Abstract:
:NMDA, AMPA, and kainate receptors are the principal excitatory receptors in the brain. These receptors have been considered as the main targets in the treatment of epilepsy in recent years. This work aimed to determine how the Ca2+ conductivity of ionotropic glutamate receptors and voltage-gated Ca2+ channels changes in an in vitro model of epilepsy. For induction of epileptiform activity, hippocampal neurons were exposed to Mg2+-free medium. It has been shown that removal of Mg2+ from the medium not only removes the block from the NMDA receptors but also stimulates the release of glutamate in a way that is independent of the NMDA receptors. Under these conditions, the structure of the bursts significantly differs from the spontaneous bursts arising in mature hippocampal cultures. We have demonstrated that the frequency and amplitude of Mg2+-free medium-induced Ca2+ oscillations decrease after the 60-min exposure. Besides, the Ca2+ conductivity of ionotropic glutamate receptors and voltage-gated calcium channels significantly reduces. Thus, the decrease of Ca2+ conductivity can be considered as one of the mechanisms of adaptation during epilepsy.
journal_name
Epilepsy Resjournal_title
Epilepsy researchauthors
Gaidin SG,Zinchenko VP,Teplov IY,Tuleukhanov ST,Kosenkov AMdoi
10.1016/j.eplepsyres.2019.106224subject
Has Abstractpub_date
2019-12-01 00:00:00pages
106224eissn
0920-1211issn
1872-6844pii
S0920-1211(19)30402-4journal_volume
158pub_type
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journal_title:Epilepsy research
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journal_title:Epilepsy research
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journal_title:Epilepsy research
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journal_title:Epilepsy research
pub_type: 杂志文章,多中心研究
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journal_title:Epilepsy research
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journal_title:Epilepsy research
pub_type: 杂志文章
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journal_title:Epilepsy research
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Epilepsy research
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Epilepsy research
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journal_title:Epilepsy research
pub_type: 杂志文章,评审
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更新日期:2019-03-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/0920-1211(92)90010-q
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pub_type: 杂志文章
doi:10.1016/j.eplepsyres.2014.08.016
更新日期:2014-11-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/j.eplepsyres.2017.04.007
更新日期:2017-07-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章,meta分析,评审
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更新日期:2012-02-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/j.eplepsyres.2003.08.001
更新日期:2003-09-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/j.eplepsyres.2014.01.009
更新日期:2014-03-01 00:00:00
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journal_title:Epilepsy research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2002-04-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章,多中心研究
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更新日期:2012-06-01 00:00:00