当前位置： SCI文献检索 > EPILEPSY RESEARCH期刊下所有文献 > Potential delays in referral and assessment for epilepsy surgery in children with drug-resistant, early-onset epilepsy.

Potential delays in referral and assessment for epilepsy surgery in children with drug-resistant, early-onset epilepsy.

Abstract：

OBJECTIVE:To study potential delays in epilepsy surgery in children with drug-resistant epilepsy (DRE) of early-onset. METHODS:Medical records were reviewed from 87 children with DRE and seizure onset before age 3 years who underwent epilepsy surgery between 2006 and 2015. Information was obtained about each child's epilepsy, treatment and specific time points in management. Time intervals along diagnostic, investigative, treatment and referral pathways were calculated. RESULTS:Median ages at seizure onset, when seen in the epilepsy surgery program and surgery were 5.9 (IQR 10), 19 (IQR 29) and 36 (IQR 67) months; the median delay from seizure onset to surgery was 30 (IQR 67) months. Most children were promptly diagnosed, treated, investigated and seen by a pediatric neurologist. Focal abnormalities were reported on initial EEGs and MRIs in most children, and DRE developed within a median of 6.3 months from commencement of medication. There were median durations of 6.2 months between seeing a neurologist and being seen in the epilepsy surgery program, and then 6.1 months in determining surgical candidacy. Median durations from potential indications for a surgical evaluation to agreed surgical candidacy were 10 (DRE), 12 (focal MRI) and 17 (focal EEG) months. Children received a median of six antiepileptic drugs prior to surgery. Median interval from agreed surgical candidacy to surgery was only 3 months. There were longer durations from seizure onset to surgery in children needing PET (p = 0.001) and in children with seizure-free periods (p < 0.001), and shorter durations in children with a history of infantile spasms (p = 0.01). SIGNIFICANCE:Delays in referral of children for epilepsy surgery are reported. Delays in assessment may be specific to centralized children's hospitals in public health systems.

journal_name

Epilepsy Res

journal_title

Epilepsy research

authors

Prideaux L,Barton S,Maixner W,Harvey AS

doi

10.1016/j.eplepsyres.2018.04.001

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

20-26

eissn

0920-1211

issn

1872-6844

pii

S0920-1211(17)30645-9

journal_volume

143

pub_type

杂志文章

相关文献

EPILEPSY RESEARCH文献大全
  • Neuroprotective effect of remacemide hydrochloride in a perforant pathway stimulation model of status epilepticus in the rat.

    abstract：:Previous studies have demonstrated that remacemide and its desglycinyl metabolite, AR-R 2495AA, reduce neuronal damage in animal models of ischemia, subarachnoid hemorrhage, and traumatic brain injury. The aim of the present study was to investigate whether remacemide hydrochloride also alleviates seizure-induced neur...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/s0920-1211(98)00122-3

    authors： Halonen T,Nissinen J,Pitkänen A

    更新日期：1999-04-01 00:00:00

  • Effects of adrenal dysfunction and high-dose adrenocorticotropic hormone on NMDA-induced spasm seizures in young Wistar rats.

    abstract：:Infantile spasms (IS) is a devastating epilepsy syndrome treated with adrenocorticotropic hormone (ACTH). To demonstrate the effects of adrenal dysfunction, adrenalectomy (ADX) and N-methyl-d-aspartate (NMDA)-induced rat model studies of IS were performed. The latency of the seizure in the ADX group decreased and the ...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2012.02.001

    authors： Wang YJ,Zhang Y,Liang XH,Yang G,Zou LP

    更新日期：2012-06-01 00:00:00

  • Intracranial EEG findings in patients with lesional lateral temporal lobe epilepsy.

    abstract：PURPOSE:Intracranial EEG in patients with lesional lateral temporal lobe epilepsy is rarely reported. Therefore, the number of patients with seizures arising independently from ipsilateral mesial structures or contralateral hemisphere has not been clarified. We analyzed the intracranial EEG of cases with localized lesi...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2007.10.009

    authors： Usui N,Mihara T,Baba K,Matsuda K,Tottori T,Umeoka S,Nakamura F,Terada K,Usui K,Inoue Y

    更新日期：2008-01-01 00:00:00

  • Resting motor threshold in idiopathic generalized epilepsies: a systematic review with meta-analysis.

    abstract：:Resting motor threshold (rMT) assessed by means of Transcranial Magnetic Stimulation (TMS) is thought to reflect trans-synaptic excitability of cortico-spinal neurons. TMS studies reporting rMT in idiopathic generalized epilepsies (IGEs) yielded discrepant results, so that it is difficult to draw a definitive conclusi...

    journal_title：Epilepsy research

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.eplepsyres.2012.03.020

    authors： Brigo F,Storti M,Benedetti MD,Rossini F,Nardone R,Tezzon F,Fiaschi A,Bongiovanni LG,Manganotti P

    更新日期：2012-08-01 00:00:00

  • Suppression of inter-ictal spikes by CM40907. A double-blind placebo-controlled investigation and review of spike counting as a methodology for assessing the antiepileptic effect of drugs.

    abstract：:To assess the efficacy of CM40907--a new antiepileptic drug--in suppressing inter-ictal spikes, 6 patients with severe intractable epilepsy and frequent spikes in their inter-ictal EEGs were entered in a double-blind placebo-controlled trial. The results show that CM40907 is efficacious in reducing spike counts in the...

    journal_title：Epilepsy research

    pub_type： 临床试验,杂志文章

    doi：10.1016/0920-1211(90)90046-x

    authors： Yepez-Lasso R,Duncan JS,Shorvon SD

    更新日期：1990-04-01 00:00:00

  • The influence of old age and enzyme inducing comedication on the pharmacokinetics of valproic acid at steady-state: A case-matched evaluation based on therapeutic drug monitoring data.

    abstract：PURPOSE:To evaluate the influence of aging on the pharmacokinetics of valproic acid (VPA) at steady-state and on the susceptibility of VPA metabolism to enzyme induction by antiepileptic comedication. METHODS:The database of the therapeutic drug monitoring service of a large neurological hospital was searched to ident...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2006.04.002

    authors： Fattore C,Messina S,Battino D,Croci D,Mamoli D,Perucca E

    更新日期：2006-08-01 00:00:00

  • High dose (4 mg/kg/day) versus usual dose (2 mg/kg/day) oral prednisolone for treatment of infantile spasms: an open-label, randomized controlled trial.

    abstract：OBJECTIVES:This study aimed to test the hypothesis that high-dose prednisolone (4 mg/kg/day) may be more efficacious than usual-dose (2 mg/kg/day) prednisolone for spasm resolution at 14-days in children with infantile spasms. METHODS:This was a randomized, open-label-trial conducted at a tertiary-level-hospital from ...

    journal_title：Epilepsy research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.eplepsyres.2014.06.019

    authors： Chellamuthu P,Sharma S,Jain P,Kaushik JS,Seth A,Aneja S

    更新日期：2014-10-01 00:00:00

  • Introduction to zonisamide.

    abstract：:Zonisamide (Zonegran), a novel antiepileptic drug (AED) approved recently in Europe as adjunctive therapy for refractory partial seizures in adults, has been used extensively in Japan and the United States. A substantial body of clinical experience has accumulated over a 14-year period, allowing the properties and pha...

    journal_title：Epilepsy research

    pub_type： 杂志文章,评审

    doi：10.1016/j.eplepsyres.2005.11.004

    authors： Baulac M

    更新日期：2006-02-01 00:00:00

  • Epileptiform activity promotes decreasing of Ca2+ conductivity of NMDARs, AMPARs, KARs, and voltage-gated calcium channels in Mg2+-free model.

    abstract：:NMDA, AMPA, and kainate receptors are the principal excitatory receptors in the brain. These receptors have been considered as the main targets in the treatment of epilepsy in recent years. This work aimed to determine how the Ca2+ conductivity of ionotropic glutamate receptors and voltage-gated Ca2+ channels changes ...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2019.106224

    authors： Gaidin SG,Zinchenko VP,Teplov IY,Tuleukhanov ST,Kosenkov AM

    更新日期：2019-12-01 00:00:00

  • The role of neurosteroids in the pathophysiology and treatment of catamenial epilepsy.

    abstract：:Catamenial epilepsy is a multifaceted neuroendocrine condition in which seizures are clustered around specific points in the menstrual cycle, most often around perimenstrual or periovulatory period. Generally, a twofold or greater increase in seizure frequency during a particular phase of the menstrual cycle could be ...

    journal_title：Epilepsy research

    pub_type： 杂志文章,评审

    doi：10.1016/j.eplepsyres.2009.02.017

    authors： Reddy DS

    更新日期：2009-07-01 00:00:00

  • Long-term functional consequences of transient occlusion of the middle cerebral artery in rats: a 1-year follow-up of the development of epileptogenesis and memory impairment in relation to sensorimotor deficits.

    abstract：:Post-stroke seizures occur in 5-20% of patients. Modeling of stroke-induced seizures in animals provides a useful tool for investigating the molecular basis of epileptogenesis and for developing therapies for stroke patients at increased risk for epileptogenesis. The questions addressed in the study were: (1) Do rats ...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/s0920-1211(03)00034-2

    authors： Karhunen H,Pitkänen A,Virtanen T,Gureviciene I,Pussinen R,Ylinen A,Sivenius J,Nissinen J,Jolkkonen J

    更新日期：2003-04-01 00:00:00

  • Population pharmacokinetics of gabapentin in infants and children.

    abstract：PURPOSE:To characterize gabapentin pharmacokinetics in infants and children using a population approach and to identify important demographic and/or physiologic determinants of gabapentin disposition. METHODS:Gabapentin was administered in single doses of 10 mg/kg (N=48 healthy subjects, age 1 month-12 years) or in mu...

    journal_title：Epilepsy research

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0920-1211(01)00311-4

    authors： Ouellet D,Bockbrader HN,Wesche DL,Shapiro DY,Garofalo E

    更新日期：2001-12-01 00:00:00

  • Seizure detection using digital trend analysis: Factors affecting utility.

    abstract：BACKGROUND:EEG monitoring is important for the early detection of seizures during the course of critical illness. However, the logistics of real time EEG interpretation is challenging for the neurophysiology and critical care medicine teams. This study evaluated factors affecting the utility of digital trend analysis (...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2010.10.018

    authors： Akman CI,Micic V,Thompson A,Riviello JJ Jr

    更新日期：2011-01-01 00:00:00

  • Excitability changes in freeze-induced neocortical microgyria.

    abstract：:A freezing probe was placed on the skull of postnatal day (PN) 1 rats to induce formation of a cerebrocortical microsulcus. Experimental studies were performed on PN days 21-24. At that time point, Nissl-stained sections revealed the presence of a microsulcus similar to that described in human dysplastic cortex. Immun...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/s0920-1211(98)00041-2

    authors： Hablitz JJ,DeFazio T

    更新日期：1998-09-01 00:00:00

  • Dysregulation of microRNA-128 expression in WHO grades 2 glioma is associated with glioma-associated epilepsy: Down-regulation of miR-128 induces glioma-associated seizure.

    abstract：OBJECTIVE:Approximately 80% of glioma patients will experience at least one seizure activity during the course of the disease, and because the etiology of glioma-related seizure is most likely multifactorial and complex, it remains poorly understood. MicroRNAs are a class of small noncoding RNAs that function as critic...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2016.08.005

    authors： Yuan Y,Xiang W,Yanhui L,Ruofei L,Yunhe M,Jiewen L,Qing M

    更新日期：2016-11-01 00:00:00

  • Involvement of nitric oxide-cGMP pathway in the anticonvulsant effects of lithium chloride on PTZ-induced seizure in mice.

    abstract：:Lithium is still the mainstay in the treatment of affective disorders as a mood stabilizer. Lithium also shows some anticonvulsant properties. While the underlying mechanisms of action of lithium are not yet exactly understood, we used a model of clonic seizure induced by pentylenetetrazole (PTZ) in male NMRI mice to ...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2010.02.001

    authors： Bahremand A,Nasrabady SE,Ziai P,Rahimian R,Hedayat T,Payandemehr B,Dehpour AR

    更新日期：2010-05-01 00:00:00

  • Exposure of hippocampal slices to magnesium-free medium produces epileptiform activity and simultaneously decreases calcium and calmodulin-dependent protein kinase II activity.

    abstract：:The effect of magnesium-free medium on electrical and CaM kinase II activity in the rat hippocampal slice was examined. Experimental slices were incubated in 2 mM Mg, then exposed to magnesium-free medium for 1 h. Control slices were concurrently run in 2 mM Mg. Slices were then frozen and CaM kinase II activity was m...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/0920-1211(91)90054-j

    authors： Churn SB,Anderson WW,DeLorenzo RJ

    更新日期：1991-09-01 00:00:00

  • Prognosis of patients with mesial temporal lobe epilepsy due to hippocampal sclerosis.

    abstract：PURPOSE:Hippocampal sclerosis (HS) is the most common pathology in mesial temporal lobe epilepsy (MTLE). There are a few reports concerning prognosis in patients with MTLE-HS treated medically. The study was carried out to determine the clinical risk factors affecting prognosis. METHODS:We enrolled 287 patients with M...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2009.03.001

    authors： Varoglu AO,Saygi S,Acemoglu H,Ciger A

    更新日期：2009-08-01 00:00:00

  • Magnetoencephalography in fronto-parietal opercular epilepsy.

    abstract：OBJECTIVE:To clarify the clinical and neurophysiological profiles of fronto-parietal opercular epilepsy in which epileptic spikes are detected with magnetoencephalography (MEG) but not with scalp electroencephalography (EEG). METHODS:Four patients presented with epileptic spikes localized to the fronto-parietal opercu...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2012.05.003

    authors： Kakisaka Y,Iwasaki M,Alexopoulos AV,Enatsu R,Jin K,Wang ZI,Mosher JC,Dubarry AS,Nair DR,Burgess RC

    更新日期：2012-11-01 00:00:00

  • Efficacy and safety of adjunctive zonisamide therapy for refractory partial seizures.

    abstract：:An approach to the selection of appropriate antiepileptic drugs (AEDs) for inclusion in polytherapy is to take into account both the efficacy of a drug and also its mechanism of action and pharmacokinetic profile. The AED zonisamide is licensed in Europe and the USA for use as adjunctive therapy in adult patients with...

    journal_title：Epilepsy research

    pub_type： 杂志文章,评审

    doi：10.1016/j.eplepsyres.2007.04.007

    authors： Baulac M,Leppik IE

    更新日期：2007-07-01 00:00:00

  • Cost-effectiveness of add-on lamotrigine therapy in clinical practice.

    abstract：OBJECTIVE:This retrospective study addresses the cost-effectiveness of add-on therapy with lamotrigine in clinical practice. METHODS:Two years' observational data of 165 patients were used. Seizure frequency, adverse effects and direct medical costs were recorded for the year before and the year after the start of lam...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2005.09.007

    authors： Knoester PD,Boendermaker AJ,Egberts AC,Hekster YA,Keyser A,Severens JL,Renier WO,Deckers CL

    更新日期：2005-12-01 00:00:00

  • Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBOX in maximal electroshock and chemoconvulsant seizure models.

    abstract：:The anticonvulsant activities of a noncompetitive (GYKI 52466) and a competitive (NBQX) AMPA/kainate antagonist were compared in the maximal electroshock (MES) seizure test and various chemoconvulsant models. Both antagonists were protective in the MES and pentylenetetrazol tests. GYKI 52466 was also protective agains...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/0920-1211(93)90054-b

    authors： Yamaguchi S,Donevan SD,Rogawski MA

    更新日期：1993-07-01 00:00:00

  • Effect of arterial blood pressure and serum glucose on brain intracellular pH, cerebral and cortical blood flow during status epilepticus in the white New Zealand rabbit.

    abstract：:Generalized seizures can induce both hypertension and hyperglycemia which may aggravate preexisting cerebral or medical conditions in patients. In vivo fluorescent imaging of regional cortical blood flow and brain intracellular pH (pHi) was performed in fasted New Zealand rabbits (n = 35) in which either mean arterial...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/0920-1211(93)90017-2

    authors： Tomlinson FH,Anderson RE,Meyer FB

    更新日期：1993-02-01 00:00:00

  • Spatiotemporal mapping of interictal epileptiform discharges in human absence epilepsy: A MEG study.

    abstract：PURPOSE:Although absence epilepsy is considered to be a prototypic type of generalized epilepsy, it is still under debate whether generalized 3 Hz spike-and-wave discharges (SWDs) might have a cortical focal origin. Here it is investigated whether focal interictal epileptiform discharges (IEDs), which typically occur i...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2015.11.013

    authors： Rozendaal YJ,van Luijtelaar G,Ossenblok PP

    更新日期：2016-01-01 00:00:00

  • Folate status in women of childbearing age with epilepsy.

    abstract：:Treatment with cytochrome P450 enzyme-inducing antiepileptic drugs (P450-inducing AEDs) is known to interfere with folate metabolism. Low folate status is of special concern in women with epilepsy who might become pregnant. Therefore, folate status was assessed in women age 16-42 treated for epilepsy. Staple food is n...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2007.04.003

    authors： Kampman MT

    更新日期：2007-06-01 00:00:00

  • Electro-clinical analysis of epilepsy patients with generalized seizures on adjunctive perampanel treatment.

    abstract：:Quantifying epileptiform discharges before and after the initiation of treatment can be useful for evaluating the efficacy of antiepileptic drugs in generalized epilepsy. The aim of this study was to determine if the selective α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor antagonist perampanel ...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2020.106378

    authors： Montoya Gutiérrez FJ,Díaz Román M,Cerveró Albert D

    更新日期：2020-09-01 00:00:00

  • Genetic and clinical features of SCN8A developmental and epileptic encephalopathy.

    abstract：OBJECTIVE:We aim to delineate the genetic and clinical features of SCN8A developmental and epileptic encephalopathy. METHODS:Nine patients with SCN8A developmental and epileptic encephalopathy were included in this study. Genetic and clinical features and effectiveness of sodium channel blockers were assessed in patie...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2019.106222

    authors： Kim HJ,Yang D,Kim SH,Kim B,Kim HD,Lee JS,Choi JR,Lee ST,Kang HC

    更新日期：2019-12-01 00:00:00

  • Unilateral cortical spreading depression is an early marker of audiogenic kindling in awake rats.

    abstract：:Spreading depression (SD), a self-propagating wave of reversible cellular depolarization, is thought to play an important role in brain pathophysiology. SD and seizures are closely related events but little is known about involvement of SD in chronic epileptogenesis. Here we show that cortical SD is the first and high...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2006.05.014

    authors： Vinogradova LV,Vinogradov VY,Kuznetsova GD

    更新日期：2006-09-01 00:00:00

  • Optimised interictal HMPAO-SPECT in the evaluation of partial epilepsies.

    abstract：:Interictal blood flow single photon emission computed tomography (SPECT) has been considered to be of limited value in the investigation of patients with partial epilepsies. Newer SPECT technologies using brain dedicated multiple detector systems have not been fully evaluated. To study the usefulness of an optimized S...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/0920-1211(95)00020-b

    authors： Schmitz EB,Costa DC,Jackson GD,Moriarty J,Duncan JS,Trimble MR,Ell PJ

    更新日期：1995-06-01 00:00:00

  • Increased indoleamine 2,3-dioxygenase (IDO) activity in idiopathic generalized epilepsy.

    abstract：PURPOSE:Indoleamine 2,3-dioxygenase (IDO) is a cytokine-inducible enzyme that participates in tryptophan (trp) and serotonin metabolism with an ability to modulate neuroinflammation. Several recent studies have shown associations between cytokines and epilepsy. In this study we investigated whether activation of IDO is...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2011.02.003

    authors： Liimatainen S,Lehtimäki K,Raitala A,Peltola M,Oja SS,Peltola J,Hurme MA

    更新日期：2011-05-01 00:00:00