Increasing structural atrophy and functional isolation of the temporal lobe with duration of disease in temporal lobe epilepsy.

Abstract:

BACKGROUND:Due to pharmacoresistant seizures and the underutilization of surgical treatments, a large number of temporal lobe epilepsy (TLE) patients experience seizures for years or decades. The goal of this study was to generate a predictive model of duration of disease with the least number of parameters possible in order to identify and quantify the significant volumetric and functional indicators of TLE progression. METHODS:Two cohorts of subjects including 12 left TLE, 21 right TLE and 20 healthy controls (duration = 0) were imaged on a 3T MRI scanner using high resolution T1-weighted structural MRI and 20 min of resting functional MRI scanning. Multivariate linear regression methods were used to compute a predictive model of duration of disease using 49 predictors including functional connectivity and gray matter volumes computed from these images. RESULTS:No model developed from the full set of data accurately predicted the duration of disease across the entire range from 3 to 50 years. We then performed the regression on 35 subjects with durations of disease in the range 10 to 35 years. The resulting predictive model showed that longer durations were associated with reductions in functional connectivity from the ipsilateral temporal lobe to the contralateral temporal lobe, precuneus and mid cingulate, and with decreases in volume of the ipsilateral hippocampus and pallidum. CONCLUSIONS:Functional and volumetric parameters accurately predicted duration of disease in TLE. The findings suggest that TLE is associated with a gradual functional isolation and significant progressive structural atrophy of the ipsilateral temporal lobe over years of duration in the range of 10-35 years. Furthermore, these changes can also be detected in the contralateral hemisphere in these patients, but to a lesser degree.

journal_name

Epilepsy Res

journal_title

Epilepsy research

authors

Morgan VL,Conrad BN,Abou-Khalil B,Rogers BP,Kang H

doi

10.1016/j.eplepsyres.2014.12.006

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

171-8

eissn

0920-1211

issn

1872-6844

pii

S0920-1211(14)00365-9

journal_volume

110

pub_type

杂志文章
  • Congenital brain dysplasias of different genesis can differently affect susceptibility to pilocarpine- or kainic acid-induced seizures in the rat.

    abstract::Interruption of neurogenesis and/or neuronal migration produces brain dysplasia modifying susceptibility to epileptic seizures in adulthood. The course of neurogenesis has a strictly defined time-table. Consequently, the developmental stage at which the interruption occurs determines what functional subsystem potentia...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2005.09.006

    authors: Setkowicz Z,Janicka D,Kowalczyk A,Turlej A,Janeczko K

    更新日期:2005-12-01 00:00:00

  • TBC1D24 mutation associated with focal epilepsy, cognitive impairment and a distinctive cerebro-cerebellar malformation.

    abstract::We describe the clinical and radiological features of a family with a homozygous mutation in TBC1D24. The phenotype comprised onset of focal seizures at 2 months with prominent eye-blinking, facial and limb jerking with an oral sensory aura. These were controllable with medication but persisted into adult life. Associ...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2013.02.005

    authors: Afawi Z,Mandelstam S,Korczyn AD,Kivity S,Walid S,Shalata A,Oliver KL,Corbett M,Gecz J,Berkovic SF,Jackson GD

    更新日期:2013-07-01 00:00:00

  • Levodropropizine suppresses seizure activity in rats with pentylenetetrazol-induced epilepsy.

    abstract:BACKGROUND:Millions of individuals worldwide suffer from epilepsy, and up to 25% of patients have seizures that are resistant to currently available antiepileptic drugs. Hence, there continues to be a need for more seizure medications that are effective yet tolerable. Levodropropizine (LVDP) is an established antitussi...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2018.12.011

    authors: Erdogan MA,Yusuf D,Erdogan A,Erbas O

    更新日期:2019-02-01 00:00:00

  • An epileptic case with mosaic ring chromosome 6 and 6q terminal deletion.

    abstract::Ring chromosomes are rare chromosome disorders that arise usually de novo. Children with ring chromosome 6 have a wide range of intellectual functioning and congenital anomalies. We report an epileptic case of a 10-year-old boy to be mild psychomotor retardation and dysmorphic traits including microcephaly, brachyceph...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2008.03.020

    authors: Kara N,Okten G,Guneş SO,Saglam Y,Tasdemir HA,Pinarli FA

    更新日期:2008-08-01 00:00:00

  • Long-term mortality in children and young adults with epilepsy--A population-based cohort study.

    abstract:PURPOSE:Epilepsy is associated with an increased mortality. This study estimates the effects of co-morbid disorders on short-term and long-term mortality and presents cause-specific mortality for children and young adults with epilepsy. METHODS:We established a population-based cohort of 1,855,946 children born in Den...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2015.05.001

    authors: Christensen J,Pedersen CB,Sidenius P,Olsen J,Vestergaard M

    更新日期:2015-08-01 00:00:00

  • Long-term safety and efficacy following conversion to eslicarbazepine acetate monotherapy in adults with focal seizures.

    abstract:OBJECTIVE:To assess the long-term safety and efficacy of eslicarbazepine acetate (ESL) monotherapy in adults with focal seizures (FS). METHODS:Study 050 was a long-term, multicenter, open-label (OL) safety extension of two conversion-to-ESL monotherapy studies in adults with refractory FS. After participating in Study...

    journal_title:Epilepsy research

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.eplepsyres.2019.03.018

    authors: Chung S,Sinha SR,Shah A,Stern JM,Cheng H,Jung J,Grinnell T,Blum D

    更新日期:2019-07-01 00:00:00

  • Vascular function and risk factors in children with epilepsy: associations with sodium valproate and carbamazepine.

    abstract:AIM:To investigate biochemical cardiovascular risk factors and vascular endothelial function and structure in children with epilepsy on antiepileptic drugs (AEDs), particularly sodium valproate (VPA) and carbamazepine (CBZ). BACKGROUND:Individuals with epilepsy have increased risk factors for vascular disease, particu...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2014.04.006

    authors: Keenan N,Sadlier LG,Wiltshire E

    更新日期:2014-08-01 00:00:00

  • Scopolamine-induced convulsions in fasted animals after food intake: sensitivity of C57BL/6J mice and Sprague-Dawley rats.

    abstract::Food intake triggers convulsions in fasted BALB/c mice and Wistar albino rats treated with antimuscarinic drugs, scopolamine or atropine. Inbred strain studies have yielded considerable information regarding genetic influences on seizure susceptibility and factors contribute to epileptogenesis in rodents. This study, ...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2015.03.001

    authors: Enginar N,Nurten A,Türkmen AZ,Çağla B

    更新日期:2015-05-01 00:00:00

  • Newly-diagnosed pediatric epilepsy is associated with elevated autoantibodies to glutamic acid decarboxylase but not cardiolipin.

    abstract::Glutamic acid decarboxylase autoantibodies (GADA) and anti-cardiolipin autoantibodies (ACA) have been detected in adult subjects with epilepsy, though the functional implications of these findings are a matter of debate. This study aimed to determine the prevalence of GADA and ACA and to investigate their clinical sig...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2013.02.009

    authors: Veri K,Uibo O,Talvik T,Talvik I,Metsküla K,Napa A,Vaher U,Õiglane-Šlik E,Rein R,Kolk A,Traat A,Uibo R

    更新日期:2013-07-01 00:00:00

  • Classification of benign infantile afebrile seizures.

    abstract:PURPOSE:The aim of this study is to classify infantile cases with benign seizures into known epileptic syndromes, thereby facilitating discussion of clinical factors that could play an important role in diagnosis. SUBJECTS:Fifty-seven patients with afebrile seizures fulfilling all of the following criteria were enroll...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2006.02.007

    authors: Tanabe T,Hara K,Kashiwagi M,Tamai H

    更新日期:2006-08-01 00:00:00

  • Association of nonsense mutation in GABRG2 with abnormal trafficking of GABAA receptors in severe epilepsy.

    abstract::Mutations in GABRG2, which encodes the γ2 subunit of GABAA receptors, can cause both genetic epilepsy with febrile seizures plus (GEFS+) and Dravet syndrome. Most GABRG2 truncating mutations associated with Dravet syndrome result in premature termination codons (PTCs) and are stably translated into mutant proteins wit...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2013.12.005

    authors: Ishii A,Kanaumi T,Sohda M,Misumi Y,Zhang B,Kakinuma N,Haga Y,Watanabe K,Takeda S,Okada M,Ueno S,Kaneko S,Takashima S,Hirose S

    更新日期:2014-03-01 00:00:00

  • Long-term functional consequences of transient occlusion of the middle cerebral artery in rats: a 1-year follow-up of the development of epileptogenesis and memory impairment in relation to sensorimotor deficits.

    abstract::Post-stroke seizures occur in 5-20% of patients. Modeling of stroke-induced seizures in animals provides a useful tool for investigating the molecular basis of epileptogenesis and for developing therapies for stroke patients at increased risk for epileptogenesis. The questions addressed in the study were: (1) Do rats ...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/s0920-1211(03)00034-2

    authors: Karhunen H,Pitkänen A,Virtanen T,Gureviciene I,Pussinen R,Ylinen A,Sivenius J,Nissinen J,Jolkkonen J

    更新日期:2003-04-01 00:00:00

  • Early effect of sodium valproate and carbamazepine monotherapy on homocysteine metabolism in children with epilepsy.

    abstract::Plasma total homocysteine (p-tHcy), serum folate (s-F), serum vitamin B-12 (s-B12) and plasma pyridoxal-5'-phosphate (p-PLP) were measured in epileptic children before and after a 20-week period of sodium valproate (group A, n=32) and carbamazepine (group B, n=20) monotherapy. P-tHcy significantly increased in both gr...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2006.06.015

    authors: Attilakos A,Papakonstantinou E,Schulpis K,Voudris K,Katsarou E,Mastroyianni S,Garoufi A

    更新日期:2006-10-01 00:00:00

  • Comparison of clinical features and surgical outcome in focal cortical dysplasia type 1 and type 2.

    abstract:INTRODUCTION:Recent ILAE classification defined focal cortical dysplasia (FCD) patients with accompanying epileptic lesions as a separate group. We investigated data of patients with sole FCD lesions regarding long-term seizure outcome and different characteristics of FCD type 1 and type 2 patients. METHODS:Eighty chi...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2017.08.008

    authors: Isler C,Kucukyuruk B,Ozkara C,Gunduz A,Is M,Tanriverdi T,Comunoglu N,Oz B,Uzan M

    更新日期:2017-10-01 00:00:00

  • Modeling epileptogenesis and temporal lobe epilepsy in a non-human primate.

    abstract::Here we describe a new non-human primate model of temporal lobe epilepsy (TLE) to better investigate the cause/effect relationships of human TLE. Status epilepticus (SE) was induced in adult marmosets by pilocarpine injection (250mg/kg; i.p.). The animals were divided in 2 groups: acute (8h post-SE) and chronic (3 and...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2011.04.015

    authors: Perez-Mendes P,Blanco MM,Calcagnotto ME,Cinini SM,Bachiega J,Papoti D,Covolan L,Tannus A,Mello LE

    更新日期:2011-09-01 00:00:00

  • Dynamic magnetic source imaging of absence seizure initialization and propagation: a magnetoencephalography study.

    abstract:PURPOSE:The present study aims to determine the initialization and propagation of typical absence seizures using magnetoencephalography (MEG). METHOD:Fourteen drug-naïve children with childhood absence epilepsy (CAE) were studied using a 275-Channel MEG system. The spectral signatures of epileptic activity were assess...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2014.01.006

    authors: Miao A,Tang L,Xiang J,Guan Q,Ge H,Liu H,Wu T,Chen Q,Yang L,Lu X,Hu Z,Wang X

    更新日期:2014-03-01 00:00:00

  • Anticonvulsive effect of dapsone (4,4'-diaminodiphenyl sulfone) on amygdala-kindled seizures in rats and cats.

    abstract::Dapsone (4,4'-diaminodiphenyl sulfone; DDS), an established anti-leprosy drug, showed anticonvulsive effects in the amygdaloid kindling model of epilepsy. Single doses of the drug in rats (6.25-12.5 mg/kg, i.p.) suppressed the kindled seizures in a dose-dependent manner without overt behavioral toxicity. With repeated...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/0920-1211(91)90001-v

    authors: Hamada K,Hiyoshi T,Kobayashi S,Ishida S,Yagi K,Seino M

    更新日期:1991-11-01 00:00:00

  • Genetic seizure susceptibility underlying acute encephalopathies in childhood.

    abstract::We herein investigated risk factors of pediatric acute encephalopathy (AE) regarding the hitherto uncharacterized genetic background of seizure susceptibility underlying the pathogenesis of AE. The study included 15 patients with a history of various types of AE in childhood. We undertook the mutational analysis of th...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2010.07.005

    authors: Kobayashi K,Ouchida M,Okumura A,Maegaki Y,Nishiyama I,Matsui H,Ohtsuka Y,Ohmori I

    更新日期:2010-10-01 00:00:00

  • The incidence of seizures in patients undergoing therapeutic hypothermia after resuscitation from cardiac arrest.

    abstract:STUDY OBJECTIVE:Non-convulsive seizures/status epilepticus occur in approximately 20% of comatose, non-cardiac arrest intensive care unit (ICU) patients, and are associated with increased mortality. The prevalence and clinical significance of seizures in comatose survivors of cardiac arrest undergoing therapeutic hypot...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2013.06.018

    authors: Knight WA,Hart KW,Adeoye OM,Bonomo JB,Keegan SP,Ficker DM,Szaflarski JP,Privitera MD,Lindsell CJ

    更新日期:2013-10-01 00:00:00

  • Lack of benefit of linoleic and alpha-linolenic polyunsaturated fatty acids on seizure latency, duration, severity or incidence in rats.

    abstract:BACKGROUND:Polyunsaturated fatty acids have been reported to increase seizure threshold and to reduce seizure duration and severity in rats. OBJECTIVE:The purpose of the present study was to test the anticonvulsant effects of an essential fatty acid mixture containing linoleic and alpha-linolenic acids at a 4:1 ratio ...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2006.05.011

    authors: Taha AY,Baghiu BM,Lui R,Nylen K,Ma DW,Burnham WM

    更新日期:2006-09-01 00:00:00

  • Treatment of paediatric epilepsy in Germany: antiepileptic drug utilisation in children and adolescents with a focus on new antiepileptic drugs.

    abstract:BACKGROUND:Treatment of paediatric epilepsy has advanced with the development of new antiepileptic drugs (AEDs). There are few data for Germany to which extent new AEDs are used in the treatment of childhood epilepsy. AIMS:To characterise utilisation of antiepileptics in children and adolescents with a specific emphas...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2012.06.008

    authors: Dörks M,Langner I,Timmer A,Garbe E

    更新日期:2013-01-01 00:00:00

  • Chronic treatment with diazepam or the inverse benzodiazepine receptor agonist FG 7142 causes differential changes in the effects of GABA receptor stimulation.

    abstract::Daily treatment of mice with diazepam leads to the development of tolerance to the anxiolytic and anticonvulsant effect of the benzodiazepine, while daily treatment with the proconvulsant benzodiazepine receptor inverse agonist FG 7142 produces sensitization to its effects in that seizures develop (chemical kindling)....

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/0920-1211(88)90016-2

    authors: Löscher W,Stephens DN

    更新日期:1988-07-01 00:00:00

  • Regional homogeneity (ReHo) changes in new onset versus chronic benign epilepsy of childhood with centrotemporal spikes (BECTS): A resting state fMRI study.

    abstract:OBJECTIVE:The purpose of this study was to investigate regional homogeneity (ReHo) in children with new-onset drug-naïve Benign Epilepsy with Centrotemporal Spikes (BECTS), chronic BECTS and healthy controls (HC) using the Regional Homogeneity (ReHo) method applied to resting state fMRI data. METHODS:Resting state fMR...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2015.06.017

    authors: Zeng H,Ramos CG,Nair VA,Hu Y,Liao J,La C,Chen L,Gan Y,Wen F,Hermann B,Prabhakaran V

    更新日期:2015-10-01 00:00:00

  • Epileptogenic networks in seizures arising from motor systems.

    abstract::Classification of seizures arising from the cortical motor system classically distinguishes between primary motor seizures and supplementary motor area (SMA) seizures. With the aim of better characterizing the underlying networks of motor seizures, we quantitatively studied the "epileptogenicity" of brain structures i...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2013.04.011

    authors: Bonini F,McGonigal A,Wendling F,Régis J,Scavarda D,Carron R,Chauvel P,Bartolomei F

    更新日期:2013-09-01 00:00:00

  • Spatially filtered magnetoencephalography compared with electrocorticography to identify intrinsically epileptogenic focal cortical dysplasia.

    abstract::This study was carried out to evaluate Synthetic Aperture Magnetometry-kurtosis (SAM(g(2))), a spatially filtered source localization technique in magnetoencephalography (MEG), for identification of epileptogenic areas of focal cortical dysplasia (FCD). Three children with FCD were investigated to localize the ictal o...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2008.06.006

    authors: Ishii R,Canuet L,Ochi A,Xiang J,Imai K,Chan D,Iwase M,Takeda M,Snead OC 3rd,Otsubo H

    更新日期:2008-10-01 00:00:00

  • Inhibition of different GABA transporter systems is required to attenuate epileptiform activity in the CA3 region of the immature rat hippocampus.

    abstract::GABA transporters (GATs) are an essential element of the GABAergic system, which regulate excitability in the central nervous system and are thus used as targets for anticonvulsive therapy. However, in the immature nervous system the functions of the GABAergic system and the expression profile of GATs are distinct fro...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2013.11.019

    authors: Sharopov S,Chen R,Sun H,Kolbaev SN,Kirischuk S,Luhmann HJ,Kilb W

    更新日期:2014-02-01 00:00:00

  • Reduced H3 histamine receptor binding densities in the upper layers of motor cortex in rats prone to audiogenic convulsive seizures.

    abstract::Fits of audiogenic seizures in rodents are considered as a model for generalized convulsive epilepsies in humans. The laminar distribution of the H3 histamine receptor binding densities was quantified in the motor cortex of two strains of rats with genetically determined generalized epilepsies, namely KM rats with aud...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2020.106543

    authors: Midzyanovskaya IS,Petrenko TE,Birioukova LM,Tuomisto LM

    更新日期:2020-12-25 00:00:00

  • Alterations in hippocampal voltage-gated calcium channel alpha 1 subunit expression patterns after kainate-induced status epilepticus in aging rats.

    abstract::Young adult and aged male Fisher 344 rats underwent kainate-induced convulsive status epilepticus (SE) for 4 h prior to sacrifice to determine potential aging-related differences in the effect of prolonged SE on the expression of hippocampal voltage-gated calcium channels (VGCCs). Immunohistochemistry was performed on...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2003.10.007

    authors: Kelly KM,Ikonomovic MD,Abrahamson EE,Kharlamov EA,Hentosz TM,Armstrong DM

    更新日期:2003-11-01 00:00:00

  • Distinct absorption characteristics of oral formulations of valproic acid/divalproex available in the United States.

    abstract::Five oral formulations of valproic acid (VPA)/divalproex sodium are approved and commonly used in the US for treatment of epilepsy, mania/bipolar disorder and migraine prophylaxis. These formulations have unique pharmacokinetic and formulation characteristics and are designed to treat distinct patient populations. We ...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2006.11.005

    authors: Dutta S,Reed RC

    更新日期:2007-03-01 00:00:00

  • Electrocorticographic events from long-term ambulatory brain recordings can potentially supplement seizure diaries.

    abstract:PURPOSE:To determine the feasibility of using epileptiform events detected by continuous electrocorticographic monitoring via a brain-responsive neurostimulation system to supplement patient-maintained seizure diaries. METHODS:Data were retrospectively analyzed from a randomized controlled trial of brain-responsive ne...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2020.106302

    authors: Quigg M,Skarpaas TL,Spencer DC,Fountain NB,Jarosiewicz B,Morrell MJ

    更新日期:2020-03-01 00:00:00