Metabolic and endocrine effects of valproic acid chronic treatment.

abstract：:The purpose of this study was to determine the influence of levetiracetam on the steady-state serum concentrations of other commonly used antiepileptic drugs (AEDs). Serum AED concentrations were measured at baseline and after adjunctive therapy with levetiracetam (1000-4000 mg/day) or placebo in four phase III trials...

journal_title：Epilepsy research

authors： Gidal BE,Baltès E,Otoul C,Perucca E

更新日期：2005-03-01 00:00:00

abstract：PURPOSE:To try to prove in patients with refractory symptomatic epilepsy due to early brain injury involving thalamus and complicated by CSWS the effects of the isolation of the injured hemisphere, performed with functional hemisperectomy, on epilepsy, namely on CSWS. METHODS:Full clinical follow-up before and after s...

journal_title：Epilepsy research

authors： Battaglia D,Veggiotti P,Lettori D,Tamburrini G,Tartaglione T,Graziano A,Veredice C,Sacco A,Chieffo D,Pecoraro A,Colosimo C,Di Rocco C,Dravet Ch,Guzzetta F

更新日期：2009-12-01 00:00:00

abstract：:This study aimed to assess neuropsychiatric comorbidities and analyze risk factors in Chinese children with epilepsy. Children with epilepsy aged between 6 and 16 years from the Children's Hospital of Fudan University were included. Children with asthma and typically developing children were matched for age and gender...

journal_title：Epilepsy research

authors： Li T,Zhou H,Li Y,Li C,Zhang Y,Zhou Y,Wang Y

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:Studies of adults who underwent temporal lobectomy for intractable temporal lobe epilepsy (TLE) demonstrated declining seizure free rates over time. Using seizure and social parameters, we followed patients who had temporal lobe surgery (TLS) in childhood to determine long-term outcomes. METHODS:We identified ...

journal_title：Epilepsy research

authors： Benifla M,Rutka JT,Otsubo H,Lamberti-Pasculli M,Elliott I,Sell E,RamachandranNair R,Ochi A,Weiss SK,Snead OC 3rd,Donner EJ

更新日期：2008-12-01 00:00:00

abstract：:The genetically epilepsy-prone rat (GEPR) has become an important model to study genetic predisposition to epilepsy involving not only the brainstem but also forebrain structures. Previous work in CA1 hippocampal cells showed a reduction in spike frequency adaptation and only subtle changes in slow afterhyperpolarizat...

journal_title：Epilepsy research

authors： Verma-Ahuja S,Evans MS,Pencek TL

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:Since intracranial electrode implantation has limited spatial sampling and carries significant risk, placement has to be effective and efficient. Structural and functional imaging of several different modalities contributes to localising the seizure onset zone (SoZ) and eloquent cortex. There is a need to su...

journal_title：Epilepsy research

authors： Rodionov R,Vollmar C,Nowell M,Miserocchi A,Wehner T,Micallef C,Zombori G,Ourselin S,Diehl B,McEvoy AW,Duncan JS

更新日期：2013-11-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate volumetric proton magnetic resonance spectroscopic imaging (MRSI) for localization of epileptogenic foci in neocortical epilepsy. METHODS:Twenty-five subjects reporting seizures considered to be of neocortical origin were recruited to take part in a 3-T MR study that inclu...

journal_title：Epilepsy research

authors： Maudsley AA,Domenig C,Ramsay RE,Bowen BC

更新日期：2010-02-01 00:00:00

abstract：:Increased excitatory amino acid transmission and decreased GABAergic inhibitory responses seem to be important mechanisms in the genesis of convulsions, where reactive oxygen species (ROS) have recently been suggested to play a critical role. Therefore, administration of antioxidants may be potentially beneficial for ...

journal_title：Epilepsy research

authors： Ribeiro MC,de Avila DS,Schneider CY,Hermes FS,Furian AF,Oliveira MS,Rubin MA,Lehmann M,Krieglstein J,Mello CF

更新日期：2005-08-01 00:00:00

abstract：PURPOSE:Although absence epilepsy is considered to be a prototypic type of generalized epilepsy, it is still under debate whether generalized 3 Hz spike-and-wave discharges (SWDs) might have a cortical focal origin. Here it is investigated whether focal interictal epileptiform discharges (IEDs), which typically occur i...

journal_title：Epilepsy research

authors： Rozendaal YJ,van Luijtelaar G,Ossenblok PP

更新日期：2016-01-01 00:00:00

abstract：:Dapsone (4,4'-diaminodiphenyl sulfone; DDS), an established anti-leprosy drug, showed anticonvulsive effects in the amygdaloid kindling model of epilepsy. Single doses of the drug in rats (6.25-12.5 mg/kg, i.p.) suppressed the kindled seizures in a dose-dependent manner without overt behavioral toxicity. With repeated...

journal_title：Epilepsy research

authors： Hamada K,Hiyoshi T,Kobayashi S,Ishida S,Yagi K,Seino M

更新日期：1991-11-01 00:00:00

abstract：:Evidence shows neurosteroids play a key role in regulating epileptogenesis. Neurosteroids such as testosterone modulate seizure susceptibility through its transformation to metabolites which show proconvulsant and anticonvulsant effects, respectively. Reduction of testosterone by aromatase generates proconvulsant 17-β...

journal_title：Epilepsy research

authors： Iqbal R,Jain GK,Siraj F,Vohora D

更新日期：2018-07-01 00:00:00

abstract：:We analyzed preoperative ictal SPECT results from 18 frontal lobe epilepsy patients who underwent epilepsy surgery (mean age 22.9 years). Seizure onset at implanted subdural electrodes was defined as the epileptic focus in 16 of 18 patients. In two additional patients, the resected area on postoperative magnetic reson...

journal_title：Epilepsy research

authors： Fukuda M,Masuda H,Honma J,Kameyama S,Tanaka R

更新日期：2006-02-01 00:00:00

abstract：INTRODUCTION:Recent ILAE classification defined focal cortical dysplasia (FCD) patients with accompanying epileptic lesions as a separate group. We investigated data of patients with sole FCD lesions regarding long-term seizure outcome and different characteristics of FCD type 1 and type 2 patients. METHODS:Eighty chi...

journal_title：Epilepsy research

authors： Isler C,Kucukyuruk B,Ozkara C,Gunduz A,Is M,Tanriverdi T,Comunoglu N,Oz B,Uzan M

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVE:To study potential delays in epilepsy surgery in children with drug-resistant epilepsy (DRE) of early-onset. METHODS:Medical records were reviewed from 87 children with DRE and seizure onset before age 3 years who underwent epilepsy surgery between 2006 and 2015. Information was obtained about each child's e...

journal_title：Epilepsy research

authors： Prideaux L,Barton S,Maixner W,Harvey AS

更新日期：2018-07-01 00:00:00

abstract：:Interactions of subclinical epileptiform EEG discharges and cognitive functioning were studied in 91 patients with epilepsy, under video monitoring, to exclude overt clinical ictal phenomena during the investigations. A short-term memory test was presented as an engaging television game, in two versions, using spatial...

journal_title：Epilepsy research

authors： Binnie CD,Kasteleijn-Nolst Trenité DG,Smit AM,Wilkins AJ

更新日期：1987-07-01 00:00:00

abstract：:Novel treatments for epilepsy are necessary because many epilepsy patients are resistant to medication. Metabotropic glutamate receptors (mGluRs), specifically mGluR 2 and 3, may serve as antiepileptic drug targets because of their role in controlling synaptic release. In this study, we administered a Group 2 mGluR ag...

journal_title：Epilepsy research

authors： Caulder EH,Riegle MA,Godwin DW

更新日期：2014-02-01 00:00:00

abstract：:The present study aimed at investigating to what extent the regulation of excitability in cortical networks, as indicated by surface-negative slow cortical potentials (SCPs), is impaired in epileptic patients and to what extent training of SCP self-regulation by means of biofeedback and instrumental learning procedure...

journal_title：Epilepsy research

authors： Rockstroh B,Elbert T,Birbaumer N,Wolf P,Düchting-Röth A,Reker M,Daum I,Lutzenberger W,Dichgans J

更新日期：1993-01-01 00:00:00

abstract：:Early Onset Absence Epilepsy constitutes an Idiopathic Generalized Epilepsy with absences starting before the age of four years. Mutations in SLC2A1, encoding the glucose transporter, account for approximately 10% of EOAE cases. The role of SLC2A1 mutations in absence epilepsies with a later onset has not been assesse...

journal_title：Epilepsy research

authors： Muhle H,Helbig I,Frøslev TG,Suls A,von Spiczak S,Klitten LL,Dahl HA,Brusgaard K,Neubauer B,De Jonghe P,Tommerup N,Stephani U,Hjalgrim H,Møller RS

更新日期：2013-07-01 00:00:00

abstract：:In order to assess the chloride channel gene CLCN2 as a candidate susceptibility gene for childhood absence epilepsy, parametric and non-parametric linkage analysis was performed in 65 nuclear pedigrees. This provided suggestive evidence for linkage with heterogeneity: NPL score=2.3, p<0.009; HLOD=1.5, alpha=0.44. Mut...

journal_title：Epilepsy research

authors： Everett K,Chioza B,Aicardi J,Aschauer H,Brouwer O,Callenbach P,Covanis A,Dooley J,Dulac O,Durner M,Eeg-Olofsson O,Feucht M,Friis M,Guerrini R,Heils A,Kjeldsen M,Nabbout R,Sander T,Wirrell E,McKeigue P,Robinson R,

更新日期：2007-07-01 00:00:00

abstract：:Clinical practitioners have often observed in the course of their daily work that the pain thresholds of epileptic patients seem to differ from those of healthy subjects. These patients can suffer from quite severe traumatic lesions without apparently experiencing any pain. Since they are usually under treatment for e...

journal_title：Epilepsy research

authors： Guieu R,Mesdjian E,Roger J,Dano P,Pouget J,Serratrice G

更新日期：1992-06-01 00:00:00

abstract：:AWD 140-190 a potent new anticonvulsant was tested on several types of epileptiform activities in entorhinal cortex hippocampal slices. AWD 140-190 suppressed completely and in a dose-dependent manner spontaneous seizure-like events induced by lowering extracellular Ca2+. In the low magnesium model, AWD 140-190 applie...

journal_title：Epilepsy research

authors： Armand V,Rundfeldt C,Heinemann U

更新日期：1997-12-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate whether there may be a correlation between the anatomical variants of Circle of Willis (CoW) and presence/laterality of mesial temporal sclerosis (MTS). METHODS:We retrospectively identified the CoW variants on Wada angiograms in 71 patients with pathologically proven...

journal_title：Epilepsy research

authors： Kuyumcu G,Byrne RW,Dawe RJ,Kocak M

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Epilepsy is among the more stigmatising diseases, leading to a negative impact on the quality of life (QoL) of people with epilepsy (PWE). Assessment of the QoL and stigma in PWE reflects the outcome of their disease, and the findings can be used to improve the management of epilepsy. To fill a gap in the li...

journal_title：Epilepsy research

authors： Mroueh L,Boumediene F,Jost J,Ratsimbazafy V,Preux PM,Salameh P,Al-Hajje A

更新日期：2020-11-01 00:00:00

abstract：:Mutations of the neuronal voltage-gated sodium channel alpha subunit type II (SCN2A) cause various epileptic syndromes, but have never been reported in association with acute encephalopathy. To validate the involvement of SCN2A mutations in acute encephalopathy, we screened 25 patients and found a novel missense mutat...

journal_title：Epilepsy research

authors： Kobayashi K,Ohzono H,Shinohara M,Saitoh M,Ohmori I,Ohtsuka Y,Mizuguchi M

更新日期：2012-11-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate by a prospective, self-controlled method, whether treatment with carbamazepine (CBZ) and sodium valproate (VPA) monotherapy may alter serum lipoprotein (a) [Lp(a)] concentrations in epileptic children. METHODS:Serum Lp(a) concentrations have been determined in 18 epilep...

journal_title：Epilepsy research

authors： Voudris KA,Attilakos A,Katsarou E,Drakatos A,Dimou S,Mastroyianni S,Skardoutsou A,Prassouli A,Garoufi A

更新日期：2006-08-01 00:00:00

abstract：PURPOSE:The present study was undertaken to clarify the participation of the GABA-ergic system in epileptogenic activity induced by teicoplanin. METHODS:Under pentobarbital anesthesia, mice were fixed to a stereotaxic apparatus, and stainless steel electrodes were implanted into the frontal cortex (FCOR), hippocampus ...

journal_title：Epilepsy research

authors： Takechi K,Fujiwara A,Watanabe Y,Kamei C

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Valproate is used widely for the treatment of epilepsy but has been associated with hyperandrogenism, hyperinsulinemia, and dyslipidemia. The mechanism for these associations is unknown, but they have been hypothesized to be secondary to valproate-associated weight gain. This study was conducted to test the ...

journal_title：Epilepsy research

authors： Morrell MJ,Isojärvi J,Taylor AE,Dam M,Ayala R,Gomez G,O'Neill F,Tennis P,Messenheimer J

更新日期：2003-05-01 00:00:00

abstract：:Single photon emission computed tomography (SPECT) is increasingly being used as an adjunctive technique in the localisation of epileptogenic foci prior to surgery. As yet, few studies have been undertaken to establish the clinical associations of areas of reduced cerebral perfusion. Sixty-three consecutive patients (...

journal_title：Epilepsy research

authors： Duncan S,Gillen G,Adams FG,Duncan R,Brodie MJ

更新日期：1992-10-01 00:00:00

abstract：:This study was carried out to evaluate Synthetic Aperture Magnetometry-kurtosis (SAM(g(2))), a spatially filtered source localization technique in magnetoencephalography (MEG), for identification of epileptogenic areas of focal cortical dysplasia (FCD). Three children with FCD were investigated to localize the ictal o...

journal_title：Epilepsy research

authors： Ishii R,Canuet L,Ochi A,Xiang J,Imai K,Chan D,Iwase M,Takeda M,Snead OC 3rd,Otsubo H

更新日期：2008-10-01 00:00:00

abstract：PURPOSE:In patients with left temporal lobe epilepsy (TLE) due to hippocampal sclerosis (HS) decreased naming ability is common, suggesting a critical role for the medial left temporal lobe in this task. We investigated the integrity of language networks with functional MRI (fMRI) in controls and TLE patients. EXPERIM...

journal_title：Epilepsy research

authors： Bonelli SB,Powell R,Thompson PJ,Yogarajah M,Focke NK,Stretton J,Vollmar C,Symms MR,Price CJ,Duncan JS,Koepp MJ

更新日期：2011-08-01 00:00:00