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Suppression of inter-ictal spikes by CM40907. A double-blind placebo-controlled investigation and review of spike counting as a methodology for assessing the antiepileptic effect of drugs.

Abstract：

:To assess the efficacy of CM40907--a new antiepileptic drug--in suppressing inter-ictal spikes, 6 patients with severe intractable epilepsy and frequent spikes in their inter-ictal EEGs were entered in a double-blind placebo-controlled trial. The results show that CM40907 is efficacious in reducing spike counts in the first hour after oral administration. The results of the study are presented and inter-ictal spike counting as a method is discussed.

journal_name

Epilepsy Res

journal_title

Epilepsy research

authors

Yepez-Lasso R,Duncan JS,Shorvon SD

doi

10.1016/0920-1211(90)90046-x

subject

Has Abstract

pub_date

1990-04-01 00:00:00

pages

247-50

issue

3

eissn

0920-1211

issn

1872-6844

pii

0920-1211(90)90046-X

journal_volume

5

pub_type

临床试验,杂志文章

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