Abstract:
OBJECTIVES:To evaluate the agreement between magnetoencephalography (MEG) and intracranial electroencephalography (ICEEG) results, to determine the characteristics that lead to concordance, and to assess how these factors relate to favorable epilepsy surgery outcome. MATERIALS:This retrospective study reviewed 50 patients who had positive MEG findings and ICEEG recordings between 2008 and 2010. The anatomical concordance between MEG and ICEEG recordings, the features of the MEG focus, and the relationship between the MEG focus and the surgically resected regions were correlated with the epilepsy surgery outcome. RESULTS:Thirty-six of the 50 patients with positive MEG and ICEEG findings underwent epilepsy surgery, and 27 (75%) of the patients had an anatomical concordance of MEG/ICEEG. Among the patients with concordant MEG/ICEEG, the seizure free outcome rate was significantly higher compared to the discordant group [18/27 (66.7%) patients concordant vs. 1/9 (11.1%) patients discordant (p<0.006)]. Nineteen (53%) of the 36 patients had complete resection when the MEG focus overlapped with the resection area, and 15 (79%) of these 19 patients became seizure-free following surgery (p<0.001); 17 (47%) of the 36 patients had an MEG focus that was not completely resected (the MEG foci of 7 patients partially overlapped the resection areas, and 10 patients had MEG foci that were in a different area from the resection area), and 13/17 (76.5%) patients had seizure recurrences (p<0.001). CONCLUSIONS:Both the anatomical concordance of MEG/ICEEG and the complete resection of the MEG foci significantly increased the chance of seizure-free outcomes following epilepsy surgery.
journal_name
Epilepsy Resjournal_title
Epilepsy researchauthors
Almubarak S,Alexopoulos A,Von-Podewils F,Wang ZI,Kakisaka Y,Mosher JC,Bulacio J,González-Martínez J,Bingaman W,Burgess RCdoi
10.1016/j.eplepsyres.2014.08.016subject
Has Abstractpub_date
2014-11-01 00:00:00pages
1581-90issue
9eissn
0920-1211issn
1872-6844pii
S0920-1211(14)00225-3journal_volume
108pub_type
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journal_title:Epilepsy research
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journal_title:Epilepsy research
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journal_title:Epilepsy research
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/j.eplepsyres.2013.02.009
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journal_title:Epilepsy research
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journal_title:Epilepsy research
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更新日期:1993-09-01 00:00:00
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journal_title:Epilepsy research
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journal_title:Epilepsy research
pub_type: 杂志文章
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更新日期:2007-03-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章,多中心研究
doi:10.1016/j.eplepsyres.2008.10.004
更新日期:2009-02-01 00:00:00
abstract::In rats, the concurrent alternate elicitation of epileptiform activity in two forebrain structures can result in both the rapid production of severe seizures and the development of fully generalized seizures in one (dominant) site, while arresting the progress of seizure activity at intermediate stages in the other (s...
journal_title:Epilepsy research
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2020-12-25 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/j.eplepsyres.2009.11.014
更新日期:2010-02-01 00:00:00
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journal_title:Epilepsy research
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章
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更新日期:2001-12-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
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更新日期:2006-12-01 00:00:00
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journal_title:Epilepsy research
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章,meta分析,评审
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更新日期:2016-03-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/j.eplepsyres.2007.05.001
更新日期:2007-07-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2000-05-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/s0920-1211(97)00031-4
更新日期:1997-07-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/j.eplepsyres.2018.04.006
更新日期:2018-07-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/0920-1211(92)90010-q
更新日期:1992-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:1999-07-01 00:00:00