Pregnancy outcomes of refractory epilepsy patients treated with Brain-responsive neurostimulation.

abstract：:Neuromodulation therapies represent an important treatment arm for patients with drug-resistant epilepsy (DRE) who are not candidates for resective surgery. Vagus nerve stimulation (VNS) - the neurostimulation modality in focus in this review - was the first available neuromodulatory therapy for DRE and was followed b...

journal_title：Epilepsy research

authors： Dibué-Adjei M,Kamp MA,Vonck K

更新日期：2019-07-01 00:00:00

abstract：:Results of previous studies suggested that the brainstem participates in amygdaloid (AM) kindled seizure generalization and the positive transfer effect at the secondary site AM. This study was undertaken to define the role of the brainstem in the patterning of AM kindling, the maintenance of AM kindled seizure and th...

journal_title：Epilepsy research

authors： Hamada K,Wada JA

更新日期：1998-01-01 00:00:00

abstract：:Involvement of opioid systems in the pathogenesis of absence epilepsy has been postulated. However, the role of the mu opioid receptor has not been fully elucidated as yet. In the present study the role of this receptor in absence epilepsy was investigated autoradiographically and pharmacologically. The density of mu ...

journal_title：Epilepsy research

authors： Przewłocka B,Lasoń W,Turchan J,de Bruin N,van Luijtelaar G,Przewłocki R,Coenen A

更新日期：1998-01-01 00:00:00

abstract：:We have reported long-term clinical follow-up for two siblings with Lafora disease, a brother and sister, one of whom autopsied. Both siblings had repeated attacks of severe myoclonus, tonic and tonic-clonic convulsions, and intractable status epilepticus. The addition of orally administered zonisamide brought about s...

journal_title：Epilepsy research

authors： Yoshimura I,Kaneko S,Yoshimura N,Murakami T

更新日期：2001-09-01 00:00:00

abstract：:Early neuropsychological changes following partial anterior callosotomy were evaluated in 15 patients with epilepsy (10 secondary generalized and 5 Lennox-Gastaut syndromes) by comparing their performances 1 month before surgery and then 15-20 and 90-100 days postoperatively without modifying the anticonvulsant treatm...

journal_title：Epilepsy research

authors： Provinciali L,Del Pesce M,Censori B,Quattrini A,Paggi A,Ortenzi A,Mancini S,Papo I,Rychlicki F

更新日期：1990-07-01 00:00:00

abstract：INTRODUCTION:Juvenile myoclonic epilepsy (JME) is a genetic generalized epilepsy syndrome. Under appropriate antiepileptic drugs (AED) up to 85% of patients become seizure-free, but many may have a relapse after AED withdrawal. METHODS:We retrospectively studied 242 patients with JME at the Department of Neurology, Me...

journal_title：Epilepsy research

authors： Höfler J,Unterberger I,Dobesberger J,Kuchukhidze G,Walser G,Trinka E

更新日期：2014-12-01 00:00:00

abstract：:In the present study, L-pGlu-(1-benzyl)-L-His-L-ProNH(2) (NP-355), a newer CNS active thyrotropin-releasing hormone (TRH) analog was evaluated for its antiepileptic potential. NP-355 (5, 10 and 20 micromol/kg; i.v.) pretreatment significantly delayed onset and reduced the frequency of convulsions in pentylenetetrazole...

journal_title：Epilepsy research

authors： Rajput SK,Singh JN,Ingole S,Jain G,Kaur N,Monga V,Meena CL,Jain R,Sharma SS

更新日期：2009-12-01 00:00:00

abstract：:The investigational anticonvulsant drug, gabapentin (GP; 1-(aminomethyl) cyclohexaneacetic acid) limited repetitive firing of sodium-dependent action potentials of mouse spinal cord and neocortical neurons in monolayer dissociated cell culture. The effect developed slowly over time with sustained exposure. The IC50 wa...

journal_title：Epilepsy research

authors： Wamil AW,McLean MJ

更新日期：1994-01-01 00:00:00

abstract：:This study was planned so as to evaluate whether magnetic field exposure has any significant effect on the pentylenetetrazol (PTZ)-induced seizures. Mice were exposed to 50 Hz, 2 G (0.2 mT) magnetic field in glass cages for 1 h. Sham exposure was produced by turning off the current while the animals were in the same e...

journal_title：Epilepsy research

authors： Keskil IS,Keskil ZA,Canseven AG,Seyhan N

更新日期：2001-04-01 00:00:00

abstract：PURPOSE:To identify predictors of seizure-outcome after epilepsy surgery and validate the findings in an independent series of patients. To use the results to develop a predictive model. METHODS:Sequential patients undergoing resective surgery for medically intractable epilepsy were identified at Yale New Haven Hospit...

journal_title：Epilepsy research

authors： Berg AT,Walczak T,Hirsch LJ,Spencer SS

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:Little is known, so far, about the cerebral structural abnormalities in drug-naïve patients with childhood absence epilepsy (CAE). We aimed to investigate regional grey matter (GM) volume differences using voxel-based morphometry (VBM) in patients and closely matched healthy control subjects. METHODS:Twenty...

journal_title：Epilepsy research

authors： Wang G,Dai ZY,Song W,Wang S,Shi H,Pan P,Chen F,Xu Y,Zhong J

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:To improve the interpretability of figures containing an amplitude-integrated electroencephalogram (aEEG), we devised a color scale that allows us to incorporate spectral edge frequency (SEF) information into aEEG figures. Preliminary clinical assessment of this novel technique, which we call aEEG/SEF, was pe...

journal_title：Epilepsy research

authors： Kobayashi K,Mimaki N,Endoh F,Inoue T,Yoshinaga H,Ohtsuka Y

更新日期：2011-10-01 00:00:00

abstract：RATIONALE:Epilepsy is the most common serious neurological condition in the world, and an important cause of mortality and disability in developing countries. Because epidemiological and clinical characteristics of epilepsy vary by region, it is important to know the peculiarities of epilepsy in this area of the Americ...

journal_title：Epilepsy research

authors： Burneo JG,Tellez-Zenteno J,Wiebe S

更新日期：2005-08-01 00:00:00

abstract：:Epilepsy - the world's most common serious brain disorder - is defined by recurrent unprovoked seizures that result from complex interactions between distributed neural populations. We explore some macroscopic characteristics of emergent ictal networks by considering intracranial recordings from human subjects with in...

journal_title：Epilepsy research

authors： Kramer MA,Kolaczyk ED,Kirsch HE

更新日期：2008-05-01 00:00:00

abstract：:A role of cholinergic nervous system in the behavioral impairments induced by repeated ECS is not understood. The α4β2 nicotinic acetylcholine receptor (nAChR) agonist ABT-418, but not the α7 nAChR agonist, significantly ameliorated the impairment of spontaneous alternation behavior in the Y-maze test. And, repeated E...

journal_title：Epilepsy research

authors： Hidaka N,Suemaru K,Kato Y,Araki H

更新日期：2013-03-01 00:00:00

abstract：:Post-stroke paroxysmal activity is a neurophysiological indicator of epileptogenesis and increase of seizure susceptibility, so treatments with neuroprotective activity and anti-paroxysmal activity can be more beneficial during post-ischemic period. The goal of this study was evaluation of levetiracetam (100 mg/kg, 7 ...

journal_title：Epilepsy research

authors： Litvinova SA,Kutepova IS,Voronina TA,Petrunina АА

更新日期：2020-11-01 00:00:00

abstract：:The aim of the study was to compare subjective complaints of epilepsy patients with objective results of neuropsychological assessment and to investigate the possible influence of depression on self-reported complaints. 62 patients from the neurology clinic were included in the study. They were asked to fill the subje...

journal_title：Epilepsy research

authors： Liik M,Vahter L,Gross-Paju K,Haldre S

更新日期：2009-04-01 00:00:00

abstract：PURPOSE:To perform a systematic review and meta-analysis to identify risk factors associated with early seizure (ES) or late seizure (LS) onset in adults following stroke. DATA SOURCES:Electronic databases (MEDLINE and EMBASE), archives of stroke or epilepsy patients, and bibliographies of relevant articles, which wer...

journal_title：Epilepsy research

authors： Zhang C,Wang X,Wang Y,Zhang JG,Hu W,Ge M,Zhang K,Shao X

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Millions of individuals worldwide suffer from epilepsy, and up to 25% of patients have seizures that are resistant to currently available antiepileptic drugs. Hence, there continues to be a need for more seizure medications that are effective yet tolerable. Levodropropizine (LVDP) is an established antitussi...

journal_title：Epilepsy research

authors： Erdogan MA,Yusuf D,Erdogan A,Erbas O

更新日期：2019-02-01 00:00:00

abstract：INTRODUCTION:Proton magnetic resonance spectroscopy ((1)H MRS) has been proposed as a lateralizing method for the presurgical evaluation of patients with medically intractable temporal lobe epilepsy (TLE). Studies have shown correlations between temporal lobe (TL) NAA and seizure frequency, and TL NAA/Cr and the durati...

journal_title：Epilepsy research

authors： Burneo JG,Knowlton RC,Faught E,Martin R,Sawrie S,Kuzniecky RI

更新日期：2004-12-01 00:00:00

abstract：:The present study investigated whether pharmacological stimulation of the GABAergic system can affect attention. The effects of vigabatrin, a novel antiepileptic drug, on the performance of rats in a 5-choice serial reaction time task assessing selective attention were studied. The effects of acute (100, 300, 500 and ...

journal_title：Epilepsy research

authors： Mazurkiewicz M,Sirviö J,Riekkinen P Sr

更新日期：1992-12-01 00:00:00

abstract：:Multiple subpial transection (MST) is an effective surgical therapy for patients with intractable seizures whose epileptogenic lesions lie in the cortex and are unresectable. Morrell developed this procedure and reported clinical results obtained using it. However, only the disappearance of epileptiform discharges aft...

journal_title：Epilepsy research

authors： Sugiyama S,Fujii M,Ito H

更新日期：1995-05-01 00:00:00

abstract：PURPOSE:Ictal magenetoencephalographic (MEG) discharges convey significant information about ictal onset and propagation, but there is no established method for analyzing ictal MEG. This study sought to clarify the usefulness of time-frequency analyses using short-time Fourier transform (STFT) for ictal onset and propa...

journal_title：Epilepsy research

authors： Yagyu K,Takeuchi F,Shiraishi H,Nakane S,Sueda K,Asahina N,Kohsaka S,Umeoka S,Usui N,Baba K,Saitoh S

更新日期：2010-08-01 00:00:00

abstract：INTRODUCTION:Tuberous sclerosis complex (TSC) is a multisystem genetic disorder affecting multiple organs, including the brain, and very often associated with epileptic activity. Language acquisition and development seems to be altered in a significant proportion of patients with TSC. In the present study, we used magn...

journal_title：Epilepsy research

authors： Gallagher A,Tanaka N,Suzuki N,Liu H,Thiele EA,Stufflebeam SM

更新日期：2013-03-01 00:00:00

abstract：:In rats, the concurrent alternate elicitation of epileptiform activity in two forebrain structures can result in both the rapid production of severe seizures and the development of fully generalized seizures in one (dominant) site, while arresting the progress of seizure activity at intermediate stages in the other (s...

journal_title：Epilepsy research

authors： Teskey GC,Thiessen EJ,Gilbert TH

更新日期：1999-04-01 00:00:00

abstract：:The present study examined whether the perceived behavioral problems of children with idiopathic epilepsy differed from those of healthy controls according to parent proxy-reports and which factors are associated with these problems. The parents of 106 children with idiopathic epilepsy and 305 healthy controls aged 6-...

journal_title：Epilepsy research

authors： Dafoulis V,Kalyva E

更新日期：2012-06-01 00:00:00

abstract：:Seletracetam (SEL), an analog of the antiepileptic drug levetiracetam (LEV), decreases seizure activity in a number of epilepsy models and binds to the synaptic vesicle protein SV2A with a higher affinity than LEV. Experiments were performed to determine if SEL, like LEV, reduces the later EPSPs in long trains of stim...

journal_title：Epilepsy research

authors： Yang X,Meehan AL,Rothman SM,Dubinsky JM

更新日期：2015-11-01 00:00:00

abstract：:The KCNAB1 gene is a candidate susceptibility factor for lateral temporal epilepsy (LTE) because of its functional interaction with LGI1, the gene responsible for the autosomal dominant form of LTE. We investigated association between polymorphic variants across the KCNAB1 gene and LTE. The allele and genotype frequen...

journal_title：Epilepsy research

authors： Busolin G,Malacrida S,Bisulli F,Striano P,Di Bonaventura C,Egeo G,Pasini E,Cianci V,Ferlazzo E,Bianchi A,Coppola G,Elia M,Mecarelli O,Gobbi G,Casellato S,Marchini M,Binelli S,Freri E,Granata T,Posar A,Parmeggiani

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Nuclear factor erythroid-2 related factor 2 (Nrf2) is a transcription factor, which activates the anti-oxidative stress response pathway. In epilepsy, oxidative stress is one of the key factors in the progression of the disease. So, the neuroprotective role of dimethyl fumarate (DMF), a Nrf2 pathway activato...

journal_title：Epilepsy research

authors： Singh N,Vijayanti S,Saha L,Bhatia A,Banerjee D,Chakrabarti A

更新日期：2018-07-01 00:00:00

abstract：:Although accumulating evidence indicates that the immunomodulatory medication thalidomide exerts anticonvulsant properties, the mechanisms underlying such effects of thalidomide are still unknown. Our previous preclinical study suggested that nitric oxide (NO) signaling may be involved in the anticonvulsant effects of...

journal_title：Epilepsy research

authors： Pourshadi N,Rahimi N,Ghasemi M,Faghir-Ghanesefat H,Sharifzadeh M,Dehpour AR

更新日期：2020-08-01 00:00:00