Tiagabine in glial tumors.

Abstract:

RATIONALE AND PURPOSE:Preliminary reports have suggested a possible 'aetiology-specific' efficacy of tiagabine (TGB) in patients with drug-resistant partial epilepsy (DRPE) related to cerebral glial tumors (GTs). This efficacy should be related to selective blocking of GAT-1 transporter by TGB. We presented our open-label, add-on TGB experience in a group of patients with GTs, compared with other symptomatic DRPEs of different aetiology. MATERIAL AND METHODS:eleven patients with DRPE related to oligodendroglioma (six cases), astrocytoma (4) or multiform gliobastoma (1); 12 patients with DRPE related to a miscellanea of CNS lesions. TGB was added to previous AEDs, at dosage of 20-60 mg per die. Responders are defined by seizure frequency reduction >50% compared with baseline. RESULTS:Seven patients are responders with three seizure-free (SF) in GTs group, a rate of efficacy much higher than in matching group (63.6 vs. 16.6%). Adverse events have been observed only rarely, not leading to discontinuation, in GTs group. CONCLUSION:This preliminary observation seems to confirm the high efficacy and tolerability of TGB in DRPE related to GTs.

journal_name

Epilepsy Res

journal_title

Epilepsy research

authors

Striano S,Striano P,Boccella P,Nocerino C,Bilo L

doi

10.1016/s0920-1211(02)00005-0

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

81-5

issue

1

eissn

0920-1211

issn

1872-6844

pii

S0920121102000050

journal_volume

49

pub_type

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