Abstract:
OBJECTIVE:Recent studies have suggested that the early introduction of a ketogenic diet (KD) could improve seizure control in myoclono-astatic epilepsy (MAE). This multicenter study sought to identify the benefits of KD use on seizure control and epilepsy and on developmental outcomes in children with resistant MAE. METHODS:Fifty children who were diagnosed with severe MAE in the French network of Reference Centers for Rare Epilepsies and who were treated with KD between 2000 and 2013 were included in this study. The seizure frequency and EEG recordings were assessed two weeks before KD introduction, 2 and 6 months after, and during the last follow-up, which also included an assessment of developmental outcome. RESULTS:Patients had a median follow up of 52 months (range 13-136) and received 4.3 antiepileptic drugs [2-9] before KD introduction. Fifty-four percent (54%) of our patients were seizure-free after 6 months of KD or more, and 86% experienced more than a 70% seizure reduction after 2 months of KD. Forty-four percent (44%) of them had a clear benefit of early KD treatment (after four AEDs failed). Early KD treatment did not result in a greater seizure reduction (p=0.055), but significantly resulted in remission (p<0.028). Fifty percent of patients with resistant MAE had normal development outcomes. Earlier KD treatment, after three AEDs failed, was correlated with a better cognitive outcome (p<0.01). SIGNIFICANCE:Early introduction of KD treatment in resistant MAE has a strong, persistent anticonvulsant effect with long-term remission and better cognitive outcomes.
journal_name
Epilepsy Resjournal_title
Epilepsy researchauthors
Stenger E,Schaeffer M,Cances C,Motte J,Auvin S,Ville D,Maurey H,Nabbout R,de Saint-Martin Adoi
10.1016/j.eplepsyres.2017.02.005subject
Has Abstractpub_date
2017-03-01 00:00:00pages
64-69eissn
0920-1211issn
1872-6844pii
S0920-1211(17)30080-3journal_volume
131pub_type
杂志文章,多中心研究abstract::Cranial MRI has been shown to be a safe procedure in patients with a vagus nerve stimulator (VNS), but body MRI may cause overheating of the stimulator lead. Here we report a case of a patient with an implanted vagus nerve stimulator who required a cervical spinal MRI due to a rapidly progressive paraparesis. The spin...
journal_title:Epilepsy research
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journal_title:Epilepsy research
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Epilepsy research
pub_type: 杂志文章,评审
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journal_title:Epilepsy research
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
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journal_title:Epilepsy research
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/j.eplepsyres.2008.11.001
更新日期:2009-02-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章,评审
doi:10.1016/j.eplepsyres.2010.09.003
更新日期:2011-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:Epilepsy research
pub_type: 杂志文章
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更新日期:2008-12-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/j.eplepsyres.2011.05.015
更新日期:2011-09-01 00:00:00
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journal_title:Epilepsy research
pub_type: 临床试验,杂志文章,meta分析,随机对照试验
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更新日期:2005-03-01 00:00:00
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journal_title:Epilepsy research
pub_type: 杂志文章
doi:10.1016/j.eplepsyres.2010.02.001
更新日期:2010-05-01 00:00:00