当前位置： SCI文献检索 > EPILEPSY RESEARCH期刊下所有文献 > Dysregulation of microRNA-128 expression in WHO grades 2 glioma is associated with glioma-associated epilepsy: Down-regulation of miR-128 induces glioma-associated seizure.

Dysregulation of microRNA-128 expression in WHO grades 2 glioma is associated with glioma-associated epilepsy: Down-regulation of miR-128 induces glioma-associated seizure.

Abstract：

OBJECTIVE:Approximately 80% of glioma patients will experience at least one seizure activity during the course of the disease, and because the etiology of glioma-related seizure is most likely multifactorial and complex, it remains poorly understood. MicroRNAs are a class of small noncoding RNAs that function as critical gene regulators. MicroRNA-128 was found to be decreased in glioblastoma, and knockout of the microRNA-128a gene could induce epilepsy in mice. Based on the Chinese Glioma Genome Atlas and previous study, we hypothesized that dysregulation of miR-128 expression may play a role in the pathogenesis of TAE in low-grade glioma. METHODS:Fifty-three low-grade glioma samples were analyzed for the expression levels of miR-128 using qRT-PCR, and candidate targets of miR-128 (Cacnge2, GRIK3, and GRIN2D) were detected by the 3'-UTR luciferase reporter assay. Four other miRs (miR-9, miR-192a, miR-92a, and miR-451) that showed dysregulation of glioblastoma in the CGGA data were also analyzed. RESULTS:The microRNA-128 expression levels were down-regulated in low-grade glioma tissue (t-test; p=0.009). Dysregulation of miR-128 expression in low-grade glioma is associated with glioma-associated epilepsy (p=0.006). No statistical significance of miR-9, miR-192a, miR-92a, and miR-451 was found to be associated with LGG. CONCLUSION:Our results here, together with other recent lines of evidence, indicate that miR-128 is an extremely attractive target for therapy in glioma patients with seizure.

journal_name

Epilepsy Res

journal_title

Epilepsy research

authors

Yuan Y,Xiang W,Yanhui L,Ruofei L,Yunhe M,Jiewen L,Qing M

doi

10.1016/j.eplepsyres.2016.08.005

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

6-11

eissn

0920-1211

issn

1872-6844

pii

S0920-1211(16)30125-5

journal_volume

127

pub_type

杂志文章

相关文献

EPILEPSY RESEARCH文献大全
  • Differences in evoked potential characteristics between DRPLA patients and patients with progressive myoclonic epilepsy: preliminary findings indicating usefulness for differential diagnosis.

    abstract：:The characteristics of evoked potentials in patients with dentatorubral-pallidoluysian atrophy (DRPLA) were investigated. Twelve patients with DRPLA and three patients with progressive myoclonic epilepsy (PME) attributable to other causes participated in the study. In 11 out of the 12 patients, the diagnosis of DRPLA ...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/s0920-1211(99)00028-5

    authors： Kasai K,Onuma T,Kato M,Kato T,Takeya J,Sekimoto M,Watanabe K,Minami N,Goto Y,Minabe Y

    更新日期：1999-10-01 00:00:00

  • Cerebrospinal fluid findings in non-infectious status epilepticus.

    abstract：OBJECTIVE:Ictal activity itself can cause pathological cerebrospinal fluid (CSF) findings. However, data regarding pathological CSF findings caused by SE itself to date remain scarce. We here evaluated the frequency and specificity of pathological CSF findings in non-infectious SE. METHODS:We performed a retrospective...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2017.12.008

    authors： Malter MP,Choi S,Fink GR

    更新日期：2018-02-01 00:00:00

  • Familial mesial temporal lobe epilepsy in Mexico: Inheritance pattern and clinical features.

    abstract：PURPOSE:The objectives of this study were to determine the inheritance pattern by which familial mesial temporal lobe epilepsy (FMTLE) is segregated in Mexican families, and to identify if there was an association between the clinical characteristics and the inheritance pattern. METHOD:We included a total of 25 famili...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2020.106450

    authors： Guzmán-Jiménez DE,Campos JB,Venegas-Vega CA,Sánchez MA,Velasco AL

    更新日期：2020-11-01 00:00:00

  • Hyponatremic coma under oxcarbazepine therapy.

    abstract：:Oxcarbazepine (OXC) is considered to be a promising new antiepileptic drug with similar efficacy and better tolerability compared to carbamazepine (CBZ). However, hyponatremia is supposed to occur even more often than with CBZ. We report on a patient who developed hyponatremic coma under OXC with a serum sodium level ...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/0920-1211(92)90023-m

    authors： Steinhoff BJ,Stoll KD,Stodieck SR,Paulus W

    更新日期：1992-03-01 00:00:00

  • Epilepsy and multiple sclerosis: Increased risk among progressive forms.

    abstract：:Multiple sclerosis (MS) patients are at higher risk for epilepsy. Epilepsy was frequent among our MS patients (6.55%). Progressive MS forms were associated with higher incidence of epilepsy (p=0.021). Partial motor seizures were observed in five patients (62.5%) and generalized tonic-clonic in three (37.5%). Electroen...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2009.01.009

    authors： Martínez-Juárez IE,López-Meza E,González-Aragón Mdel C,Ramírez-Bermúdez J,Corona T

    更新日期：2009-04-01 00:00:00

  • TBC1D24 mutation associated with focal epilepsy, cognitive impairment and a distinctive cerebro-cerebellar malformation.

    abstract：:We describe the clinical and radiological features of a family with a homozygous mutation in TBC1D24. The phenotype comprised onset of focal seizures at 2 months with prominent eye-blinking, facial and limb jerking with an oral sensory aura. These were controllable with medication but persisted into adult life. Associ...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2013.02.005

    authors： Afawi Z,Mandelstam S,Korczyn AD,Kivity S,Walid S,Shalata A,Oliver KL,Corbett M,Gecz J,Berkovic SF,Jackson GD

    更新日期：2013-07-01 00:00:00

  • Prescription patterns of antiepileptic drugs in patients with epilepsy in a nation-wide population.

    abstract：BACKGROUND:Many new antiepileptic drugs (AEDs) have become available in recent years. Investigations of prescription patterns and exposure of AEDs to different patient groups are important regarding drug safety aspects. The aim of this study was to investigate the use of AEDs in epilepsy, with focus on exposure of AEDs...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2011.02.012

    authors： Landmark CJ,Fossmark H,Larsson PG,Rytter E,Johannessen SI

    更新日期：2011-06-01 00:00:00

  • Age-dependent anticonvulsant action of antagonists of group I glutamate metabotropic receptors in rats.

    abstract：SUMMARY:Metabotropic glutamate receptors (mGluR) may represent a perspective target for anticonvulsant therapy but spectrum of their anticonvulsant effects is not sufficiently known. Our study was aimed at comparison of anticonvulsant actions of antagonists of mGluR1 and mGluR5 subtypes in immature rats. Seven-, 12-, 1...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2008.11.004

    authors： Mares P

    更新日期：2009-02-01 00:00:00

  • Pharmacokinetics, exposure-cognition, and exposure-efficacy relationships of perampanel in adolescents with inadequately controlled partial-onset seizures.

    abstract：OBJECTIVE:To characterize, in adolescents aged 12-17, the pharmacokinetic (PK) profile of perampanel, the impact of intrinsic and extrinsic factors on PK, and the relationships between perampanel exposure and cognitive function, seizure frequency, and responder status. METHODS:Population PK analysis used plasma concen...

    journal_title：Epilepsy research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.eplepsyres.2016.08.025

    authors： Villanueva V,Majid O,Nabangchang C,Yang H,Laurenza A,Ferry J,Hussein Z

    更新日期：2016-11-01 00:00:00

  • Effects of levetiracetam as a monotherapy on bone mineral density and biochemical markers of bone metabolism in patients with epilepsy.

    abstract：PURPOSE:Antiepileptic drugs (AEDs) may have adverse effects on bone metabolism and bone mineral density (BMD). The aim of this study is to determine the changes of bone metabolism and BMD in epilepsy patients who are undergoing levetiracetam (LEV) monotherapy. METHODS:Drug-naïve, sixty-one patients with recent onset e...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2012.09.002

    authors： Koo DL,Joo EY,Kim D,Hong SB

    更新日期：2013-03-01 00:00:00

  • Electrocorticographic events from long-term ambulatory brain recordings can potentially supplement seizure diaries.

    abstract：PURPOSE:To determine the feasibility of using epileptiform events detected by continuous electrocorticographic monitoring via a brain-responsive neurostimulation system to supplement patient-maintained seizure diaries. METHODS:Data were retrospectively analyzed from a randomized controlled trial of brain-responsive ne...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2020.106302

    authors： Quigg M,Skarpaas TL,Spencer DC,Fountain NB,Jarosiewicz B,Morrell MJ

    更新日期：2020-03-01 00:00:00

  • Rufinamide: a double-blind, placebo-controlled proof of principle trial in patients with epilepsy.

    abstract：OBJECTIVE:This was the first proof of principle clinical trial assessing the efficacy and safety of rufinamide as adjunctive therapy in epileptic patients. The pharmacokinetic (PK) profile of rufinamide was also determined. METHODS:Fifty patients with diagnoses of partial or primary generalized tonic-clonic seizures w...

    journal_title：Epilepsy research

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/s0920-1211(00)00185-6

    authors： Pålhagen S,Canger R,Henriksen O,van Parys JA,Rivière ME,Karolchyk MA

    更新日期：2001-02-01 00:00:00

  • Family history and frontal lobe seizures predict long-term remission in newly diagnosed cryptogenic focal epilepsy.

    abstract：PURPOSE:Cryptogenic focal epilepsy (CFE) is a heterogeneous clinical disorder including patients with severe refractory forms and patients with a fairly good prognosis. Predictors of prognosis in CFE are poorly understood. The aim of this retrospective study is to identify long-term (5-year) prognostic predictors in pa...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2013.07.004

    authors： Gasparini S,Ferlazzo E,Beghi E,Tripepi G,Labate A,Mumoli L,Leonardi CG,Cianci V,Latella MA,Gambardella A,Aguglia U

    更新日期：2013-11-01 00:00:00

  • Dynamic magnetic source imaging of absence seizure initialization and propagation: a magnetoencephalography study.

    abstract：PURPOSE:The present study aims to determine the initialization and propagation of typical absence seizures using magnetoencephalography (MEG). METHOD:Fourteen drug-naïve children with childhood absence epilepsy (CAE) were studied using a 275-Channel MEG system. The spectral signatures of epileptic activity were assess...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2014.01.006

    authors： Miao A,Tang L,Xiang J,Guan Q,Ge H,Liu H,Wu T,Chen Q,Yang L,Lu X,Hu Z,Wang X

    更新日期：2014-03-01 00:00:00

  • Felbamate-induced apoptosis of hematopoietic cells is mediated by redox-sensitive and redox-independent pathways.

    abstract：:Felbamate (FBM; 2-phenyl-1,3-propanediol dicarbamate) is an approved antiepileptic drug shown to be effective in a variety of seizure disorders refractory to other treatments. However, its use has been restricted because of association with occurrence of rare cases of aplastic anemia and hepatic failure. Since it was ...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/s0920-1211(01)00320-5

    authors： Husain Z,Pinto C,Sofia RD,Yunis EJ

    更新日期：2002-01-01 00:00:00

  • The long-term retention of pregabalin in a large cohort of patients with epilepsy at a tertiary referral centre.

    abstract：:Pregabalin (PGB) is a new antiepileptic drug (AED) which is a structural, non-functional analogue of gamma-aminobutyric acid. It acts at presynaptic calcium channels to modulate neurotransmitter release in the CNS. While the efficacy and tolerability of PGB have been demonstrated in several randomised controlled trial...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2009.08.001

    authors： Yuen AW,Singh R,Bell GS,Bhattacharjee A,Neligan A,Heaney DC,Duncan JS,Sander JW

    更新日期：2009-12-01 00:00:00

  • Serotonin depletion effects on the pilocarpine model of epilepsy.

    abstract：:The monoamine content in cerebral structures has been related to neuronal excitability and several approaches have been used to study this phenomenon during seizure vulnerability. In the present work, we have described the effects of serotonin (5-HT) depletion after the administration of 5,7-dihydroxytryptamine (5,7-D...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2008.08.010

    authors： Trindade-Filho EM,de Castro-Neto EF,de A Carvalho R,Lima E,Scorza FA,Amado D,Naffah-Mazzacoratti Mda G,Cavalheiro EA

    更新日期：2008-12-01 00:00:00

  • A common genetic basis for idiosyncratic toxicity of warfarin and phenytoin.

    abstract：:CYP2C9 is mainly responsible for the metabolic clearance of phenytoin and (S)-warfarin. We have shown previously that mutations in the CYP2C9 gene are associated with diminished metabolism of (S)-warfarin, and so we have now studied the metabolism of phenytoin to its primary inactive metabolite, (S)-pHPPH, by these mu...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/s0920-1211(99)00017-0

    authors： Rettie AE,Haining RL,Bajpai M,Levy RH

    更新日期：1999-07-01 00:00:00

  • Reduced H3 histamine receptor binding densities in the upper layers of motor cortex in rats prone to audiogenic convulsive seizures.

    abstract：:Fits of audiogenic seizures in rodents are considered as a model for generalized convulsive epilepsies in humans. The laminar distribution of the H3 histamine receptor binding densities was quantified in the motor cortex of two strains of rats with genetically determined generalized epilepsies, namely KM rats with aud...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2020.106543

    authors： Midzyanovskaya IS,Petrenko TE,Birioukova LM,Tuomisto LM

    更新日期：2020-12-25 00:00:00

  • Glutamate AMPA receptors in the fascia dentata of human and kainate rat hippocampal epilepsy.

    abstract：:The present study examined the relationship between the patterns and densities of glutamate AMPA receptor sub-units GluR1 and GluR2/3 in the molecular layer of the fascia dentata and aberrant mossy fiber neoinnervation in human and kainate rat hippocampal epilepsy. Because AMPA sub-units modulate the fast glutamate sy...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/s0920-1211(96)00053-8

    authors： Babb TL,Mathern GW,Leite JP,Pretorius JK,Yeoman KM,Kuhlman PA

    更新日期：1996-12-01 00:00:00

  • The relationship between seizure frequency, seizure type and quality of life: findings from three European countries.

    abstract：:Understanding the relationship between seizure frequency, seizure type and scores obtained from quality of life (QOL) measures is important if the incorporation of QOL measures into epilepsy clinical trials is to become standard practice. There is also a need to consider cross-cultural differences obtained from QOL me...

    journal_title：Epilepsy research

    pub_type： 杂志文章,多中心研究

    doi：10.1016/s0920-1211(98)00010-2

    authors： Baker GA,Gagnon D,McNulty P

    更新日期：1998-05-01 00:00:00

  • Mutual interaction between remacemide hydrochloride and phenytoin.

    abstract：:A randomised, double-blind, placebo-controlled crossover study of add-on remacemide hydrochloride was carried out in epilepsy patients being treated with phenytoin (PHT) monotherapy. Eleven patients were recruited, ten of whom completed the study. Plasma concentration profiles of PHT, remacemide, and its active desgly...

    journal_title：Epilepsy research

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0920-1211(96)01005-4

    authors： Leach JP,Girvan J,Jamieson V,Jones T,Richens A,Brodie MJ

    更新日期：1997-01-01 00:00:00

  • When is a child with status epilepticus likely to have Dravet syndrome?

    abstract：PURPOSE:To identify clinical risk factors for Dravet syndrome (DS) in a population of children with status epilepticus (SE). MATERIAL AND METHODS:Children aged between 1 month and 16 years with at least one episode of SE were referred from 6 pediatric neurology centers in Switzerland. SE was defined as a clinical seiz...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2014.02.019

    authors： Le Gal F,Lebon S,Ramelli GP,Datta AN,Mercati D,Maier O,Combescure C,Rodriguez MI,Seeck M,Roulet E,Korff CM

    更新日期：2014-05-01 00:00:00

  • Lennox-Gastaut syndrome in adulthood: clinical and EEG features.

    abstract：PURPOSE:We performed a retrospective study to investigate seizure, EEG, social and cognitive outcome in adult LGS subjects. METHODS:We retrospectively evaluated 27 LGS patients aged 40-59 years. We assessed in particular the evolution of different seizure types and EEG findings, as well as cognitive and social outcome...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2010.01.012

    authors： Ferlazzo E,Nikanorova M,Italiano D,Bureau M,Dravet C,Calarese T,Viallat D,Kölmel M,Bramanti P,De Santi L,Genton P

    更新日期：2010-05-01 00:00:00

  • The effects of anticonvulsant agents on 4-aminopyridine induced epileptiform activity in rat hippocampus in vitro.

    abstract：:Six anticonvulsant drugs, phenytoin (PHT), carbamazepine (CBZ), valproate (VPA), U-54494A, losigamone (LOS), and D-20443, were studied using rat hippocampal slices and standard electrophysiological techniques. The K+ channel blocker, 4-aminopyridine (4-AP), was used as neuronal stimulant. The extracellular parameters ...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/0920-1211(94)00077-a

    authors： Yonekawa WD,Kapetanovic IM,Kupferberg HJ

    更新日期：1995-02-01 00:00:00

  • Prognosis of patients with mesial temporal lobe epilepsy due to hippocampal sclerosis.

    abstract：PURPOSE:Hippocampal sclerosis (HS) is the most common pathology in mesial temporal lobe epilepsy (MTLE). There are a few reports concerning prognosis in patients with MTLE-HS treated medically. The study was carried out to determine the clinical risk factors affecting prognosis. METHODS:We enrolled 287 patients with M...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2009.03.001

    authors： Varoglu AO,Saygi S,Acemoglu H,Ciger A

    更新日期：2009-08-01 00:00:00

  • Effects of seizures and carbamazepine on interictal spiking in amygdala kindled cats.

    abstract：:We examined the influence of seizures and carbamazepine (CBZ) on spiking rates in kindled cats. In the first experiment, spiking rates were measured before and after seizures, with and without CBZ. CBZ was administered immediately after seizures in order not to affect them. Spiking rates were measured over 9 h during ...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/0920-1211(91)90065-n

    authors： Gigli GL,Gotman J

    更新日期：1991-04-01 00:00:00

  • Comparison of PET measurements of cerebral blood flow and glucose metabolism for the localization of human epileptic foci.

    abstract：:We compared the relative sensitivity of two interictal PET techniques, bolus injection of [15O] labeled water for estimation of cerebral blood flow (H2(15)O CBF-PET), and 18F 2-deoxyglucose (18FDG-PET) for cerebral glucose metabolism (CMRglc), and T2-weighted magnetic resonance imaging, in 28 patients with medically i...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/0920-1211(92)90071-z

    authors： Leiderman DB,Balish M,Sato S,Kufta C,Reeves P,Gaillard WD,Theodore WH

    更新日期：1992-11-01 00:00:00

  • Standard dose valproic acid does not cause additional cognitive impact in a rodent model of intractable epilepsy.

    abstract：:Children with epilepsy face significant cognitive and behavioral impairments. These impairments are due to a poorly characterized interaction between the underlying etiology, the effect of seizures and the effect of medication. The large variation in these factors make understanding the main drivers of cognitive impai...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2014.11.005

    authors： Jellett AP,Jenks K,Lucas M,Scott RC

    更新日期：2015-02-01 00:00:00

  • Semiological differences of focal onset bilateral motor (convulsive) seizure between mesial temporal lobe epilepsy and neocortical epilepsy.

    abstract：OBJECTIVE:We investigated the semiology of focal onset bilateral motor (convulsive) seizure (FBMS) in patients with intractable focal epilepsy who underwent epilepsy surgery to understand its value in localizing the origin of the seizure. METHODS:The study included 20 patients who underwent resective surgery after int...

    journal_title：Epilepsy research

    pub_type： 杂志文章

    doi：10.1016/j.eplepsyres.2021.106553

    authors： Punyawai P,Usui N,Kondo A,Ichikawa N,Tottori T,Terada K,Takahashi Y,Inoue Y

    更新日期：2021-01-07 00:00:00