Are some idiopathic epilepsies disorders of ion channels?: A working hypothesis.


:Epilepsy is a common neurological disease and encompasses a variety of disorders with paroxysms. Although there is a genetic component in the pathogenesis of epilepsy, the molecular mechanisms of this syndrome remains poorly understood. Linkage analysis and positional cloning have not been sufficient tools for determining the pathogenic mechanisms of common idiopathic epilepsies, and hence, novel approaches, based on the etiology of epilepsy, are necessary. Recently, many paroxysmal disorders, including, epilepsy, have been considered to be due to ion channel abnormalities or channelopathies. Results of recent studies employing gene analysis in animal models of epilepsy and human familial epilepsies support the hypothesis that at least some of the so called idiopathic epilepsies, i.e. epilepsies currently, classified as idiopathic could be considered as a channelopathy. This hypothesis is consistent with the putative prerequisites for genes responsible for the majority of idiopathic epilepsies that can adequately explain the following characteristics of epilepsy. Neuronal hyperexcitability, dominant inheritance with various penetrance, pharmacological role of some conventional antiepileptic drugs, age dependency in the onset of epilepsy, and the involvement of genetic factors in the pathogenesis of post-traumatic epilepsy. Search for mutations in ion channels expressed in the central nervous system may help in finding defects underlying some of idiopathic epilepsies, thereby enhancing, our understanding of the molecular pathogenesis of epilepsy. A working hypothesis to view certain idiopathic epilepsies as disorders of ion channels should provide a new insight to our understanding of epilepsy and allow the design of novel therapies.


Epilepsy Res


Epilepsy research


Hirose S,Okada M,Kaneko S,Mitsudome A




Has Abstract


2000-10-01 00:00:00














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    journal_title:Epilepsy research

    pub_type: 杂志文章,评审


    authors: Lux AL,Osborne JP

    更新日期:2006-08-01 00:00:00

  • Increased membrane shedding--indicated by an elevation of CD133-enriched membrane particles--into the CSF in partial epilepsy.

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    authors: Huttner HB,Corbeil D,Thirmeyer C,Coras R,Köhrmann M,Mauer C,Kuramatsu JB,Kloska SP,Doerfler A,Weigel D,Klucken J,Winkler J,Pauli E,Schwab S,Hamer HM,Kasper BS

    更新日期:2012-03-01 00:00:00

  • Gabapentin bioavailability: effect of dose and frequency of administration in adult patients with epilepsy.

    abstract:UNLABELLED:Gabapentin (GBP) is a non-metabolized antiepileptic drug that is eliminated by renal excretion and displays saturable, dose dependent absorption. The recommended dosing schedule for GBP is t.i.d. At large daily doses, oral bioavailability (F) may be improved by giving the daily dose more frequently. OBJECTI...

    journal_title:Epilepsy research

    pub_type: 临床试验,杂志文章


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    更新日期:1998-07-01 00:00:00

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    abstract::Post-stroke paroxysmal activity is a neurophysiological indicator of epileptogenesis and increase of seizure susceptibility, so treatments with neuroprotective activity and anti-paroxysmal activity can be more beneficial during post-ischemic period. The goal of this study was evaluation of levetiracetam (100 mg/kg, 7 ...

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    authors: Litvinova SA,Kutepova IS,Voronina TA,Petrunina АА

    更新日期:2020-11-01 00:00:00

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    pub_type: 杂志文章,评审


    authors: Zuberi SM,O'Regan ME

    更新日期:2006-08-01 00:00:00

  • Cannabis for refractory epilepsy in children: A review focusing on CDKL5 Deficiency Disorder.

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    pub_type: 杂志文章,评审


    authors: Dale T,Downs J,Olson H,Bergin AM,Smith S,Leonard H

    更新日期:2019-03-01 00:00:00

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    pub_type: 杂志文章


    authors: Koo DL,Joo EY,Kim D,Hong SB

    更新日期:2013-03-01 00:00:00

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    pub_type: 杂志文章


    authors: Scorzin JE,Kaaden S,Quesada CM,Müller CA,Fimmers R,Urbach H,Schramm J

    更新日期:2008-11-01 00:00:00

  • Effects of vitamin D and paricalcitol on epileptogenesis and behavioral properties of WAG/Rij rats with absence epilepsy.

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    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Aygun H,Ayyildiz M,Agar E

    更新日期:2019-11-01 00:00:00

  • Anticonvulsant Effects of Thalidomide on Pentylenetetrazole-Induced Seizure in Mice: A Role for Opioidergic and Nitrergic Transmissions.

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    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Pourshadi N,Rahimi N,Ghasemi M,Faghir-Ghanesefat H,Sharifzadeh M,Dehpour AR

    更新日期:2020-08-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:2014-12-01 00:00:00

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    pub_type: 杂志文章,随机对照试验


    authors: Rogathe JJ,Todd J,Hunter E,Walker R,Ngugi A,Newton C,Burton K

    更新日期:2014-10-01 00:00:00

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    pub_type: 杂志文章


    authors: Warner TA,Liu Z,Macdonald RL,Kang JQ

    更新日期:2017-08-01 00:00:00

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    pub_type: 杂志文章


    authors: Caulder EH,Riegle MA,Godwin DW

    更新日期:2014-02-01 00:00:00

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    pub_type: 杂志文章


    authors: Gómez-Lira G,Mendoza-Torreblanca JG,Granados-Rojas L

    更新日期:2011-09-01 00:00:00

  • Spatiotemporal mapping of interictal epileptiform discharges in human absence epilepsy: A MEG study.

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    pub_type: 杂志文章


    authors: Rozendaal YJ,van Luijtelaar G,Ossenblok PP

    更新日期:2016-01-01 00:00:00

  • Predictive value of hippocampal internal architecture asymmetry in temporal lobe epilepsy.

    abstract:BACKGROUND:Asymmetry of hippocampal internal architecture (HIA) clarity has been suggested to be a sign of hippocampal sclerosis (HS) and is frequently associated with other MRI findings of HS. The goal of this work is to use a previously developed HIA visual scoring system (Ver Hoef et al., 2013) to quantify HIA asymm...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Ver Hoef LW,Williams FB,Kennedy RE,Szaflarski JP,Knowlton RC

    更新日期:2013-09-01 00:00:00

  • Evolution of neuropsychological changes after partial callosotomy in intractable epilepsy.

    abstract::Early neuropsychological changes following partial anterior callosotomy were evaluated in 15 patients with epilepsy (10 secondary generalized and 5 Lennox-Gastaut syndromes) by comparing their performances 1 month before surgery and then 15-20 and 90-100 days postoperatively without modifying the anticonvulsant treatm...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Provinciali L,Del Pesce M,Censori B,Quattrini A,Paggi A,Ortenzi A,Mancini S,Papo I,Rychlicki F

    更新日期:1990-07-01 00:00:00

  • Optimised interictal HMPAO-SPECT in the evaluation of partial epilepsies.

    abstract::Interictal blood flow single photon emission computed tomography (SPECT) has been considered to be of limited value in the investigation of patients with partial epilepsies. Newer SPECT technologies using brain dedicated multiple detector systems have not been fully evaluated. To study the usefulness of an optimized S...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Schmitz EB,Costa DC,Jackson GD,Moriarty J,Duncan JS,Trimble MR,Ell PJ

    更新日期:1995-06-01 00:00:00

  • Historical trend toward improved long-term outcome in childhood absence epilepsy.

    abstract::We retrospectively analyzed published studies to investigate historical trends in outcome of childhood absence epilepsy (CAE). We included patients based on onset of absence seizures in childhood, 3 Hz bilateral spike-wave discharges on EEG, and availability of seizure-free outcome data. The primary endpoint was seizu...

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    pub_type: 历史文章,杂志文章,meta分析


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    更新日期:2019-05-01 00:00:00

  • Dysregulation of microRNA-128 expression in WHO grades 2 glioma is associated with glioma-associated epilepsy: Down-regulation of miR-128 induces glioma-associated seizure.

    abstract:OBJECTIVE:Approximately 80% of glioma patients will experience at least one seizure activity during the course of the disease, and because the etiology of glioma-related seizure is most likely multifactorial and complex, it remains poorly understood. MicroRNAs are a class of small noncoding RNAs that function as critic...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Yuan Y,Xiang W,Yanhui L,Ruofei L,Yunhe M,Jiewen L,Qing M

    更新日期:2016-11-01 00:00:00

  • Inhalation of 10% carbon dioxide rapidly terminates Scn1a mutation-related hyperthermia-induced seizures.

    abstract::The aim of this study was to assess the anticonvulsant effect of carbon dioxide (CO2) on Scn1a mutation-related febrile seizures. We examined physiological changes in the blood gas levels after the induction of hyperthermia-induced seizures (HISs), which were associated with the Scn1a missense mutation. We determined ...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Ohmori I,Hayashi K,Wang H,Ouchida M,Fujita N,Inoue T,Michiue H,Nishiki T,Matsui H

    更新日期:2013-07-01 00:00:00

  • Successful radiofrequency ablation of the cerebral cortex in pigs using the venous system: possible implications for treating CNS disorders.

    abstract:BACKGROUND:When pharmacotherapy for epilepsy fails, surgical options, although efficacious, are highly invasive. We explored whether ablation of the cerebral cortex can be performed utilizing the cerebral venous system. METHODS:Mapping and radiofrequency ablation was performed via the venous system in two pigs. RESUL...

    journal_title:Epilepsy research

    pub_type: 杂志文章


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    更新日期:2008-08-01 00:00:00

  • Ketogenic diet increases calbindin-D28k in the hippocampi of male ICR mice with kainic acid seizures.

    abstract::The ketogenic diet (KD) increased the expression of calbindin-D(28k) (CB) in the interneurons of the hippocampus compared with the normal diet (ND)-fed mice. Also, 2 days after kainic acid (KA) administration, numerous CB-expressing astrocytes were found in the KD-fed mice compared with those of the ND-fed mice. These...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Noh HS,Kang SS,Kim DW,Kim YH,Park CH,Han JY,Cho GJ,Choi WS

    更新日期:2005-07-01 00:00:00

  • Preclinical characterization of MDL 27,192 as a potential broad spectrum anticonvulsant agent with neuroprotective properties.

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    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Kehne JH,Kane JM,Chaney SF,Hurst G,McCloskey TC,Petty MA,Senyah Y,Wolf HH,Zobrist R,White HS

    更新日期:1997-04-01 00:00:00

  • The sleep-deprived brain in normals and patients with juvenile myoclonic epilepsy: a perturbational approach to measuring cortical reactivity.

    abstract::Simultaneous electroencephalography-transcranial magnetic stimulation (EEG-TMS) investigates cortical reactivity to external perturbations. TMS evoked potentials (TEPs) have been described in normals during sleep and wake but not after sleep deprivation or in pathologically enhanced excitability, i.e., epilepsy. The a...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Del Felice A,Fiaschi A,Bongiovanni GL,Savazzi S,Manganotti P

    更新日期:2011-09-01 00:00:00

  • Neuroprotective effect of Nrf2 activator dimethyl fumarate, on the hippocampal neurons in chemical kindling model in rat.

    abstract:BACKGROUND:Nuclear factor erythroid-2 related factor 2 (Nrf2) is a transcription factor, which activates the anti-oxidative stress response pathway. In epilepsy, oxidative stress is one of the key factors in the progression of the disease. So, the neuroprotective role of dimethyl fumarate (DMF), a Nrf2 pathway activato...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Singh N,Vijayanti S,Saha L,Bhatia A,Banerjee D,Chakrabarti A

    更新日期:2018-07-01 00:00:00

  • Age-dependent anticonvulsant action of antagonists of group I glutamate metabotropic receptors in rats.

    abstract:SUMMARY:Metabotropic glutamate receptors (mGluR) may represent a perspective target for anticonvulsant therapy but spectrum of their anticonvulsant effects is not sufficiently known. Our study was aimed at comparison of anticonvulsant actions of antagonists of mGluR1 and mGluR5 subtypes in immature rats. Seven-, 12-, 1...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Mares P

    更新日期:2009-02-01 00:00:00

  • Smartphone applications for seizure care and management in children and adolescents with epilepsy: Feasibility and acceptability assessment among caregivers in China.

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    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Liu X,Wang R,Zhou D,Hong Z

    更新日期:2016-11-01 00:00:00

  • Alterations in hippocampal voltage-gated calcium channel alpha 1 subunit expression patterns after kainate-induced status epilepticus in aging rats.

    abstract::Young adult and aged male Fisher 344 rats underwent kainate-induced convulsive status epilepticus (SE) for 4 h prior to sacrifice to determine potential aging-related differences in the effect of prolonged SE on the expression of hippocampal voltage-gated calcium channels (VGCCs). Immunohistochemistry was performed on...

    journal_title:Epilepsy research

    pub_type: 杂志文章


    authors: Kelly KM,Ikonomovic MD,Abrahamson EE,Kharlamov EA,Hentosz TM,Armstrong DM

    更新日期:2003-11-01 00:00:00