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Gradient magnetic-field topography reflecting cortical activities of neocortical epilepsy spikes.

Abstract：

PURPOSE:To compare and validate the gradient magnetic-field topography (GMFT) method of current source localization for understanding epileptic zones against equivalent current dipole (ECD) and intracranial video-EEG (IVEEG) data in patients with intractable neocortical epilepsy. METHODS:We used retrospective data from eight patients to determine GMFT at onset (O) and peak (P) of interictal magnetoencephalography (MEG) spikes and mapped GMFT(O) and GMFT(P) locations and distributions using 12 zones in unilateral hemisphere. We compared GMFT with ECD, ictal onset zones (IOZ) and interictal zones on IVEEG, and seizure outcomes. RESULTS:We projected GMFT(Os) and (Ps) for all spikes on volume-rendered brain surfaces. We localized ECDs for 6-61% of spikes (mean, 28.4%). GMFT(Ps) (mean, 10.3 zones) extended over more zones than GMFT(Os) (6.3 zones) for each spike (p<0.01). The ECD distributions (2.3 zones) were almost equal to the zones of IOZ and surgical areas. GMFT(O) localizations distributed much more extensively than IOZs and surgical areas in three patients with residual seizures comparing with those in five seizure-free patiens. CONCLUSION:We validate the potential of GMFT to study the distribution of MEG spikes. GMFT has an advantage in analyzing the cortical activity and propagation from MEG spikes in neocortical epilepsy.

journal_name

Epilepsy Res

journal_title

Epilepsy research

authors

Shirozu H,Iida K,Hashizume A,Hanaya R,Kiura Y,Kurisu K,Arita K,Otsubo H

doi

10.1016/j.eplepsyres.2010.04.002

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

121-31

issue

1-2

eissn

0920-1211

issn

1872-6844

pii

S0920-1211(10)00109-9

journal_volume

90

pub_type

杂志文章

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