Seizure anticipation by patients with focal and generalized epilepsy: a multicentre assessment of premonitory symptoms.

Abstract:

PURPOSE:To assess subjective seizure anticipation in patients with focal and generalized epilepsy. METHODS:Five hundred consecutively recruited out-patients (251 male, 249 female, mean age 38.1 year) from three German tertiary epilepsy referral centres filled out questionnaires regarding subjective anticipation of seizures by at least 30 min and to timing and semiologic characteristics of their premonitory symptoms versus those of ictal phenomena. Patients were not regarded as having prodromi if the semiology of symptoms reported long before a seizure was identical to auras. RESULTS:6.2% of patients reported that they were able to anticipate seizures. Premonitory symptoms were classified as stereotyped in all but one patient. An intraindividual semiologic analysis showed that the majority of these patients had symptoms, which were distinct from ictal experiences during auras. Seizure anticipation was reported both by patients with focal and idiopathic generalized epilepsy. The median estimated time interval between occurrence of premonitory symptoms and seizure onset was 90 min. CONCLUSIONS:This study gives evidence that both patients with focal and idiopathic generalized epilepsy may subjectively anticipate the occurrence of epileptic seizures. Premonitory symptoms are distinct from auras in terms of semiology and time of occurrence. The lower percentage of patients regarded as having premonitory symptoms as compared to some earlier reports may be related to stricter criteria and to the exclusion of auras, which could directly evolve into seizures, and other ictal events. Premonitory symptoms occur at similar periods prior to seizures as anticipatory EEG-changes have been reported using methods from time series analysis.

journal_name

Epilepsy Res

journal_title

Epilepsy research

authors

Schulze-Bonhage A,Kurth C,Carius A,Steinhoff BJ,Mayer T

doi

10.1016/j.eplepsyres.2006.02.001

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

83-8

issue

1

eissn

0920-1211

issn

1872-6844

pii

S0920-1211(06)00060-X

journal_volume

70

pub_type

杂志文章,多中心研究
  • Bupropion-induced convulsions: preclinical evaluation of antiepileptic drugs.

    abstract::Bupropion, a unique, non-nicotine smoking cessation aid and an effective antidepressant, is well known to produce seizures following overdosing in humans. However, the experimental background for the usefulness of antiepileptic drugs in the protection against bupropion-induced convulsions has not been established yet....

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2005.01.006

    authors: Tutka P,Mróz T,Klucha K,Piekarczyk M,Wielosz M

    更新日期:2005-03-01 00:00:00

  • Unilateral cortical spreading depression is an early marker of audiogenic kindling in awake rats.

    abstract::Spreading depression (SD), a self-propagating wave of reversible cellular depolarization, is thought to play an important role in brain pathophysiology. SD and seizures are closely related events but little is known about involvement of SD in chronic epileptogenesis. Here we show that cortical SD is the first and high...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2006.05.014

    authors: Vinogradova LV,Vinogradov VY,Kuznetsova GD

    更新日期:2006-09-01 00:00:00

  • Differential sensitivity to inverse agonists of GABA(A)/benzodiazepine receptors in rats with genetic absence-epilepsy.

    abstract::A strain of Wistar rats, genetic absence epilepsy rats from Strasbourg (GAERS), was selected and inbred over 40 generations for occurrence of spontaneous spike-wave discharges characteristic of absence seizures, simultaneously with a strain of non-epileptic rats (NER). GAERS demonstrate an excessive sensitivity to ant...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/s0920-1211(01)00292-3

    authors: Vergnes M,Boehrer A,He X,Greney H,Dontenwill M,Cook J,Marescaux C

    更新日期:2001-11-01 00:00:00

  • Focal features in patients with idiopathic generalized epilepsy.

    abstract:PURPOSE:The stringent dichotomy between focal and generalized epilepsies has become a contentious issue, since neuropathological studies as well as structural and functional imaging data hypothesized the existence of focal brain abnormalities in patients with well-documented idiopathic generalized epilepsy. The aim of ...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/s0920-1211(02)00084-0

    authors: Leutmezer F,Lurger S,Baumgartner C

    更新日期:2002-08-01 00:00:00

  • Anticonvulsant efficacy of melatonin in an experimental model of hyperthermic febrile seizures.

    abstract:INTRODUCTION:The anticonvulsant effects of melatonin (MT) have been demonstrated in several different experimental seizure models. Thus, the present study aimed to determine the anticonvulsant efficacy of MT, the optimum time for its administration prior to the induction of a seizure, and its effective dose in a rat mo...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2015.11.004

    authors: Aydin L,Gundogan NU,Yazici C

    更新日期:2015-12-01 00:00:00

  • Can a generalized kindling seizure induce a reward state?

    abstract::The postictal behavioral depression (PBD), characterized by behavioral immobility and unresponsiveness to environmental stimuli, observed after a stage 5 kindling seizure is opioid dependent. Morphine injection prolongs while naloxone and naltrexone (opioid antagonists) reduce or eliminate PBD. Opioids have clear rewa...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/s0920-1211(99)00101-1

    authors: Paredes RG,Muzzi G,Aguirre E,Romero V

    更新日期:2000-02-01 00:00:00

  • Potential delays in referral and assessment for epilepsy surgery in children with drug-resistant, early-onset epilepsy.

    abstract:OBJECTIVE:To study potential delays in epilepsy surgery in children with drug-resistant epilepsy (DRE) of early-onset. METHODS:Medical records were reviewed from 87 children with DRE and seizure onset before age 3 years who underwent epilepsy surgery between 2006 and 2015. Information was obtained about each child's e...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2018.04.001

    authors: Prideaux L,Barton S,Maixner W,Harvey AS

    更新日期:2018-07-01 00:00:00

  • Patient-specific bivariate-synchrony-based seizure prediction for short prediction horizons.

    abstract::This paper evaluates the patient-specific seizure prediction performance of pre-ictal changes in bivariate-synchrony between pairs of intracranial electroencephalographic (iEEG) signals within 15min of a seizure in patients with pharmacoresistant focal epilepsy. Prediction horizons under 15min reduce the durations of ...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2010.07.014

    authors: Kuhlmann L,Freestone D,Lai A,Burkitt AN,Fuller K,Grayden DB,Seiderer L,Vogrin S,Mareels IM,Cook MJ

    更新日期:2010-10-01 00:00:00

  • No association found between polymorphisms in genes encoding mGluR7 and mGluR8 and idiopathic generalised epilepsy in a case control study.

    abstract::The genes of two group III metabotropic glutamate receptors, mGluR7 and 8, are candidate susceptibility genes for epilepsy. The Tyr433Phe polymorphism of mGluR7 and a novel polymorphism in the mGluR8 gene located 29 bp after the termination codon (2756C/T) were investigated in case control association studies performe...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/s0920-1211(99)00096-0

    authors: Goodwin H,Curran N,Chioza B,Blower J,Nashef L,Asherson P,Makoff AJ

    更新日期:2000-03-01 00:00:00

  • The neuronal excitability time-dependently changes after lipopolysaccharide administration in mice: possible role of cyclooxygenase-2 induction.

    abstract::The parameters of pentylenetetrazol (PTZ)-induced seizures have been evaluated at various time intervals after lipopolysaccharide (LPS; Escherichia coli O111:B4, 100 microg/kg, i.p.) administration in mice. A proconvulsant effect occurred 4h after LPS injection with decreased seizure latency and enhanced seizure inten...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2006.06.009

    authors: Akarsu ES,Ozdayi S,Algan E,Ulupinar F

    更新日期:2006-10-01 00:00:00

  • Pharmacometrics of clobazam in pediatrics: Prediction of effective clobazam doses for Dravet syndrome.

    abstract:OBJECTIVE:To describe the use of a population pharmacokinetic (PopPK) model incorporating weight and ontogeny to identify effective clobazam (CLB) dosing for use in a clinical trial in pediatric patients with Dravet syndrome. METHODS:Pharmacokinetic data were combined from 3 CLB trials (OV-1012, OV-1017, and study 301...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2019.106182

    authors: Tolbert D,Chu HM,Ette EI

    更新日期:2019-11-01 00:00:00

  • Developmental outcome in benign myoclonic epilepsy in infancy and reflex myoclonic epilepsy in infancy: a literature review and six new cases.

    abstract::Benign myoclonic epilepsy in infancy is a rare syndrome with just over 100 cases reported since the first syndromic description by Dravet and Bureau [Dravet, C., Bureau, M., 1981. The benign myoclonic epilepsy of infancy. Rev. Elecroencephalogr. Neurophysiol. Clin. 11, 438-444]. This includes 23 infants with reflex my...

    journal_title:Epilepsy research

    pub_type: 杂志文章,评审

    doi:10.1016/j.eplepsyres.2006.01.014

    authors: Zuberi SM,O'Regan ME

    更新日期:2006-08-01 00:00:00

  • Effect of levetiracetam on the pharmacokinetics of adjunctive antiepileptic drugs: a pooled analysis of data from randomized clinical trials.

    abstract::The purpose of this study was to determine the influence of levetiracetam on the steady-state serum concentrations of other commonly used antiepileptic drugs (AEDs). Serum AED concentrations were measured at baseline and after adjunctive therapy with levetiracetam (1000-4000 mg/day) or placebo in four phase III trials...

    journal_title:Epilepsy research

    pub_type: 临床试验,杂志文章,meta分析,随机对照试验

    doi:10.1016/j.eplepsyres.2005.01.005

    authors: Gidal BE,Baltès E,Otoul C,Perucca E

    更新日期:2005-03-01 00:00:00

  • Opioid peptide systems following a subconvulsant dose of pentylenetetrazol in rats.

    abstract::The development of epilepsy and a progressive increase in susceptibility to seizures may involve changes in inhibitory and excitatory systems from the beginning of the process. The present study was focused to analyze the opioid peptide changes induced by a chemical sub-convulsant stimulation. Experiments were carried...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/s0920-1211(99)00056-x

    authors: Rocha L,Cano A,Cruz C,Omaña-Zapata I,Villalobos R,Maidment NT

    更新日期:1999-11-01 00:00:00

  • Valproate and palmitate binding to serum albumin in valproate-treated patients. Relation to obesity.

    abstract::Binding of valproate and palmitate to serum albumin was studied in 29 valproate-treated epileptic patients. The results were compared with similar observations in a reference group of 43 non valproate-treated individuals. The binding affinity for palmitate was decreased (P < 0.0001) resulting in increased availability...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/0920-1211(93)90040-e

    authors: Vorum H,Gram L,Honoré B

    更新日期:1993-09-01 00:00:00

  • Functional hemispherectomy in children with epilepsy and CSWS due to unilateral early brain injury including thalamus: sudden recovery of CSWS.

    abstract:PURPOSE:To try to prove in patients with refractory symptomatic epilepsy due to early brain injury involving thalamus and complicated by CSWS the effects of the isolation of the injured hemisphere, performed with functional hemisperectomy, on epilepsy, namely on CSWS. METHODS:Full clinical follow-up before and after s...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2009.09.014

    authors: Battaglia D,Veggiotti P,Lettori D,Tamburrini G,Tartaglione T,Graziano A,Veredice C,Sacco A,Chieffo D,Pecoraro A,Colosimo C,Di Rocco C,Dravet Ch,Guzzetta F

    更新日期:2009-12-01 00:00:00

  • Etiology and site of temporal lobe epilepsy influence postictal cytokine release.

    abstract::Inflammatory mechanisms are involved in the pathogenesis of epilepsy. Vice versa, immune functions are regulated by the brain. We measured postictal changes in serum levels of the immuno-modulating cytokines IL-1beta, IL-6 and TNFalpha in patients with well-defined temporal lobe epilepsy (TLE) and determined modifying...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2009.05.009

    authors: Bauer S,Cepok S,Todorova-Rudolph A,Nowak M,Köller M,Lorenz R,Oertel WH,Rosenow F,Hemmer B,Hamer HM

    更新日期:2009-09-01 00:00:00

  • Testing broad-spectrum and isoform-preferring HCN channel blockers for anticonvulsant properties in mice.

    abstract::Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels have been implicated in the pathogenesis of epilepsy and consequently as targets for anticonvulsant drugs. Consistent with this, broad-spectrum block of HCN-mediated current (Ih) reduces seizure susceptibility in a variety of epilepsy models. However, ...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2020.106484

    authors: Kharouf Q,Pinares-Garcia P,Romanelli MN,Reid CA

    更新日期:2020-12-01 00:00:00

  • Administration of diazepam during status epilepticus reduces development and severity of epilepsy in rat.

    abstract::Prevention of epileptogenesis after brain insults, such as status epilepticus (SE), head trauma, or stroke, remains a challenge. Even if epilepsy cannot be prevented, it would be beneficial if the pathologic process could be modified to result in a less severe disease. We examined whether early discontinuation of SE r...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2004.10.003

    authors: Pitkänen A,Kharatishvili I,Narkilahti S,Lukasiuk K,Nissinen J

    更新日期:2005-01-01 00:00:00

  • Pharmacokinetics, exposure-cognition, and exposure-efficacy relationships of perampanel in adolescents with inadequately controlled partial-onset seizures.

    abstract:OBJECTIVE:To characterize, in adolescents aged 12-17, the pharmacokinetic (PK) profile of perampanel, the impact of intrinsic and extrinsic factors on PK, and the relationships between perampanel exposure and cognitive function, seizure frequency, and responder status. METHODS:Population PK analysis used plasma concen...

    journal_title:Epilepsy research

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.eplepsyres.2016.08.025

    authors: Villanueva V,Majid O,Nabangchang C,Yang H,Laurenza A,Ferry J,Hussein Z

    更新日期:2016-11-01 00:00:00

  • GC-MS-Based metabolomics discovers a shared serum metabolic characteristic among three types of epileptic seizures.

    abstract:OBJECTIVE:Understanding the overall and common metabolic changes of seizures can provide novel clues for their control and prevention. Here, we aim to investigate the global metabolic feature of serum for three types of seizures. METHODS:We recruited 27 patients who had experienced a seizure within 48h (including 11 w...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2016.07.003

    authors: Wang D,Wang X,Kong J,Wu J,Lai M

    更新日期:2016-10-01 00:00:00

  • Use of dietary and herbal supplements in adult patients with epilepsy.

    abstract:PURPOSE:To study the extent and characteristics of dietary and herbal supplements use in a large cohort of adult patients with epilepsy. METHODS:This prospective study included 490 patients receiving care at a university epilepsy clinic. A number of variables, including demographics, characteristics of epilepsy and it...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2019.106168

    authors: Bosak M,Mołek P,Słowik A

    更新日期:2019-10-01 00:00:00

  • Involvement of α4β2 nicotinic acetylcholine receptors in working memory impairment induced by repeated electroconvulsive seizures in rats.

    abstract::A role of cholinergic nervous system in the behavioral impairments induced by repeated ECS is not understood. The α4β2 nicotinic acetylcholine receptor (nAChR) agonist ABT-418, but not the α7 nAChR agonist, significantly ameliorated the impairment of spontaneous alternation behavior in the Y-maze test. And, repeated E...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2012.09.017

    authors: Hidaka N,Suemaru K,Kato Y,Araki H

    更新日期:2013-03-01 00:00:00

  • How trial designs impact on guidelines.

    abstract::Evidence-based treatment guidelines and practice parameters have been developed in most areas of medicine. They are important because insurance companies, formulary managers, and health maintenance organizations rely on guidelines for formulary and coverage decisions. The methodology for practice parameter development...

    journal_title:Epilepsy research

    pub_type: 杂志文章,评审

    doi:10.1016/j.eplepsyres.2005.09.021

    authors: French JA

    更新日期:2006-01-01 00:00:00

  • Introduction to zonisamide.

    abstract::Zonisamide (Zonegran), a novel antiepileptic drug (AED) approved recently in Europe as adjunctive therapy for refractory partial seizures in adults, has been used extensively in Japan and the United States. A substantial body of clinical experience has accumulated over a 14-year period, allowing the properties and pha...

    journal_title:Epilepsy research

    pub_type: 杂志文章,评审

    doi:10.1016/j.eplepsyres.2005.11.004

    authors: Baulac M

    更新日期:2006-02-01 00:00:00

  • Depression in patients with temporal lobe epilepsy is related to mesial temporal sclerosis.

    abstract::Depression is a frequent psychiatric symptom in epilepsy and has been related to epilepsy of temporal origin, especially of left-sided foci. No study differentiated the precise localization of the epileptogenic lesion within the temporal lobe. Regarding this issue, we evaluated depression assessed by the Beck Depressi...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/s0920-1211(99)00117-5

    authors: Quiske A,Helmstaedter C,Lux S,Elger CE

    更新日期:2000-04-01 00:00:00

  • Effects of seizures and carbamazepine on interictal spiking in amygdala kindled cats.

    abstract::We examined the influence of seizures and carbamazepine (CBZ) on spiking rates in kindled cats. In the first experiment, spiking rates were measured before and after seizures, with and without CBZ. CBZ was administered immediately after seizures in order not to affect them. Spiking rates were measured over 9 h during ...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/0920-1211(91)90065-n

    authors: Gigli GL,Gotman J

    更新日期:1991-04-01 00:00:00

  • Altered extrafocal iomazenil activity in mesial temporal lobe epilepsy.

    abstract::To investigate involvement of extrafocal regions in mesial temporal lobe epilepsy (MTLE), we retrospectively explored abnormalities in distribution of iomazenil (IMZ) activity by identifying interhemispheric asymmetry on IMZ-SPECT images of patients with MTLE. Fourteen MTLE patients in whom a good surgical outcome was...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2012.07.001

    authors: Hosomi K,Kishima H,Oshino S,Hirata M,Tani N,Maruo T,Khoo HM,Shimosegawa E,Hatazawa J,Kato A,Yoshimine T

    更新日期:2013-02-01 00:00:00

  • Suppression of inter-ictal spikes by CM40907. A double-blind placebo-controlled investigation and review of spike counting as a methodology for assessing the antiepileptic effect of drugs.

    abstract::To assess the efficacy of CM40907--a new antiepileptic drug--in suppressing inter-ictal spikes, 6 patients with severe intractable epilepsy and frequent spikes in their inter-ictal EEGs were entered in a double-blind placebo-controlled trial. The results show that CM40907 is efficacious in reducing spike counts in the...

    journal_title:Epilepsy research

    pub_type: 临床试验,杂志文章

    doi:10.1016/0920-1211(90)90046-x

    authors: Yepez-Lasso R,Duncan JS,Shorvon SD

    更新日期:1990-04-01 00:00:00

  • Anticonvulsant Effects of Thalidomide on Pentylenetetrazole-Induced Seizure in Mice: A Role for Opioidergic and Nitrergic Transmissions.

    abstract::Although accumulating evidence indicates that the immunomodulatory medication thalidomide exerts anticonvulsant properties, the mechanisms underlying such effects of thalidomide are still unknown. Our previous preclinical study suggested that nitric oxide (NO) signaling may be involved in the anticonvulsant effects of...

    journal_title:Epilepsy research

    pub_type: 杂志文章

    doi:10.1016/j.eplepsyres.2020.106362

    authors: Pourshadi N,Rahimi N,Ghasemi M,Faghir-Ghanesefat H,Sharifzadeh M,Dehpour AR

    更新日期:2020-08-01 00:00:00