Inhalation of 10% carbon dioxide rapidly terminates Scn1a mutation-related hyperthermia-induced seizures.

Abstract:

:The aim of this study was to assess the anticonvulsant effect of carbon dioxide (CO2) on Scn1a mutation-related febrile seizures. We examined physiological changes in the blood gas levels after the induction of hyperthermia-induced seizures (HISs), which were associated with the Scn1a missense mutation. We determined the efficacy of inhalation of 5% or 10% CO2 to treat HISs. HISs were evoked in Scn1a mutant and wild-type (WT) rats by hot water baths. To determine the anticonvulsant effect of CO2 inhalation, rats were placed in a chamber filled with air or mixed gas containing 5% CO2 or 10% CO2 for 3 min, immediately after the induction of HISs. We also analyzed the blood gas levels at the end of inhalation of CO2. Hot water bathing induced a significant reduction in the partial pressure of CO2 (pCO2) and respiratory alkalosis in the WT and Scn1a mutant rats. HISs were evoked in 100% of the Scn1a mutant rats within 5 min, but in none of the WT rats. The Scn1a mutant rats demonstrated a higher HISs susceptibility associated with respiratory alkalosis than the WT rats. Inhalation of 10% CO2 shortened the seizure duration from 62.6±12.1 s to 15.5±1.0 s. Blood gas analysis after the inhalation of 10% CO2 demonstrated an elevated pCO2 level and respiratory acidosis. Inhalation of 10% CO2 demonstrated a potent and fast-acting anticonvulsant effect against HISs.

journal_name

Epilepsy Res

journal_title

Epilepsy research

authors

Ohmori I,Hayashi K,Wang H,Ouchida M,Fujita N,Inoue T,Michiue H,Nishiki T,Matsui H

doi

10.1016/j.eplepsyres.2013.01.003

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

220-4

issue

1-2

eissn

0920-1211

issn

1872-6844

pii

S0920-1211(13)00016-8

journal_volume

105

pub_type

杂志文章
  • A common genetic basis for idiosyncratic toxicity of warfarin and phenytoin.

    abstract::CYP2C9 is mainly responsible for the metabolic clearance of phenytoin and (S)-warfarin. We have shown previously that mutations in the CYP2C9 gene are associated with diminished metabolism of (S)-warfarin, and so we have now studied the metabolism of phenytoin to its primary inactive metabolite, (S)-pHPPH, by these mu...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/s0920-1211(99)00017-0

    authors: Rettie AE,Haining RL,Bajpai M,Levy RH

    更新日期:1999-07-01 00:00:00

  • Multivariable prediction of seizure outcome one year after resective epilepsy surgery: development of a model with independent validation.

    abstract:PURPOSE:To identify predictors of seizure-outcome after epilepsy surgery and validate the findings in an independent series of patients. To use the results to develop a predictive model. METHODS:Sequential patients undergoing resective surgery for medically intractable epilepsy were identified at Yale New Haven Hospit...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/s0920-1211(97)00083-1

    authors: Berg AT,Walczak T,Hirsch LJ,Spencer SS

    更新日期:1998-02-01 00:00:00

  • Driving cost factors in adult outpatients with refractory epilepsy: a daily clinical practice in clinics of neurology in Spain.

    abstract:OBJECTIVE:To explore the association between patient-reported-outcomes measurements and costs in adult outpatients with drug refractory epilepsy (DRE) in Spain. METHODS:Secondary analysis of a cross-sectional study to determine resources utilization and related costs of refractory epilepsy in Spain (LINCE study). Cons...

    journal_title:Epilepsy research

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.eplepsyres.2008.10.004

    authors: Peña P,Sancho J,Rufo M,Martínez S,Rejas J,LINCE Study Collaborative Group.

    更新日期:2009-02-01 00:00:00

  • Progress report on new antiepileptic drugs: a summary of the fourth Eilat conference (EILAT IV).

    abstract::The Fourth Eilat Conference on New Antiepileptic Drugs (AEDs) was held at the Royal Beach Hotel, Eilat, Israel, from 6th to 10th September 1998. Epileptologists and scientists from 20 countries attended the conference, which was held to discuss a number of issues in drug development, including outcome assessment in ep...

    journal_title:Epilepsy research

    pub_type:

    doi:10.1016/s0920-1211(98)00108-9

    authors: Bialer M,Johannessen SI,Kupferberg HJ,Levy RH,Loiseau P,Perucca E

    更新日期:1999-03-01 00:00:00

  • A gut feeling about the ketogenic diet in epilepsy.

    abstract::The ketogenic diet has been used to treat intractable epilepsy for many years, yet the mechanism(s) underlying its effectiveness have not been completely elucidated. However, emerging evidence indicates that the ketogenic diet may correct or otherwise alter a 'dystopic' gut microbiota that exhibits altered fecal micro...

    journal_title:Epilepsy research

    pub_type: 杂志文章,评审

    doi:10.1016/j.eplepsyres.2020.106409

    authors: Pittman QJ

    更新日期:2020-10-01 00:00:00

  • Predictive value of hippocampal internal architecture asymmetry in temporal lobe epilepsy.

    abstract:BACKGROUND:Asymmetry of hippocampal internal architecture (HIA) clarity has been suggested to be a sign of hippocampal sclerosis (HS) and is frequently associated with other MRI findings of HS. The goal of this work is to use a previously developed HIA visual scoring system (Ver Hoef et al., 2013) to quantify HIA asymm...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2013.05.008

    authors: Ver Hoef LW,Williams FB,Kennedy RE,Szaflarski JP,Knowlton RC

    更新日期:2013-09-01 00:00:00

  • Autosomal dominant lateral temporal epilepsy: absence of mutations in ADAM22 and Kv1 channel genes encoding LGI1-associated proteins.

    abstract::Mutations in the LGI1 gene are linked to autosomal dominant lateral temporal epilepsy (ADTLE) in about half of the families tested, suggesting that ADLTE is genetically heterogeneous. Recently, the Lgi1 protein has been found associated with different protein complexes and two distinct molecular mechanisms possibly un...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2008.03.001

    authors: Diani E,Di Bonaventura C,Mecarelli O,Gambardella A,Elia M,Bovo G,Bisulli F,Pinardi F,Binelli S,Egeo G,Castellotti B,Striano P,Striano S,Bianchi A,Ferlazzo E,Vianello V,Coppola G,Aguglia U,Tinuper P,Giallonardo AT,

    更新日期:2008-07-01 00:00:00

  • Effects of the ketogenic diet on neurogenesis after kainic acid-induced seizures in mice.

    abstract::The ketogenic diet (KD) remains a therapy in search of explanation although it is an established treatment of intractable epilepsy. Recent studies suggest that the KD may be both anticonvulsant and antiepileptogenic. Epileptic seizures have been shown to stimulate the proliferation rate of neuronal progenitor cells in...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2007.11.010

    authors: Kwon YS,Jeong SW,Kim DW,Choi ES,Son BK

    更新日期:2008-02-01 00:00:00

  • How trial designs impact on guidelines.

    abstract::Evidence-based treatment guidelines and practice parameters have been developed in most areas of medicine. They are important because insurance companies, formulary managers, and health maintenance organizations rely on guidelines for formulary and coverage decisions. The methodology for practice parameter development...

    journal_title:Epilepsy research

    pub_type: 杂志文章,评审

    doi:10.1016/j.eplepsyres.2005.09.021

    authors: French JA

    更新日期:2006-01-01 00:00:00

  • Medicare claims can identify post-stroke epilepsy.

    abstract:OBJECTIVE:There have been no validated Medicare claims-based algorithms available to identify epilepsy by discrete etiology of stroke (e.g., post-stroke epilepsy, PSE) in community-dwelling elderly individuals, despite the increasing availability of large datasets. Our objective was to validate algorithms that detect w...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2019.02.002

    authors: Moura LMVR,Smith JR,Blacker D,Vogeli C,Schwamm LH,Hsu J

    更新日期:2019-03-01 00:00:00

  • Abnormalities in the levels of extracellular and tissue amino acids in the brain of the seizure-susceptible rat.

    abstract::Basal and high potassium-stimulated release of endogenous amino acids was measured using brain dialysis in the hippocampus of urethane-anesthetized seizure-resistant (SR) and seizure-susceptible (SS) rats. Moreover, the tissue level of amino acids was determined in the hippocampus, sensorimotor cortex, cerebellum and ...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/0920-1211(89)90040-5

    authors: Lehmann A

    更新日期:1989-03-01 00:00:00

  • Long-term evaluation of the efficacy and safety of loreclezole as add-on therapy in patients with uncontrolled partial seizures: a 1-year open follow-up.

    abstract::The effect and safety of loreclezole were evaluated during a long-term follow-up trial targeting higher plasma concentrations than those of the preceding controlled trial. The result is better than in the double-blind trial, in which loreclezole doses were administered to reach plasma concentrations of 1-2 mg/l and 6/...

    journal_title:Epilepsy research

    pub_type: 临床试验,杂志文章

    doi:10.1016/0920-1211(91)90048-k

    authors: Rentmeester T,Janssen A,Hulsman J,Scholtes F,van der Kleij B,Overweg J,Meijer J,de Beukelaar F

    更新日期:1991-05-01 00:00:00

  • Functional hemispherectomy in children with epilepsy and CSWS due to unilateral early brain injury including thalamus: sudden recovery of CSWS.

    abstract:PURPOSE:To try to prove in patients with refractory symptomatic epilepsy due to early brain injury involving thalamus and complicated by CSWS the effects of the isolation of the injured hemisphere, performed with functional hemisperectomy, on epilepsy, namely on CSWS. METHODS:Full clinical follow-up before and after s...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2009.09.014

    authors: Battaglia D,Veggiotti P,Lettori D,Tamburrini G,Tartaglione T,Graziano A,Veredice C,Sacco A,Chieffo D,Pecoraro A,Colosimo C,Di Rocco C,Dravet Ch,Guzzetta F

    更新日期:2009-12-01 00:00:00

  • Epileptiform activity promotes decreasing of Ca2+ conductivity of NMDARs, AMPARs, KARs, and voltage-gated calcium channels in Mg2+-free model.

    abstract::NMDA, AMPA, and kainate receptors are the principal excitatory receptors in the brain. These receptors have been considered as the main targets in the treatment of epilepsy in recent years. This work aimed to determine how the Ca2+ conductivity of ionotropic glutamate receptors and voltage-gated Ca2+ channels changes ...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2019.106224

    authors: Gaidin SG,Zinchenko VP,Teplov IY,Tuleukhanov ST,Kosenkov AM

    更新日期:2019-12-01 00:00:00

  • Heat induced temperature dysregulation and seizures in Dravet Syndrome/GEFS+ Gabrg2+/Q390X mice.

    abstract::It has been established that febrile seizures and its extended syndromes like generalized epilepsy with febrile seizures (FS) plus (GEFS+) and Dravet syndrome have been associated with mutations especially in SCN1A and GABRG2 genes. In patients, the onset of FS is likely due to the combined effect of temperature and i...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2017.04.020

    authors: Warner TA,Liu Z,Macdonald RL,Kang JQ

    更新日期:2017-08-01 00:00:00

  • Efficacy and safety of adjunctive zonisamide therapy for refractory partial seizures.

    abstract::An approach to the selection of appropriate antiepileptic drugs (AEDs) for inclusion in polytherapy is to take into account both the efficacy of a drug and also its mechanism of action and pharmacokinetic profile. The AED zonisamide is licensed in Europe and the USA for use as adjunctive therapy in adult patients with...

    journal_title:Epilepsy research

    pub_type: 杂志文章,评审

    doi:10.1016/j.eplepsyres.2007.04.007

    authors: Baulac M,Leppik IE

    更新日期:2007-07-01 00:00:00

  • Benign childhood epilepsy with occipital paroxysms: neuropsychological findings.

    abstract::Benign childhood epilepsy with occipital paroxysms is classified among childhood benign partial epilepsies. The absence of neurological and neuropsychological deficits has long been considered as a prerequisite for a diagnosis of benign childhood partial epilepsy. Much evidence has been reported in literature in the l...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2005.03.004

    authors: Germanò E,Gagliano A,Magazù A,Sferro C,Calarese T,Mannarino E,Calamoneri F

    更新日期:2005-05-01 00:00:00

  • A serial study of regional cerebral blood flow before and after hemispherectomy in a child.

    abstract::Hemimegalencephaly (HME) is a severe unilateral brain malformation the prognosis of which may be improved by hemispherectomy. HME also provides a unique opportunity to compare normal and pathological hemispheric function in the same patient. We performed a serial functional cerebral imaging study in a child suffering ...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/0920-1211(91)90069-r

    authors: Chiron C,Raynaud C,Jambaqué I,Dulac O,Zilbovicius M,Syrota A

    更新日期:1991-04-01 00:00:00

  • Effect of acute caffeine administration on PTZ-induced seizure threshold in mice: Involvement of adenosine receptors and NO-cGMP signaling pathway.

    abstract:PURPOSE:Caffeine is a non-selective antagonist of A1 and A2A adenosine receptors (ARs). In this regard, nitric oxide (NO) is partly involved in the central effects of caffeine. In this study, we examined the effect of acute caffeine administration on pentylenetetrazole (PTZ)-induced seizure threshold by focusing on A1R...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2018.10.013

    authors: Esmaili Z,Heydari A

    更新日期:2019-01-01 00:00:00

  • Retrospective genotype-phenotype analysis in a 305 patient cohort referred for testing of a targeted epilepsy panel.

    abstract:PURPOSE:Epilepsy is a diverse neurological condition with extreme genetic and phenotypic heterogeneity. The introduction of next-generation sequencing into the clinical laboratory has made it possible to investigate hundreds of associated genes simultaneously for a patient, even in the absence of a clearly defined synd...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2018.05.004

    authors: Hesse AN,Bevilacqua J,Shankar K,Reddi HV

    更新日期:2018-08-01 00:00:00

  • Psychomotor seizures of temporal lobe onset: analysis of symptom clusters and sequences.

    abstract::We analyzed 91 psychomotor seizures from 31 patients seizure free at least one year after temporal lobectomy (implying temporal lobe onset). Fifty symptoms were looked for in every seizure and their time of onset and ending noted. Statistical analysis was used to define symptom clusters and the order of appearance of ...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/0920-1211(94)00055-2

    authors: Kotagal P,Lüders HO,Williams G,Nichols TR,McPherson J

    更新日期:1995-01-01 00:00:00

  • Propagation of epileptiform potentials in the guinea-pig piriform cortex is sustained by associative fibres.

    abstract::The role of the associative connections in the propagation of epileptiform discharges originating from an acute, localized epileptic focus in the anterior piriform cortex has been characterized recently in the in vitro isolated guinea-pig brain preparation. The present study demonstrates that the dorsal propagation of...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/0920-1211(96)00014-9

    authors: Biella G,Forti M,de Curtis M

    更新日期:1996-07-01 00:00:00

  • Optimal window for ictal blood flow mapping. Insight from the study of discrete temporo-limbic seizures in rats.

    abstract:RATIONALE:Measurement of local cerebral blood flow (LCBF) is routinely used to locate the areas involved in the generation and spread of seizures in epileptic patients. Since the spatial distribution and extent of ictal LCBF depends on the epileptogenic network, but also on the timing of injection of tracer, we used a ...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2006.01.008

    authors: Chassagnon S,André V,Koning E,Ferrandon A,Nehlig A

    更新日期:2006-05-01 00:00:00

  • The effects of anticonvulsant agents on 4-aminopyridine induced epileptiform activity in rat hippocampus in vitro.

    abstract::Six anticonvulsant drugs, phenytoin (PHT), carbamazepine (CBZ), valproate (VPA), U-54494A, losigamone (LOS), and D-20443, were studied using rat hippocampal slices and standard electrophysiological techniques. The K+ channel blocker, 4-aminopyridine (4-AP), was used as neuronal stimulant. The extracellular parameters ...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/0920-1211(94)00077-a

    authors: Yonekawa WD,Kapetanovic IM,Kupferberg HJ

    更新日期:1995-02-01 00:00:00

  • Association of apolipoprotein E polymorphisms with temporal lobe epilepsy in a Chinese Han population.

    abstract::Apolipoprotein E (ApoE) has been implicated as one of the susceptibility genes for temporal lobe epilepsy (TLE). Previous studies indicate that ApoE ɛ4 is associated with several disease-related traits including the increased risk of late posttraumatic seizures, earlier onset of TLE, refractory complex partial seizure...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2010.07.020

    authors: Fu YH,Lv RJ,Jin LR,Lu Q,Shao XQ,He JS,Wu LW,Zhang LS,Hu HG

    更新日期:2010-10-01 00:00:00

  • Do the epilepsies, pain syndromes, and affective disorders share common kindling-like mechanisms?

    abstract::Kindling, in the classical sense, involves progressively increasing responsivity to the intermittent repetition of the same 1-s subthreshold electrical stimulation over time, with the amygdala being the area most frequently studied. Such repeated subthreshold stimulation is associated with: lowering of the after-disch...

    journal_title:Epilepsy research

    pub_type: 杂志文章,评审

    doi:10.1016/s0920-1211(02)00081-5

    authors: Post RM

    更新日期:2002-06-01 00:00:00

  • Interictal SPECT of rCBF is of clinical utility in the preoperative evaluation of patients with partial epilepsy.

    abstract::Fifty-eight patients with drug-resistant partial epilepsy were studied preoperatively by interictal rCBF measurements using 99mTc-HMPAO and a dedicated brain SPECT camera (Tomomatic 64). Follow-up of seizure outcome, using the "Engel score", was at least 3 years. The data were analyzed in a blinded set-up, first visua...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/0920-1211(96)00018-6

    authors: Andersen AR,Hansen BA,Høgenhaven H,Herning M,Paulson O,Dam M

    更新日期:1996-09-01 00:00:00

  • Clinical effects of topiramate against secondarily generalized tonic--clonic seizures.

    abstract:OBJECTIVE:Intensive and quantitative evaluation of the duration, intensity and frequency of tonic and clonic signs of secondarily generalized tonic-clonic seizures (GTCS) in patients with pharmacoresistant partial seizures during topiramate (TPM) treatment. METHODS:Thirty patients suffering from refractory partial sei...

    journal_title:Epilepsy research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0920-1211(02)00014-1

    authors: Wang Y,Zhou D,Wang B,Kirchner A,Hopp P,Kerling F,Pauli E,Stefan H

    更新日期:2002-04-01 00:00:00

  • The NMDA antagonist MK-801 suppresses behavioral seizures, augments afterdischarges, but does not block development of perforant path kindling.

    abstract::The role of N-methyl-D-aspartate (NMDA) in the development and expression of kindled seizures was assessed using a crossover design. Rats were stimulated once daily in the perforant path for 10 consecutive days 30 min following daily administration of saline or the NMDA antagonist MK-801 (1.0 mg/kg) (phase I). Five to...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/0920-1211(94)90014-0

    authors: Gilbert ME

    更新日期:1994-02-01 00:00:00

  • Modeling epileptogenesis and temporal lobe epilepsy in a non-human primate.

    abstract::Here we describe a new non-human primate model of temporal lobe epilepsy (TLE) to better investigate the cause/effect relationships of human TLE. Status epilepticus (SE) was induced in adult marmosets by pilocarpine injection (250mg/kg; i.p.). The animals were divided in 2 groups: acute (8h post-SE) and chronic (3 and...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2011.04.015

    authors: Perez-Mendes P,Blanco MM,Calcagnotto ME,Cinini SM,Bachiega J,Papoti D,Covolan L,Tannus A,Mello LE

    更新日期:2011-09-01 00:00:00