiogenic kindling in awake rats.

    abstract：:Spreading depression (SD), a self-propagating wave of reversible cellular depolarization, is thought to play an important role in brain pathophysiology. SD and seizures are closely related events but little is known about involvement of SD in chronic epileptogenesis. Here we show that cortical SD is the first and high...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2006.05.014

    authors： Vinogradova LV,Vinogradov VY,Kuznetsova GD

    更新日期：2006-09-01 00:00:00