Validation of the Chinese version of the Liverpool Adverse Events Profile in patients with epilepsy.


:The objective of the study was to validate the Chinese version of The Liverpool Adverse Events Profile (LAEP) in patients with epilepsy. The scale was translated from the English version into a Chinese version and was then back-translated to examine its accuracy. Content validity, concurrent validity, and construct validity were then used to examine the overall validity of this scale. A cross-sectional design with convenience sampling was used to recruit participants from three medical centers. The LAEP Chinese version was tested with respect to validity and reliability in 357 patients with epilepsy, and another 28 patients were invited to evaluate the test-retest reliability of the scale in a 2-week interval. There was a good content validity index (CVI=1.0). Patients undergoing polytherapy had more adverse effects (χ(2)=6.10, p<0.01) and higher LAEP scores (t=-2.91, p<0.01) than patients undergoing monotherapy, indicating a good concurrent validity. Factor analysis included three factors classified by symptoms in the 22-item Chinese version of the LAEP. The total variance of these three factors was 39.3% for the scale. Internal consistency (Cronbach's α=0.92) and the intraclass correlation coefficient (ICC=0.80) were satisfactory. Moreover, the LAEP can be completed in a short time, is perceived as easy to complete, and there was no relevant information missing. The results indicated that the Chinese version of the LAEP yielded highly acceptable parameters of validity and reliability and can be used for measuring adverse effects of antiepileptic drugs among Chinese-speaking patients with epilepsy in Taiwan.


Epilepsy Res


Epilepsy research


Chen HF,Tsai YF,Shih MS,Chen JC




Has Abstract


2011-03-01 00:00:00














  • No major role of common SV2A variation for predisposition or levetiracetam response in epilepsy.

    abstract::Levetiracetam (LEV), a newer antiepileptic drug (AED) useful for several epilepsy syndromes, binds to SV2A. Identifying genetic variants that influence response to LEV may allow more tailored use of LEV. Obvious candidate genes are SV2A, SV2B and SV2C, which encode the only known binding site, synaptic vesicle protein...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Lynch JM,Tate SK,Kinirons P,Weale ME,Cavalleri GL,Depondt C,Murphy K,O'Rourke D,Doherty CP,Shianna KV,Wood NW,Sander JW,Delanty N,Goldstein DB,Sisodiya SM

    更新日期:2009-01-01 00:00:00

  • Do polio survivors have a higher risk of epilepsy?

    abstract::We planned this study to investigate the frequency of epilepsy in paralytic polio survivors. We analyzed the clinical data of 91 paralytic polio survivors. Patients who had been diagnosed with epilepsy were examined by electroencephalography and brain magnetic resonance imaging. 11 of the 91 patients had epilepsy (12%...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Demir CF,Berilgen MS,Mungen B,Bulut S

    更新日期:2012-01-01 00:00:00

  • Intrapatient variation in antiepileptic drug plasma concentration after generic substitution vs stable brand-name drug regimens.

    abstract::Generic substitution of antiepileptic drugs (AEDs) is still a matter of controversy and concern among clinicians and patients. We aimed to assess intrasubject variation in plasma concentrations of lamotrigine (LTG), levetiracetam (LEV) and topiramate (TPM) after generic substitution compared with a stable brand-name d...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Contin M,Alberghini L,Candela C,Benini G,Riva R

    更新日期:2016-05-01 00:00:00

  • Inhibition of photosensitive seizures in man by the beta-carboline, ZK 95962, a selective benzodiazepine receptor agonist.

    abstract::A single-dose study of the beta-carboline, ZK 95962, on photosensitive generalized paroxysmal activity in the EEG was conducted in 6 patients with primary generalized epilepsy. Four of the patients were newly diagnosed and did not receive any antiepileptic drug or other medication during the study. Two were receiving ...

    journal_title:Epilepsy research

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Møller A,Jensen LH,Skrumsager B,Blatt-Lyon B,Pedersen B,Dam M

    更新日期:1990-03-01 00:00:00

  • Smartphone applications for seizure care and management in children and adolescents with epilepsy: Feasibility and acceptability assessment among caregivers in China.

    abstract:OBJECTIVE:to determine the feasibility as well as the attitudes among caregivers of children and adolescents with epilepsy in China towards the use of smart phone applications (apps) for the management of seizures. METHODS:The caregivers of children and adolescents with epilepsy, ages ranging from 0 to 15 years, were ...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Liu X,Wang R,Zhou D,Hong Z

    更新日期:2016-11-01 00:00:00

  • Cardiac changes in epileptic baboons with high-frequency microburst VNS therapy: A pilot study.

    abstract::The epileptic baboon provides a natural model of idiopathic generalized epilepsy and sudden unexpected death in epilepsy (SUDEP). We sought to evaluate autonomic differences, including heart rate (HR), heart rate variability (HRV) and corrected QT-duration (QTc) between two epileptic (EB1, EB2) and one control (CB) ba...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: de la Garza MA,Poldiak D,Shade R,Salinas FS,Papanastassiou AM,Szabó CÁ

    更新日期:2019-09-01 00:00:00

  • Role of choroid plexus epithelium in the removal of valproic acid from the central nervous system.

    abstract::Previous experiments suggest the primary route of valproic acid (VPA) removal from the rabbit central nervous system (CNS) is by probenecid-sensitive transporters at the blood-brain barrier but not at the choroid plexus. The purpose of this study was to determine if other transport mechanisms at the choroid plexus pla...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Adkison KD,Artru AA,Powers KM,Nochlin D,Shen DD

    更新日期:1995-03-01 00:00:00

  • Involvement of nitric oxide-cGMP pathway in the anticonvulsant effects of lithium chloride on PTZ-induced seizure in mice.

    abstract::Lithium is still the mainstay in the treatment of affective disorders as a mood stabilizer. Lithium also shows some anticonvulsant properties. While the underlying mechanisms of action of lithium are not yet exactly understood, we used a model of clonic seizure induced by pentylenetetrazole (PTZ) in male NMRI mice to ...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Bahremand A,Nasrabady SE,Ziai P,Rahimian R,Hedayat T,Payandemehr B,Dehpour AR

    更新日期:2010-05-01 00:00:00

  • Positive effect of calcitonin on the seizures induced by pentylenetetrazole in rats.

    abstract::There are many difficulties involved with the treatment of epilepsy, and these problems have driven the search for new agents to control epileptic seizures. Calcitonin is a peptide hormone that has been well studied and shown to have a positive effect on neuropathic and chronic pain. The mechanism by which calcitonin ...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Aksoy D,Solmaz V,Erbas O

    更新日期:2014-03-01 00:00:00

  • Early and persistent increase in serum lipoprotein (a) concentrations in epileptic children treated with carbamazepine and sodium valproate monotherapy.

    abstract:PURPOSE:The aim of this study was to investigate by a prospective, self-controlled method, whether treatment with carbamazepine (CBZ) and sodium valproate (VPA) monotherapy may alter serum lipoprotein (a) [Lp(a)] concentrations in epileptic children. METHODS:Serum Lp(a) concentrations have been determined in 18 epilep...

    journal_title:Epilepsy research

    pub_type: 临床试验,杂志文章


    authors: Voudris KA,Attilakos A,Katsarou E,Drakatos A,Dimou S,Mastroyianni S,Skardoutsou A,Prassouli A,Garoufi A

    更新日期:2006-08-01 00:00:00

  • Autosomal dominant lateral temporal epilepsy: absence of mutations in ADAM22 and Kv1 channel genes encoding LGI1-associated proteins.

    abstract::Mutations in the LGI1 gene are linked to autosomal dominant lateral temporal epilepsy (ADTLE) in about half of the families tested, suggesting that ADLTE is genetically heterogeneous. Recently, the Lgi1 protein has been found associated with different protein complexes and two distinct molecular mechanisms possibly un...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Diani E,Di Bonaventura C,Mecarelli O,Gambardella A,Elia M,Bovo G,Bisulli F,Pinardi F,Binelli S,Egeo G,Castellotti B,Striano P,Striano S,Bianchi A,Ferlazzo E,Vianello V,Coppola G,Aguglia U,Tinuper P,Giallonardo AT,

    更新日期:2008-07-01 00:00:00

  • Gabapentin modifies extracellular opioid peptide content in amygdala: a microdialysis study.

    abstract::Opioid peptide release was monitored in the amygdala and hippocampus of freely moving rats following a single oral administration of gabapentin using microdialysis. Extracellular opioid peptide levels were elevated above basal levels in the amygdala within the first 60 (54%) and 90 min (68%) after gabapentin administr...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Rocha L,Ondarza-Rovira R,Maidment NT

    更新日期:1999-05-01 00:00:00

  • Regional homogeneity (ReHo) changes in new onset versus chronic benign epilepsy of childhood with centrotemporal spikes (BECTS): A resting state fMRI study.

    abstract:OBJECTIVE:The purpose of this study was to investigate regional homogeneity (ReHo) in children with new-onset drug-naïve Benign Epilepsy with Centrotemporal Spikes (BECTS), chronic BECTS and healthy controls (HC) using the Regional Homogeneity (ReHo) method applied to resting state fMRI data. METHODS:Resting state fMR...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Zeng H,Ramos CG,Nair VA,Hu Y,Liao J,La C,Chen L,Gan Y,Wen F,Hermann B,Prabhakaran V

    更新日期:2015-10-01 00:00:00

  • Association of apolipoprotein E polymorphisms with temporal lobe epilepsy in a Chinese Han population.

    abstract::Apolipoprotein E (ApoE) has been implicated as one of the susceptibility genes for temporal lobe epilepsy (TLE). Previous studies indicate that ApoE ɛ4 is associated with several disease-related traits including the increased risk of late posttraumatic seizures, earlier onset of TLE, refractory complex partial seizure...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Fu YH,Lv RJ,Jin LR,Lu Q,Shao XQ,He JS,Wu LW,Zhang LS,Hu HG

    更新日期:2010-10-01 00:00:00

  • Seizure anticipation by patients with focal and generalized epilepsy: a multicentre assessment of premonitory symptoms.

    abstract:PURPOSE:To assess subjective seizure anticipation in patients with focal and generalized epilepsy. METHODS:Five hundred consecutively recruited out-patients (251 male, 249 female, mean age 38.1 year) from three German tertiary epilepsy referral centres filled out questionnaires regarding subjective anticipation of sei...

    journal_title:Epilepsy research

    pub_type: 杂志文章,多中心研究


    authors: Schulze-Bonhage A,Kurth C,Carius A,Steinhoff BJ,Mayer T

    更新日期:2006-07-01 00:00:00

  • Retrospective genotype-phenotype analysis in a 305 patient cohort referred for testing of a targeted epilepsy panel.

    abstract:PURPOSE:Epilepsy is a diverse neurological condition with extreme genetic and phenotypic heterogeneity. The introduction of next-generation sequencing into the clinical laboratory has made it possible to investigate hundreds of associated genes simultaneously for a patient, even in the absence of a clearly defined synd...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Hesse AN,Bevilacqua J,Shankar K,Reddi HV

    更新日期:2018-08-01 00:00:00

  • Alternate-site kindling in the guinea-pig results in accelerated seizure progression and generalization.

    abstract::In rats, the concurrent alternate elicitation of epileptiform activity in two forebrain structures can result in both the rapid production of severe seizures and the development of fully generalized seizures in one (dominant) site, while arresting the progress of seizure activity at intermediate stages in the other (s...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Teskey GC,Thiessen EJ,Gilbert TH

    更新日期:1999-04-01 00:00:00

  • Feasibility of multimodal 3D neuroimaging to guide implantation of intracranial EEG electrodes.

    abstract:BACKGROUND:Since intracranial electrode implantation has limited spatial sampling and carries significant risk, placement has to be effective and efficient. Structural and functional imaging of several different modalities contributes to localising the seizure onset zone (SoZ) and eloquent cortex. There is a need to su...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Rodionov R,Vollmar C,Nowell M,Miserocchi A,Wehner T,Micallef C,Zombori G,Ourselin S,Diehl B,McEvoy AW,Duncan JS

    更新日期:2013-11-01 00:00:00

  • Relative bioavailability of topiramate administered rectally.

    abstract:OBJECTIVE:To determine the relative bioavailability and tolerability of a topiramate (TPM) suspension after rectal administration. DESIGN/METHOD:Seven healthy men and five healthy non-pregnant women were enrolled. A 100 or 200 mg tablet of TPM was given orally and a 200 mg dose was given rectally in a randomized, open...

    journal_title:Epilepsy research

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Conway JM,Birnbaum AK,Kriel RL,Cloyd JC

    更新日期:2003-05-01 00:00:00

  • Defining incident cases of epilepsy in administrative data.

    abstract:PURPOSE:To determine the minimum enrollment duration for identifying incident cases of epilepsy in administrative data. METHODS:We performed a retrospective dynamic cohort study using Ohio Medicaid data from 1992 to 2006 to identify a total of 5037 incident epilepsy cases who had at least 1 year of follow-up prior to ...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Bakaki PM,Koroukian SM,Jackson LW,Albert JM,Kaiboriboon K

    更新日期:2013-09-01 00:00:00

  • Hippocampal activation correlates with visual confrontation naming: fMRI findings in controls and patients with temporal lobe epilepsy.

    abstract:PURPOSE:In patients with left temporal lobe epilepsy (TLE) due to hippocampal sclerosis (HS) decreased naming ability is common, suggesting a critical role for the medial left temporal lobe in this task. We investigated the integrity of language networks with functional MRI (fMRI) in controls and TLE patients. EXPERIM...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Bonelli SB,Powell R,Thompson PJ,Yogarajah M,Focke NK,Stretton J,Vollmar C,Symms MR,Price CJ,Duncan JS,Koepp MJ

    更新日期:2011-08-01 00:00:00

  • Anticonvulsive effect of dapsone (4,4'-diaminodiphenyl sulfone) on amygdala-kindled seizures in rats and cats.

    abstract::Dapsone (4,4'-diaminodiphenyl sulfone; DDS), an established anti-leprosy drug, showed anticonvulsive effects in the amygdaloid kindling model of epilepsy. Single doses of the drug in rats (6.25-12.5 mg/kg, i.p.) suppressed the kindled seizures in a dose-dependent manner without overt behavioral toxicity. With repeated...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Hamada K,Hiyoshi T,Kobayashi S,Ishida S,Yagi K,Seino M

    更新日期:1991-11-01 00:00:00

  • GABA and epileptogenesis: comparing gabrb3 gene-deficient mice with Angelman syndrome in man.

    abstract::The GABAergic system has long been implicated in epilepsy with defects in GABA neurotransmission being linked to epilepsy in both experimental animal models and human syndromes (Olsen and Avoli, 1997). However, to date no human epileptic syndrome has been directly attributed to an altered GABAergic system. The observe...

    journal_title:Epilepsy research

    pub_type: 杂志文章,评审


    authors: DeLorey TM,Olsen RW

    更新日期:1999-09-01 00:00:00

  • Epileptiform activity promotes decreasing of Ca2+ conductivity of NMDARs, AMPARs, KARs, and voltage-gated calcium channels in Mg2+-free model.

    abstract::NMDA, AMPA, and kainate receptors are the principal excitatory receptors in the brain. These receptors have been considered as the main targets in the treatment of epilepsy in recent years. This work aimed to determine how the Ca2+ conductivity of ionotropic glutamate receptors and voltage-gated Ca2+ channels changes ...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Gaidin SG,Zinchenko VP,Teplov IY,Tuleukhanov ST,Kosenkov AM

    更新日期:2019-12-01 00:00:00

  • Relationship of hippocampal sclerosis to duration and age of onset of epilepsy, and childhood febrile seizures in temporal lobectomy patients.

    abstract::Controversy exists as to whether hippocampal sclerosis (HS) is a preexisting cause or a consequence of seizures. We investigated 122 consecutive patients who underwent anterior temporal lobectomy for intractable epilepsy between 1989 and 1992. MRI scans were normal apart from evidence of HS in 5 cases. The degree of H...

    journal_title:Epilepsy research

    pub_type: 临床试验,杂志文章


    authors: Davies KG,Hermann BP,Dohan FC Jr,Foley KT,Bush AJ,Wyler AR

    更新日期:1996-06-01 00:00:00

  • A meta-analysis of voxel-based morphometry studies on unilateral refractory temporal lobe epilepsy.

    abstract:PURPOSE:To identify consistent results of voxel-based morphometry (VBM) studies in unilateral refractory temporal lobe epilepsy (TLE). METHODS:Whole-brain VBM studies comparing refractory TLE patients with healthy controls (HC) were systematically searched in PubMed, ISI Web of Science, Embase, and Medline databases f...

    journal_title:Epilepsy research

    pub_type: 杂志文章,meta分析,评审


    authors: Li J,Zhang Z,Shang H

    更新日期:2012-02-01 00:00:00

  • The ketogenic diet does not alter brain expression of orexigenic neuropeptides.

    abstract::Neuropeptide Y (NPY) and galanin are neuropeptides that are regulated by energy states and are also anticonvulsant. We tested the hypothesis that the anticonvulsant efficacy of the ketogenic diet (KD) is mediated by increased expression of NPY and galanin via alterations in food intake and energy metabolism. In situ h...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Tabb K,Szot P,White SS,Liles LC,Weinshenker D

    更新日期:2004-11-01 00:00:00

  • Seizure outcome in 175 patients with juvenile myoclonic epilepsy--a long-term observational study.

    abstract:INTRODUCTION:Juvenile myoclonic epilepsy (JME) is a genetic generalized epilepsy syndrome. Under appropriate antiepileptic drugs (AED) up to 85% of patients become seizure-free, but many may have a relapse after AED withdrawal. METHODS:We retrospectively studied 242 patients with JME at the Department of Neurology, Me...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Höfler J,Unterberger I,Dobesberger J,Kuchukhidze G,Walser G,Trinka E

    更新日期:2014-12-01 00:00:00

  • Drug-induced pertubation of the aminothiol redox-status in patients with epilepsy: improvement by B-vitamins.

    abstract:OBJECTIVES:Patients with epilepsy have excess morbidity and mortality due to ischemic cardiovascular disease. Many of these patients have elevated concentrations of plasma total homocysteine (Hcy), which is an acknowledged risk factor for cardiovascular disease, venous thromboembolic disease, foetal malformations and d...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Apeland T,Frøyland ES,Kristensen O,Strandjord RE,Mansoor MA

    更新日期:2008-11-01 00:00:00

  • The effects of octanol on penicillin induced epileptiform activity in rats: an in vivo study.

    abstract::The common features of all types of epilepsy are the synchronized and uncontrolled discharges of nerve cell assemblies. The reason for the pathologically synchronized discharges of the neuron is not exactly known yet. Recent reports claim that gap junctions have a critical role in neuronal synchronization. The present...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Bostanci MO,Bağirici F

    更新日期:2006-10-01 00:00:00