Validation of the Chinese version of the Liverpool Adverse Events Profile in patients with epilepsy.


:The objective of the study was to validate the Chinese version of The Liverpool Adverse Events Profile (LAEP) in patients with epilepsy. The scale was translated from the English version into a Chinese version and was then back-translated to examine its accuracy. Content validity, concurrent validity, and construct validity were then used to examine the overall validity of this scale. A cross-sectional design with convenience sampling was used to recruit participants from three medical centers. The LAEP Chinese version was tested with respect to validity and reliability in 357 patients with epilepsy, and another 28 patients were invited to evaluate the test-retest reliability of the scale in a 2-week interval. There was a good content validity index (CVI=1.0). Patients undergoing polytherapy had more adverse effects (χ(2)=6.10, p<0.01) and higher LAEP scores (t=-2.91, p<0.01) than patients undergoing monotherapy, indicating a good concurrent validity. Factor analysis included three factors classified by symptoms in the 22-item Chinese version of the LAEP. The total variance of these three factors was 39.3% for the scale. Internal consistency (Cronbach's α=0.92) and the intraclass correlation coefficient (ICC=0.80) were satisfactory. Moreover, the LAEP can be completed in a short time, is perceived as easy to complete, and there was no relevant information missing. The results indicated that the Chinese version of the LAEP yielded highly acceptable parameters of validity and reliability and can be used for measuring adverse effects of antiepileptic drugs among Chinese-speaking patients with epilepsy in Taiwan.


Epilepsy Res


Epilepsy research


Chen HF,Tsai YF,Shih MS,Chen JC




Has Abstract


2011-03-01 00:00:00














  • The correlation of magnetoencephalography to intracranial EEG in localizing the epileptogenic zone: a study of the surgical resection outcome.

    abstract:OBJECTIVES:To evaluate the agreement between magnetoencephalography (MEG) and intracranial electroencephalography (ICEEG) results, to determine the characteristics that lead to concordance, and to assess how these factors relate to favorable epilepsy surgery outcome. MATERIALS:This retrospective study reviewed 50 pati...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Almubarak S,Alexopoulos A,Von-Podewils F,Wang ZI,Kakisaka Y,Mosher JC,Bulacio J,González-Martínez J,Bingaman W,Burgess RC

    更新日期:2014-11-01 00:00:00

  • Aromatase inhibition by letrozole attenuates kainic acid-induced seizures but not neurotoxicity in mice.

    abstract::Evidence shows neurosteroids play a key role in regulating epileptogenesis. Neurosteroids such as testosterone modulate seizure susceptibility through its transformation to metabolites which show proconvulsant and anticonvulsant effects, respectively. Reduction of testosterone by aromatase generates proconvulsant 17-β...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Iqbal R,Jain GK,Siraj F,Vohora D

    更新日期:2018-07-01 00:00:00

  • Unilateral cortical spreading depression is an early marker of audiogenic kindling in awake rats.

    abstract::Spreading depression (SD), a self-propagating wave of reversible cellular depolarization, is thought to play an important role in brain pathophysiology. SD and seizures are closely related events but little is known about involvement of SD in chronic epileptogenesis. Here we show that cortical SD is the first and high...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Vinogradova LV,Vinogradov VY,Kuznetsova GD

    更新日期:2006-09-01 00:00:00

  • Neuropsychologist's (re-)view: Resective versus ablative amygdalohippocampectomies.

    abstract::Pharmacoresistant mesial temporal lobe epilepsy (mTLE) represents the major indication for epilepsy surgery. Since epilepsy surgery is an elective treatment option, preserving cognition is a high priority. Given the essential role of temporomesial structures in declarative long-term memory formation, surgical treatmen...

    journal_title:Epilepsy research

    pub_type: 杂志文章,评审


    authors: Witt JA,Hoppe C,Helmstaedter C

    更新日期:2018-05-01 00:00:00

  • Cardiac changes in epileptic baboons with high-frequency microburst VNS therapy: A pilot study.

    abstract::The epileptic baboon provides a natural model of idiopathic generalized epilepsy and sudden unexpected death in epilepsy (SUDEP). We sought to evaluate autonomic differences, including heart rate (HR), heart rate variability (HRV) and corrected QT-duration (QTc) between two epileptic (EB1, EB2) and one control (CB) ba...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: de la Garza MA,Poldiak D,Shade R,Salinas FS,Papanastassiou AM,Szabó CÁ

    更新日期:2019-09-01 00:00:00

  • Frequency-dependent enhancement of hippocampal inhibition by GABA uptake blockers.

    abstract::The effects of GABA uptake inhibitors, SKF 89976A and SKF 100330A, on recurrent inhibition were studied in the rat hippocampal slice preparation by the antidromic-orthodromic stimulation test. Population spikes evoked orthodromically by stimulation of the stratum radiatum and recorded in the CA1 pyramidal cell body la...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Capek R,Esplin B

    更新日期:1993-10-01 00:00:00

  • 18FDG-PET in epilepsies of infantile onset with pharmacoresistant generalised tonic-clonic seizures.

    abstract:AIMS:To investigate the pathophysiology of pharmacoresistant epilepsies with cryptogenic generalised tonic-clonic seizures (GTCS) from infancy. METHODS:18F-Deoxy-Glucose-Positron Emission Tomography 18FDG-PET) with statistical parametric mapping (SPM). Inclusion criteria were: pharmacoresistant chronic epilepsy with G...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Korinthenberg R,Bauer-Scheid C,Burkart P,Martens-Le Bouar H,Kassubek J,Juengling FD

    更新日期:2004-06-01 00:00:00

  • Decision-making in temporal lobe epilepsy examined with the Iowa gambling task.

    abstract::Although memory, language, and executive functions have been extensively studied in patients with mesial temporal lobe epilepsy (MTLE), few investigations of the decision-making abilities of these patients have been performed. We studied implicit decision-making (decisions under ambiguity) in right and left MTLE patie...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Yamano M,Akamatsu N,Tsuji S,Kobayakawa M,Kawamura M

    更新日期:2011-01-01 00:00:00

  • Interictal HM-PAO SPECT: a routine investigation in patients with medically intractable complex partial seizures?

    abstract::Single photon emission computed tomography (SPECT) is increasingly being used as an adjunctive technique in the localisation of epileptogenic foci prior to surgery. As yet, few studies have been undertaken to establish the clinical associations of areas of reduced cerebral perfusion. Sixty-three consecutive patients (...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Duncan S,Gillen G,Adams FG,Duncan R,Brodie MJ

    更新日期:1992-10-01 00:00:00

  • The risk of asymptomatic hyperammonemia in children with idiopathic epilepsy treated with valproate: relationship to blood carnitine status.

    abstract:PURPOSE:Valproate (VPA) administration may be associated with adverse metabolic effects, among is hyperammonemia, which could suggest metabolic abnormalities as carnitine deficiency. This study aimed to evaluate the risk frequency of hyperammonemia and abnormal carnitine levels in children receiving VPA who were otherw...

    journal_title:Epilepsy research

    pub_type: 临床试验,杂志文章


    authors: Hamed SA,Abdella MM

    更新日期:2009-09-01 00:00:00

  • Amplitude-integrated EEG colored according to spectral edge frequency.

    abstract:OBJECTIVE:To improve the interpretability of figures containing an amplitude-integrated electroencephalogram (aEEG), we devised a color scale that allows us to incorporate spectral edge frequency (SEF) information into aEEG figures. Preliminary clinical assessment of this novel technique, which we call aEEG/SEF, was pe...

    journal_title:Epilepsy research

    pub_type: 临床试验,杂志文章


    authors: Kobayashi K,Mimaki N,Endoh F,Inoue T,Yoshinaga H,Ohtsuka Y

    更新日期:2011-10-01 00:00:00

  • The NMDA antagonist MK-801 suppresses behavioral seizures, augments afterdischarges, but does not block development of perforant path kindling.

    abstract::The role of N-methyl-D-aspartate (NMDA) in the development and expression of kindled seizures was assessed using a crossover design. Rats were stimulated once daily in the perforant path for 10 consecutive days 30 min following daily administration of saline or the NMDA antagonist MK-801 (1.0 mg/kg) (phase I). Five to...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Gilbert ME

    更新日期:1994-02-01 00:00:00

  • TRPV1 mediates the anticonvulsant effects of acetaminophen in mice.

    abstract:OBJECTIVE:Acetaminophen is one of the most commonly used analgesic and antipyretic drugs. It has been reported that acetaminophen has anticonvulsant effects in several animal models of seizure. An active metabolite of acetaminophen, AM404, inhibits the uptake of the endocannabinoid anandamide. However, the mechanism of...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Suemaru K,Yoshikawa M,Aso H,Watanabe M

    更新日期:2018-09-01 00:00:00

  • Familial temporal lobe epilepsy autosomal dominant inheritance in a large pedigree from southern Italy.

    abstract::To further elucidate the inheritance pattern and range of phenotypic manifestations of benign familial temporal lobe epilepsy (FTLE), we report a large family recently identified in southern Italy. There were 8 patients (4 men), ranging in age from 31 to 68 years in three generations. One affected patient was deceased...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Gambardella A,Messina D,Le Piane E,Oliveri RL,Annesi G,Zappia M,Andermann E,Quattrone A,Aguglia U

    更新日期:2000-02-01 00:00:00

  • Cervical spinal MRI in a patient with a vagus nerve stimulator (VNS).

    abstract::Cranial MRI has been shown to be a safe procedure in patients with a vagus nerve stimulator (VNS), but body MRI may cause overheating of the stimulator lead. Here we report a case of a patient with an implanted vagus nerve stimulator who required a cervical spinal MRI due to a rapidly progressive paraparesis. The spin...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Roebling R,Huch K,Kassubek J,Lerche H,Weber Y

    更新日期:2009-04-01 00:00:00

  • The role of neurosteroids in the pathophysiology and treatment of catamenial epilepsy.

    abstract::Catamenial epilepsy is a multifaceted neuroendocrine condition in which seizures are clustered around specific points in the menstrual cycle, most often around perimenstrual or periovulatory period. Generally, a twofold or greater increase in seizure frequency during a particular phase of the menstrual cycle could be ...

    journal_title:Epilepsy research

    pub_type: 杂志文章,评审


    authors: Reddy DS

    更新日期:2009-07-01 00:00:00

  • Safety of an IV formulation of carbamazepine.

    abstract::An intravenous formulation of carbamazepine (CBZ) was administered to 113 (60 male; 53 female) persons with epilepsy aged 19-87 years. Subjects received 100mg of study drug as replacement for 100mg of their usual morning dose of CBZ. There were no significant changes in blood pressure or heart rate suggesting that thi...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Conway JM,White JR,Birnbaum AK,Eugene Ramsay R,Pennell PB,Rarick JO,Musib L,Leppik IE,Cloyd JC

    更新日期:2009-04-01 00:00:00

  • Immediate versus late effects of vigabatrin on spike and wave discharges.

    abstract::Vigabatrin increases GABA concentrations by inhibiting GABA transaminase. In previous studies, it was shown that vigabatrin increases the incidence of Spike and Wave Discharges (SWD) in the WAG/Rij rat model for absence epilepsy. Since following a single dose of vigabatrin GABA concentrations are known to be increased...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Perescis MFJ,van Luijtelaar G,van Rijn CM

    更新日期:2020-09-01 00:00:00

  • Folate status in women of childbearing age with epilepsy.

    abstract::Treatment with cytochrome P450 enzyme-inducing antiepileptic drugs (P450-inducing AEDs) is known to interfere with folate metabolism. Low folate status is of special concern in women with epilepsy who might become pregnant. Therefore, folate status was assessed in women age 16-42 treated for epilepsy. Staple food is n...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Kampman MT

    更新日期:2007-06-01 00:00:00

  • Visualizing Meyer's loop: A comparison of deterministic and probabilistic tractography.

    abstract:BACKGROUND:Diffusion tensor tractography of the anterior extent of the optic radiation - Meyer's loop - prior to temporal lobe resection (TLR) may reduce the risk for postoperative visual field defect. Currently there is no standardized way to perform tractography. OBJECTIVE:To visualize Meyer's loop using determinist...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Lilja Y,Ljungberg M,Starck G,Malmgren K,Rydenhag B,Nilsson DT

    更新日期:2014-03-01 00:00:00

  • Effect of levetiracetam on the pharmacokinetics of adjunctive antiepileptic drugs: a pooled analysis of data from randomized clinical trials.

    abstract::The purpose of this study was to determine the influence of levetiracetam on the steady-state serum concentrations of other commonly used antiepileptic drugs (AEDs). Serum AED concentrations were measured at baseline and after adjunctive therapy with levetiracetam (1000-4000 mg/day) or placebo in four phase III trials...

    journal_title:Epilepsy research

    pub_type: 临床试验,杂志文章,meta分析,随机对照试验


    authors: Gidal BE,Baltès E,Otoul C,Perucca E

    更新日期:2005-03-01 00:00:00

  • The uncommon causes of status epilepticus: a systematic review.

    abstract::This paper reports the first systematic review of uncommon causes of status epilepticus reported in the literature between 1990 and 2008. Uncommon causes are defined as those not listed in the main epidemiological studies of status epilepticus. 181 causes were identified. These were easily categorised into 5 specific ...

    journal_title:Epilepsy research

    pub_type: 杂志文章,评审


    authors: Tan RY,Neligan A,Shorvon SD

    更新日期:2010-10-01 00:00:00

  • An in vitro study of focal epileptogenesis in combined hippocampal-parahippocampal slices.

    abstract::Brain slices from adult rats that included ventral hippocampus and adjacent parahippocampal areas were studied at various sites for the appearance of epileptiform discharges as extracellular potassium ([K+]o) was systematically varied over the range of 3 mM to 10 mM. The development of evoked epileptiform discharges (...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Bear J,Lothman EW

    更新日期:1993-03-01 00:00:00

  • Meta-analysis of perinatal factors associated with epilepsy in tropical countries.

    abstract::Most people with epilepsy live in tropical countries. Perinatal factors seem to play a significant role in the occurrence of epilepsy. Available data provide different and sometimes contradictory conclusions on the role and the burden of these factors. The aim of our study was to evaluate the effect of these perinatal...

    journal_title:Epilepsy research

    pub_type: 杂志文章,meta分析,评审


    authors: Dassi Tchoupa Revegue MH,Marin B,Ibinga E,Boumediene F,Preux PM,Ngoungou EB

    更新日期:2018-10-01 00:00:00

  • Effect of arterial blood pressure and serum glucose on brain intracellular pH, cerebral and cortical blood flow during status epilepticus in the white New Zealand rabbit.

    abstract::Generalized seizures can induce both hypertension and hyperglycemia which may aggravate preexisting cerebral or medical conditions in patients. In vivo fluorescent imaging of regional cortical blood flow and brain intracellular pH (pHi) was performed in fasted New Zealand rabbits (n = 35) in which either mean arterial...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Tomlinson FH,Anderson RE,Meyer FB

    更新日期:1993-02-01 00:00:00

  • Etiology and site of temporal lobe epilepsy influence postictal cytokine release.

    abstract::Inflammatory mechanisms are involved in the pathogenesis of epilepsy. Vice versa, immune functions are regulated by the brain. We measured postictal changes in serum levels of the immuno-modulating cytokines IL-1beta, IL-6 and TNFalpha in patients with well-defined temporal lobe epilepsy (TLE) and determined modifying...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Bauer S,Cepok S,Todorova-Rudolph A,Nowak M,Köller M,Lorenz R,Oertel WH,Rosenow F,Hemmer B,Hamer HM

    更新日期:2009-09-01 00:00:00

  • Developmental outcome in benign myoclonic epilepsy in infancy and reflex myoclonic epilepsy in infancy: a literature review and six new cases.

    abstract::Benign myoclonic epilepsy in infancy is a rare syndrome with just over 100 cases reported since the first syndromic description by Dravet and Bureau [Dravet, C., Bureau, M., 1981. The benign myoclonic epilepsy of infancy. Rev. Elecroencephalogr. Neurophysiol. Clin. 11, 438-444]. This includes 23 infants with reflex my...

    journal_title:Epilepsy research

    pub_type: 杂志文章,评审


    authors: Zuberi SM,O'Regan ME

    更新日期:2006-08-01 00:00:00

  • Proton MR spectroscopy of metabolite concentrations in temporal lobe epilepsy and effect of temporal lobe resection.

    abstract:PURPOSE:To use proton Magnetic Resonance Spectroscopy (MRS) to measure in vivo temporal lobe GABA and glutamate plus glutamine (GLX) concentrations in patients with temporal lobe epilepsy (TLE) attributable to unilateral hippocampal sclerosis (HS) before and following anterior temporal lobe resection (ATLR). METHODS:W...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Simister RJ,McLean MA,Barker GJ,Duncan JS

    更新日期:2009-02-01 00:00:00

  • Nonconvulsive status epilepticus with frontal features: quantitating severity of subclinical epileptiform discharges provides a marker for treatment efficacy, recurrence and outcome.

    abstract::Nonconvulsive status epilepticus (NCSE) is difficult to diagnose but is an important cause of cognitive impairment. Electroencephalogram (EEG) monitoring is required for diagnosis and treatment. Little is known regarding the stability of subclinical epileptiform discharges (SEDs) preceding NCSE nor what strategies may...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Licht EA,Fujikawa DG

    更新日期:2002-09-01 00:00:00

  • Brief asymmetric tonic posturing with diffuse low-voltage fast activity in seizures arising from the mesial parietal region.

    abstract:AIM:Seizures originating from the parietal lobe can demonstrate variable semiology. Our aim was to describe the electroclinical features of seizures originating from the mesial parietal lobe. METHOD:We identified four patients through the Comprehensive Epilepsy Program at our institution, who had strong evidence of a ...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Khan SA,Carney PW,Archer JS

    更新日期:2014-12-01 00:00:00