Progress report on new antiepileptic drugs: a summary of the fourth Eilat conference (EILAT IV).

abstract：:Use of non-vitamin K antagonist oral anticoagulants (NOACs), including dabigatran etexilate, rivaroxaban, apixaban, edoxaban or betrixaban provides a safe and convenient alternative to the traditional anticoagulation with vitamin K antagonists or heparin derivatives. Many patients receiving long-term seizure prophylax...

journal_title：Epilepsy research

authors： Taha M,Li W,Schmidt CM,Gonzalez-Castellon M,Taraschenko O

更新日期：2020-05-01 00:00:00

abstract：:The objective of the study was to validate the Chinese version of The Liverpool Adverse Events Profile (LAEP) in patients with epilepsy. The scale was translated from the English version into a Chinese version and was then back-translated to examine its accuracy. Content validity, concurrent validity, and construct va...

journal_title：Epilepsy research

authors： Chen HF,Tsai YF,Shih MS,Chen JC

更新日期：2011-03-01 00:00:00

abstract：:The effect and safety of loreclezole were evaluated during a long-term follow-up trial targeting higher plasma concentrations than those of the preceding controlled trial. The result is better than in the double-blind trial, in which loreclezole doses were administered to reach plasma concentrations of 1-2 mg/l and 6/...

journal_title：Epilepsy research

authors： Rentmeester T,Janssen A,Hulsman J,Scholtes F,van der Kleij B,Overweg J,Meijer J,de Beukelaar F

更新日期：1991-05-01 00:00:00

abstract：:The purpose of the study was to evaluate the efficacy and safety of topiramate (TPM) as adjunctive therapy in children, adolescents and young adults with Lennox-Gastaut syndrome (LGS). We performed a prospective open label add-on study in 45 patients (age 4-34 years, mean 15.9 years) with LGS and refractory seizures. ...

journal_title：Epilepsy research

authors： Coppola G,Caliendo G,Veggiotti P,Romeo A,Tortorella G,De Marco P,Pascotto A

更新日期：2002-09-01 00:00:00

abstract：:Outbred rats are widely used in biomedical research studies. The genotypic variation, different housing and handling conditions during development, and gender of used rats can be expected to cause variations in behavior and epileptogenesis. We tested the hypothesis that adult female Wistar rats from different breeders...

journal_title：Epilepsy research

authors： Honndorf S,Lindemann C,Töllner K,Gernert M

更新日期：2011-03-01 00:00:00

abstract：:Recognition of the role of genetics in the epilepsies has increased dramatically, impacting on clinical practice across many epilepsy syndromes. There is limited research investigating the impact of gene identification on individuals and families with epilepsy. While research has focused on the impact of delivering ge...

journal_title：Epilepsy research

authors： Vears DF,Dunn KL,Wake SA,Scheffer IE

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:To analyze electroclinical features of absence seizures during sleep. PRINCIPAL RESULTS:30 children with genetic generalized epilepsy had 52 paroxysms of GSW >2s during sleep. 18/52 (35%) demonstrated a clinical sign. Ictal GSW lasted an average of 6.5s. CONCLUSION:Motor manifestations are seen during GSW>2s ...

journal_title：Epilepsy research

authors： Sadleir LG,Farrell K,Smith S,Connolly MB,Scheffer IE

更新日期：2011-02-01 00:00:00

abstract：:The KCNAB1 gene is a candidate susceptibility factor for lateral temporal epilepsy (LTE) because of its functional interaction with LGI1, the gene responsible for the autosomal dominant form of LTE. We investigated association between polymorphic variants across the KCNAB1 gene and LTE. The allele and genotype frequen...

journal_title：Epilepsy research

authors： Busolin G,Malacrida S,Bisulli F,Striano P,Di Bonaventura C,Egeo G,Pasini E,Cianci V,Ferlazzo E,Bianchi A,Coppola G,Elia M,Mecarelli O,Gobbi G,Casellato S,Marchini M,Binelli S,Freri E,Granata T,Posar A,Parmeggiani

更新日期：2011-03-01 00:00:00

abstract：:The inbred Wistar Albino Glaxo Rats from Rijswijk (WAG/Rij) and the Genetic Absence Epilepsy Rats from Strasbourg (GAERS) are well-validated genetic models of absence epilepsy. Although they share similar characteristics including the spike-and-wave discharges (SWDs) in the EEG, some differences have been reported bet...

journal_title：Epilepsy research

authors： Akman O,Demiralp T,Ates N,Onat FY

更新日期：2010-05-01 00:00:00

abstract：:Early neuropsychological changes following partial anterior callosotomy were evaluated in 15 patients with epilepsy (10 secondary generalized and 5 Lennox-Gastaut syndromes) by comparing their performances 1 month before surgery and then 15-20 and 90-100 days postoperatively without modifying the anticonvulsant treatm...

journal_title：Epilepsy research

authors： Provinciali L,Del Pesce M,Censori B,Quattrini A,Paggi A,Ortenzi A,Mancini S,Papo I,Rychlicki F

更新日期：1990-07-01 00:00:00

abstract：:Depression is a frequent psychiatric symptom in epilepsy and has been related to epilepsy of temporal origin, especially of left-sided foci. No study differentiated the precise localization of the epileptogenic lesion within the temporal lobe. Regarding this issue, we evaluated depression assessed by the Beck Depressi...

journal_title：Epilepsy research

authors： Quiske A,Helmstaedter C,Lux S,Elger CE

更新日期：2000-04-01 00:00:00

abstract：:Seizures that occur during early development are associated with adverse neurodevelopmental outcomes. Causation and mechanisms are currently under investigation. Induction of an early life seizure by kainic acid (KA) in immature rats on post-natal day (P) 7 results in behavioral changes in the adult rat that reflect s...

journal_title：Epilepsy research

authors： O'Leary H,Vanderlinden L,Southard L,Castano A,Saba LM,Benke TA

更新日期：2020-03-01 00:00:00

abstract：:Evidence-based treatment guidelines and practice parameters have been developed in most areas of medicine. They are important because insurance companies, formulary managers, and health maintenance organizations rely on guidelines for formulary and coverage decisions. The methodology for practice parameter development...

journal_title：Epilepsy research

authors： French JA

更新日期：2006-01-01 00:00:00

abstract：:Mutations in the LGI1 gene are linked to autosomal dominant lateral temporal epilepsy (ADTLE) in about half of the families tested, suggesting that ADLTE is genetically heterogeneous. Recently, the Lgi1 protein has been found associated with different protein complexes and two distinct molecular mechanisms possibly un...

journal_title：Epilepsy research

authors： Diani E,Di Bonaventura C,Mecarelli O,Gambardella A,Elia M,Bovo G,Bisulli F,Pinardi F,Binelli S,Egeo G,Castellotti B,Striano P,Striano S,Bianchi A,Ferlazzo E,Vianello V,Coppola G,Aguglia U,Tinuper P,Giallonardo AT,

更新日期：2008-07-01 00:00:00

abstract：:Generalized epilepsy with febrile seizures plus (GEFS+) comprises a group of clinically and genetically heterogeneous epilepsy syndrome. Here, we provide the first report of clinical presentation and mutational analysis of SCN1A gene in 36 Malaysian GEFS+ patients. Mutational analysis of SCN1A gene revealed twenty sev...

journal_title：Epilepsy research

authors： Tan EH,Razak SA,Abdullah JM,Mohamed Yusoff AA

更新日期：2012-12-01 00:00:00

abstract：PURPOSE:To characterize gabapentin pharmacokinetics in infants and children using a population approach and to identify important demographic and/or physiologic determinants of gabapentin disposition. METHODS:Gabapentin was administered in single doses of 10 mg/kg (N=48 healthy subjects, age 1 month-12 years) or in mu...

journal_title：Epilepsy research

authors： Ouellet D,Bockbrader HN,Wesche DL,Shapiro DY,Garofalo E

更新日期：2001-12-01 00:00:00

abstract：:Severe paediatric epilepsies such as CDKL5 Deficiency Disorder (CDD) are extremely debilitating, largely due to the early-onset and refractory nature of the seizures. Existing treatment options are often ineffective and associated with a host of adverse effects, causing those that are affected to seek alternative trea...

journal_title：Epilepsy research

authors： Dale T,Downs J,Olson H,Bergin AM,Smith S,Leonard H

更新日期：2019-03-01 00:00:00

abstract：:Surgical resection of the seizure onset zone (SOZ) requires that this region of the cortex is accurately localized. The onset of a seizure may be marked by transient discharges, but it also may be accompanied by oscillatory, sinusoidal electrographic activity, such as the EEG theta rhythm. However, because of the supe...

journal_title：Epilepsy research

authors： Kuo CC,Tucker DM,Luu P,Jenson K,Tsai JJ,Ojemann JG,Holmes MD

更新日期：2018-10-01 00:00:00

abstract：:Photosensitive epilepsy (PSE) offers a highly reproducible model to investigate whether changes in neuronal activity preceding the transition to an epileptic photoparoxysmal response (PPR) may be detected. We investigated this possibility in patients with idiopathic PSE using MEG, as well as normal controls and non-ph...

journal_title：Epilepsy research

authors： Lopes da Silva FH,Harding GF

更新日期：2011-12-01 00:00:00

abstract：:The effects of a novel anticonvulsant, zonisamide (3-sulfamoylmethyl-1,2-benzisoxazole), on photically induced seizures were studied in the lateral geniculate-kindled cat. Zonisamide was found to reduce the behavioral severity of seizure responses to photic stimulation in a dose-related manner. This anticonvulsant eff...

journal_title：Epilepsy research

authors： Wada Y,Hasegawa H,Yamaguchi N

更新日期：1990-11-01 00:00:00

abstract：:Triheptanoin, the triglyceride of heptanoate, is used to treat certain hereditary metabolic diseases in USA because of its anaplerotic potential. In two chronic mouse seizure models this clear tasteless oil was found to be reproducibly anticonvulsant. Here we investigated the effects of triheptanoin feeding in C3H and...

journal_title：Epilepsy research

authors： Thomas NK,Willis S,Sweetman L,Borges K

更新日期：2012-05-01 00:00:00

abstract：PURPOSE:We performed a retrospective study to investigate seizure, EEG, social and cognitive outcome in adult LGS subjects. METHODS:We retrospectively evaluated 27 LGS patients aged 40-59 years. We assessed in particular the evolution of different seizure types and EEG findings, as well as cognitive and social outcome...

journal_title：Epilepsy research

authors： Ferlazzo E,Nikanorova M,Italiano D,Bureau M,Dravet C,Calarese T,Viallat D,Kölmel M,Bramanti P,De Santi L,Genton P

更新日期：2010-05-01 00:00:00

abstract：:Mutations in voltage-gated sodium channel genes cause several types of human epilepsies. Often, individuals with the same sodium channel mutation exhibit diverse phenotypes. This suggests that factors beyond the primary mutation influence disease severity, including genetic modifiers. Mouse epilepsy models with voltag...

journal_title：Epilepsy research

authors： Hawkins NA,Kearney JA

更新日期：2016-01-01 00:00:00

abstract：:Application of 4-aminopyridine (4-AP, 100μM) in a solution containing 0.6mM Mg(2+) and 1.2mM Ca(2+) to hippocampal-entorhinal-perirhinal slices of adult rat brain induced ictal-like epileptiform activity in entorhinal and perirhinal cortices as revealed by electrophysiological field potential recordings. The ictal-lik...

journal_title：Epilepsy research

authors： Salah A,Perkins KL

更新日期：2011-05-01 00:00:00

abstract：:Involvement of opioid systems in the pathogenesis of absence epilepsy has been postulated. However, the role of the mu opioid receptor has not been fully elucidated as yet. In the present study the role of this receptor in absence epilepsy was investigated autoradiographically and pharmacologically. The density of mu ...

journal_title：Epilepsy research

authors： Przewłocka B,Lasoń W,Turchan J,de Bruin N,van Luijtelaar G,Przewłocki R,Coenen A

更新日期：1998-01-01 00:00:00

abstract：:Plasma total homocysteine (p-tHcy), serum folate (s-F), serum vitamin B-12 (s-B12) and plasma pyridoxal-5'-phosphate (p-PLP) were measured in epileptic children before and after a 20-week period of sodium valproate (group A, n=32) and carbamazepine (group B, n=20) monotherapy. P-tHcy significantly increased in both gr...

journal_title：Epilepsy research

authors： Attilakos A,Papakonstantinou E,Schulpis K,Voudris K,Katsarou E,Mastroyianni S,Garoufi A

更新日期：2006-10-01 00:00:00

abstract：:A role of cholinergic nervous system in the behavioral impairments induced by repeated ECS is not understood. The α4β2 nicotinic acetylcholine receptor (nAChR) agonist ABT-418, but not the α7 nAChR agonist, significantly ameliorated the impairment of spontaneous alternation behavior in the Y-maze test. And, repeated E...

journal_title：Epilepsy research

authors： Hidaka N,Suemaru K,Kato Y,Araki H

更新日期：2013-03-01 00:00:00

abstract：INTRODUCTION:Prior research has shown that people with epilepsy are at risk for a poorer health-related quality of life (HRQOL). However, patients differ greatly in how well they adjust to their epilepsy. To better understand these differences, the present study examined the role of personality. More specifically, we e...

journal_title：Epilepsy research

authors： Rassart J,Luyckx K,Verdyck L,Mijnster T,Mark RE

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Since intracranial electrode implantation has limited spatial sampling and carries significant risk, placement has to be effective and efficient. Structural and functional imaging of several different modalities contributes to localising the seizure onset zone (SoZ) and eloquent cortex. There is a need to su...

journal_title：Epilepsy research

authors： Rodionov R,Vollmar C,Nowell M,Miserocchi A,Wehner T,Micallef C,Zombori G,Ourselin S,Diehl B,McEvoy AW,Duncan JS

更新日期：2013-11-01 00:00:00

abstract：:In the immature brain the neurotransmitter γ-amino butyric acid (GABA) mediates a membrane depolarization and can contribute to both, inhibition and excitation. Therefore the consequences of a positive modulation of GABA(A) receptors by neurosteroids on epileptiform activity are hard to predict. In order to analyze wh...

journal_title：Epilepsy research

authors： Sharopov S,Winkler P,Uehara R,Lombardi A,Halbhuber L,Okabe A,Luhmann HJ,Kilb W

更新日期：2019-11-01 00:00:00