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Driving cost factors in adult outpatients with refractory epilepsy: a daily clinical practice in clinics of neurology in Spain.

Abstract：

OBJECTIVE:To explore the association between patient-reported-outcomes measurements and costs in adult outpatients with drug refractory epilepsy (DRE) in Spain. METHODS:Secondary analysis of a cross-sectional study to determine resources utilization and related costs of refractory epilepsy in Spain (LINCE study). Consecutive adult outpatients fulfilling criteria for DRE were analyzed. Health-related quality of life (HRQoL), anxiety and depression, self-perceived health status and patient's satisfaction with treatment were assessed respectively by QOLIE-10, HAD scales, EQ-5D-VAS and SATMED-Q questionnaire. Costs were estimated from public tariffs computing healthcare and non-healthcare resources use in the year 2005. RESULTS:Seven hundred sixty two consecutive patients (728 (95.5%) valuables; 50.8% males, 40.5+/-13.5 years) were analyzed. Severe levels of anxiety and depression were both associated with higher costs: from a mean yearly total cost of 6291 euros +/- 7748 (no anxiety) to 10325.8 euros +/-9900.8 (severe), p<0.0012 and from 5983.5 euros +/-6726.1 (no depression) to 12691.4 euros +/-11745.9 (severe), p<0.0001. Total yearly cost was inversely associated with HRQoL, self-perceived health status and satisfaction with treatment: from 11517.3 euros +/-11449.2 to 5430.2 euros +/-7776.6, first and tenth QOLIE-10 decile intervals, respectively, from 11494 euros +/- 11668 to 5334.3 +/- 7606, first and tenth VAS decile intervals, respectively, and from 9762.6 euros +/- 9956.6 to 4746.4 euros +/- 5616.7, first and tenth SATMED-Q decile intervals, respectively, p<0.0001. CONCLUSIONS:Higher costs of refractory epilepsy were associated with poorer patient-reported-outcomes scores. These findings may be of interest for both health decision makers and clinicians when evaluating the resources devoted to epilepsy.

journal_name

Epilepsy Res

journal_title

Epilepsy research

authors

Peña P,Sancho J,Rufo M,Martínez S,Rejas J,LINCE Study Collaborative Group.

doi

10.1016/j.eplepsyres.2008.10.004

subject

Has Abstract

pub_date

2009-02-01 00:00:00

pages

133-43

issue

2-3

eissn

0920-1211

issn

1872-6844

pii

S0920-1211(08)00308-2

journal_volume

83

pub_type

杂志文章,多中心研究

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