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Reduced H3 histamine receptor binding densities in the upper layers of motor cortex in rats prone to audiogenic convulsive seizures.

Abstract：

:Fits of audiogenic seizures in rodents are considered as a model for generalized convulsive epilepsies in humans. The laminar distribution of the H3 histamine receptor binding densities was quantified in the motor cortex of two strains of rats with genetically determined generalized epilepsies, namely KM rats with audiogenic seizures only, and WAGRij rats with both audiogenic seizures and absence seizures. It was found that H3 histamine receptor binding densities in layer 2/3d of the primary and secondary motor cortices of the rats that experienced audiogenic seizure fits were significantly lower than in the cortices of control rats. Possible explanations are discussed.

journal_name

Epilepsy Res

journal_title

Epilepsy research

authors

Midzyanovskaya IS,Petrenko TE,Birioukova LM,Tuomisto LM

doi

10.1016/j.eplepsyres.2020.106543

subject

Has Abstract

pub_date

2020-12-25 00:00:00

pages

106543

eissn

0920-1211

issn

1872-6844

pii

S0920-1211(20)30594-5

journal_volume

170

pub_type

杂志文章

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